293 Predictive utility of a brief scale to identify U.S. Army Soldiers who are genetically vulnerable and resilient to sleep loss

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A117-A117
Author(s):  
Janna Mantua ◽  
Carolyn Mickelson ◽  
Jacob Naylor ◽  
Bradley Ritland ◽  
Alexxa Bessey ◽  
...  
Keyword(s):  
Decision Making ◽  
Reaction Time ◽  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Response Inhibition ◽  
Sleep Loss ◽  
Cutoff Score ◽  
Cognitive Subscale ◽  
Army Soldiers ◽  
Psychomotor Vigilance

Abstract Introduction Sleep loss that is inherent to military operations can lead to cognitive errors and potential mission failure. Single Nucleotide Polymorphisms (SNPs) allele variations of several genes (COMT, ADORA2A, TNFa, CLOCK, DAT1) have been linked with inter-individual cognitive resilience to sleep loss through various mechanisms. U.S. Army Soldiers with resilience-related alleles may be better-suited to perform cognitively-arduous duties under conditions of sleep loss than those without these alleles. However, military-wide genetic screening is costly, arduous, and infeasible. This study tested whether a brief survey of subjective resilience to sleep loss (1) can demarcate soldiers with and without resilience-related alleles, and, if so, (2) can predict cognitive performance under conditions of sleep loss. Methods Six SNPs from the aforementioned genes were sequenced from 75 male U.S. Army special operations Soldiers (age 25.7±4.1). Psychomotor vigilance, response inhibition, and decision-making were tested after a night of mission-driven total sleep deprivation. The Iowa Resilience to Sleeplessness Test (iREST) Cognitive Subscale, which measures subjective cognitive resilience to sleep loss, was administered after a week of recovery sleep. A receiver operating characteristic (ROC) curve was used to determine whether the iREST Cognitive Subscale can discriminate between gene carriers, and a cutoff score was determined. Cognitive performance after sleep deprivation was compared between those below/above the cutoff score using t-tests or Mann-Whitney U tests. Results The iREST discriminated between allele variations for COMT (ROC=.65,SE=.07,p=.03), with an optimal cutoff score of 3.03 out of 5, with 90% sensitivity and 51.4% specificity. Soldiers below the cutoff score had significantly poorer for psychomotor vigilance reaction time (t=-2.39,p=.02), response inhibition errors of commission (U=155.00,W=246.00,p=.04), and decision-making reaction time (t=2.13,p=.04) than Soldiers above the cutoff score. Conclusion The iREST Cognitive Subscale can discriminate between those with and without specific vulnerability/resilience-related genotypes. If these findings are replicated, the iREST Cognitive Subscale could be used to help military leaders make decisions about proper personnel placement when sleep loss is unavoidable. This would likely result in increased safety and improved performance during military missions. Support (if any) Support for this study came from the Military Operational Medicine Research Program of the United States Army Medical Research and Development Command.

Self-Reported Sleep Need, Subjective Resilience, and Cognitive Performance Following Sleep Loss and Recovery Sleep

2020 ◽  
pp. 003329411989989
Author(s):  
Janna Mantua ◽  
Allison J. Brager ◽  
Sara E. Alger ◽  
Folarin Adewle ◽  
Lillian Skeiky ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Test Performance ◽  
Cost Effective ◽  
Sleep Loss ◽  
Subjective Sleep ◽  
Psychomotor Vigilance Test ◽  
Recovery Sleep ◽  
Vigilance Test ◽  
Psychomotor Vigilance

