‘Beautiful in His Miracles, Beautiful in Calling to Life’

2020 ◽  
pp. 65-86
Author(s):  
Gerald O’Collins, S.J.
Keyword(s):  
Disabled Persons ◽  
Prodigal Son ◽  
Good Samaritan ◽  
The Dead ◽  
The Impact

The beauty that Augustine found in the miracles of Christ is exemplified in the healing of a leper, the feeding of the five thousand, and the raising of the dead son of a widow in Nain. The same manifestation of beauty occurs in other miracles, like two healings of disabled persons that took place in a synagogue on a Sabbath day. Such parables as those of the Good Samaritan and the Prodigal Son show Jesus to be beautiful in his preaching. Beauty also comes through the beatitudes which, according to Matthew and Luke, characterized and summarized the teaching of Jesus. All four Gospels witness to the impact that the beauty of Jesus enjoyed on his audiences, and not least on children who were drawn to him.

scholarly journals The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2574
Author(s):  
Jee Soo Park ◽  
Myung Eun Lee ◽  
Won Sik Jang ◽  
Koon Ho Rha ◽  
Seung Hwan Lee ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Quantitative Polymerase Chain Reaction ◽  
Parp Inhibitor ◽  
Renal Tumors ◽  
Low Grade ◽  
Normal Kidney ◽  
The Dead ◽  
The Impact

Genes associated with the DEAD-box helicase DDX11 are significant biomarkers of aggressive renal cell carcinoma (RCC), but their molecular function is poorly understood. We analyzed the molecular pathways through which DDX11 is involved in RCC cell survival and poly (ADP-ribose) polymerase (PARP) inhibitor sensitivity. Immunohistochemistry and immunoblotting determined DDX11 expression in normal kidney tissues, benign renal tumors, and RCC tissues and cell lines. Quantitative polymerase chain reaction validated the downregulation of DDX11 in response to transfection with DDX11-specific small interfering RNA. Proliferation analysis and apoptosis assays were performed to determine the impact of DDX11 knockdown on RCC cells, and the relevant effects of sunitinib, olaparib, and sunitinib plus olaparib were evaluated. DDX11 was upregulated in high-grade, advanced RCC compared to low-grade, localized RCC, and DDX11 was not expressed in normal kidney tissues or benign renal tumors. DDX11 knockdown resulted in the inhibition of RCC cell proliferation, segregation defects, and rapid apoptosis. DDX11-deficient RCC cells exhibited significantly increased sensitivity to olaparib compared to sunitinib alone or sunitinib plus olaparib combination treatments. Moreover, DDX11 could determine PARP inhibitor sensitivity in RCC. DDX11 could serve as a novel therapeutic biomarker for RCC patients who are refractory to conventional targeted therapies and immunotherapies.

Disability and the Urban Environment: A Perspective on Los Angeles

1986 ◽  
Vol 4 (3) ◽  
pp. 273-288 ◽  
Author(s):  
H Hahn
Keyword(s):  
Los Angeles ◽  
Sense Of Community ◽  
Minority Group ◽  
Primary Source ◽  
Disabled Persons ◽  
Social Attitudes ◽  
Geographic Dispersion ◽  
Personal Appearance ◽  
The Individual ◽  
The Impact

Increasingly, research on disability has been guided by a definition that focuses on the interaction between the individual and the environment and by a minority-group perspective based on the propositions that discriminatory attitudes are the primary source of the problems of disabled citizens, that the environment is shaped by public policy, and that policies reflect prevalent social attitudes and values. The implications of this approach for an analysis of the experience of disabled persons in Los Angeles are examined by assessing major characteristics of this urban area such as geographic dispersion, the absence of a sense of community, and the impact of pervasive standards of personal appearance. The investigation indicates a pressing need to provide increased accessibility for disabled residents to fulfill constitutional principles of freedom and equality.

scholarly journals Near East Desertification: impact of Dead Sea drying on convective rainfall

2019 ◽  
Author(s):  
Samiro Khodayar ◽  
Johannes Hoerner
Keyword(s):  
Lake Level ◽  
Weather Prediction ◽  
Regional Climate ◽  
Atmospheric Stability ◽  
Lower Boundary ◽  
Heavy Precipitation ◽  
Dead Sea ◽  
Decadal Scale ◽  
The Dead ◽  
The Impact

