541 Cognitive Hyperarousal, Sleep Problems and Temperament Linked to Impaired Maternal-Infant Bonding

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A213-A214
Author(s):  
Lily Arnett ◽  
David Kalmbach ◽  
Louise O’Brien ◽  
D’Angela Pitts ◽  
Nicholas Harb ◽  
...  
Keyword(s):  
Relationship Quality ◽  
Daytime Sleepiness ◽  
Emotional Regulation ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Clinical Symptoms ◽  
Infant Sleep ◽  
Blood Institute ◽  
Perseverative Thinking ◽  
Fetal Attachment

Abstract Introduction Emerging evidence links maternal and infant sleep problems to impairments in the mother-to-infant bond, but the independence and directionality of these associations remain unclear. The present study characterized concurrent and prospective effects of maternal sleep disturbances and poor infant sleep on the mother-infant relationship. As common sequalae of problematic sleep, nocturnal cognitive hyperarousal and daytime sleepiness were investigated as facilitating mechanisms. Methods Sociodemographic information and clinical symptoms were measured prenatally then weekly across the first two postpartum months in 67 women. Participants reported insomnia symptoms, sleep duration, snoring, daytime sleepiness, nocturnal cognitive arousal (broadly focused and perinatal-specific), perseverative thinking, depression, infant colic, infant sleep quality, and mother-infant relationship quality. Mixed effects models were conducted to test hypotheses. Results Prenatal snoring and weak maternal-fetal attachment augured poorer postpartum bonding. Poor infant sleep was associated with increased odds for maternal insomnia and short sleep. Impairments in the mother-to-infant bond were linked to maternal insomnia, nocturnal perinatal-focused rumination, daytime sleepiness, depression, and poor infant sleep. Postnatal insomnia predicted future decreases in mother-infant relationship quality, and nocturnal cognitive hyperarousal partially mediated this association. Conclusion Both maternal and infant sleep problems were associated with impairments in mother-to-infant bonding, independent of the effects of maternal depression and difficult infant temperament. Perseverative thinking at night, particularly on infant-related concerns, was linked to impaired bonding, rejection and anger, and infant-focused anxiety. Improving maternal and infant sleep, as well as maternal cognitive-emotional regulation, may improve the maternal-to-infant bond. Support (if any) This work was funded by the American Academy of Sleep Medicine (198-FP-18, PI: Kalmbach). Dr. Cheng’s effort was supported by the National Heart, Lung, and Blood Institute (K23 HL138166, PI: Cheng).

scholarly journals Evaluating Sleep Disturbances in Children with Rare Genetic Neurodevelopmental Syndromes

2021 ◽  
Author(s):  
Olivia J. Veatch ◽  
Beth A. Malow ◽  
Hye-Seung Lee ◽  
Aryn Knight ◽  
Judy O. Barrish ◽  
...  
Keyword(s):  
Daytime Sleepiness ◽  
Sleep Disturbances ◽  
Sleep Disordered Breathing ◽  
Sleep Problems ◽  
Research Network ◽  
Typically Developing ◽  
Genetic Syndromes ◽  
Sleep Habits ◽  
Positive Health ◽  
Disordered Breathing

AbstractBackgroundAdequate sleep is important for proper neurodevelopment and positive health outcomes. Sleep disturbances are more prevalent in children with genetically determined neurodevelopmental syndromes compared to typically developing counterparts. We characterize sleep behavior in Rett (RTT), Angelman (AS) and Prader-Willi (PWS) syndromes in order to identify effective approaches for treating sleep problems in these populations. We compared sleep-related symptoms across individuals with these different syndromes to each other, and to typically developing controls.MethodsChildren were recruited from the Rare Diseases Clinical Research Network (RDCRN) consortium registries; unaffected siblings were enrolled as related controls. For each participant, a parent completed multiple sleep questionnaires including: Pediatric Sleep Questionnaire (Sleep-Disordered Breathing [SDB]); Children’s Sleep Habits Questionnaire; Pediatric Daytime Sleepiness Scale.ResultsSleep data were analyzed from 714 participants, ages 2-18 years. Young children with AS had more reported sleep problems than children with RTT or PWS. Older children with RTT had more reported daytime sleepiness than those with AS or PWS. Finally, all individuals with RTT had more evidence of sleep-disordered breathing when compared to individuals with PWS. Notably, typically developing siblings were also reported to have sleep problems, except for sleep-related breathing disturbances which were associated with each of the genetic syndromes.ConclusionsIndividuals with RTT, AS and PWS frequently experience sleep problems, including sleep-disordered breathing. Screening for sleep problems in individuals with these and other neurogenetic disorders should be included in clinical assessment and managements. These data may also be useful in developing treatment strategies and in clinical trials.

