scholarly journals Neural responses reveal associations between personal values and value-based decisions

2020 ◽  
Vol 15 (12) ◽  
pp. 1299-1309
Author(s):  
Yun-Shiuan Chuang ◽  
Yu-Shiang Su ◽  
Joshua O S Goh
Keyword(s):  
Functional Connectivity ◽  
Personal Values ◽  
Functional Brain Imaging ◽  
Anterior Cingulate ◽  
Affective Processing ◽  
Dorsal Anterior Cingulate Cortex ◽  
Whole Brain ◽  
Personal Value ◽  
Schwartz Value Survey ◽  
Dorsolateral Prefrontal

Abstract Personal values are thought to modulate value-based decisions, but the neural mechanisms underlying this influence remain unclear. Using a Lottery Choice Task functional brain imaging experiment, we examined the associations between personal value for hedonism and security (based on the Schwartz Value Survey) and subjective neurocognitive processing of reward and loss probability and magnitude objectively coded in stimuli. Hedonistic individuals accepted more losing stakes and showed increased right dorsolateral prefrontal and striatal and left parietal responses with increasing probability of losing. Individuals prioritizing security rejected more stakes and showed reduced right inferior frontal and amygdala responses with increasing stake magnitude, but increased precuneus responses for high-magnitude high-winning probability. With higher hedonism, task-related functional connectivity with the whole brain was higher in right insula and lower in bilateral habenula. For those with higher security ratings, whole-brain functional connectivity was higher in bilateral insula, supplementary motor areas, right superior frontal gyrus, dorsal anterior cingulate cortex, and lower in right middle occipital gyrus. These findings highlight distinct neural engagement across brain systems involved in reward and affective processing, and cognitive control that subserves how individual differences in personal value for gaining rewards or maintaining status quo modulate value-based decisions

scholarly journals Neural Basis of Ambivalence towards Ideal Self-Image in Schizophrenia

2020 ◽  
Vol 17 (5) ◽  
pp. 452-459
Author(s):  
Byung-Hoon Kim ◽  
Yu-Bin Shin ◽  
Sunghyon Kyeong ◽  
Seon-Koo Lee ◽  
Jae-Jin Kim
Keyword(s):  
Functional Connectivity ◽  
Cognitive Conflict ◽  
Anterior Cingulate ◽  
Conflict Monitoring ◽  
Ideal Self ◽  
Neural Basis ◽  
Dorsal Anterior Cingulate Cortex ◽  
Value Judgment ◽  
Self Image ◽  
Dorsolateral Prefrontal

Objective Little has been explored about a reflection towards self-image in schizophrenia, though it can be related to heterogeneous symptoms of the illness. We identified the neural basis of ambivalence towards ideal self-image in patients with schizophrenia.Methods 20 patients with schizophrenia and 20 healthy controls underwent functional MRI while the self-image reflection tasks of determining whether to agree with sentences describing their actual or ideal self-image that contained one of the adjective pairs with opposite valence. The interaction between the group and ideal ambivalence score was examined, and group differences in functional connectivity related to ambivalence towards ideal self-image were further studied.Results The interaction of group-by-ideal ambivalence score was shown in the dorsal anterior cingulate cortex and dorsolateral prefrontal cortex, where activities were positively correlated with the level of ideal self-image ambivalence in patients, but not in controls. Task-related decrease in functional connectivity was shown between the orbitofrontal cortex and cerebellum in patients.Conclusion The process of reflecting on ambivalent ideal self-image in schizophrenia may be related to aberrant prefrontal activity and connectivity. Abnormality in the prefrontal regions that take part in cognitive conflict monitoring and value judgment may underlie the pathophysiology of increased ambivalence towards ideal self-image.

scholarly journals Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
G. R. Wylie ◽  
B. Yao ◽  
H. M. Genova ◽  
M. H. Chen ◽  
J. DeLuca
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Dorsolateral Prefrontal Cortex ◽  
Functional Neuroimaging ◽  
Anterior Cingulate ◽  
Healthy Individuals ◽  
Dorsal Anterior Cingulate Cortex ◽  
Mental Work ◽  
Cognitive Fatigue ◽  
Dorsolateral Prefrontal

