scholarly journals Nutrition as a modifiable factor in the onset and progression of pulmonary function impairment in COPD: a systematic review

2021 ◽  
Author(s):  
Lieke E J van Iersel ◽  
Rosanne J H C G Beijers ◽  
Harry R Gosker ◽  
Annemie M W J Schols
Keyword(s):  
Systematic Review ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Nutrient Status ◽  
Dietary Quality ◽  
Airflow Limitation ◽  
Processed Meat ◽  
Pubmed Database ◽  
Increased Risk ◽  
Modifiable Factor

Abstract Context Chronic obstructive lung disease (COPD) is a progressive lung disease characterized by persistent airflow limitation. An increasing amount of evidence suggests an effect of dietary quality on the risk of COPD in the general population and pulmonary function decline in patients with COPD. Objective The association of dietary intake and nutrient status with COPD risk and onset, as well as pulmonary function decline (change in forced expiratory volume in 1 second, forced vital capacity, or the ratio of the former to the latter) in patients with COPD was investigated in this systematic review. Data Sources The PubMed database was searched by combining terms of pulmonary function or COPD with diet, nutrient status, or nutritional supplementation. Data Extraction Original studies and systematic reviews and meta-analyses were included. Articles obtained were independently screened for relevance on the bases of title and abstract by 2 researchers. Eventually, 89 articles were included in the analysis. Results The unhealthy Western-style diet is associated with an increased risk of COPD and an accelerated decline of pulmonary function. Intake of fruit, vegetables, dietary fibers, vitamins C and E, polyphenols, and β-carotene were individually associated with lower COPD risk, whereas consumption of processed meat was associated with higher COPD risk. Data on the effect of dietary quality on pulmonary function decline in patients with COPD are limited and inconsistent. Strong evidence for beneficial effects on pulmonary function decline was found only for vitamin D supplementation. Conclusion Considering the increasing burden of COPD, more attention should be given to dietary quality as a modifiable factor in disease development and progression in patients with COPD. Systematic Review Registration PROSPERO registration no. CRD42021240183.

scholarly journals Massage Therapy for Pulmonary Function in Patients Recovering From Covid-19: A Protocol for Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Kelin Zhou ◽  
Shuo Dong ◽  
Guobing Fu ◽  
Shusheng Cui ◽  
Sheng Guo
Keyword(s):  
Systematic Review ◽  
Pulmonary Function ◽  
Alternative Medicine ◽  
Data Extraction ◽  
Meta Analysis ◽  
Massage Therapy ◽  
Respiratory Illness ◽  
Current Evidence ◽  
Pubmed Database ◽  
Tuina Therapy

Abstract Background:Starting in December 2019 in Wuhan (Hubei province, China), a novel coronavirus, designated SARS-CoV-2, has caused an international outbreak of a respiratory illness and rapidly evolved into a pandemic.Given the rapidly growing pandemic and the overwhelmedmedical system, the number of self‐quarantined and recovering patients is increasing.There is an urgentneed of alternative medicine to help patients relieve symptoms duringself‐quarantine, and possibly to help increase their chances of survivaland recovery from COVID-19.Massage (tuina) therapy is one of the widely employed complementary and alternative medicine interventions in the world.Long-term clinicalpractices and experiences have shown that massage therapy could significantly contribute to the healing of most respiratory conditions and lung disease.This systematic review and meta-analysis will summarize the current evidence of tuina (massage) used as an intervention for pulmonary function in COVID-19 recovering patients.Methods:We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy inimproving pulmonary function ofCOVID-19 recovering patients: Wanfang and Pubmed Database, CNKI, CENTRAL, CINAHL, EMBASE and MEDLINE. Each database will be searched from inception to June 2020. The entire process will include study selection, data extraction, risk of bias assessment and meta-analyses.Discussion:This proposed systematic review will evaluate the existing evidence and explore the potential roleof massage therapyon the effectiveness and safety in pulmonary function of COVID-19 recovering patients.The outcomes will include the improvement of pulmonary function and adverse effect.PROSPERO registration number:CRD42020192107

scholarly journals Lifestyle, WCRF/AICR Recommendations and Esophageal Adenocarcinoma Risk. A Systematic Review of the Literature

