scholarly journals Comparative Sensitivity of Transthoracic and Transesophageal Echocardiography in Diagnosis of Infective Endocarditis Among Veterans With Staphylococcus aureus Bacteremia

2017 ◽  
Vol 4 (2) ◽  
Author(s):  
Poorani Sekar ◽  
James R. Johnson ◽  
Joseph R. Thurn ◽  
Dimitri M. Drekonja ◽  
Vicki A. Morrison ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Infective Endocarditis ◽  
Transesophageal Echocardiography ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Valve Surgery ◽  
Related Factors ◽  
Staphylococcus Aureus Bacteremia ◽  
Patient Refusal

Abstract Background Echocardiography is fundamental for diagnosing infective endocarditis (IE) in patients with Staphylococcus aureus bacteremia (SAB), but whether all such patients require transesophageal echocardiography (TEE) is controversial. Methods We identified SAB cases between February 2008 and April 2012. We compared sensitivity and specificity of transthoracic echocardiography (TTE) and TEE for evidence of IE, and we determined impacts of IE risk factors and TTE image quality on comparative sensitivities of TTE and TEE and their impact on clinical decision making. Results Of 215 evaluable SAB cases, 193 (90%) had TTE and 130 (60%) had TEE. In 119 cases with both tests, IE was diagnosed in 29 (24%), for whom endocardial involvement was evident in 25 (86%) by TEE, vs only 6 (21%) by TTE (P < .001). Transesophageal echocardiography was more sensitive than TTE regardless of risk factors. Even among the 66 cases with adequate or better quality TTE images, sensitivity was only 4 of 17 (24%) for TTE, vs 16 of 17 (94%) for TEE (P < .001). Among 130 patients with TEE, the TEE results, alone or with TTE results, influenced treatment duration in 56 (43%) cases and led to valve surgery in at least 4 (6%). It is notable that, despite vigorous efforts to obtain both tests routinely, TEE was not done in 86 cases (40%) for various reasons, including pathophysiological contraindications (14%), patient refusal or other patient-related factors (16%), and provider declination or system issues (10%). Conclusions Patients with SAB should undergo TEE when possible to detect evidence for IE, especially if the results might affect management.

scholarly journals Clinical Risk Factors for Infective Endocarditis in Staphylococcus aureus Bacteremia

2017 ◽  
Vol 44 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Vincent Bryan D. Salvador ◽  
Bikash Chapagain ◽  
Astha Joshi ◽  
Debra J. Brennessel
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Infective Endocarditis ◽  
High Risk ◽  
Transesophageal Echocardiography ◽  
Univariate Analysis ◽  
Clinical Risk Factors ◽  
Methicillin Resistant ◽  
Clinical Risk ◽  
Staphylococcus Aureus Bacteremia

Crucial to the management of staphylococcal bacteremia is an accurate evaluation of associated endocarditis, which has both therapeutic and prognostic implications. Because the clinical presentation of endocarditis can be nonspecific, the judicious use of echocardiography is important in distinguishing patients at high risk of developing endocarditis. In the presence of high-risk clinical features, an early transesophageal echocardiogram is warranted without prior transthoracic echocardiography. The purpose of this study was to investigate the clinical risk factors for staphylococcal infective endocarditis that might warrant earlier transesophageal echocardiography and to describe the incidence of endocarditis in cases of methicillin-resistant and methicillin-sensitive Staphylococcus aureus bacteremia. A retrospective case-control study was conducted by means of chart review of 91 patients consecutively admitted to a community hospital from January 2009 through January 2013. Clinical risk factors of patients with staphylococcal bacteremia were compared with risk factors of patients who had definite diagnoses of infective endocarditis. There were 69 patients with bacteremia alone (76%) and 22 patients with endocarditis (24%), as verified by echocardiography. Univariate analysis showed that diabetes mellitus (P=0.024), the presence of an automatic implantable cardioverter-defibrillator/pacemaker (P=0.006) or a prosthetic heart valve (P=0.003), and recent hospitalization (P=0.048) were significantly associated with developing infective endocarditis in patients with S. aureus bacteremia. The incidence of methicillin-resistant and methicillin-sensitive S. aureus bacteremia was similar in the bacteremia and infective-endocarditis groups (P=0.437). In conclusion, identified high-risk clinical factors in the presence of bacteremia can suggest infective endocarditis. Early evaluation with transesophageal echocardiography might well be warranted.

scholarly journals Diagnósticos de enfermagem de pacientes em tratamento radioterápico

2018 ◽  
Vol 12 (11) ◽  
pp. 3060
Author(s):  
Camila Marcon ◽  
Gabriela Vicari ◽  
Patricia Poltroni ◽  
Aline Maffissoni ◽  
Kauana Dall' Agnese Caregnatto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Radiation Therapy ◽  
Skin Color ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Related Factors ◽  
Cross Sectional ◽  
Color Changes ◽  
Factores De Riesgo ◽  
Nursing Diagnoses

