The role of Vitamin K and spinach rich in Vitamin K on functional recovery of injured rabbit sciatic nerve

Coronary artery disease (CAD) is widely recognized as one of the most important clinical entities. In recent years, a large body of accumulated data suggest that coronary artery calcification, a process highly prevalent in patients with CAD, occurs via well-organized biologic processes, rather than passively, as previously regarded. Matrix Gla protein (MGP), a vitamin K-dependent protein, emerged as an important inhibitor of both intimal and medial vascular calcification. The functionality of MGP hinges on two post-translational modifications: phosphorylation and carboxylation. Depending on the above-noted modifications, various species of MGP may exist in circulation, each with their respective level of functionality. Emerging data suggest that dysfunctional species of MGP, markedly, dephosphorylated-uncarboxylated MGP, might find its application as biomarkers of microvascular health, and assist in clinical decision making with regard to initiation of vitamin K supplementation. Hence, in this review we summarized the current knowledge with respect to the role of MGP in the complex network of vascular calcification with concurrent inferences to CAD. In addition, we discussed the effects of warfarin use on MGP functionality, with concomitant implications to coronary plaque stability.

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Role of S100β Glial Protein as a Serological Marker for Analysis of Acute Ischemic Stroke

Journal of Stroke Medicine ◽

10.1177/25166085211011284 ◽

2021 ◽

pp. 251660852110112

Author(s):

Kiran Buddharaju ◽

Mahendra Javali ◽

Anish Mehta ◽

R Srinivasa ◽

Purushottam Acharya

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Functional Recovery ◽

Protein Level ◽

Serological Marker ◽

Protein Levels ◽

S100β Protein ◽

Asymptomatic Volunteers ◽

Scale Scores

Background: Stroke is a major cause of neurological disability, which can be often predicted with serological markers. Glial-derived S100β protein is a potential biomarker for cerebral ischemia and may be helpful in predicting the severity, outcome, and recovery of stroke. Aim: This study aimed to study the role of S100β glial protein as a serological marker in predicting the severity of acute ischemic stroke (AIS), outcome, and functional recovery after 1 month. Methods: A hospital-based prospective case control study included 43 consecutive patients, >18 years old, who were admitted with acute middle cerebral artery (MCA) territory infarcts within 72 h of onset of neurological deficits. Control group comprised of 43 age-matched asymptomatic volunteers. Independent t-test and chi square test were used to compare the means and evaluate the association between protein level and various parameters. P ≤ .05 was statistically significant. Results: S100β protein level in AIS patients was significantly higher compared to controls ( P < .05). Elevated serum S100β protein level was found to be associated with larger infarct volumes, higher National Institute Health Stroke Scale scores, and higher modified Rankin Scale scores at admission ( P < .05). Patients with higher S100β protein levels at admission had poor recovery at 1 month compared to patients having normal S100β protein levels. Conclusion: S100β protein levels at admission after an acute MCA territory infarct may be used as a reliable serological tool in predicting the severity, outcome, and functional recovery in stroke.

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Triptolide improves nerve regeneration and functional recovery following crush injury to rat sciatic nerve

Neuroscience Letters ◽

10.1016/j.neulet.2013.12.068 ◽

2014 ◽

Vol 561 ◽

pp. 198-202 ◽

Cited By ~ 12

Author(s):

Yong-Guang Zhang ◽

Qing-Song Sheng ◽

Hong-Kun Wang ◽

Li Lv ◽

Jun Zhang ◽

...

Keyword(s):

Sciatic Nerve ◽

Nerve Regeneration ◽

Functional Recovery ◽

Crush Injury ◽

Rat Sciatic Nerve

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Vitamin K Dependent Proteins and the Role of Vitamin K2 in the Modulation of Vascular Calcification: A Review

Oman Medical Journal ◽

10.5001/omj.2014.44 ◽

2014 ◽

Vol 29 (3) ◽

pp. 172-177 ◽

Cited By ~ 33

Author(s):

Margueritta El Asmar ◽

Joseph Naoum ◽

Elias Arbid

Keyword(s):

Vascular Calcification ◽

Vitamin K ◽

Vitamin K2

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Functional Recovery and Vitamin E Level Following Sciatic Nerve Crush Injury in Normal and Diabetic Rats

International Journal of Neuroscience ◽

10.3109/00207459808986472 ◽

1998 ◽

Vol 96 (3-4) ◽

pp. 245-254 ◽

Cited By ~ 10

Author(s):

Khalaf Al Moutaery ◽

Mohammed Arshaduddin ◽

Mohammad Tariq ◽

Saleh Al Deeb

Keyword(s):

Vitamin E ◽

Sciatic Nerve ◽

Functional Recovery ◽

Diabetic Rats ◽

Crush Injury ◽

Sciatic Nerve Crush ◽

Nerve Crush ◽

Nerve Crush Injury

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The approach to patients with cognitive impairment and hip fracture: the role of orthogeriatric care

Reviews in Clinical Gerontology ◽

10.1017/s0959259814000100 ◽

2014 ◽

Vol 24 (3) ◽

pp. 219-227 ◽

Cited By ~ 2

Author(s):