AbstractCognitive fatigue, or fatigue related to mental work, is a common experience. A growing body of work using functional neuroimaging has identified several regions that appear to be related to cognitive fatigue and that potentially comprise a “fatigue network”. These include the striatum of the basal ganglia, the dorsolateral prefrontal cortex (DLPFC), the dorsal anterior cingulate cortex (dACC), the ventro-medial prefrontal cortex (vmPFC) and the anterior insula. However, no work has been conducted to assess whether the connectivity between these regions changes as a function of cognitive fatigue. We used a task-based functional neuroimaging paradigm to induce fatigue in 39 healthy individuals, regressed the signal associated with the task out of the data, and investigated how the functional connectivity between these regions changed as cognitive fatigue increased. We observed functional connectivity between these regions and other frontal regions largely decreased as cognitive fatigue increased while connectivity between these seeds and more posterior regions increased. Furthermore the striatum, the DLPFC, the insula and the vmPFC appeared to be central ‘nodes’ or hubs of the fatigue network. These findings represent the first demonstration that the functional connectivity between these areas changes as a function of cognitive fatigue.

scholarly journals Alexithymia and frontal–amygdala functional connectivity in North Korean refugees

2019 ◽  
Vol 50 (2) ◽  
pp. 334-341 ◽  
Author(s):  
Nambeom Kim ◽  
Inkyung Park ◽  
Yu Jin Lee ◽  
Sehyun Jeon ◽  
Soohyun Kim ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Emotional Processing ◽  
Anterior Cingulate ◽  
Traumatic Experiences ◽  
Resting State Functional Connectivity ◽  
Dorsal Anterior Cingulate Cortex ◽  
North Korean Refugees ◽  
Dorsolateral Prefrontal ◽  
Resting State Connectivity

AbstractBackgroundRefugees commonly experience difficulties with emotional processing, such as alexithymia, due to stressful or traumatic experiences. However, the functional connectivity of the amygdala, which is central to emotional processing, has yet to be assessed in refugees. Thus, the present study investigated the resting-state functional connectivity of the amygdala and its association with emotional processing in North Korean (NK) refugees.MethodsThis study included 45 NK refugees and 40 native South Koreans (SK). All participants were administered the Toronto Alexithymia Scale (TAS), Beck Depression Inventory (BDI), and Clinician-administered PTSD Scale (CAPS), and differences between NK refugees and native SK in terms of resting-state functional connectivity of the amygdala were assessed. Additionally, the association between the strength of amygdala connectivity and the TAS score was examined.ResultsResting-state connectivity values from the left amygdala to the bilateral dorsolateral prefrontal cortex (dlPFC) and dorsal anterior cingulate cortex (dACC) were higher in NK refugees than in native SK. Additionally, the strength of connectivity between the left amygdala and right dlPFC was positively associated with TAS score after controlling for the number of traumatic experiences and BDI and CAPS scores.ConclusionsThe present study found that NK refugees exhibited heightened frontal–amygdala connectivity, and that this connectivity was correlated with alexithymia. The present results suggest that increased frontal–amygdala connectivity in refugees may represent frontal down-regulation of the amygdala, which in turn may produce alexithymia.

Effects of unilateral deactivations of dorsolateral prefrontal cortex and anterior cingulate cortex on saccadic eye movements

2014 ◽  
Vol 111 (4) ◽  
pp. 787-803 ◽  
Author(s):  
Michael J. Koval ◽  
R. Matthew Hutchison ◽  
Stephen G. Lomber ◽  
Stefan Everling
Keyword(s):  
Prefrontal Cortex ◽  
Eye Movements ◽  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Saccadic Eye Movements ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Dorsolateral Prefrontal ◽  
Single Neuron Recording

The dorsolateral prefrontal cortex (dlPFC) and anterior cingulate cortex (ACC) have both been implicated in the cognitive control of saccadic eye movements by single neuron recording studies in nonhuman primates and functional imaging studies in humans, but their relative roles remain unclear. Here, we reversibly deactivated either dlPFC or ACC subregions in macaque monkeys while the animals performed randomly interleaved pro- and antisaccades. In addition, we explored the whole-brain functional connectivity of these two regions by applying a seed-based resting-state functional MRI analysis in a separate cohort of monkeys. We found that unilateral dlPFC deactivation had stronger behavioral effects on saccades than unilateral ACC deactivation, and that the dlPFC displayed stronger functional connectivity with frontoparietal areas than the ACC. We suggest that the dlPFC plays a more prominent role in the preparation of pro- and antisaccades than the ACC.