2021 ◽  
Author(s):  
Daniele Nucci ◽  
Alessio Marino ◽  
Stefano Realdon ◽  
Mariateresa Nardi ◽  
Cristina Fatigoni ◽  
...  
Keyword(s):  
Systematic Review ◽  
Esophageal Adenocarcinoma ◽  
Developed Countries ◽  
Whole Grains ◽  
Processed Meat ◽  
Inclusion Criteria ◽  
Direct Role ◽  
Increased Risk ◽  
Rising Incidence ◽  
Red And Processed Meat

One of the most notable changes in the Esophageal Cancer (EC) epidemiology is the rising incidence and prevalence of esophageal adenocarcinoma (EAC) in developed countries, likely due to lifestyle and/or environmental factors that may play an important role in EAC onset. The aim of this systematic review was to collect and summarize all the available evidence regarding lifestyle, diet and EAC risk. We searched the PubMed and Scopus databases in January 2021 for studies providing information about lifestyle, diet, WCRF/AICR recommendations and EAC risk. A total of 106 publications met the inclusion criteria. Body mass index (BMI) and waist circumference (WC) are associated with increased EAC risk. Physical activity does not appear to have a significant direct role in EAC risk. A diet rich in fruit, vegetables, and whole grains appeared to be more protective than a diet rich in animal fat, red meat, and processed meat. Alcohol does not seem to be related to EAC whereas smokers, particularly heavy smokers, have an increased risk of EAC. Primary prevention remains the best option to avert EAC. BMI and WC, along with low consumption of red and processed meat, high consumption of plant food, and the avoidance of smoking are pivotal for EAC prevention.

Abstract WP249: Association of Reduced FEV1 and Stroke Risk

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Stephanie Lyden ◽  
Adam De Havenon ◽  
Vivek Reddy
Keyword(s):  
Ischemic Stroke ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Hemorrhagic Stroke ◽  
Stroke Risk ◽  
Secondary Outcome ◽  
Cardiovascular Health Study ◽  
Increased Risk ◽  
Abnormal Pulmonary Function

Background: The systemic inflammation and oxidative stress of obstructive lung disease could promote cerebrovascular dysfunction and platelet hyperactivity, thereby increasing stroke risk 1-2 . There have been studies in the literature supporting an increased risk for stroke (ischemic and hemorrhagic) in patients with obstructive lung disease 3-4 . We aim to assess whether this association is confirmed using data collected from the Cardiovascular Health Study (CHS). Methods: This is a secondary analysis of CHS. The primary outcome is ischemic stroke and the secondary outcome is hemorrhagic stroke. The primary predictor is abnormal pulmonary function at the baseline visit, defined as FEV1<80% of predicted. We fit Cox proportional hazards models and adjusted for baseline covariates that were associated with the outcomes, which for ischemic stroke included age, race, smoking, cholesterol, diabetes, hypertension, atrial fibrillation, and history of TIA or myocardial infarction; and for hemorrhagic stroke included age, cholesterol, diabetes, and hypertension. Results: We included 5,438 patients, of whom 880 (16.2%) had ischemic stroke and 142 (2.6%) had hemorrhagic stroke. Mean (SD) days of follow-up was 4,458 (2,499). There were 331/5,438 (6.1%) of patients with abnormal pulmonary function at baseline, who had a higher risk of ischemic stroke (HR 1.36, 95% CI 1.05-1.76, p=0.019) (Figure 1). This remained significant in the adjusted multivariate model (HR 1.43, 95% CI 1.08-1.90, p=0.013). Abnormal pulmonary function was not associated with hemorrhagic stroke risk in either the unadjusted (p=0.635) or adjusted models (p=0.659). Conclusion: Patient’s with a reduced FEV1<80% were found to have an increased risk for ischemic stroke. However, this was not associated with an increased risk for hemorrhagic stroke, suggesting a less robust link between obstructive lung disease and hemorrhagic stroke risk.

scholarly journals Pulmonary function tests as outcomes for systemic sclerosis interstitial lung disease