Abstract. The Dead Sea desertification-threatened region is affected by continual lake level decline and occasional, but life-endangering flash-floods. Climate change has aggravated such issues in the past decades. In this study, the impact of the Dead Sea drying on the severe convection generating heavy precipitation in the region is investigated. Perturbation simulations with the high-resolution convection-permitting regional climate model COSMO-CLM and several numerical weather prediction (NWP) runs on an event time scale are performed over the Dead Sea area. A reference simulation covering the 2003 to 2013 period and a twin sensitivity experiment, in which the Dead Sea is dried out and set to bare soil, are compared. NWP simulations focus on heavy precipitation events exhibiting relevant differences between the reference and the sensitivity decadal realization to assess the impact on the underlying convection-related processes. On a decadal scale, the difference between the simulations points out that in future regional climate, under ongoing lake level decline, a decrease in evaporation, higher air temperatures and less precipitation is to expect. Particularly, an increase in the number of dry days and in the intensity of heavy precipitation is foreseen. The drying of the Dead Sea is seen to affect the atmospheric conditions leading to convection in two ways: (a) the local decrease in evaporation reduces moisture availability in the lower boundary layer locally and in the neighbouring, directly affecting atmospheric stability. Weaker updrafts characterize the drier and more stable atmosphere of the simulations where the Dead Sea has been dried out. (b) Thermally driven wind system circulations and resulting divergence/convergence fields are altered preventing in many occasions convection initiation because of the omission of convergence lines.

scholarly journals The impact of SCIAMACHY near-infrared instrument calibration on CH<sub>4</sub> and CO total columns

2005 ◽  
Vol 5 (9) ◽  
pp. 2369-2383 ◽  
Author(s):  
A. M. S. Gloudemans ◽  
H. Schrijver ◽  
Q. Kleipool ◽  
M. M. P. van den Broek ◽  
A. G. Straume ◽  
...  
Keyword(s):  
Near Infrared ◽  
Transport Model ◽  
Random Effect ◽  
Model Calculations ◽  
Instrument Calibration ◽  
The Dead ◽  
The Impact ◽  
Dark Signal ◽  
Orbital Variation ◽  
Good Agreement

Abstract. The near-infrared spectra measured with the SCIAMACHY instrument on board the ENVISAT satellite suffer from several instrument calibration problems. The effects of three important instrument calibration issues on the retrieved methane (CH4) and carbon monoxide (CO) total columns have been investigated: the effects of the growing ice layer on the near-infrared detectors, the effects of the orbital variation of the instrument dark signal, and the effects of the dead/bad detector pixels. Corrections for each of these instrument calibration issues have been defined. The retrieved CH4 and CO total columns including these corrections show good agreement with CO measurements from the MOPITT satellite instrument and with CH4 model calculations by the chemistry transport model TM3. Using a systematic approach, it is shown that all three instrument calibration issues have a significant effect on the retrieved CH4 and CO total columns. However, the impact on the CH4 total columns is more pronounced than for CO, because of its smaller variability. Results for three different wavelength ranges are compared and show good agreement. The growing ice layer and the orbital variation of the dark signal show a systematic, but time-dependent effect on the retrieved CH4 and CO total columns, whereas the effect of the dead/bad pixels is rather unpredictable: some dead pixels show a random effect, some more systematic, and others no effect at all. The importance of accurate corrections for each of these instrument calibration issues is illustrated using examples where inaccurate corrections lead to a wrong interpretation of the results.

Lake level changes in the Dead Sea during the late Pleistocene recorded by fossil lake shorelines

2020 ◽  
Author(s):  
Julius Jara-Muñoz ◽  
Amotz Agnon ◽  
Jens Fohlmeister ◽  
Jürgen Mey ◽  
Norbert Frank ◽  
...  
Keyword(s):  
Carbon Isotopes ◽  
Lake Level ◽  
Late Quaternary ◽  
Dead Sea ◽  
Climatic Changes ◽  
Balance Model ◽  
Oxygen And Carbon Isotopes ◽  
Lake Level Changes ◽  
The Dead ◽  
The Impact