Francisco J Tarazona-Santabalbina ◽

Juan R Doménech-Pascual ◽

Ángel Belenguer-Varea A ◽

Eduardo Rovira Daudi

Keyword(s):

Cognitive Impairment ◽

Hip Fracture ◽

Functional Recovery ◽

Functional Outcomes ◽

Older Patients ◽

Future Research ◽

Research Perspectives ◽

Increased Risk ◽

Risk Of Falls

SummaryHip fracture is very common among older patients, who are characterized by increased co-morbidities, including cognitive impairment. These patients have an increased risk of falls and fractures, poorer functional recovery and lower survival both in hospital and 12 months after discharge. We review the survival and functional outcomes of older patients with cognitive impairment and hip fracture managed in orthogeriatric units, and highlight the gaps in our knowledge of the efficacy and efficiency of specific orthogeriatric programmes for such patients and the future research perspectives in this field.

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PROTECTIVE ROLE OF FICUS RACEMOSA IN DIABETES INDUCED NEUROPATHY: STRUCTURAL AND FUNCTIONAL EVIDENCES

INDIAN DRUGS ◽

10.53879/id.54.11.10855 ◽

2017 ◽

Vol 54 (11) ◽

pp. 58-60

Author(s):

N Solanki ◽

◽

S. K Bhavsar

Keyword(s):

Sciatic Nerve ◽

Diabetic Neuropathy ◽

Ethanolic Extract ◽

Protective Role ◽

Diabetic Rats ◽

Dependent Manner ◽

Traditional System ◽

Ficus Racemosa ◽

Dose Dependent

Ficus racemosa is used in traditional system of medicine for various health problems and diseases, and is commonly known as Gular fig. The main objective was to study its effects against streptozotocin induced diabetic neuropathy by structural and functional marker. Investigation of diabetic neuropathy was carried out through functional and structural assessment in streptozotocin induced in diabetic rats. Diabetic rats were treated for 28 days in dose dependent manner of Ficus racemosa aqueous extract (250 mg/kg and 500 mg/kg) and ethanolic extract (200 mg/kg and 400 mg/kg). Study showed marked protection observed by Ficus racemosa in hippocampus region of brain and sciatic nerve tissues. Ficus racemosa treatment showed improvement in functional and structural markers, which strongly suggest its protective role in diabetic neuropathy.

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Transgenic overexpression of cardiac A1adenosine receptors mimics ischemic preconditioning

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.2000.279.3.h1071 ◽

2000 ◽

Vol 279 (3) ◽

pp. H1071-H1078 ◽

Cited By ~ 27

Author(s):

R. Ray Morrison ◽

Rachael Jones ◽

Anne M. Byford ◽

Alyssa R. Stell ◽

Jason Peart ◽

...

Keyword(s):

Infarct Size ◽

Functional Recovery ◽

Ischemic Preconditioning ◽

Adenosine Receptors ◽

Myocardial Function ◽

Wild Type ◽

Beneficial Effects ◽

Pressure Development ◽

Ldh Release

The role of A1adenosine receptors (A1AR) in ischemic preconditioning was investigated in isolated crystalloid-perfused wild-type and transgenic mouse hearts with increased A1AR. The effect of preconditioning on postischemic myocardial function, lactate dehydrogenase (LDH) release, and infarct size was examined. Functional recovery was greater in transgenic versus wild-type hearts (44.8 ± 3.4% baseline vs. 25.6 ± 1.7%). Preconditioning improved functional recovery in wild-type hearts from 25.6 ± 1.7% to 37.4 ± 2.2% but did not change recovery in transgenic hearts (44.8 ± 3.4% vs. 44.5 ± 3.9%). In isovolumically contracting hearts, pretreatment with selective A1 receptor antagonist 1,3-dipropyl-8-cyclopentylxanthine attenuated the improved functional recovery in both wild-type preconditioned (74.2 ± 7.3% baseline rate of pressure development over time untreated vs. 29.7 ± 7.3% treated) and transgenic hearts (84.1 ± 12.8% untreated vs. 42.1 ± 6.8% treated). Preconditioning wild-type hearts reduced LDH release (from 7,012 ± 1,451 to 1,691 ± 1,256 U · l−1 · g−1 · min−1) and infarct size (from 62.6 ± 5.1% to 32.3 ± 11.5%). Preconditioning did not affect LDH release or infarct size in hearts overexpressing A1AR. Compared with wild-type hearts, A1AR overexpression markedly reduced LDH release (from 7,012 ± 1,451 to 917 ± 1,123 U · l−1 · g−1 · min−1) and infarct size (from 62.6 ± 5.1% to 6.5 ± 2.1%). These data demonstrate that murine preconditioning involves endogenous activation of A1AR. The beneficial effects of preconditioning and A1AR overexpression are not additive. Taken with the observation that A1AR blockade equally eliminates the functional protection resulting from both preconditioning and transgenic A1AR overexpression, we conclude that the two interventions affect cardioprotection via common mechanisms or pathways.

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