2018 ◽  
Vol 27 (148) ◽  
pp. 170102 ◽  
Author(s):  
Melissa Caron ◽  
Sabrina Hoa ◽  
Marie Hudson ◽  
Kevin Schwartzman ◽  
Russell Steele
Keyword(s):  
Systematic Review ◽  
Systemic Sclerosis ◽  
Interstitial Lung Disease ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Validation Studies ◽  
Pulmonary Function Tests ◽  
Outcome Studies ◽  
Surrogate Markers ◽  
Function Tests

Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc). We performed a systematic review to characterise the use and validation of pulmonary function tests (PFTs) as surrogate markers for systemic sclerosis-associated interstitial lung disease (SSc-ILD) progression.Five electronic databases were searched to identify all relevant studies. Included studies either used at least one PFT measure as a longitudinal outcome for SSc-ILD progression (i.e. outcome studies) and/or reported at least one classical measure of validity for the PFTs in SSc-ILD (i.e. validation studies).This systematic review included 169 outcome studies and 50 validation studies. Diffusing capacity of the lung for carbon monoxide (DLCO) was cumulatively the most commonly used outcome until 2010 when it was surpassed by forced vital capacity (FVC). FVC (% predicted) was the primary endpoint in 70.4% of studies, compared to 11.3% for % predicted DLCO. Only five studies specifically aimed to validate the PFTs: two concluded that DLCO was the best measure of SSc-ILD extent, while the others did not favour any PFT. These studies also showed respectable validity measures for total lung capacity (TLC).Despite the current preference for FVC, available evidence suggests that DLCO and TLC should not yet be discounted as potential surrogate markers for SSc-ILD progression.

scholarly journals Pulmonary ventilation defects in older never-smokers

2014 ◽  
Vol 117 (3) ◽  
pp. 297-306 ◽  
Author(s):  
Khadija Sheikh ◽  
Gregory A. Paulin ◽  
Sarah Svenningsen ◽  
Miranda Kirby ◽  
Nigel A. M. Paterson ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Pulmonary Function Tests ◽  
Pulmonary Ventilation ◽  
Forced Expiratory Volume ◽  
Airflow Limitation ◽  
Second Hand Smoke ◽  
Chronic Obstructive ◽  
Never Smokers

Hyperpolarized 3He MRI previously revealed spatially persistent ventilation defects in healthy, older compared with healthy, younger never-smokers. To understand better the physiological consequences and potential relevance of 3He MRI ventilation defects, we evaluated 3He-MRI ventilation-defect percent (VDP) and the effect of deep inspiration (DI) and salbutamol on VDP in older never-smokers. To identify the potential determinants of ventilation defects in these subjects, we evaluated dyspnea, pulmonary function, and cardiopulmonary exercise test (CPET) measurements, as well as occupational and second-hand smoke exposure. Fifty-two never-smokers (71 ± 6 yr) with no history of chronic respiratory disease were evaluated. During a single visit, pulmonary function tests, CPET, and 3He MRI were performed and the Burden of Obstructive Lung Disease questionnaire administered. For eight of 52 subjects, there was spirometry evidence of airflow limitation (Global Initiative for Chronic Obstructive Lung Disease-Unclassified, I, and II), and occupational exposure was reported in 13 of 52 subjects. In 13 of 52 (25%) subjects, there were no ventilation defects and in 39 of 52 (75%) subjects, ventilation defects were observed. For those subjects with ventilation defects, six of 39 showed a VDP response to DI/salbutamol. Ventilation heterogeneity and VDP were significantly greater, and forced expiratory volume in 1 s (FEV1)/forced vital capacity was significantly lower ( P < 0.05) for subjects with ventilation defects with a response to DI/salbutamol than subjects with ventilation defects without a response to DI/salbutamol and subjects without ventilation defects. In a step-wise, forward multivariate model, FEV1, inspiratory capacity, and airway resistance significantly predicted VDP ( R2 = 0.45, P < 0.001). In conclusion, most never-smokers had normal spirometry and peripheral ventilation defects not reversed by DI/salbutamol; such ventilation defects were likely related to irreversible airway narrowing/collapse but not to dyspnea and decreased exercise capacity.