Objective Individuals vary in response to sleep loss: some individuals are “vulnerable” and demonstrate cognitive decrements following insufficient sleep, while others are “resistant” and maintain baseline cognitive capability. Physiological markers (e.g., genetic polymorphisms) have been identified that can predict relative vulnerability. However, a quick, cost-effective, and feasible subjective predictor tool has not been developed. The objective of the present study was to determine whether two factors—“subjective sleep need” and “subjective resilience”—predict cognitive performance following sleep deprivation. Methods Twenty-seven healthy, sleep-satiated young adults participated. These individuals were screened for sleep disorders, comorbidities, and erratic sleep schedules. Prior to 40 hours of in-laboratory total sleep deprivation, participants were questioned on their subjective sleep need and completed a validated resilience scale. During and after sleep deprivation, participants completed a 5-minute psychomotor vigilance test every 2 hours. Results Both subjective resilience and subjective sleep need individually failed to predict performance during sleep loss. However, these two measures interacted to predict performance. Individuals with low resilience and low sleep need had poorer cognitive performance during sleep loss. However, in individuals with medium or high resilience, psychomotor vigilance test performance was not predicted by subjective sleep need. Higher resilience may be protective against sleep loss-related neurobehavioral impairments in the context of subjective sleep need. Conclusions Following sleep loss (and recovery sleep), trait resilient individuals may outperform those with lower resiliency on real-world tasks that require continuous attention. Future studies should determine whether the present findings generalize to other, operationally relevant tasks and additional cognitive domains.

scholarly journals Cognition and Alertness in Medical Students: Effects of a Single Night of Partial Sleep Deprivation

2020 ◽  
Vol 27 (2) ◽  
pp. 57-62
Author(s):  
Priyadarshini Mishra ◽  
Madhuri Panigrahi ◽  
D. Ankit
Keyword(s):  
Reaction Time ◽  
Medical Students ◽  
Sleep Deprivation ◽  
Event Related Potential ◽  
Care Hospital ◽  
Variable Effect ◽  
Indian Context ◽  
Partial Sleep Deprivation ◽  
Single Night ◽  
Psychomotor Vigilance

Background: Partial sleep deprivation is common among young adults today. Though multiple studies have stressed on the benefits of having a good sleep, medical students often compromise their sleep due to academic targets and stress. This can lead to changes in attention and cognition. The effects of acute partial sleep deprivation of a single night have been studied less and studies in the past in Indian context have shown controversial results that reaction time is decreased following acute partial sleep deprivation. Purpose: The purpose of the study was to evaluate the effects of a single night of partial sleep deprivation on the cognitive status and alertness of medical students in the Indian context and to find out the change in auditory event-related potential (AERP) and psychomotor vigilance of medical students following a single night of partial sleep deprivation. Methods: The study was a before–after experimental trial conducted among 20 medical student volunteers of a tertiary care hospital of eastern India. Baseline psychomotor vigilance task measured by unprepared serial reaction time, and AERP measured by P300, were assessed at baseline (after normal sleep) and after four hours of sleep deprivation (intervention). Results: It was seen that median RT had increased from 320.4 ms to 337.6 ms after acute partial sleep deprivation ( P < .001). P300 and lapses ( P < .05) were also found to increase significantly ( P < .05), while there was significant decrease in correctness ( P < .01). Conclusion: The study concluded that cognition is affected, including alertness and latency, following partial sleep deprivation even for a single night and contradicted earlier results of Indian studies stating variable effect on psychomotor vigilance.

scholarly journals Effects of Sleep Deprivation on Brain Bioenergetics, Sleep, and Cognitive Performance in Cocaine-Dependent Individuals

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
George H. Trksak ◽  
Bethany K. Bracken ◽  
J. Eric Jensen ◽  
David T. Plante ◽  
David M. Penetar ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Sleep Loss ◽  
Continuous Performance ◽  
Digit Symbol ◽  
Continuous Performance Task ◽  
Performance Task ◽  
Recovery Sleep ◽  
Symbol Substitution ◽  
Healthy Control