scholarly journals The Effect of Rotigotine on Cognitive Function and Sleep Problems in Parkinson's Disease: an Open-Label Pilot Study

2021 ◽  
Author(s):  
Keisuke Suzuki ◽  
Kei Funakoshi ◽  
Hiroaki Fujita ◽  
Koichi Hirata
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Function ◽  
Daytime Sleepiness ◽  
Sleep Disturbances ◽  
Rating Scale ◽  
Sleep Problems ◽  
Motor Symptoms ◽  
Open Label ◽  
Updrs Part

Abstract Background: We hypothesized that rotigotine may have a positive effect on cognitive function in patients with Parkinson’s disease (PD) by improving daytime motor function and nighttime sleep status due to its 24-hour sustained properties.Methods: We evaluated the effect of rotigotine on motor symptoms, cognitive function, daytime sleepiness, sleep disturbances, and motor symptoms in 10 PD patients with sleep disturbances, defined as a PD Sleep Scale (PDSS)-2 score of ≥ 15, in a single-center, 3-month open-label study. Participants received 24 mg/24 h (patch content: 4.5-9 mg) rotigotine for a 3-month period. At baseline and 3 months, patients were evaluated on the Movement Disorder Society Revision of the Unified PD Rating Scale (MDS-UPDRS) parts III and IV and cognitive assessments, such as the Mini-Mental State Examination (MMSE), frontal assessment battery (FAB) and Montreal Cognitive Assessment (MoCA). The Epworth Sleepiness Scale (ESS) and PDSS-2 were administered at baseline and at 1 month, 2 months and 3 months.Results: At 3 months, MDS-UPDRS part III (-10.7, p<0.001) and MDS-UPDRS part IV (-1.0, p=0.023) scores significantly decreased, MoCA scores (1.7, p=0.0095) significantly increased, and off time significantly decreased (-43.0 min; p=0.029) from baseline. PDSS-2 scores significantly decreased from baseline at 2 months (-14.5, p<0.05) and 3 months (-20.0, p<0.001). ESS, MMSE or FAB scores did not significantly change after rotigotine treatment.Conclusion: Our preliminary findings suggest that low-dose rotigotine could improve motor symptoms, sleep disturbance, and cognitive function without worsening daytime sleepiness in patients with PD.

Daytime sleepiness, sleep disturbance and functioning impairment in bipolar disorder

2013 ◽  
Vol 25 (2) ◽  
pp. 101-104 ◽  
Author(s):  
Julio C. Walz ◽  
Pedro V. Magalhães ◽  
Ramiro Reckziegel ◽  
Monise Costanzi ◽  
Larriany Giglio ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Sleep Disturbance ◽  
Daytime Sleepiness ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Control Group ◽  
Multivariable Model ◽  
Healthy Control ◽  
Short Test ◽  
Functioning Assessment

ObjectiveTo verify the prevalence and clinical impact of excessive daytime sleepiness (EDS) in outpatients with bipolar disorder.MethodsEighty‐one outpatients with bipolar disorder and 79 healthy control subjects were recruited. Patients were required not to be acutely manic or depressed. We used the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index and the Functioning Assessment Short Test to assess sleepiness, sleep problems and functioning, respectively.ResultsPatients had a higher prevalence of sleepiness (40%) than the control group (18%). Sleepiness and sleep disturbance had independent impacts on disability in the multivariable model.ConclusionsThis study suggests that EDS is a relevant clinical dimension in patients with bipolar disorder. It is a frequent symptom that often overlaps with other sleep disturbances. This study also reveals that once present it has the potential to increase functional impairment.

scholarly journals Clinical long-term nocturnal sleeping disturbances and excessive daytime sleepiness in Parkinson’s disease

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0259935
Author(s):  
Rocio Del Pino ◽  
Ane Murueta-Goyena ◽  
Unai Ayala ◽  
Marian Acera ◽  
Mónica Fernández ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Motor Impairment ◽  
Nocturnal Sleep ◽  
Nocturnal Problems ◽  
Over Time