RESUMOObjetivo: identificar a incidência dos diagnósticos de enfermagem, bem como características definidoras, fatores relacionados e fatores de risco, com base na taxonomia NANDA-I de pacientes em tratamento radioterápico. Método: trata-se de estudo quantitativo, transversal, exploratório-descritivo, realizado com 60 pacientes em um ambulatório. Resultados: identificou-se 23 Diagnósticos de Enfermagem, sendo os mais incidentes: risco de integridade da pele prejudicada (35%), mobilidade física prejudicada (15%) e eliminação urinária prejudicada (7%). As características definidoras evidenciadas foram amplitude limitada de movimentos (15,3%), incontinência e dificuldade para deglutir (7,2%). Dentre os fatores relacionados, estão dor (18,3%), desconforto (10,7%) e radiação (6%) e os fatores de risco radiação (56%), mudanças na pigmentação da pele/mudanças no turgor da pele (26,3%) e estado nutricional desequilibrado (6,3%). Conclusão: os resultados do estudo contribuem para atender às necessidades de saúde dos pacientes em tratamento radioterápico e na tomada de decisão clínica pelo enfermeiro. Descritores: Enfermagem; Oncologia; Radioterapia; Processos de Enfermagem; Diagnóstico de Enfermagem; Pesquisa em Enfermagem.ABSTRACT Objective: to identify the incidence of nursing diagnoses, as well as defining characteristics, related factors and risk factors, based on the NANDA-I taxonomy of patients undergoing radiation therapy. Method: quantitative, cross-sectional, exploratory and descriptive study, performed with 60 patients in an outpatient clinic. Results: 23 Nursing Diagnoses were identified, of which the most prevalent were risk for impaired skin integrity (35%), impaired physical mobility (15%) and impaired urinary elimination (7%). The defining characteristics were limited transfer ability (15.3%), incontinence and impaired swallowing (7.2%). The related factors were pain (18.3%), discomfort (10.7%) and radiation (6%), and the risk factors are radiation (56%), skin color changes/alteration in skin turgor (26.3%) and imbalanced nutritional state (6.3%). Conclusion: The results of the present may study contribute to meet the health needs of patients undergoing radiation therapy and clinical decision making by the nurse. Descriptors: Nursing; Oncology; Radiotherapy; Nursing Process; Nursing Diagnosis; Nursing Research.RESUMEN Objetivo: identificar la incidencia de los diagnósticos de enfermería, así como características definidoras, factores relacionados y factores de riesgo, con base en la taxonomía NANDA-I de pacientes en tratamiento radioterápico. Método: estudio cuantitativo, transversal, exploratorio-descriptivo, realizado con 60 pacientes en un ambulatorio. Resultados: se identificaron 23 Diagnósticos de Enfermería, siendo los más incidentes: riesgo de integridad de la piel perjudicada (35%), movilidad física perjudicada (15%) y eliminación urinaria perjudicada (7%). Las características definidoras evidenciadas fueron amplitud limitada de movimientos (15,3%), incontinencia y dificultad para deglutir (7,2%). Dentro de los factores relacionados, están el dolor (18,3%), el malestar (10,7%) y la radiación (6%) y los factores de riesgo radiación (56%), cambios en la pigmentación de la piel/cambios en la turgencia de la piel (26,3%) y estado nutricional desequilibrado (6,3%). Conclusión: los resultados del estudio contribuyen para atender a las necesidades de salud de los pacientes en tratamiento radioterápico y en la tomada de decisión clínica por el enfermero. Descriptores: Enfermería; Oncología Médica; Radioterapia; Proceso de Enfermería; Diagnóstico de Enfermería; Investigación en Enfermería.

Risk Factors for Infective Endocarditis and Outcome of Patients With Staphylococcus aureus Bacteremia

2007 ◽  
Vol 82 (10) ◽  
pp. 1165-1169 ◽  
Author(s):  
Evelyn E. Hill ◽  
Steven Vanderschueren ◽  
Jan Verhaegen ◽  
Paul Herijgers ◽  
Piet Claus ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Infective Endocarditis ◽  
Staphylococcus Aureus Bacteremia

Risk Factors for Methicillin-Resistance among Patients with Staphylococcus aureus Bacteremia at the Time of Hospital Admission

2002 ◽  
Vol 323 (3) ◽  
pp. 117-123 ◽  
Author(s):  
Nilton A. Rezende ◽  
Henry M. Blumberg ◽  
Susan M. Ray ◽  
Brian S. Metzger ◽  
Nina M. Larsen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Hospital Admission ◽  
Methicillin Resistance ◽  
Staphylococcus Aureus Bacteremia

Abstract 16873: Association of Preoperative Cell-Free DNA Levels and Outcome Following Pediatric Cardiopulmonary Bypass

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Justinn Tanem ◽  
John Scott ◽  
George M Hoffman ◽  
Robert A Niebler ◽  
Aoy TOMITA-MITCHELL ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Primary Outcome ◽  
Clinical Decision Making ◽  
Treatment Strategies ◽  
Clinical Decision ◽  
Related Factors ◽  
Cell Free Dna ◽  
Free Dna