&lt;p&gt;&lt;span&gt;High-resolution records of lake-level changes are crucial to elucidate the impact of local and global climatic changes in lacustrine basins. The Late Quaternary evolution of the Dead Sea has been characterized by substantial variability apparently linked with global climatic changes, beign subject of many research efforts since decades. Previous studies have defined two main lake phases, the Lake Lisan and the Dead Sea, the earlier was a highstand period that lasted between ~70 and ~15 ka, the&amp;#160; latter was the lowstand period that persisted until the present. Here we focus on the switch between Lake Lisan and Dead Sea studying fossil lake shorelines, a sequence that comprises dozens of levels exposed along the rims of the Dead Sea, containing abundant fossil stromatolites that we dated by mean of radiocarbon and U-decay series. We determined 90 radiocarbon and 35 U-Th ages from stromatolites from almost every shoreline level. We compared U-Th and radiocarbon ages to estimating a radiocarbon reservoir between 0.2 and 0.8 ka, used to correct the remaining radiocarbon ages before calibration. The resulting ages range between ~45 &amp;#160;and ~20 ka. Dating was &lt;/span&gt;&lt;span&gt;complemented with analysis of stable oxygen and carbon isotopes. Furthermore, we applied a distributed hydrological balance model to constrain past precipitation and temperature conditions. Our results suggest that the duration of the last Lake Lisan highstand was shorter than previously estimated. Taking this at face value, the switch between Lake Lisan and Dead Sea occurred at ~28 ka, ~10 ka earlier than previously suggested. Oxygen and carbon isotopes show a consistent pattern, displaying a switch between wet and dry conditions at ~28 ka. Preliminary results from the hydrological model indicate a much stronger sensitivity of the lake level to precipitation amounts than to air temperature. From our results we can&amp;#8217;t observe a clear link between global temperature variations and lake-level changes in the Lisan/Dead Sea lakes. Similar non-linear response to northern hemisphere climatic changes have been also documented in Holocene Dead Sea paleoclimatic records, suggesting that global climatic variations may led to variable lake-level responses. The results of this study adds further complexity to the understanding of factors controlling climate variability in the Dead Sea. &lt;/span&gt;&lt;/p&gt;

The Determination of Stagnant Rate of Servo System Based on Adaptive Chatter Algorithm

2013 ◽  
Vol 860-863 ◽  
pp. 1787-1790
Author(s):  
Ting Zhao ◽  
Xiao Zhi Qiu ◽  
Ding Cai ◽  
Bao Hua Huang
Keyword(s):  
Dead Zone ◽  
Servo System ◽  
Signal Frequency ◽  
Determination Method ◽  
Dynamic Effects ◽  
Change Rate ◽  
The Dead ◽  
The Impact ◽  
Selection Of

The current determination of stagnant rate cannot eliminate the dynamic effects, especially the change rate of speed. Consider the problem of the current determination of stagnant rate, this work presents one determination method based on adaptive chatter algorithm .Simulation shows it can eliminate the impact of dynamics effectively. The method achieves the measurement online due to the signal of chatter can adapt to the dead zone of servo system. At last, the selection of the signal frequency is discussed.

Talking through the Dead: The Impact and Interplay of Lived Grief after Suicide

2014 ◽  
Vol 68 (2) ◽  
pp. 111-121 ◽  
Author(s):  
Kathy McKay ◽  
Joe Tighe
Keyword(s):  
Lived Experiences ◽  
Suicide Death ◽  
Suicide Bereavement ◽  
The Dead ◽  
The Impact

In the aftermath of suicide, grief becomes a multi-faceted experience. Traditionally, this grief was silenced where the shame attached to suicide invalidated a person's need for expression. Even now, it can be difficult for people to fully articulate their grief, let alone find an empathetic audience. How do we examine this grief to more clearly hear the voices of the bereaved, and to better understand how to support those who are grieving a suicide death? Indeed, the ripple of suicide grief touches more than those traditionally considered to be impacted by the death. Whole communities can be affected and it cannot be presumed that researchers do not have their own lived experiences of suicide bereavement. In this way, the newly-opened discourse around the experience of suicide grief needs to be dissected within more practical and appropriate research. A balance needs to be created in research where the voices of grief can be included but the experiential context understood and respected.

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