Objective To prospectively evaluate nocturnal sleep problems and excessive daytime sleepiness (EDS) in Parkinson’s disease (PD) patients, and analyze the influence of motor symptoms, treatment, and sex differences on sleep problems in PD. Methods Sleep disturbances of 103 PD patients were assessed with Parkinson’s Disease Sleep Scale (PDSS) and the Epworth Sleepiness Scale (ESS). Student’s t-test for related samples, one-way ANOVA with Tukey’s HSD post hoc test were used to assess group differences. Bivariate correlations and mixed-effects linear regression models were used to analyze the association between clinical aspects and sleep disturbances over time. Results At baseline, 48.5% of PD patients presented nocturnal problems and 40% of patients presented EDS. The PDSS and ESS total score slightly improve over time. Nocturnal problems were associated with age and motor impartment, explaining the 51% of the variance of the PDSS model. Males presented less nocturnal disturbances and more EDS than females. Higher motor impairment and combined treatment (L-dopa and agonist) were related to more EDS, while disease duration and L-dopa in monotherapy were related to lower scores, explaining the 59% of the model. Conclusions Sleep disturbances changed over time and age, diseases duration, motor impairment, treatment and sex were associated with nocturnal sleep problems and EDS. Agonist treatment alone or in combination with L-dopa might predict worse daytime sleepiness, while L-dopa in monotherapy is related to lower EDS, which significantly affects the quality of life of PD patients.

scholarly journals REVIEW LITERATURE: MENGKAJI PEMBERIAN PIJAT BAYI DENGAN MUROTTAL AL-QUR’AN UNTUK MENINGKATKAN DURASI TIDUR BAYI USIA 3-12 BULAN

2021 ◽  
Vol 16 (1) ◽  
pp. 101-105
Author(s):  
Dian Wahyuningtyas
Keyword(s):  
Sleep Duration ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Electronic Media ◽  
Review Literature ◽  
Significant Problem ◽  
International Literature ◽  
Infant Sleep ◽  
Infant Massage ◽  
The Brain

ABSTRACT   Introduction: Most babies (44.2%) had sleep disturbances, and 72% of parents thought that this was not a significant problem. Sleep problems in babies are generally due to insufficient sleep in the baby. One of the efforts to improve baby sleep uration is by offering baby massage accompanied by the chanting of the Al-Qur'an murottal. Methods: International literature searched using electronic media by using several databases such as Google Scholar, Link Spinger and PubMed. The article used is 8 articles that discuss the effect of baby massage on baby sleep and the effect of listening to the Murottal Al-Quran on the duration of baby sleep. Results: There was a significant effect between infant massage and murottal Al-Qur'an on the increase in infant sleep duration. Discussion: One way to meet the sleep needs of babies is by increasing the duration of the baby's sleep. Efforts to increase sleep duration in babies can be done by giving baby massage accompanied by Al-Qur'an murottals. Baby massage can increase serotonin neurotansmiter levels, and listening to the murottal Al-Qur'an, the brain can produce neuropeptide substances so that it provides feedback in the form of a sense of comfort, safety, after that the baby's sleep will be more soundly. Conclusion: Baby massage with murottal Al-Qur'an is effective for increasing sleep duration in babies. Keywords: Baby massage; Murottal; length of sleep for babies

Examining sleep, fatigue, and daytime sleepiness in pediatric multiple sclerosis patients

2011 ◽  
Vol 18 (4) ◽  
pp. 481-488 ◽  
Author(s):  
Abu-Bakar Zafar ◽  
Jayne Ness ◽  
Sarah Dowdy ◽  
Kristin Avis ◽  
Khurram Bashir
Keyword(s):  
Multiple Sclerosis ◽  
Sleep Quality ◽  
Daytime Sleepiness ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Sleep Hygiene ◽  
Control Group ◽  
Stability Dimension ◽  
Multiple Sclerosis Patients ◽  
Historical Controls