In cocaine-dependent individuals, sleep is disturbed during cocaine use and abstinence, highlighting the importance of examining the behavioral and homeostatic response to acute sleep loss in these individuals. The current study was designed to identify a differential effect of sleep deprivation on brain bioenergetics, cognitive performance, and sleep between cocaine-dependent and healthy control participants. 14 healthy control and 8 cocaine-dependent participants experienced consecutive nights of baseline, total sleep deprivation, and recovery sleep in the research laboratory. Participants underwent[31]P magnetic resonance spectroscopy (MRS) brain imaging, polysomnography, Continuous Performance Task, and Digit Symbol Substitution Task. Following recovery sleep,[31]P MRS scans revealed that cocaine-dependent participants exhibited elevated global brainβ-NTP (direct measure of adenosine triphosphate),α-NTP, and total NTP levels compared to those of healthy controls. Cocaine-dependent participants performed worse on the Continuous Performance Task and Digit Symbol Substitution Task at baseline compared to healthy control participants, but sleep deprivation did not worsen cognitive performance in either group. Enhancements of brain ATP levels in cocaine dependent participants following recovery sleep may reflect a greater impact of sleep deprivation on sleep homeostasis, which may highlight the importance of monitoring sleep during abstinence and the potential influence of sleep loss in drug relapse.

Lack of Degradation in Visuospatial Perception of Line Orientation after One Night of Sleep Loss

2007 ◽  
Vol 105 (1) ◽  
pp. 276-286 ◽  
Author(s):  
William D. S. Killgore ◽  
Athena P. Kendall ◽  
Jessica M. Richards ◽  
Sharon A. McBride
Keyword(s):  
Sleep Deprivation ◽  
Cognitive Abilities ◽  
Spatial Perception ◽  
Sleep Loss ◽  
Line Orientation ◽  
Performance Deficits ◽  
Visuospatial Perception ◽  
Psychomotor Vigilance ◽  
The Brain ◽  
Orientation Test

Sleep deprivation impairs a variety of cognitive abilities including vigilance, attention, and executive function. Although sleep loss has been shown to impair tasks requiring visual attention and spatial perception, it is not clear whether these deficits are exclusively a function of reduced attention and vigilance or if there are also alterations in visuospatial perception. Visuospatial perception and sustained vigilance performance were therefore examined in 54 healthy volunteers at rested baseline and again after one night of sleep deprivation using the Judgment of Line Orientation Test and a computerized test of psychomotor vigilance. Whereas psychomotor vigilance declined significantly from baseline to sleep-deprived testing, scores on the Judgment of Line Orientation did not change significantly. Results suggest that documented performance deficits associated with sleep loss are unlikely to be the result of dysfunction within systems of the brain responsible for simple visuospatial perception and processing of line angles.

scholarly journals 0307 Gray Matter Volume Correlates of Psychomotor Vigilance Speed During Sleep Deprivation

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A116-A116
Author(s):  
C E Meinhausen ◽  
J R Vanuk ◽  
M A Grandner ◽  
W D Killgore
Keyword(s):  
Prefrontal Cortex ◽  
Sleep Deprivation ◽  
Gray Matter ◽  
Inferior Frontal Gyrus ◽  
Gray Matter Volume ◽  
Sleep Loss ◽  
Grey Matter Volume ◽  
Matter Volume ◽  
The Right ◽  
Psychomotor Vigilance

Abstract Introduction Sleep deprivation has often been associated with decreased cognitive control, including deficits in the ability to sustain attention. Psychomotor vigilance speed slows following a period of fatigue, and can lead to disastrous results in daily life. In order to determine the brain areas correlated with reduced psychomotor vigilance speed, as a result of diminished sleep, a voxel-based morphometry analysis was performed prior to a period of monitored sleep deprivation. The mean speed of response time during the final 17 hours of a 29-hour sleep deprivation was then measured with the Psychomotor Vigilance Test (PVT), a reaction-timed task that measures the speed participants respond to a visual stimulus. Methods 45 healthy individuals (male=23 female=22) between the ages of 20-43 years (M=25.4 SD=5.6) participated in the study. Structural neuroimaging data were collected using a T3 magnetic resonance imaging scanner following a typical night’s sleep. Mean PVT speed was monitored with an hourly 10-minute PVT assessment during a monitored overnight sleep deprivation session. Speed was defined as the reciprocal of reaction time (1/RT). Results PVT speed was negatively correlated with grey matter volume (P&lt;.05 FWE-corrected) in the prefrontal cortex, specifically the right posterior inferior frontal gyrus (p=.030; MNI coordinates = 36, 12, 26). Conclusion Our findings indicate that gray matter within the right posterior inferior frontal gyrus is greater in individuals who are more vulnerable to slowing of PVT responses during an overnight period of sleep deprivation. These findings suggest that inter-individual differences in the ability to sustain psychomotor vigilance during sleep loss may be related to increased gray matter in the right lateral prefrontal cortex and could have implications for understanding the neurobiological substrates of vulnerability and resilience to sleep loss. Support  

