scholarly journals 446. Prognostic Value of Absolute Lymphocyte Count for Disease Severity and Clinical Outcomes in Adult COVID-19 Inpatients

2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S324-S324
Author(s):  
Jianli Niu ◽  
Candice Sareli ◽  
Maria Deane ◽  
Aharon E Sareli
Keyword(s):  
Lactate Dehydrogenase ◽  
Clinical Outcomes ◽  
Disease Severity ◽  
Interleukin 6 ◽  
Lymphocyte Count ◽  
Absolute Lymphocyte Count ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Icu Admission ◽  
Reactive Protein

Abstract Background Lymphopenia has been reported as a relatively frequent finding in patients with coronavirus disease 2019 (COVID-19). This study aimed to assess the use of absolute lymphocyte count (ALC) as a prognostic biomarker for disease severity and clinical outcomes. Methods A cohort of adult patients with COVID-19 admitted to Memorial Healthcare System, Hollywood, Florida from March 7, 2020 to January 18, 2021 was retrospectively analyzed. An absolute lymphocyte count (ALC) < 1.1 × 109/L was used as cutoff point to define lymphopenia. Correlations of ALC upon admission with age and serum levels of C-reactive protein, interleukin-6, lactate dehydrogenase, and creatinine were analyzed. Univariate and multivariate regression models were developed to assess the association of lymphopenia with the risk of ICU admission and clinical outcomes. Results 4,485 hospitalized patients were included in the final analyses. Median age was 61 (interquartile range, 47-73) years and 2,311 (51.5%) were men. Lymphopenia was more frequent in patients admitted to the ICU compared to those that were not admitted to the ICU, with an odds ratio of 2.14 (95% confidence interval [CI], 1.78-2.56, p < .0001) (Figure 1). The actual value of the ALC was negatively correlated with age and serum levels of C-reactive protein, interleukin-6, lactate dehydrogenase, and creatinine (all p < 0.005). Patients with lymphopenia (n=2,409) compared to those without lymphopenia (n=2,076) had multivariable-adjusted odds ratios of 1.85 (95% CI, 1.53-2.24) for ICU admission, 2.08 (95% CI, 1.67-2.58) for intubation, 1.98 (95% CI, 1.31-3.00) for development of acute kidney failure, and 2.23 (95% CI, 1.79-2.79) for in-hospital mortality (Table 1). Analyses were adjusted for age, gender, race, hypertension, diabetes, chronic obstructive pulmonary disease, chronic kidney disease, coronary artery disease, malignancy, obesity, and smoking. Conclusion Lymphopenia in adult COVID -19 hospitalized patients was associated with increased risk of disease severity (as evidenced by need for ICU admission) and poor clinical outcomes. Absolute lymphocyte count may help with prognostication in individuals hospitalized with COVID-19. Disclosures All Authors: No reported disclosures

scholarly journals Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study

2020 ◽  
Author(s):  
Dan Wang ◽  
Ruifang Li ◽  
Juan Wang ◽  
Qunqun Jiang ◽  
Chang Gao ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Disease Severity ◽  
Serum Potassium ◽  
Critically Ill Patients ◽  
Lymphocyte Count ◽  
Serum Amyloid A ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Amyloid A ◽  
D Dimer

Abstract Background: Coronavirus disease 2019 ( COVID-19 ) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan and has quickly spread across the world. The mortality rate in critically ill patients with COVID-19 is high. This study analyzed clinical and biochemical parameters between mild and severe patients, helping to identify severe or critical patients early. Methods: In this single center, cross-sectional study, 143 patients were included and divided to mild/moderate and sever/critical groups. Correlation between the disease criticality and clinical features and peripheral blood biochemical markers was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve. Results: Significantly, disease severity was associated with age (r = 0.458, P < 0.001) , comorbidities (r = 0.445, P < 0.001) , white cell counts (r = 0.229, P = 0.006) , neutrophil count (r = 0.238, P = 0.004) , lymphocyte count (r = -0.295, P < 0.001) , albumin (r = -0.603, P < 0.001) , high-density lipoprotein cholesterol (r= -0.362, P < 0.001) , serum potassium (r = -0.237, P = 0.004) , plasma glucose (r = 0.383, P < 0.001) , total bilirubin (r = 0.340, P < 0.001) , serum amyloid A (r = 0.58, P < 0.001) , procalcitonin (r = 0.345, P < 0.001) , C-reactive protein ( r = 0.477, P < 0.001) , lactate dehydrogenase (r = 0.548, P < 0.001) , aspartate aminotransferase (r = 0.342, P < 0.001) , alanine aminotransferase (r = 0.264, P = 0.001) , erythrocyte sedimentation rate (r = 0.284, P = 0.001) and D-dimer (r = 0.477, P ＜ 0.001) . Conclusion: With following parameters such as age > 52 years, C-reactive protein > 64.79 mg/L, lactate dehydrogenase > 245 U/L, D-dimer > 0.96 ug/mL, serum amyloid A > 100.02 mg/L, or a lbumin ＜ 36 g/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Lymphocyte count, serum potassium and procalcitonin may also be a prognostic indicator .

