ImmunoStart: preparing patients for immunosuppression
Abstract Objectives Patients with immune-mediated inflammatory disease (IMID) present an increased risk of infection. Here, we present the concept of a preventive consultation called ImmunoStart and the first results of its implementation in the care pathway of patients with IMID. Methods Relevant information about vaccination history, TB exposition and other infectious risks are collected through blood sampling, complete anamnesis, chest X-Ray and Mantoux test. During ImmunoStart consultation, vaccination schedules, specific treatments and risk considerations are discussed. Results Between October 2016 and February 2020, 437 patients were seen at the ImmunoStart consultation, mainly referred by rheumatologists (56%), dermatologists (25%), and gastroenterologists (18%). A total of 421 (96%) patients needed at least one vaccine (a mean of 3.3 vaccines per patient). Live attenuated vaccine was indicated for 45 patients (10%), requiring them to reduce or interrupt their immunosuppressive drug(s). Ninety-two patients (21%) were treated for latent TB infection. Conclusion This preventive consultation provides a centralized and systematic setting for the direct management of patients with IMID in need of vaccination, treatment of latent disease and specific advice regarding their immunomodulating treatments.