Uneventful delivery of two pregnancies in a woman with severe factor XII deficiency: case report and systematic review

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Stamatios Petousis ◽  
George Karavas ◽  
Chrysoula Margioula-Siarkou ◽  
Themistoklis Dagklis ◽  
Paraskevi Karapavlidou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Reports ◽  
Case Series ◽  
Signs And Symptoms ◽  
Factor Xii ◽  
Case Presentation ◽  
Severe Deficiency ◽  
Pubmed Database ◽  
Increased Risk

Abstract Background Deficiency of factor XII (FXII) is widely considered to have a detrimental effect on pregnancy. Several reports underline the increased risk for antenatal complications with few published case reports of uncomplicated deliveries. The main objective of our article is to perform a systematic review to highlight pregnancies with severe deficiency of FXII that have been delivered uneventfully, along with presenting our relative case of a woman with severe deficiency of FXII. Materials and methods A systematic review was performed in the Pubmed database. Inclusion criteria were considered to be case reports and case series presenting delivery of uncomplicated pregnancies in women with severe FXII deficiency. Medical records of our patient were also reviewed in terms of signs and symptoms, laboratory and imaging examinations and neonatal outcomes. Results There were 62 abstracts derived while 44 were assessed for eligibility. There were finally three case reports of women with FXII deficiency delivering live newborns and one case series of 12 women with a final outcome of 19 deliveries. Regarding our case presentation, the woman with FXII levels <12%, after a neonatal death because of extreme prematurity (24 weeks + 4 days), was set in regular follow-up and treatment with bemiparin natriate, 3.5 mg/kg and acetylsalicylic acid, 100 mg/day. She finally managed to have her second pregnancy delivered at 38 weeks + 3 days, her third pregnancy ended up as a miscarriage and her fourth pregnancy was also delivered at 37 weeks + 4 days. Conclusion Despite the increased risk for antenatal complications, appropriate follow-up of pregnancies with severe FXII pregnancy may finally lead to an uneventful delivery.

Risk Analysis of Perioperative Injections in Arthroscopic Reconstruction of the Rotator Cuff of the Shoulder – A Systematic Review

2021 ◽  
Author(s):  
Marius von Knoch ◽  
Mike H. Baums ◽  
Wolfgang Lehmann ◽  
Stephan Frosch
Keyword(s):  
Systematic Review ◽  
Rotator Cuff ◽  
Revision Surgery ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Risk Of Infection ◽  
Arthroscopic Reconstruction ◽  
Pubmed Database ◽  
Increased Risk ◽  
Insurance Data

Abstract Background The present study used a systematic review to analyse the risk of perioperative injections during arthroscopic reconstruction of the rotator cuff of the shoulder. The questions of interest were whether perioperative local injection increases the infection risk and whether the number of postoperative revisions is increased. Material and Methods A systematic review of the U. S. National Library of Medicine/National Institutes of Health (PubMed) database and the Cochrane Library was performed using the PRISMA checklist. The keywords used were “shoulder” and “arthroscopy” and “injection” and “risk”. In the course of the study, work that was not also primarily concerned with the reconstruction of the rotator cuff was excluded. English original articles and case series were included that contained at least some arthroscopic reconstructions of the rotator cuff. The risk of bias was determined using the Newcastle-Ottawa Scale. The content of the articles relevant to the research questions was analysed. Results 48 hits were primarily generated. 9 articles corresponded to the inclusion criteria and were analysed. In the 6 studies with details on the injected substances, cortisone was used in 98 – 100% of the cases. The reported infection and revision rates based on insurance data were higher with injection than without. The risk of bias in the studies analysed here was rather low based on the Newcastle-Ottawa Score. The risk of infection after a cortisone injection before, during or after surgery was increased. Injection was associated with infection in up to 8% of cases with injections within two weeks of surgery. The risk of infection was increased by up to 11 times with injections within 4 weeks after the operation. Likewise, the risk of revision surgery after injection was increased, with the time intervals between injection and surgery sometimes differing between studies. Discussion Local infections and to a lesser extent revision surgery are associated with perioperative injections (with cortisone) within 3 months preoperatively and 4 weeks postoperatively. However, there were only database studies of insurance data with several studies from a few centres. Thus, no causal relationships could be proven. Currently, however, the following can be recommended using a cautious approach: The interval between injection with cortisone before surgery should be at least 2 weeks, better 3 months. No cortisone injections should be applied intraoperatively. Postoperatively, cortisone should not be injected for at least 4 weeks. If, in exceptional cases, deviations from these time limits are required, patients should be informed about an increased risk of complications.

