Effect of hepatitis C eradication with DAA on type II diabetes mellitus control as regard insulin resistance & lipid profile

Abstract Background Patients with chronic hepatitis C have both higher prevalence of diabetes mellitus type 2 (T2DM) and increased cardiovascular risk compared to never infected people. The patients with chronic HCV infection can have fatty liver, hypobetalipoproteinemia, and hypercholesterolemia that may cause lipid and lipid protein metabolism disorders. Objective To determine the effect of HCV eradication (SVR 12) on type II Diabetic patients as regard insulin resistance & lipid profile. Patients and Methods This study was conducted at the gastroenterology and hepatology unit, Ain shams university hospital and Ahmed Maher teaching hospital, Written informed consent was obtained from all subjects before participating in this study. 100 Egyptian patients with chronic hepatitis C and type II Diabetes mellitus were recruited and received (sofosbuvir & daclatasvir) for 3 months. patients continue on same antidiabetics all over the study. Results The data from the present study provide evidence of an improvement in IR after clearance of HCV by oral DAA regimen. On the basis of these data, it is possible to hypothesize that HCV clearance by DAAs improving IR and reducing stress on beta-cell function prevents or delay the development of type 2 diabetes mellitus and/or metabolic syndrome in chronic HCV infected patients. Conclusion The overall data of this study show that glycemic control improves in patients with diabetes after DAA induced SVR. Patients not only have an improvement in HbA1c level after achieving SVR, they are also less likely to require insulin. the viral clearance due to DAA also led to an improvement of glucose metabolism associated with a global worsening of lipid profile. The HCV clearance by DAA treatment reverses or improves IR and reduces stress on beta-cell function by emphasizing the role of HCV in the development of IR and that this result can prevent IR-related pathological conditions such as worsening liver fibrosis, development of type 2 diabetes, metabolic syndrome and cardio-vascular disorders.

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Genetic variability of the SUR1 promoter in relation to beta-cell function and Type II diabetes mellitus

Diabetologia ◽

10.1007/s001250100651 ◽

2001 ◽

Vol 44 (10) ◽

pp. 1330-1334 ◽

Cited By ~ 19

Author(s):

T. Hansen ◽

L. Ambye ◽

N. Grarup ◽

L. Hansen ◽

S. M. Echwald ◽

...

Keyword(s):

Diabetes Mellitus ◽

Genetic Variability ◽

Beta Cell ◽

Type Ii Diabetes ◽

Beta Cell Function ◽

Cell Function ◽

Type Ii Diabetes Mellitus ◽

Type Ii

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DIABETIC STRIATOPATHY: A RARE PRESENTATION OF NONKETOTIC HYPERGLYCEMIA

10.36106/gjra/3609974 ◽

2021 ◽

pp. 108-109

Author(s):

Ranjan Mallick ◽

Shyam Sunder Hembram ◽

Ram Chandra Bhadra Chandra Bhadra

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type Ii Diabetes ◽

Western Europe ◽

Rare Complication ◽

Type Ii Diabetes Mellitus ◽

Type Ii ◽

Rare Presentation ◽

Acute Hyperglycaemia

Type II Diabetes Mellitus is one of the most common non-communicable diseases with innumerable & potentially life threatening complications. In 2017, approximately 462 million individuals were affected by type 2 diabetes corresponding to 6.28% of the world's population (4.4% of those aged 15-49 years, 15% of those aged 50-69, and 22% of those aged 70+), or a prevalence rate of 6059 cases per 100,000. Over 1 million deaths per year can be attributed to diabetes alone, making it the ninth leading cause of mortality. The burden of diabetes mellitus is rising globally, and at a much faster rate in developed regions, such as Western Europe. The gender distribution is equal, and the incidence peaks at around 55 years of age. Global prevalence of type 2 diabetes is projected to increase to 7079 individuals per 100,000 by 2030, reecting a continued rise across all regions of the world.[¹] . Two of the common complications due to acute hyperglycaemia are Diabetic Ketocidosis & Non ketotic hyperosmolar coma which are considered a spectrum of the same complication due to low circulating levels of insulin leading to impaired glucose metabolism by insulin dependant tissues with rising levels of anti-insulin hormones like glucagon, cortisol & catecholamines due to intracellular starvation resulting in hypergylcemia & fatty acid breakdown & ketonemia. Amongst the numerous complications of Type II Diabetes Mellitus, here we present a rare complication of acute hyperglycaemia and its radiological picture in the central nervous system. A 56 year old female patient with a history of Type II Diabetes Mellitus with Hypertension under long term medication came for a private consultation with a complaint of Right sided involuntary, random, irregular, inging and ailing, rapid, non-patterned movements for past 7 days. The patient was advised for an urgent MRI of Brain which demonstrated high T1 signal & low T2/FLAIR intensity with no diffusion restriction of DWI & ADC map in left sided putamen & head of caudate nucleus. We illustrated a rare classical nding of acute hyperglycemic effect on brain in a case of long standing Type II Diabetes Mellitus despite being on medications

