scholarly journals Model to Predict Probability of Significant Skin Burn Injury From a Directed-Energy Source

2021 ◽  
Vol 186 (Supplement_1) ◽  
pp. 408-415
Author(s):  
Anthony Iyoho ◽  
Laurel J Ng
Keyword(s):  
Millimeter Wave ◽  
Dose Response ◽  
Burn Injury ◽  
The Body ◽  
Response Models ◽  
Experimental Burn ◽  
Burn Probability ◽  
Directed Energy ◽  
Significant Injury ◽  
Second Degree

ABSTRACT Introduction Millimeter wave directed energy in the frequency regime of 94-95 GHz has potential for use in numerous military applications including crowd control and area denial. Although proven to be very safe, millimeter wave energy has the potential, because of accidental over exposure, to produce significant injuries. Currently, the Dynamic Thermal Model (DTM), developed by Beason and colleagues, is used to calculate the temperature profile in skin undergoing (millimeter wave) heating, using an all-or-nothing threshold of injury. Risk of significant injury (RSI) is determined by product of the probability of an injury outcome on a region of the body times the probability of that the injury will occur. Thus, a threshold injury determination may over predict burn probability and fail safety requirements. This work augments the DTM, replacing the current threshold value of injury with a probabilistic risk of injury to better quantify the risk of significant injury. Materials and Methods In this study, continuous probabilistic dose–response models using logistic regression analysis have been developed to account for mild second-degree, deep second-degree, and third-degree burn injuries based on a historic experimental burn dataset. Statistical analysis methods such as Hosmer–Lemeshow statistics, McFadden’s pseudo R2 and receiver operator characteristic were used to validate the models against an independent experimental burn dataset. Results Comparison of logistic models fit using damage coefficients from the literature showed that Mehta and Wong provided the best fits historic burn data, which was corroborated by the McFadden pseudo R2 statistic for mild second-degree, deep second-degree, and third-degree severity. Conclusion The dose–response models developed in this study are shown to be an excellent predictor of burn injury for each severity. The DTM was repackaged with the probabilistic burn models to more accurately determine the risk of significant burn injury.

scholarly journals INDICATORS OF THE CARDIOMYOCYTES` CELLS CYCLE UNDER INFUSION OF BLOOD SUBSTITUTES AND IN THE CORRECTION OF EXPERIMENTAL BURN INJURY BY 0,9% NACL SOLUTION

2018 ◽  
Vol 24 (1) ◽  
pp. 62-68
Author(s):  
R.V. Radoga
Keyword(s):  
Cell Cycle ◽  
Burn Injury ◽  
Vena Cava ◽  
Left Ventricular ◽  
Blood Substitutes ◽  
The Body ◽  
Synthetic Activity ◽  
Myocardial Cells ◽  
Nacl Solution ◽  
Experimental Burn

According to the WHO, the thermal trauma is on the third place among other injuries. Burned injury is not only damage to the skin, but also the traumatization of all organs and systems of the body as a result of the stress response of the vascular system and the effects of toxic products coming from the area of burn injury. Firstly, such damages affect cardiomyocytes and the microcirculation vessels of the heart. The purpose of our study was to evaluate the changes in the cell cycle of myocardial cells in the left ventricle of rats under conditions of blood substitutes infusion and in the correction of experimental burn injury with a 0,9% solution of NaCl. The burn trauma was modeled using the Regas’ method and placed a catheter into the lower vena cava for intravenous infusion. The following solutions were used for infusion: 0,9% NaCl solution, lactoproteinum with sorbitol (Lactoproteinum-C) and colloidal-hyperosmolar HAES-LX-5% solution. Flow cytometry of the nuclear suspension of left ventricular cardiomyocytes was performed on the 1st, 3rd, and 7th days of the experiment. The statistical analysis of the results was carried out using the “STATISTICA 6.1” program package. The results of the performed study show a fairly stable picture of cell cycle parameters in myocardial cells of animals without burn injury with a predominance, on the one hand, of cells present in the G0G1 phase and the presence of a certain balance between the processes of creation of nuclear DNA synthesis and apoptosis. Changes in the phase of cardiac myocyte cell cycle against the background of the thermal injury of the skin throughout the observation time indicate a prolonged, uncorrected cell cycle disorder and a lack of effective normalization on the background of the physiological solution usage in the first 7 days after burning trauma of the skin. The protective effect of HAES-LX-5% prevents over-strain of cells, as evidenced by the lower synthetic activity of nuclei of cardiomyocytes at all times of the experiment.

EPIDEMIOLOGY AND OUTCOMES OF ELECTRIC BURN INJURY AT TERTIARY CARE CENTER IN JODHPUR, RAJASTHAN

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Bharti Saraswat ◽  
Ashok Yadav ◽  
Krishna Kumar Maheshwari
Keyword(s):  
Burn Injury ◽  
Low Voltage ◽  
Care Center ◽  
Tertiary Care ◽  
The Body ◽  
Electrical Injury ◽  
Age Group ◽  
Electric Circuits ◽  
Medical College ◽  
Social Burden

Background- Electric burns and injuries are the result of electric current passing through the body. Temporary or permanent damage can occur to the skin, tissues, and major organs. Methods- This prospective study was carried out on patients admitted in burn unit of department of surgery M.G. Hospital associated with Dr. S.N. Medical College Jodhpur. Records of the patients admitted from January 2018 to December 2018 were studied. Bed head tickets of the patients evaluated in detail. Results- In our study out of 113 patients maximum no. of patients were in age group of 21-30 years 44 (38.94%) followed by age group <11 years in 21 (18.58%) patients and age group of > 60 years in only 3 (2.65%).39 (34.51%) patients were farmer and 15 (13.27%) were electrician in out of 113 total patients, while 37 (32.74%) were without any occupation. 65 (57.52%) cases of high voltage (HV) electrical injury and 48 (42.48%) cases were of low voltage (LV) electrical injury. Conclusion- Morbidity leading to permanent disabilities make the person physically dependent on others. It can be prevented by educating the people about the proper handling to electric circuits & devices. Proper communication among the electricians may help in lowering such accidents. Proper rehabilitation of the handicapped person & employment to the member of the affected family may reduce the social burden caused by such electricity concerned accidents.