scholarly journals The Acute Readiness Monitoring Scale: Assessing Predictive and Concurrent Validation

2021 ◽  
Vol 12 ◽  
Author(s):  
Simon J. Summers ◽  
Richard J. Keegan ◽  
Andrew Flood ◽  
Kristy Martin ◽  
Andrew McKune ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Cognitive Performance ◽  
Biological Markers ◽  
Salivary Cortisol ◽  
Concurrent Validity ◽  
Cognitive Task ◽  
Vigilance Task ◽  
Concurrent Validation ◽  
Wide Range ◽  
Psychomotor Vigilance

To complement and enhance readiness-monitoring capability, the Acute Readiness Monitoring Scale (ARMS) was developed: a widely applicable, simple psychometric measure of perceived readiness. While this tool may have widespread utility in sport and military settings, it remains unknown if the ARMS demonstrates predictive and concurrent validity. Here, we investigated whether the ARMS is: (1) responsive to an acute manipulation of readiness using sleep deprivation, (2) relates to biological markers of readiness [cortisol/heart-rate variability (HRV)], and (3) predicts performance on a cognitive task. Thirty young adults (aged 23 ± 4 years; 18 females) participated. All participants engaged in a 24-h sleep deprivation protocol. Participants completed the ARMS, biological measures of readiness (salivary cortisol, HRV), and cognitive performance measures (psychomotor vigilance task) before, immediately after, 24-, and 48-h post-sleep deprivation. All six of the ARMS subscales changed in response to sleep deprivation: scores on each subscale worsened (indicating reductions in perceived readiness) immediately after sleep deprivation, returning to baseline 24/48 h post. Lower perceived readiness was associated with reduced awakening responses in cortisol and predicted worse cognitive performance (slower reaction time). No relationship was observed between the ARMS and HRV, nor between any biological markers of readiness (cortisol/HRV) and cognitive performance. These data suggest that the ARMS may hold practical utility in detecting, or screening for, the wide range of deleterious effects caused by sleep deprivation; may constitute a quick, cheap, and easily interpreted alternative to biological measures of readiness; and may be used to monitor or mitigate potential underperformance on tasks requiring attention and vigilance.

scholarly journals Impact of total sleep deprivation and related mood changes on approach-avoidance decisions to threat-related facial displays

SLEEP ◽  
2021 ◽  
Author(s):  
Julie Grèzes ◽  
Mégane Erblang ◽  
Emma Vilarem ◽  
Michael Quiquempoix ◽  
Pascal Van Beers ◽  
...  
Keyword(s):  
Decision Making ◽  
Sleep Deprivation ◽  
Sustained Attention ◽  
Positive Mood ◽  
Sleep Loss ◽  
Total Sleep Deprivation ◽  
Mood Changes ◽  
Approach Avoidance ◽  
The Impact