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Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

Annals of Clinical Chemistry and Laboratory Medicine ◽

10.3126/acclm.v2i2.15590 ◽

2017 ◽

Vol 2 (2) ◽

pp. 26-34

Author(s):

Hridaya Parajuli ◽

Jyotsna Shakya ◽

Bashu Dev Pardhe ◽

Puspa Raj Khanal ◽

Narayan Prasad Parajuli ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Uric Acid ◽

Serum Uric Acid ◽

Type Ii Diabetes ◽

Type Ii Diabetes Mellitus ◽

Diabetic Patients ◽

Type Ii ◽

Significant Difference

Background: Hyperuricemia is associated with type 2 diabetes, which is a metabolic disorder of multiple etiologies resulting from defects in insulin action. The present study wascarried out to look for any association between uric acid and Type II Diabetes Mellitus and also status of triacylglycerol level among those patients.Methods: The blood samples were collected 100 diabetic and 100 non-diabetic individuals in the department of biochemistry and then analyzed for estimation of blood glucose, Uric Acid and Triacylglycerol level.Results: The average level of serum uric acid in diabetic patients was higher (5.706±1.617) in comparison to non diabetic subjects (4.322±0.784) with statistically significant difference (p≤0.05). For female the result indicate there was a positive correlation between (FBS and triglycerides) and (triglycerides and uric acids) which was statistically significant (r =-0.465, n = 41, p = 0.002) and(r =-0.370, n = 41, p = 0.017) respectively.Conclusions: This study documents that hyperuricemia is associated with type 2 diabetes mellitus. Furthermore, the serum triacylglycerol and serum uric acid is also found to be associated risk factors for diabetic complications. Hence, timely diagnosis and management of diabetes is vital to control the complications related to diabetes.Ann. Clin. Chem. Lab. Med. 2016:2(1); 26-34

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Evaluation of outer hair cell function and medial olivocochlear efferent system in patients with type II diabetes mellitus

TURKISH JOURNAL OF MEDICAL SCIENCES ◽

10.3906/sag-1207-99 ◽

2014 ◽

Vol 44 ◽

pp. 150-156 ◽

Cited By ~ 8

Author(s):

Hayriye KARABULUT ◽

İsmail KARABULUT ◽

Muharrem DAĞLI ◽

Yıldırım Ahmet BAYAZIT ◽

Şule BİLEN ◽

...

Keyword(s):

Diabetes Mellitus ◽

Hair Cell ◽

Type Ii Diabetes ◽

Outer Hair Cell ◽

Cell Function ◽

Type Ii Diabetes Mellitus ◽

Type Ii ◽

Efferent System ◽

Medial Olivocochlear ◽

Medial Olivocochlear Efferent System

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Influence of Glycated Haemoglobin Levels on Intraocular Pressure in patients with Type –II Diabetes Mellitus

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v11i1.25412 ◽

2019 ◽

Vol 11 (1) ◽

pp. 19-23

Author(s):