Introduction: Preoperative risk stratification in congenital cardiac surgery includes patient and procedure related factors, which may be used in clinical decision making as well program performance evaluation. Despite these tools, unidentified factors contribute to wide variation in outcomes both within and between centers. Identification of latent physiologic risk factors may strengthen predictive models. Hypothesis: Total cell-free DNA (TCF) functions as a biomarker for cellular injury as well as a pro-inflammatory cytokine. We hypothesized that elevated preoperative TCF would be associated with poor outcome following pediatric cardiac surgery requiring cardiopulmonary bypass (CPB). Methods: Prospective observational study of children age < 18 yr and wt > 3 kg undergoing planned CPB surgery. The Children’s Wisconsin Institutional Review Board approved the protocol . A serum TCF sample was obtained after induction of anesthesia prior to surgical incision. The primary outcome measure was a composite of postoperative cardiac arrest, ECMO, or death (CAED). Association of outcome to TCF was assessed by logistic regression with a cutpoint chosen by ROC curve exploration. Odds ratios with 95% CI were calculated. Results: Data were available in 117 patients, median age 0.9 years (range 0-17.4), median weight 7.8kg (range 3.2-98). The primary outcome (CAED) was met in 6/117 (5.1%). Table 1 summarizes characteristics of patients with and without CAED. Risk of CAED was 2% with TCF<20 ng/ml, and 27% with TCF>20 ng/ml (OR=18.2, CI 2.2- 212, p<0.01). Elevated TCF was associated to fewer hospital free days (GLM p<0.01). Data in table reported as median [IQR]. Conclusions: Preoperative TCF has an important association with postoperative cardiac arrest, ECMO, and death. Alternative or intensified treatment strategies could be considered in patients with elevated preoperative TCF.

scholarly journals 925A Normal Transthoracic Echocardiogram can be Used to Rule Out Infective Endocarditis in Patients with Staphylococcus aureus Bacteremia

2014 ◽  
Vol 1 (suppl_1) ◽  
pp. S267-S267
Author(s):  
Adrienne Showler ◽  
Lisa Burry ◽  
Anthony Bai ◽  
Daniel Ricciuto ◽  
Marilyn Steinberg ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Infective Endocarditis ◽  
Transthoracic Echocardiogram ◽  
Staphylococcus Aureus Bacteremia ◽  
Rule Out

scholarly journals 172. Risk Factors for 30-Day Mortality in Patients with Staphylococcus aureus Bacteremia at a Community Hospital: A Prospective Case–Control Study

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S109-S110
Author(s):  
Charles Hoffmann ◽  
Gordon Watkins ◽  
Patrick DeSimone ◽  
Peter Hallisey ◽  
David Hutchinson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Staphylococcus Aureus ◽  
Case Control Study ◽  
Community Hospital ◽  
Univariate Analysis ◽  
Case Control ◽  
Blood Cultures ◽  
Staphylococcus Aureus Bacteremia ◽  
Initial Blood ◽  
Control Study

Abstract Background Staphylococcus aureus bacteremia (SAB) is associated with 30-day all-cause mortality rates approaching 20–30%. The purpose of this case–control study was to evaluate risk factors for 30-day mortality in patients with SAB at a community hospital. Methods As part of an antimicrobial stewardship program (ASP) initiative mandating Infectious Diseases consultation for episodes of SAB, our ASP prospectively monitored all cases of SAB at a 341-bed community hospital in Jefferson Hills, PA from April 2017–February 2019. Cases included patients with 30-day mortality from the initial positive blood culture. Only the first episode of SAB was included; patients were excluded if a treatment plan was not established (e.g., left against medical advice). Patient demographics, comorbidities, laboratory results, and clinical management of SAB were evaluated. Inferential statistics were used to analyze risk factors associated with 30-day mortality. Results 100 patients with SAB were included; 18 (18%) experienced 30-day mortality. Cases were older (median age 76.5 vs. 64 years, P < 0.001), more likely to be located in the intensive care unit (ICU) at time of ASP review (55.6% vs. 30.5%, P = 0.043), and less likely to have initial blood cultures obtained in the emergency department (ED) (38.9% vs. 80.5%, P < 0.001). Variables associated with significantly higher odds for 30-day mortality in univariate analysis: older age, location in ICU at time of ASP review, initial blood cultures obtained at a location other than the ED, and total Charlson Comorbidity Index (CCI). Variables with P < 0.2 on univariate analysis were analyzed via multivariate logistic regression (Table 1). Conclusion Results show that bacteremia due to MRSA and total CCI were not significantly associated with 30-day mortality in SAB, whereas older age was identified as a risk factor. Patients with initial blood cultures obtained at a location other than the ED were at increased odds for 30-day mortality on univariate analysis, which may raise concern for delayed diagnosis. Disclosures All authors: No reported disclosures.

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