scholarly journals Vancomycin-Nonsusceptible Enterococci Mediated by vanC at a Large Children’s Hospital: Prevalence, Susceptibility, and Impact on Care of Enterococcal Bacteremia

2020 ◽  
Vol 7 (5) ◽  
Author(s):  
Daniel S Dodson ◽  
Samuel R Dominguez ◽  
Christine E MacBrayne ◽  
Manon C Williams ◽  
Sarah K Parker

Abstract Enterococcus gallinarum and casseliflavus have inherent vancomycin resistance and, though known as pathogens, have not been well characterized in pediatric patients. We identified a significant prevalence of these enterococcal species among immunocompromised patients at a large pediatric institution and describe the impact on patient care, antibiotic stewardship, and infection control.

2015 ◽  
Vol 53 (7) ◽  
pp. 2225-2229 ◽  
Author(s):  
Alireza Eshaghi ◽  
Dea Shahinas ◽  
Aimin Li ◽  
Ruwandi Kariyawasam ◽  
Philip Banh ◽  
...  

The ability of vancomycin resistance determinants to be horizontally transferred within enterococci species is a concern. Identification and characterization of vancomycin-resistant enterococci (VRE) in a clinical isolate have a significant impact on infection control practices. In this study, we describe a clinical isolate ofEnterococcus gallinarumexhibiting high-level resistance to vancomycin and teicoplanin. The genetic characterization of this isolate showed the presence ofvanAandvanBgenes in addition to the naturally carriedvanCgene.vanAwas identified on pA6981, a 35,608-bp circular plasmid with significant homology to plasmid pS177. ThevanBoperon was integrated into the bacterial chromosome and showed a high level of homology to previously reported Tn1549and Tn5382. To the best of our knowledge, this is the first report ofE. gallinarumcarrying bothvanAandvanBoperons, indicating the importance of identifying the vancomycin resistance mechanism in non-E. faeciumand non-E. faecalisenterococcal species.


2018 ◽  
Vol 13 (1) ◽  
pp. 39-42
Author(s):  
Kelley Wadson

A Review of: Giles-Smith, L., Spencer, A., Shaw, C., Porter, C., & Lobchuk, M. (2017). A study of the impact of an educational intervention on nurse attitudes and behaviours toward mobile device and application use in hospital settings. Journal of the Canadian Health Libraries Association/Journal de l'Association des bibliothèques de la santé du Canada, 38(1), 12-29. doi: 10.5596/c17-003 Abstract Objective - To describe nurses’ usage of and attitudes toward mobile devices and apps and assess the impact of an educational intervention by hospital librarians and educators Design - Descriptive, cross-sectional survey, one-group pre- and post-test, and post-intervention focus group Setting - One 251-bed community hospital and one 554-bed tertiary care hospital in Winnipeg, Canada Subjects - 348 inpatient medical and surgical nurses Methods – The study had two phases. In Phase I, respondents completed a survey of 21 fixed and open-ended questions offered online or in print to a convenience sample from the community hospital and a random sample of medical and surgical units from the tertiary hospital. The survey collected demographic data and included questions about mobile devices and apps covering current awareness of hospital policy, ownership, internet access, usage patterns, concerns, and attitudes toward their use for direct patient care. It also included information to recruit volunteers for Phase II. In Phase II, participants attended four 30-minute educational sessions facilitated by the researchers. The first session addressed the regional health authority’s policies, Personal Health Information Act, and infection control practices. Subsequent sessions covered relevance, features, and training exercises for one or more selected apps. Participants installed five free or low-cost apps, which were chosen by the librarians and nurse educators, on their mobile devices: Medscape, Lab Tests Online, Lexicomp, Twitter, and Evernote. Participants were then given a two-month period to use the apps for patient care. Afterward, they completed the same survey from Phase I and their pre- and post-intervention responses were matched for comparative analysis. Phase II concluded with a one-hour audio-recorded focus group using ten open-ended questions to gather feedback on the impact of the educational sessions. Main Results – 94 nurses completed the Phase I survey for a response rate of 27%. Although 89 respondents reported owning a mobile device, less than half used them for patient care. Just under half the respondents were unsure if they were allowed to use mobile devices at work and a similar number answered that devices were not allowed. Two-thirds of respondents were unsure whether any institutional policies existed regarding mobile device use. Of the 16 participants that volunteered for Phase II, 14 completed the post-intervention survey and 6 attended the focus group. In comparison to the Phase I survey, post-intervention survey responses showed more awareness of institutional policies and increased concern about mobile devices causing distraction. In the Phase I survey, just over half of the nurses expressed a desire to use mobile devices in patient care. Four themes emerged from the survey’s qualitative responses in Phase I: (1) policy: nurses were unsure of institutional policy or experienced either disapproval or bans on mobile device use from management; (2) barriers to use, namely cost, potential damage to or loss of devices, infection control, and lack of familiarity with technology; (3) patient perceptions, including generational differences with younger patients seen as more accepting than older patients; and (4) nurse perceptions: most valued access to information but expressed concerns about distraction, undermining of professionalism, and use of technology. Qualitative responses in the Phase II survey and focus group also revealed four themes: (1) barriers: participants did not cite loss of device or infection control as concerns as in Phase I; (2) patient acceptance and non-acceptance: education and familiarity with mobile devices were noted as positive influential factors; (3) information need, accessibility, and convenience: nurses reported needing easy-to-use apps, particularly Lexicomp, and appreciated improved access to information; and (4) nurse behaviour and attitude: participants reported more time would be needed for changes to occur in these areas. Conclusion – The study found that although most nurses own mobile devices and express strong interest in using them for patient care, there are significant barriers including lack of clarity about institutional policies and concerns about infection control, risk of damage to personal devices, costs, lack of experience with the technology, distraction, and negative patient perceptions. To address these concerns, the authors recommend that hospital librarians and educators work together to offer training and advocate for improved communication and policies regarding use of mobile devices in hospital settings. Moreover, the study affirmed the benefits of using mobile devices and apps to support evidence-based practice, for example by providing access to reliable drug information. The authors conclude that additional research is needed to inform policy and develop strategies that hospital librarians and nurse educators can use to promote the most effective application of mobile technologies for patient care.


