scholarly journals Exploring the role of a nicotine quantity–frequency use criterion in the classification of nicotine dependence and the stability of a nicotine dependence continuum over time

2010 ◽  
Vol 12 (3) ◽  
pp. 207-216 ◽  
Author(s):  
Orla McBride ◽  
David R. Strong ◽  
Christopher W. Kahler
2020 ◽  
Vol 8 (7_suppl6) ◽  
pp. 2325967120S0049
Author(s):  
Celeste Quitiquit Dickason ◽  
Thomas Jinguji ◽  
susan shenoi ◽  
Mahesh Thapa ◽  
Michael Saper ◽  
...  

Objectives: To determine the prevalence and severity of OCD in patients with JIA. Methods: This was a retrospective review of patients with JIA and OCD treated between January 2008 and March 2019 at one children’s hospital. We queried Department of Rheumatology records for JIA patients treated during this interval as well as Departments of Orthopedics and Radiology records for patients with OCD. Demographic information, classification of the stability of OCD lesions by review of magnetic resonance imaging, and clinical details of treatment were recorded. Results: 2,021 JIA patients were identified, 20 of whom (19 girls, 1 boy) had OCD of the knee and/or talus for a prevalence of 1/100 or 1000/100,000, or approximately 30-200x that of the general population. These 20 patients had a total of 28 OCD lesions: 43% (9 femur, 3 talus) were radiographically stable over time, 50% (10 femur, 2 patella, and 2 talus) were unstable at initial diagnosis, and 7% (femur) were initially stable but progressed to unstable lesions despite drilling. Eleven patients (55%) underwent surgery: 5 with stable femoral lesions for persistent symptoms despite prolonged non-operative treatment, and 6 for treatment of their unstable lesions (femur and patella). Of these 11 patients, 3 underwent two or more surgeries for OCDs, and 3 were treated with hemiepiphysiodesis for concomitant genu valgum. Conclusion: OCD lesions are 30-200x more prevalent in JIA compared to the general population. In JIA, OCD often presents at an advanced stage requiring surgery for stabilization. Patients with JIA may benefit by early screening, to potentially allow for treatment of an OCD lesion prior to the progression to instability.


2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Min Ye ◽  
Hongkun Zuo

Ca2+ oscillations play an important role in various cell types. Thus, understanding the dynamical mechanisms underlying astrocytic Ca2+ oscillations is of great importance. The main purpose of this article was to investigate dynamical behaviors and bifurcation mechanisms associated with astrocytic Ca2+ oscillations, including stability of equilibrium and classification of different dynamical activities including regular and chaotic Ca2+ oscillations. Computation results show that part of the reason for the appearance and disappearance of spontaneous astrocytic Ca2+ oscillations is that they embody the subcritical Hopf and the supercritical Hopf bifurcation points. In more details, we theoretically analyze the stability of the equilibrium points and illustrate the regular and chaotic spontaneous calcium firing activities in the astrocytes model, which are qualitatively similar to actual biological experiment. Then, we investigate the effectiveness and the accuracy of our nonlinear dynamical mechanism analysis via computer simulations. These results suggest the important role of spontaneous Ca2+ oscillations in conjunction with the adjacent neuronal input that may help correlate the connection of both the glia and neuron.


Author(s):  
Nataliia Zhmurko ◽  
Olga Rudyk ◽  
Tetiana Hrynkevych

The appropriate use of debt funds and proper servicing of public debt is determined by the stability of the economy. The solution to these issues will determine the effectiveness of the implementation of budgetary policy in the state, the stability of the national currency. To solve these problems, the search for ways and methods for effective management and servicing of public debt in the country is being carried out. It is quite reasonable to consider public debt as an important instrument of financial policy in the state. It is the main criterion for determining how effective the economy is and how well the state performs its functions both at the national and international levels. Economists at different times had different approaches to determining public debt, the expediency of borrowing by the state and the role of the state in the economic life of the country and the resulting further opportunity to accept debts and manage financial resources. However, today economists cite a number of features, functions of public debt, and scientists have developed different approaches to understanding this concept based on the criteria of the sources of their formation and characteristics. Approaches to the interpretation of public debt are extremely different, thereby complementing each other and show how complex the subject of research is and how broadly it can be interpreted. There are many approaches to determining public debt, as well as its impact on the state economy. Some approaches complement each other, others completely contradict each other. However, the tendency for the state to take on debts, whether external or internal, remains inevitable. And the expediency and justification of taking such, it will be possible to speak only on the fact of use of these means and development or, on the contrary, decline of economy. However, public debt as an economic category is an integral part of the state’s economy, where the state acts as an active participant in debt relations. That is why in the article the authors highlight the economic content and purpose of public debt on the basis of the works of well-known domestic and foreign economists highlight its main functions, carry out a detailed classification of debt borrowings according to a number of features.


2017 ◽  
Vol 38 (7) ◽  
pp. 947-965 ◽  
Author(s):  
Davide Marengo ◽  
Emanuela Rabaglietti ◽  
Franca Tani

The present study investigated the stability of friendship nominations over the course of a school year as a function of early adolescents’ and their classroom best friends’ internalizing symptoms (i.e., depression, anxiety, and somatization). Sample consisted of 156 early adolescents (57.1% female; [Formula: see text] age = 12.62; SD = 0.62) involved in 78 same-sex best friendship dyads. We assessed best friendship (classroom) nominations at beginning (T1) and end (T2) of the school year. Results of longitudinal analyses performed with the Actor-Partner Interdependence Model indicated adolescents’ and their classroom best friends’ depressive symptoms predicted lower stability of best friendships over time, whereas best friends’ somatization emerged as a predictor of higher friendship stability. In addition, positive dyadic friendship quality predicted greater stability over time. These findings highlight the importance of employing a dyadic framework when examining the role of internalizing symptoms in friendship stability.


2010 ◽  
Vol 31 (2) ◽  
pp. 68-73 ◽  
Author(s):  
María José Contreras ◽  
Víctor J. Rubio ◽  
Daniel Peña ◽  
José Santacreu

Individual differences in performance when solving spatial tasks can be partly explained by differences in the strategies used. Two main difficulties arise when studying such strategies: the identification of the strategy itself and the stability of the strategy over time. In the present study strategies were separated into three categories: segmented (analytic), holistic-feedback dependent, and holistic-planned, according to the procedure described by Peña, Contreras, Shih, and Santacreu (2008) . A group of individuals were evaluated twice on a 1-year test-retest basis. During the 1-year interval between tests, the participants were not able to prepare for the specific test used in this study or similar ones. It was found that 60% of the individuals kept the same strategy throughout the tests. When strategy changes did occur, they were usually due to a better strategy. These results prove the robustness of using strategy-based procedures for studying individual differences in spatial tasks.


2013 ◽  
Vol 44 (6) ◽  
pp. 380-389 ◽  
Author(s):  
Sabine Förderer ◽  
Christian Unkelbach

Evaluative conditioning (EC) refers to valence changes in neutral stimuli (CSs) through repeated pairing with liked or disliked stimuli (USs). The present study examined the stability of EC effects in the course of 1 week. We investigated how this stability depends on memory for US valence and US identity. We also investigated whether CSs evaluations occurring immediately after conditioning (i.e., evaluative consolidation) are necessary for stable EC effects. Participants showed stable EC effects on direct and indirect measures, independent of evaluations immediately after conditioning. EC effects depended on memory for US valence but not for US identity. And although memory decreased significantly over time, EC effects remained stable. These data suggest that evaluative consolidation is not necessary, and that conditioned preferences and attitudes might persist even when people do not remember the concrete source anymore.


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