Abstract Study Objectives Total sleep deprivation is known to have significant detrimental effects on cognitive and socio-emotional functioning. Nonetheless, the mechanisms by which total sleep loss disturbs decision-making in social contexts are poorly understood. Here, we investigated the impact of total sleep deprivation on approach/avoidance decisions when faced with threatening individuals, as well as the potential moderating role of sleep-related mood changes. Methods Participants (n = 34) made spontaneous approach/avoidance decisions in the presence of task-irrelevant angry or fearful individuals, while rested or totally sleep deprived (27 hours of continuous wakefulness). Sleep-related changes in mood and sustained attention were assessed using the Positive and Negative Affective Scale and the psychomotor vigilance task, respectively. Results Rested participants avoided both fearful and angry individuals, with stronger avoidance for angry individuals, in line with previous results. On the contrary, totally sleep deprived participants favored neither approach nor avoidance of fearful individuals, while they still comparably avoided angry individuals. Drift-diffusion models showed that this effect was accounted for by the fact that total sleep deprivation reduced value-based evidence accumulation toward avoidance during decision making. Finally, the reduction of positive mood after total sleep deprivation positively correlated with the reduction of fearful display avoidance. Importantly, this correlation was not mediated by a sleep-related reduction in sustained attention. Conclusions All together, these findings support the underestimated role of positive mood-state alterations caused by total sleep loss on approach/avoidance decisions when facing ambiguous socio-emotional displays, such as fear.

122 Different Duration Psychomotor Vigilance Tests Show Robust Stable Relationships Across Sleep Loss That Deteriorate in Recovery

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A50-A50
Author(s):  
Caroline Antler ◽  
Erika Yamazaki ◽  
Courtney Casale ◽  
Tess Brieva ◽  
Namni Goel
Keyword(s):  
Sleep Deprivation ◽  
Repeated Measures ◽  
Response Speed ◽  
Sleep Loss ◽  
Sleep Restriction ◽  
Psychomotor Vigilance Test ◽  
Time In Bed ◽  
Psychomotor Vigilance ◽  
The Relationship ◽  
Time Point

Abstract Introduction The Psychomotor Vigilance Test (PVT), a behavioral attention measure widely used to capture sleep loss deficits, is available in 10-minute (PVT10) and 3-minute (PVT3) versions. The PVT3 is a briefer and presumably comparable assessment to the more commonly used PVT10 yet the relationship between the measures from the two versions across specific time points and in recovery after sleep loss has not been investigated. Repeated measures correlation (rmcorr) evaluated within-individual associations between measures on the PVT10 and PVT3 throughout a highly controlled sleep deprivation study. Methods Forty-one healthy adults (ages 21-49; mean±SD, 33.9±8.9y; 18 females) participated in a 13-night experiment consisting of 2 baseline nights (10h-12h time in bed, TIB) followed by 5 sleep restriction (SR1-5) nights (4h TIB), 4 recovery nights (R1-R4; 12h TIB), and 36h total sleep deprivation (TSD). A neurobehavioral test battery, including the PVT10 and PVT3 was completed every 2h during wakefulness. Rmcorr compared PVT10 and PVT3 lapses (reaction time [RT] &gt;355ms [PVT3] or &gt;500ms [PVT10]) and response speed (1/RT) by examining correlations by day (e.g., baseline day 2) and by time point (e.g., 1000h-2000h). Rmcorr ranges were as follows: 0.1-0.3, small; 0.3-0.5, moderate; 0.5-0.7, large; 0.7-0.9, very large. Results All time point correlations (1000h-2000h) were significant (moderate to large for lapses; large to very large for 1/RT). Lapses demonstrated large correlations during R1, moderate correlations during SR1-SR5 and TSD, and small correlations during R2 and R4, and showed no significant correlations during baseline or R3. 1/RT correlations were large for SR1-SR4 and TSD, moderate for SR5 and R1-R4, and small for baseline. Conclusion The various PVT relationships were consistently strong at specific times of day throughout the study. In addition, higher correlations observed for 1/RT relative to lapses and during SR and TSD relative to baseline and recovery suggest that the PVT10 and PVT3 are most similar and best follow performance when most individuals are experiencing behavioral attention deficits during sleep loss. Both measures track SR and TSD performance well, with 1/RT presenting as more comparable between the PVT10 and PVT3. Support (if any) ONR Award N00014-11-1-0361; NIH UL1TR000003; NASA NNX14AN49G and 80NSSC20K0243; NIHR01DK117488

scholarly journals Recovery sleep after extended wakefulness restores elevated A1adenosine receptor availability in the human brain