scholarly journals The effect of treatment with N-acetylcysteine on the serum levels of C-reactive protein and interleukin-6 in patients on hemodialysis

2014 ◽  
Vol 25 (1) ◽  
pp. 66 ◽  
Author(s):  
Fereshteh Saddadi ◽  
Sudabeh Alatab ◽  
Farahnaz Pasha ◽  
MohammadReza Ganji ◽  
Tayebeh Soleimanian
Keyword(s):  
Interleukin 6 ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Effect Of Treatment

scholarly journals Effects of metformin treatment on serum levels of C-reactive protein and interleukin-6 in women with polycystic ovary syndrome

Medicine ◽  
2017 ◽  
Vol 96 (39) ◽  
pp. e8183 ◽  
Author(s):  
Jiao Wang ◽  
Lingyan Zhu ◽  
Kaixiang Hu ◽  
Yunliang Tang ◽  
Xiangxia Zeng ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Interleukin 6 ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Metformin Treatment ◽  
C Reactive Protein ◽  
Ovary Syndrome ◽  
Reactive Protein

scholarly journals Comparative Effect of Aspirin, Meloxicam and Terminalia catappa Leaf Extract on Serum Levels of Some Inflammatory Markers in Alloxan Induced Diabetic Rats

2019 ◽  
pp. 1-10
Author(s):  
Ezekiel E. Ben ◽  
Asuquo E. Asuquo ◽  
Daniel U. Owu
Keyword(s):  
Body Weight ◽  
Interleukin 6 ◽  
Leaf Extract ◽  
Serum Levels ◽  
Diabetic Rats ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Terminalia Catappa ◽  
Aqueous Leaf Extract ◽  
Anti Inflammatory

Background: The association between diabetes mellitus and inflammation is established but the use of non-steroidal anti-inflammatory drugs is not without some health risk. Aim: The study was aimed at comparing the levels of some inflammatory biomarkers in diabetic rats treated with aqueous leaf extract of Terminalia catappa, non steroidal anti-inflammatory drugs (NSAIDs) and exogenous insulin. Materials and Methods: Thirty six (36) Wistar rats were assigned to 6 groups of 6 animals each. Group 1 and 2 served as normal and diabetic controls and received orally 5ml/kg body weight of distilled water. Group 3 was diabetic treated orally with 130mg/kg body weight of aqueous leaf extract of Terminalia catappa.  And groups 4, 5 and 6 were administered orally with aspirin (30mg/kg), meloxicam (2mg/kg) and 0.75U/kg body weight of insulin subcutaneously. Diabetes was induced with intraperitoneal injection of 150mg/kg body weight of alloxan solution and diabetes confirmed after 72 hours with blood glucose levels ≥200mg/dl. The experiment lasted for 14 days and blood was collected by cardiac puncture for serum analysis of C-reactive protein, Interleukin-6 and Fibrinogen by ELISA method. Results: The results showed significant (P<0.05) increase in serum levels of C-reactive protein, Interleukin-6 and blood fibrinogen in diabetic group compared to control. These inflammatory biomarker were significantly (P<0.05) reduced by the extract, aspirin, meloxicam and insulin.  Conclusion: The reduced levels of C-reactive protein, Interleukin-6 and fibrinogen by aqueous leaf extract of Terminalia catappa was significant compared to aspirin and meloxicam. This may present the extract as a potent anti-inflammatory agent and could complement the function of insulin in diabetes treatment.

scholarly journals C-Reactive Protein and Absolute Lymphocyte Count Can Predict Overall Survival of Patients Treated With Eribulin

2020 ◽  
Vol 40 (7) ◽  
pp. 4147-4156
Author(s):  
ATSUSHI SATA ◽  
REIKO FUKUI ◽  
YOSHIMASA MIYAGAWA ◽  
AYAKO BUN ◽  
HIROMI OZAWA ◽  
...  
Keyword(s):  
Overall Survival ◽  
Lymphocyte Count ◽  
Absolute Lymphocyte Count ◽  
C Reactive Protein ◽  
Reactive Protein
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