Risk of rash with nilotinib: A systematic review of the literature and meta-analysis.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 9088-9088
Author(s):  
Aaron Mark Drucker ◽  
Shenhong Wu ◽  
Ellin Berman ◽  
Mario E. Lacouture
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Fixed Effects ◽  
Systemic Mastocytosis ◽  
Meta Analysis ◽  
Significant Risk ◽  
Myelogenous Leukemia ◽  
High Grade ◽  
Pubmed Database ◽  
Increased Risk

9088 Background: Nilotinib is indicated for the treatment of chronic myelogenous leukemia (CML). The reported incidence and risk of rash from this medication vary widely and have been inconsistently reported in published trials. Therefore we conducted a systematic review and meta-analysis of the literature to determine the incidence and risk of developing rash. Methods: Relevant studies were identified from the PubMed database (1998-2012), abstracts presented at ASCO and ASH Conferences (2004-2011) and Web of Science database (1998-2012). Eligible studies were limited to prospective Phase II-III clinical trials in which patients received nilotinib at doses of either 300 mg or 400 mg twice daily. Incidence, relative risk (RR), and 95% confidence intervals (CI) were calculated using random-effects or fixed-effects models based on heterogeneity of included studies. Results: Data from a total of 3,186 patients receiving nilotinib in 16 clinical trials were available for analysis. The overall incidence of all-grade and high-grade (grade ≥3) rash were 33.1% (95% CI: 27.7-39.1) and 2.6% (95% CI: 2.1-3.4), respectively. Incidence of all-grade rash for patients with CML, gastrointestinal stromal tumor (GIST) and systemic mastocytosis were 33.2% (95% CI: 27.2-39.9), 25.7% (95% CI: 14.0-42.5) and 25.0% (95% CI: 15.7-37.4), respectively. Nilotinib was associated with increased risk of all-grade rash (RR=2.891, 95% CI: 2.079-4.020; P<0.001) when compared to patients treated with imatinib. Risk of high-grade rash was increased compared to imatinib (RR=1.823, 95% CI: 0.670-4.957), but this was not statistically significant (P=0.24). Conclusions: Patients with hematologic malignancies and GIST who are treated with nilotinib are at significant risk for developing a rash. Further studies for characterization, prevention and treatment of this untoward toxicity are needed in order to maintain patients’ quality of life and minimize the need for dose modification, which may impact clinical outcome.

scholarly journals Respiratory disease and lower pulmonary function as risk factors for subsequent dementia: a systematic review with meta-analysis

2019 ◽  
Author(s):  
Tom C. Russ ◽  
Mika Kivimäki ◽  
G. David Batty
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Pulmonary Function ◽  
Longitudinal Studies ◽  
Respiratory Disease ◽  
Respiratory Illness ◽  
Similar Degree ◽  
Dementia Risk ◽  
Increased Risk ◽  
Poor Pulmonary Function

ABSTRACTBackgroundIn addition to affecting the oxygen supply to the brain, pulmonary function is a marker of multiple insults throughout life (including smoking, illness, and socioeconomic deprivation). By meta-analysing existing studies, we tested the hypothesis that lower pulmonary function and respiratory illness are linked to an elevated risk of dementia.AimsTo review the best available evidence, taken from longitudinal studies, for pulmonary function and respiratory disease as risk factors of dementia.MethodWe conducted a systematic review of longitudinal studies using PubMed until April 1st, 2019 and, where possible, pooled results in random-effects meta-analyses.ResultsWe identified eleven studies relating pulmonary function to later dementia risk, and eleven studies of respiratory illness and dementia (including one which studied both). The lowest quartile of lung function measure Forced Expiratory Volume in one second (FEV1) compared with the highest was associated with a 1.5-fold (1.51, 95%CI 0.94-2.42) increased dementia risk (Ntotal=127,710, 3 studies). Respiratory illness was also associated with increased dementia risk to a similar degree (1.54, 1.30-1.81, Ntotal=288,641, 11 studies).ConclusionsIndividuals with poor pulmonary function are at increased risk of dementia. The extent to which the association between poor pulmonary function and dementia is causal remains unclear.

Sign in / Sign up

Export Citation Format

Share Document