2017 ◽  
Vol 114 (16) ◽  
pp. 4243-4248 ◽  
Author(s):  
David Elmenhorst ◽  
Eva-Maria Elmenhorst ◽  
Eva Hennecke ◽  
Tina Kroll ◽  
Andreas Matusch ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Human Brain ◽  
Cognitive Performance ◽  
Brain Regions ◽  
Sleep Loss ◽  
Control Group ◽  
Sleep Episode ◽  
Recovery Sleep ◽  
Positron Emission ◽  
Performance Impairment

Adenosine and functional A1adenosine receptor (A1AR) availability are supposed to mediate sleep–wake regulation and cognitive performance. We hypothesized that cerebral A1AR availability after an extended wake period decreases to a well-rested state after recovery sleep. [18F]CPFPX positron emission tomography was used to quantify A1AR availability in 15 healthy male adults after 52 h of sleep deprivation and following 14 h of recovery sleep. Data were additionally compared with A1AR values after 8 h of baseline sleep from an earlier dataset. Polysomnography, cognitive performance, and sleepiness were monitored. Recovery from sleep deprivation was associated with a decrease in A1AR availability in several brain regions, ranging from 11% (insula) to 14% (striatum). A1AR availabilities after recovery did not differ from baseline sleep in the control group. The degree of performance impairment, sleepiness, and homeostatic sleep-pressure response to sleep deprivation correlated negatively with the decrease in A1AR availability. Sleep deprivation resulted in a higher A1AR availability in the human brain. The increase that was observed after 52 h of wakefulness was restored to control levels during a 14-h recovery sleep episode. Individuals with a large increase in A1AR availability were more resilient to sleep-loss effects than those with a subtle increase. This pattern implies that differences in endogenous adenosine and A1AR availability might be causal for individual responses to sleep loss.

scholarly journals Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A1 receptors

2018 ◽  
Vol 115 (31) ◽  
pp. 8009-8014 ◽  
Author(s):  
Eva-Maria Elmenhorst ◽  
David Elmenhorst ◽  
Sibylle Benderoth ◽  
Tina Kroll ◽  
Andreas Bauer ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Alcohol Intake ◽  
Vigilance Task ◽  
Brain Regions ◽  
Sleep Loss ◽  
Molecular Response ◽  
Ethanol Infusion ◽  
Positron Emission ◽  
Individual Trait ◽  
Psychomotor Vigilance

Trait-like differences in cognitive performance after sleep loss put some individuals more at risk than others, the basis of such disparities remaining largely unknown. Similarly, interindividual differences in impairment in response to alcohol intake have been observed. We tested whether performance impairments due to either acute or chronic sleep loss can be predicted by an individual’s vulnerability to acute alcohol intake. Also, we used positron emission tomography (PET) to test whether acute alcohol infusion results in an up-regulation of cerebral A1 adenosine receptors (A1ARs), similar to the changes previously observed following sleep deprivation. Sustained attention in the psychomotor vigilance task (PVT) was tested in 49 healthy volunteers (26 ± 5 SD years; 15 females) (i) under baseline conditions: (ii) after ethanol intake, and after either (iii) total sleep deprivation (TSD; 35 hours awake; n = 35) or (iv) partial sleep deprivation (PSD; four nights with 5 hours scheduled sleep; n = 14). Ethanol- versus placebo-induced changes in cerebral A1AR availability were measured in 10 healthy male volunteers (31 ± 9 years) with [18F]8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine (CPFPX) PET. Highly significant correlations between the performance impairments induced by ethanol and sleep deprivation were found for various PVT parameters, including mean speed (TSD, r = 0.62; PSD, r = 0.84). A1AR availability increased up to 26% in several brain regions with ethanol infusion. Our studies revealed individual trait characteristics for being either vulnerable or resilient to both alcohol and to sleep deprivation. Both interventions induce gradual increases in cerebral A1AR availability, pointing to a potential common molecular response mechanism.

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