Clinical Utility of an Exoskeleton Robot Using 3-Dimensional Scanner Modeling in Burn Patient: A Case Report

2021 ◽  
Author(s):  
So Young Joo ◽  
Seung Yeol Lee ◽  
Yoon Soo Cho ◽  
Sangho Yi ◽  
Cheong Hoon Seo
Keyword(s):  
Burn Injury ◽  
Hand Function ◽  
Three Dimensional ◽  
The Body ◽  
3D Technology ◽  
Early Management ◽  
3 Dimensional ◽  
Exoskeleton Robot ◽  
Physical Abilities ◽  
Upper Limb Dysfunction

Abstract Hands are the part of the body that are most commonly involved in burns, and the main complications are finger joint contractures and nerve injuries. Hypertrophic scarring cannot be avoided despite early management of acute hand burn injuries, and some patients may need application of an exoskeleton robot to restore hand function. To do this, it is essential to individualize the customization of the robot for each patient. Three-dimensional (3D) technology, which is widely used in the field of implants, anatomical models, and tissue fabrication, makes this goal achievable. Therefore, this report is a study on the usefulness of an exoskeleton robot using 3D technology for patients who lost bilateral hand function due to burn injury. Our subject was a 45-year-old man with upper limb dysfunction of 560 days after a flame and chemical burn injury, with resultant impairment of manual physical abilities. After wearing an exoskeleton robot made using 3D printing technology, he could handle objects effectively and satisfactorily. This innovative approach provided considerable advantages in terms of customization of size and reduction in manufacturing time and costs, thereby showing great potential for use in patients with hand dysfunction after burn injury.

scholarly journals Weighted mixed-effects dose–response models for tables of correlated contrasts

2021 ◽  
Vol 21 (2) ◽  
pp. 320-347
Author(s):  
Nicola Orsini
Keyword(s):  
Dose Response ◽  
Response Pattern ◽  
Mixed Effects ◽  
Data Generation ◽  
Measures Of Association ◽  
Response Models ◽  
Response Data ◽  
Hazard Ratios ◽  
Health Related ◽  
Generation Mechanisms

Recognizing a dose–response pattern based on heterogeneous tables of contrasts is hard. Specification of a statistical model that can consider the possible dose–response data-generating mechanism, including its variation across studies, is crucial for statistical inference. The aim of this article is to increase the understanding of mixed-effects dose–response models suitable for tables of correlated estimates. One can use the command drmeta with additive (mean difference) and multiplicative (odds ratios, hazard ratios) measures of association. The postestimation command drmeta_graph greatly facilitates the visualization of predicted average and study-specific dose–response relationships. I illustrate applications of the drmeta command with regression splines in experimental and observational data based on nonlinear and random-effects data-generation mechanisms that can be encountered in health-related sciences.

A rat model of unilateral hindpaw burn injury: Slowly developing rightwards shift of the morphine dose–response curve

Pain ◽  
2005 ◽  
Vol 116 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Shuxing Wang ◽  
Grewo Lim ◽  
Liling Yang ◽  
Qing Zeng ◽  
Backil Sung ◽  
...  
Keyword(s):  
Dose Response ◽  
Rat Model ◽  
Response Curve ◽  
Burn Injury ◽  
Dose Response Curve ◽  
Morphine Dose

scholarly journals Comparative study of Negative Pressure Wound therapy Vs. Local antibiotic cream dressings in acute hand burns second-degree superficial to deep

2021 ◽  
pp. 28-32
Author(s):  
Ganesh Chaudhari ◽  
Satish Sonawane
Keyword(s):  
Comparative Study ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
The Body ◽  
Topical Antibiotic ◽  
Wound Therapy ◽  
Hand Part ◽  
Hand Burns ◽  
Local Antibiotic ◽  
Second Degree

Background: The hand is one of the most common parts of the body involved in burns, i.e., 80%. Even minor burns in the hand may result in severe limitations of function. Early initiation of physiotherapy, topical antibiotic cream treatment, collagen application, splintage, passive exercise for second-degree superficial burns. Materials and methods: A prospective comparative study was conducted in 10 patients with acute hand burns due to thermal burns (scald, flame). All patients with second-degree superficial to intermediate thickness burns were given Negative pressure wound therapy (indigenous NPWT Kit) to one hand and local antibiotic cream to the other hand or other parts of the body to study clinical profile and outcome. Results: A total of 10 patients were studied. The majority of patients were in 19 to 30 years of age group 6 patients (60%), five females, and one male. Pediatric patients account for 4 patients (40%), two female and two male children. Incidence of burns in females 70% and males’ group 30%. Significant reduction in postburn edema in NPWT hand compared to topical antibiotic cream dressing. Healing is fast in NPWT applied hand/part. Conclusion: Negative Pressure Wound Therapy for Acute second-degree superficial burns showed promising results in wound healing and reduced post-burn edema burn in hand in our study.

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