Ajai Agrawal ◽

Shubham Ahuja ◽

Anupam Singh ◽

Ramanuj Samanta ◽

Sanjeev Kumar Mittal

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Intraocular Pressure ◽

Type Ii Diabetes ◽

Type Ii Diabetes Mellitus ◽

Type Ii ◽

Group I ◽

Hba1c Levels

Introduction: Patients with diabetes mellitus are at a higher risk of developing primary open angle glaucoma (POAG) as compared to non-diabetic patients. Objectives: To determine whether there is a correlation between hyperglycemic levels and intraocular pressure (IOP) and to identify patients of Type II diabetes mellitus who are at a higher risk of developing glaucoma. Materials and Methods: This was a hospital based, cross sectional study performed on patients with type II diabetes mellitus, at a tertiary health care center in Uttarakhand, India between July, 2018 and September, 2018. 318 eyes of 159 patients with Type2 diabetes mellitus were included in the study. IOP was measured by Goldmannappla nation to no meter and central corneal thickness was measured with specula microscope in all patients, in addition to glycated hemoglobin levels (HbA1c) and fasting and post-prandial blood glucose levels. The data was analysed using SPSS 22 software. Results: Mean IOP was found to be 15.75 ± 3.18 mm Hg in patients with HbA1c levels between 6.5%-12% (Group I) and 17.42 ± 2.67 mm Hg in patients with HbA1c levels more than 12 % (Group II). The difference between the two groups was statistically significant (P =0.013). Out of 159 patients with Type 2 Diabetes mellitus, a total of 11 patients had IOP more than 21mm Hg in one or both the eyes. Conclusion: Hyperglycaemic levels as determined by raised HbA1c levels are associated with higher intraocular pressures in patients with type 2 diabetes mellitus.

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Clinical evaluation of an Ayurvedic Formulation in the management of Avaranajanya Madhumeha (Type 2 Diabetes Mellitus)

Dev Sanskriti Interdisciplinary International Journal ◽

10.36018/dsiij.v1i.10 ◽

2019 ◽

Vol 1 ◽

pp. 50-64

Author(s):

DEVASHISH BHARDWAJ ◽

VEENIT K. AGNIHOTRI ◽

PRANAV PANDYA

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Blood Sugar ◽

Type Ii Diabetes ◽

Type Ii Diabetes Mellitus ◽

Type Ii ◽

Research Plan ◽

Urine Sugar ◽

Diabetes Patients

A research plan has been developed in the present study to address the problems associated with Avaranajanya Madhumeha (type 2 diabetes). This research plan is based on the treatment methods of Ayurveda (ancient Indian medicine) and utilization of modern scientific methods as research tools. A specific ayurvedic herbo-mineral formulation has been prepared in Ghansatt (solid extract) form; the selected eight herbs and one herbo-mineral have anti-hyperglycemic (PRAMEHA HARA) and antihypercholestermic (MEDOHARA) properties with rejuvenative (RASAYANA) effects as described in classical ayurvedic methods. 15 diagnosed type II diabetes mellitus patients were selected through accidental sampling. Ayurvedic formulation was prescribed to type II diabetes patients for one year along with dietary restrictions. Diabetic diagnostic parameters of these patients like Fasting Blood Sugar (FBS), Post Patrum Blood Sugar (PPBS), Glycocylated Hemoglobin (HbA1C) and Urine Sugar Fasting were monitored every three months; these were measured before and after intervention. The obtained data were statistically analyzed through paired t-test. There was significant reduction in FBS level, PPBS level, HbA1C level and urine fasting sugar level in type 2 diabetes patients who completed the clinical trial successfully. Thus, ayurvedic formulation treatment lead to an overall significant reduction in blood sugar and urine sugar levels in type II diabetes patients. No side effects were noted during the study period. This study suggests that the ayurvedic formulation had very good hypoglycemic effects proved by clinical improvement and bio-chemical analysis of diabetes parameters in the treatment of type II diabetes mellitus.

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MICROALBUMINEMIA;

The Professional Medical Journal ◽

10.29309/tpmj/2017.24.03.1618 ◽

2017 ◽

Vol 24 (03) ◽

pp. 478-481

Author(s):

Muhammad Mahboob Alam ◽

Muhammad Akhtar Parvez ◽

Muhammad Murtaza

Keyword(s):

Diabetes Mellitus ◽

Lipid Profile ◽

Type Ii Diabetes ◽

Type Ii Diabetes Mellitus ◽

Diabetic Patients ◽

Type Ii

Objective: to determine the frequency of microalbuminemia in type IIdiabetic patients and to compare lipid profile in type II diabetic patients with and withoutmicroalbuminuria. Settings: Department of Medicine, Allied Hospital, Faisalabad. Durationof study: From: January 2015 to December 2015. Results: In our study, mean age was53.18+9.32 years, 43.90% (n=151) were male and 56.10% (n=193) were females, frequencyof microalbuminuria in type II diabetes mellitus was recorded in 32.56%(n=112). Conclusion:the frequency of microalbuminemia in type II diabetic patients is higher while the frequencyof hypertriglyceridemias, increased LDL-C and decreased HDL-C in Type II diabetic patientsis significantly higher in patients with microalbuminuria when compared them withoutmicroalbuminuria..

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