2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S116-S116
Author(s):  
Julia Sessa ◽  
Helen Jacoby ◽  
Bruce Blain ◽  
Lisa Avery

Abstract Background Measuring antimicrobial consumption data is a foundation of antimicrobial stewardship programs. There is data to support antimicrobial scorecard utilization to improve antibiotic use in the outpatient setting. There is a lack of data on the impact of an antimicrobial scorecard for hospitalists. Our objective was to improve antibiotic prescribing amongst the hospitalist service through the development of an antimicrobial scorecard. Methods Conducted in a 451-bed teaching hospital amongst 22 full time hospitalists. The antimicrobial scorecard for 2019 was distributed in two phases. In October 2019, baseline antibiotic prescribing data (January – September 2019) was distributed. In January 2020, a second scorecard was distributed (October – December 2019) to assess the impact of the scorecard. The scorecard distributed via e-mail to physicians included: Antibiotic days of therapy/1,000 patient care days (corrected for attending census), route of antibiotic prescribing (% intravenous (IV) vs % oral (PO)) and percentage of patients prescribed piperacillin-tazobactam (PT) for greater than 3 days. Hospitalists received their data in rank order amongst their peers. Along with the antimicrobial scorecard, recommendations from the antimicrobial stewardship team were included for hospitalists to improve their antibiotic prescribing for these initiatives. Hospitalists demographics (years of practice and gender) were collected. Descriptive statistics were utilized to analyze pre and post data. Results Sixteen (16) out of 22 (73%) hospitalists improved their antibiotic prescribing from pre- to post-scorecard (χ 2(1)=3.68, p = 0.055). The median antibiotic days of therapy/1,000 patient care days decreased from 661 pre-scorecard to 618 post-scorecard (p = 0.043). The median PT use greater than 3 days also decreased significantly, from 18% pre-scorecard to 11% post-scorecard (p = 0.0025). There was no change in % of IV antibiotic prescribing and no correlation between years of experience or gender to antibiotic prescribing. Conclusion Providing antimicrobial scorecards to our hospitalist service resulted in a significant decrease in antibiotic days of therapy/1,000 patient care days and PT prescribing beyond 3 days. Disclosures All Authors: No reported disclosures


2021 ◽  
pp. 136749352091931
Author(s):  
Emanuela Tiozzo ◽  
Valentina Biagioli ◽  
Matilde Brancaccio ◽  
Riccardo Ricci ◽  
Anna Marchetti ◽  
...  

A prospective comparative study was conducted in 487 pediatric patients (69% male, mean age = 6.4 ± 4.0) to evaluate (a) the incidence, intensity, and characteristics of pain in pediatric patients at home during the first 24 hours and 5 days after surgery and (b) the factors associated with higher pain intensity, including the impact of an application (App) compared to the paper-and-pencil approach. Postoperative pain was assessed by patients or their parents at home using the ‘Bambino Gesù’ Children’s Hospital (Ospedale Pediatrico Bambino Gesù, OPBG) tool for participants aged 4–17 years or the Faces, Legs, Arms, Cry, and Consolability scale for participants less than four years old. Participants were assigned to two groups: those who used the paper-and-pencil version of the pain scale and those who used the App. Overall, 209 of the 472 (44%) participants reported pain during the first 24 hours, and 92 of the 420 (22%) reported pain between one and five days after surgery. Higher pain intensity scores were associated with being in the App group, directly assessing own pain, and using the OPBG tool. The App was effective in facilitating pain assessment. Health professionals could empower pediatric patients and their parents in assessing pain at home through a dedicated App.


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