scholarly journals Altered Long- and Short-Range Functional Connectivity in Patients with Betel Quid Dependence: A Resting-State Functional MRI Study

2016 ◽  
Vol 40 (6) ◽  
pp. 1626-1636 ◽  
Author(s):  
Tao Liu ◽  
Jianjun Li ◽  
Zhiqiang Zhang ◽  
Qiang Xu ◽  
Guangming Lu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Long Range ◽  
Short Range ◽  
Anterior Cingulate ◽  
Betel Quid ◽  
Posterior Lobe ◽  
Functional Connectivity Density ◽  
Dorsolateral Prefrontal ◽  
The Right ◽  
Mri Study

Objective: Addiction is a chronic relapsing brain disease. Brain structural abnormalities may constitute an abnormal neural network that underlies the risk of drug dependence. We hypothesized that individuals with Betel Quid Dependence (BQD) have functional connectivity alterations that can be described by long- and short-range functional connectivity density(FCD) maps. Methods: We tested this hypothesis using functional magnetic resonance imaging (fMRI) data from subjects of the Han ethnic group in Hainan, China. Here, we examined BQD individuals (n = 33) and age-, sex-, and education-matched healthy controls (HCs) (n = 32) in a rs-fMRI study to observe FCD alterations associated with the severity of BQD. Results: Compared with HCs, long-range FCD was decreased in the right anterior cingulate cortex (ACC) and increased in the left cerebellum posterior lobe (CPL) and bilateral inferior parietal lobule (IPL) in the BQD group. Short-range FCD was reduced in the right ACC and left dorsolateral prefrontal cortex (dlPFC), and increased in the left CPL. The short-range FCD alteration in the right ACC displayed a negative correlation with the Betel Quid Dependence Scale (BQDS) (r=-0.432, P=0.012), and the long-range FCD alteration of left IPL showed a positive correlation with the duration of BQD(r=0.519, P=0.002) in BQD individuals. Conclusions: fMRI revealed differences in long- and short- range FCD in BQD individuals, and these alterations might be due to BQ chewing, BQ dependency, or risk factors for developing BQD.

scholarly journals Dorsal anterior cingulate cortex intrinsic functional connectivity linked to electrocortical measures of error-monitoring

2020 ◽  
Author(s):  
Hayley Gilbertson ◽  
Lin Fang ◽  
Jeremy A. Andrzejewski ◽  
Joshua M. Carlson
Keyword(s):  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Flanker Task ◽  
Monitoring Network ◽  
Cingulate Cortex ◽  
Event Related Potential ◽  
Anterior Cingulate ◽  
Functional Coupling ◽  
Error Monitoring ◽  
Dorsal Anterior Cingulate Cortex

AbstractThe error-related negativity (ERN) is a response-locked event-related potential, occurring approximately 50 ms following an erroneous response at frontocentral electrode sites. Source localization and functional magnetic resonance imaging (fMRI) research indicate that the ERN is likely generated by activity in the dorsal anterior cingulate cortex (dACC). The dACC is thought to be a part of a broader network of brain regions that collectively comprise an error-monitoring network. However, little is known about how intrinsic connectivity within the dACC-based error-monitoring network contributes to variability in ERN amplitude. The purpose of this study was to assess the relationship between dACC functional connectivity and ERN amplitude. In a sample of 53 highly trait-anxious individuals, the ERN was elicited in a flanker task and functional connectivity was assessed in a 10-minute resting-state fMRI scan. Results suggest that the strength of dACC seeded functional connectivity with the supplementary motor area is correlated with the ΔERN (i.e., incorrect – correct responses) amplitude such that greater ΔERN amplitude was accompanied by greater functional coupling between these regions. In addition to the dACC, exploratory analyses found that functional connectivity in the caudate, cerebellum, and a number of regions in the error-monitoring network were linked to variability in ΔERN amplitude. In sum, ERN amplitude appears to be related to the strength of functional connectivity between error-monitoring and motor control regions of the brain.

scholarly journals Altered resting-state dorsal anterior cingulate cortex functional connectivity in patients with post-traumatic stress disorder

