scholarly journals Peripheral Blood Leukocyte Gene Expression Patterns and Metabolic Parameters in Habitually Snoring and Non-Snoring Children with Normal Polysomnographic Findings

SLEEP ◽  
2011 ◽  
Vol 34 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Abdelnaby Khalyfa ◽  
Sina A. Gharib ◽  
Jinkwan Kim ◽  
Oscar Sans Capdevila ◽  
Leila Kheirandish-Gozal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Peripheral Blood ◽  
Expression Patterns ◽  
Peripheral Blood Leukocyte ◽  
Metabolic Parameters ◽  
Gene Expression Patterns ◽  
Blood Leukocyte

scholarly journals Pre-treatment clinical and gene expression patterns predict developmental change in early intervention in autism

2021 ◽  
Author(s):  
Michael V. Lombardo ◽  
Elena Maria Busuoli ◽  
Laura Schreibman ◽  
Aubyn C. Stahmer ◽  
Tiziano Pramparo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Treatment Outcome ◽  
Early Intervention ◽  
Developmental Change ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Time In Treatment ◽  
Pre Treatment ◽  
Blood Leukocyte ◽  
The Impact

AbstractEarly detection and intervention are believed to be key to facilitating better outcomes in children with autism, yet the impact of age at treatment start on the outcome is poorly understood. While clinical traits such as language ability have been shown to predict treatment outcome, whether or not and how information at the genomic level can predict treatment outcome is unknown. Leveraging a cohort of toddlers with autism who all received the same standardized intervention at a very young age and provided a blood sample, here we find that very early treatment engagement (i.e., <24 months) leads to greater gains while controlling for time in treatment. Pre-treatment clinical behavioral measures predict 21% of the variance in the rate of skill growth during early intervention. Pre-treatment blood leukocyte gene expression patterns also predict the rate of skill growth, accounting for 13% of the variance in treatment slopes. Results indicated that 295 genes can be prioritized as driving this effect. These treatment-relevant genes highly interact at the protein level, are enriched for differentially histone acetylated genes in autism postmortem cortical tissue, and are normatively highly expressed in a variety of subcortical and cortical areas important for social communication and language development. This work suggests that pre-treatment biological and clinical behavioral characteristics are important for predicting developmental change in the context of early intervention and that individualized pre-treatment biology related to histone acetylation may be key.

scholarly journals Gene expression patterns in CD4+ peripheral blood cells in healthy subjects and stage IV melanoma patients

2015 ◽  
Vol 64 (11) ◽  
pp. 1437-1447 ◽  
Author(s):  
Sara J. Felts ◽  
Virginia P. Van Keulen ◽  
Adam D. Scheid ◽  
Kathleen S. Allen ◽  
Renee K. Bradshaw ◽  
...  
Keyword(s):  
Gene Expression ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Healthy Subjects ◽  
Expression Patterns ◽  
Stage Iv ◽  
Gene Expression Patterns ◽  
Peripheral Blood Cells ◽  
Melanoma Patients ◽  
Stage Iv Melanoma

scholarly journals Differential Effects of Influenza Virus NA, HA Head, and HA Stalk Antibodies on Peripheral Blood Leukocyte Gene Expression during Human Infection

mBio ◽  
2019 ◽  
Vol 10 (3) ◽  
Author(s):  
Kathie-Anne Walters ◽  
Ruoqing Zhu ◽  
Michael Welge ◽  
Kelsey Scherler ◽  
Jae-Keun Park ◽  
...  
Keyword(s):  
Gene Expression ◽  
Disease Severity ◽  
Peripheral Blood ◽  
Serum Antibody ◽  
Peripheral Blood Leukocyte ◽  
Global Gene Expression ◽  
Clinical Disease ◽  
Viral Shedding ◽  
Antibody Titers ◽  
Blood Leukocyte

ABSTRACT In this study, we examined the relationships between anti-influenza virus serum antibody titers, clinical disease, and peripheral blood leukocyte (PBL) global gene expression during presymptomatic, acute, and convalescent illness in 83 participants infected with 2009 pandemic H1N1 virus in a human influenza challenge model. Using traditional statistical and logistic regression modeling approaches, profiles of differentially expressed genes that correlated with active viral shedding, predicted length of viral shedding, and predicted illness severity were identified. These analyses further demonstrated that challenge participants fell into three peripheral blood leukocyte gene expression phenotypes that significantly correlated with different clinical outcomes and prechallenge serum titers of antibodies specific for the viral neuraminidase, hemagglutinin head, and hemagglutinin stalk. Higher prechallenge serum antibody titers were inversely correlated with leukocyte responsiveness in participants with active disease and could mask expression of peripheral blood markers of clinical disease in some participants, including viral shedding and symptom severity. Consequently, preexisting anti-influenza antibodies may modulate PBL gene expression, and this must be taken into consideration in the development and interpretation of peripheral blood diagnostic and prognostic assays of influenza infection. IMPORTANCE Influenza A viruses are significant human pathogens that caused 83,000 deaths in the United States during 2017 to 2018, and there is need to understand the molecular correlates of illness and to identify prognostic markers of viral infection, symptom severity, and disease course. Preexisting antibodies against viral neuraminidase (NA) and hemagglutinin (HA) proteins play a critical role in lessening disease severity. We performed global gene expression profiling of peripheral blood leukocytes collected during acute and convalescent phases from a large cohort of people infected with A/H1N1pdm virus. Using statistical and machine-learning approaches, populations of genes were identified early in infection that correlated with active viral shedding, predicted length of shedding, or disease severity. Finally, these gene expression responses were differentially affected by increased levels of preexisting influenza antibodies, which could mask detection of these markers of contagiousness and disease severity in people with active clinical disease.

scholarly journals Gene Expression Patterns in Peripheral Blood Correlate with the Extent of Coronary Artery Disease

PLoS ONE ◽  
2009 ◽  
Vol 4 (9) ◽  
pp. e7037 ◽  
Author(s):  
Peter R. Sinnaeve ◽  
Mark P. Donahue ◽  
Peter Grass ◽  
David Seo ◽  
Jacky Vonderscher ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Peripheral Blood ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Artery Disease

scholarly journals Early detection of breast cancer based on gene-expression patterns in peripheral blood cells

2005 ◽  
Vol 7 (5) ◽  
Author(s):  
Praveen Sharma ◽  
Narinder S Sahni ◽  
Robert Tibshirani ◽  
Per Skaane ◽  
Petter Urdal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Early Detection ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Peripheral Blood Cells
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