Background: About 2–5% of patients with multiple sclerosis (MS) experience their first symptoms before age 18. Sleep disorders occur frequently in MS. The prevalence of sleep problems and their impact on fatigue and daytime sleepiness in pediatric MS is unknown. Objective: To determine whether pediatric MS patients have more sleep disturbances, fatigue, and daytime sleepiness compared with an age-, sex-, and race-matched control group. Methods: Patients and age-, sex-, and race-matched controls were surveyed to quantify daytime sleepiness via the modified Epworth Sleepiness Scale, sleep quality and hygiene through the Adolescent Sleep Wake and Hygiene Scale, respectively, and fatigue using the PediatricQL Multidimensional Fatigue Scale. Results: Pediatric MS patients ( n = 30) and age-, sex-, and race-matched controls ( n = 52) had similar levels of fatigue; however, when compared with previously published historical controls, both groups reported worse fatigue across all dimensions ( p < 0.05). Pediatric MS patients also had similar sleep quality compared with the matched controls, but reported better sleep hygiene on the ‘sleep stability’ dimension ( p < 0.05). In addition, pediatric MS patients had less daytime sleepiness than the matched controls ( p < 0.05). Conclusion: Although patients with MS reported similar levels of fatigue, they have better sleep hygiene, which could possibly account for the decreased amount of excessive daytime sleepiness. Also, when compared with historical controls, the MS and control samples reported more fatigue. Thus, caution must be taken when using published control data, especially when not properly matched.

scholarly journals Association between sleep disorders and cognitive dysfunctions in non-demented patients with advanced Parkinson’s disease

2021 ◽  
Author(s):  
Elisa Montanaro ◽  
Alberto Romagnolo ◽  
Margherita Fabbri ◽  
Carlo Alberto Artusi ◽  
Gabriele Imbalzano ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Executive Functions ◽  
Daytime Sleepiness ◽  
Sleep Disturbances ◽  
Short Term Memory ◽  
Sleep Problems ◽  
Neuropsychological Test ◽  
Neuropsychological Functions ◽  
The Relationship

Abstract Background Parkinson’s disease (PD) is increasingly recognized as a multidimensional disorder, characterized by several non-motor symptoms, including disturbances of sleep and cognition. Current studies on the relationship between sleep problems and neuropsychological functions, mainly conducted in early to moderate PD patients, outline mixed results. In this study, we analysed the relationship between subjectively reported sleep alterations and cognitive functions in a large cohort of 181 advanced PD patients. Methods All consecutive, non-demented, advanced PD patients candidates for device-aided therapy completed two self-administered sleep questionnaires—the Parkinson’s Disease Sleep Scale (PDSS-2) and the Epworth Sleepiness Scale (ESS)—and underwent a comprehensive battery of neuropsychological tests encompassing five cognitive domains (reasoning, memory, attention, frontal executive functions, and language). Results Patients showed mild to moderate sleep problems (PDSS-2 score: 23.4 ± 1.2) and mild daytime sleepiness (ESS 8.6 ± 5.1). A significant correlation was found between PDSS-2 total score and non-verbal reasoning, as well as attentive skills, executive functions, and language abilities. No correlations were found between sleep measures and memory tests scores. Patients with clinically relevant sleep disturbances performed worse on attention, executive functions, and language. No significant correlations were found between daytime sleepiness and any neuropsychological test. Conclusions In advanced PD patients, sleep disturbances selectively correlate with specific neuropsychological functions and not with short-term memory and consolidation. Even if confirmations by means of longitudinal studies are needed, our observations suggest the importance of considering treatment of sleep disturbances to minimize their potential impact on cognition.

scholarly journals Sleep Disturbances in Individuals Quarantined Due to SARS-CoV-2 Pandemic in Poland: A Mixed Methods Design Study

2021 ◽  
Vol 10 ◽  
pp. 216495612110207
Author(s):  
Sabina Krupa ◽  
Witt Paweł ◽  
Wioletta Mędrzycka-Dąbrowska ◽  
Agnieszka Lintowska ◽  
Dorota Ozga
Keyword(s):  
Mixed Methods ◽  
Sleep Disturbances ◽  
Acute Stress ◽  
Sleep Problems ◽  
Severity Index ◽  
Structured Interview ◽  
Mixed Methods Design ◽  
Design Study ◽  
Insomnia Severity Index ◽  
Insomnia Severity