2018 ◽  
Vol 53 (1) ◽  
pp. 68-79 ◽  
Author(s):  
Hui Juan Chen ◽  
Li Zhang ◽  
Jun Ke ◽  
Rongfeng Qi ◽  
Qiang Xu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Anterior Cingulate Cortex ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Post Traumatic Stress ◽  
Dorsal Anterior Cingulate Cortex ◽  
Post Traumatic

Objective: The brain functional alterations at regional and network levels in post-traumatic stress disorder patients are still unclear. This study explored brain functional alterations at regional and network levels in post-traumatic stress disorder patients with resting-state functional magnetic resonance imaging and evaluated the relationship between brain function and clinical indices in post-traumatic stress disorder. Methods: Amplitude of low-frequency fluctuation and seed-based functional connectivity analyses were conducted among typhoon survivors with ( n = 27) and without post-traumatic stress disorder ( n = 33) and healthy controls ( n = 30) to assess the spontaneous brain activity and network-level brain function. Pearson correlation analyses were performed to examine the association of brain function with clinical symptom and social support. Results: Both the post-traumatic stress disorder group and the trauma-exposed control group showed decreased amplitude of low-frequency fluctuation in the dorsal anterior cingulate cortex relative to the healthy control group. The post-traumatic stress disorder group showed increased dorsal anterior cingulate cortex functional connectivity with the right paracentral lobule and bilateral precentral gyrus/postcentral gyrus relative to both control groups. Both traumatized groups exhibited decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus and left cerebellum relative to the healthy control group. More decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus was found in the post-traumatic stress disorder group. The Checklist-Civilian Version score positively correlated with functional connectivity between the dorsal anterior cingulate cortex and the right paracentral lobule as well as between the dorsal anterior cingulate cortex and the right precentral gyrus/postcentral gyrus. The social support was associated with functional connectivity between the dorsal anterior cingulate cortex and the bilateral precentral gyrus/postcentral gyrus as well as the dorsal anterior cingulate cortex and the left middle frontal gyrus. Conclusion: Trauma exposure may result in aberrant local and network-level functional connectivity in individuals with or without post-traumatic stress disorder. Altered amplitude of low-frequency fluctuation in the dorsal anterior cingulate cortex may be a predisposing risk factor for post-traumatic stress disorder development following trauma exposure. More prominent decreased dorsal anterior cingulate cortex functional connectivity with the right hippocampus might be specific in the post-traumatic stress disorder group. Improvement of social support might possibly be significant for post-traumatic stress disorder patients.

scholarly journals Increased Resting State Triple Network Functional Connectivity in Undergraduate Problematic Cannabis Users: A Preliminary EEG Coherence Study

2020 ◽  
Vol 10 (3) ◽  
pp. 136 ◽  
Author(s):  
Claudio Imperatori ◽  
Chiara Massullo ◽  
Giuseppe Alessio Carbone ◽  
Angelo Panno ◽  
Marta Giacchini ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Large Scale ◽  
Posterior Parietal Cortex ◽  
Cannabis Use ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
Addictive Disorders ◽  
Eeg Recordings ◽  
Large Scale Networks

An increasing body of experimental data have suggested that aberrant functional interactions between large-scale networks may be the most plausible explanation of psychopathology across multiple mental disorders, including substance-related and addictive disorders. In the current research, we have investigated the association between problematic cannabis use (PCU) and triple-network electroencephalographic (EEG) functional connectivity. Twelve participants with PCU and 24 non-PCU participants were included in the study. EEG recordings were performed during resting state (RS). The exact Low-Resolution Electromagnetic Tomography software (eLORETA) was used for all EEG analyses. Compared to non-PCU, PCU participants showed an increased delta connectivity between the salience network (SN) and central executive network (CEN), specifically, between the dorsal anterior cingulate cortex and right posterior parietal cortex. The strength of delta connectivity between the SN and CEN was positively and significantly correlated with higher problematic patterns of cannabis use after controlling for age, sex, educational level, tobacco use, problematic alcohol use, and general psychopathology (rp = 0.40, p = 0.030). Taken together, our results show that individuals with PCU could be characterized by a specific dysfunctional interaction between the SN and CEN during RS, which might reflect the neurophysiological underpinnings of attentional and emotional processes of cannabis-related thoughts, memories, and craving.

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