Objectives The study aimed to assess sleep disturbances in patients subjected to home quarantine due to suspected SARS-CoV-2 infection. The study used a mixed methods design study as a research methodology. Methods A semi-structured interview and the scale for Insomnia Severity Index (ISI) were used to achieve the aim of the study. The survey was conducted from 16 to 20 April 2020 and 1 to 2 September 2020 in Poland, at the during of SARS-CoV-2 epidemic in this country. The data were coded and cross-processed. The (COREQ) checklist was followed. Results Interviews with patients and a thorough analysis of recordings revealed commonly used phrases in the following categories: “anxiety”, “ Am I going crazy?”, “Sleep problems”. 10 out of 11 respondents reported sleep disorders of varying severity according to the Insomnia Severity Index scale. Patients presented a fear related to the return to society and normal functioning after quarantine. Additionally, some study participants voiced concerns related to their mental health; some cases of hallucinations were reported. Conclusions Further global population studies should be conducted to analyse this phenomenon. Acute Stress Disorder should be understood as a threat to life and health of an isolated society in quarantine. Further research in this area should be promoted and the need for global guidelines for the entire population should be developed.

747 Suicidal Ideation Associated with Cognitive Hyperarousal, Rumination and Insomnia in Depressed Perinatal Women

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A291-A292
Author(s):  
Lily Arnett ◽  
David Kalmbach ◽  
Brian Ahmedani ◽  
Bizu Gelaye ◽  
Christopher Drake ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Cognitive Activity ◽  
Late Pregnancy ◽  
Future Research ◽  
Blood Institute ◽  
Cognitive Arousal ◽  
Early Postpartum ◽  
National Heart Lung ◽  
Perseverative Thinking ◽  
Perinatal Women

Abstract Introduction This prospective study explored associations among clinical insomnia, nocturnal cognitive hyperarousal, and nocturnal perinatal-focused rumination with suicidal ideation (SI) in perinatal women with mild-to-moderate depression. Methods From late pregnancy through early postpartum, 39 women with depression completed 17 weekly surveys assessing insomnia, depression, suicidal ideation, perceived stress, and three cognitive arousal indices. Results Women with nocturnal cognitive hyperarousal at baseline, relative to those with low nocturnal cognitive arousal, were at greater risk for developing new onset SI in late pregnancy or early postpartum (33% vs 1%). Moreover, nocturnal perinatal-focused rumination was independently associated with SI. SI-risk was highest when women reported clinical insomnia combined with nocturnal cognitive hyperarousal (OR=5.66, p=.037) or perinatal-focused rumination (OR=11.63, p=.018). Daytime perseverative thinking was not uniquely associated with SI. Conclusion Cognitive hyperarousal and perinatal-focused rumination at night are uniquely associated with SI among perinatal women with depression. Moreover, insomnia augments the suicidogenicity of nighttime cognitive activity. Future research should determine whether alleviating nocturnal cognitive arousal, pregnancy- and fetal/infant-related concerns, and insomnia with psychotherapy reduces SI for women with perinatal depression. Support (if any) This study was funded by the American Academy of Sleep Medicine (198-FP-18, PI: Kalmbach). Dr. Cheng’s effort was supported by the National Heart, Lung, and Blood Institute (K23-HL13866, PI: Cheng).

scholarly journals Effects of work organization on the occurrence and resolution of sleep disturbances among night shift workers: a longitudinal observational study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Seungho Lee ◽  
Jae Bum Park ◽  
Kyung-Jong Lee ◽  
Seunghon Ham ◽  
Inchul Jeong
Keyword(s):  
Work Experience ◽  
Sleep Disturbances ◽  
Sleep Problems ◽  
Night Shift ◽  
Work Organization ◽  
Severity Index ◽  
Estimating Equation ◽  
Health Examination ◽  
Related Factors ◽  
Shift Workers

AbstractThis study aimed to investigate the association between work organization and the trajectories of insomnia patterns among night shift workers in a hospital. The health examination data of hospital workers, recorded from January 2014 to December 2018, were collected; 6765 records of 2615 night shift workers were included. Insomnia was defined as a score of ≥ 15 on the Insomnia Severity Index (ISI). Participants were categorized into five groups according to insomnia patterns derived from the analysis of their ISI scores. Work organization and socio-demographic characteristics were also investigated. Generalized estimating equation models and linear mixed models were constructed to analyze the longitudinal data. Of the total participants, 53.0% reported insomnia at least once during the follow-up period. The lack of nap opportunities and work-time control was associated with the occurrence of insomnia, whereas more than 5 years of shift work experience was related to the resolution of insomnia. All work-related factors were significantly related to insomnia risk; however, the effects were not significant in the sustained insomnia group. Although sleep problems are inevitable in night shift workers, well-designed work schedules and better work organization can help reduce the occurrence of insomnia among them.

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