Point Mutation in Sigma‐1 Receptor Inhibits Neuronal Cell Differentiation

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Yahong Zhang ◽  
Felix J Kim ◽  
Gavril W Pasternak
Keyword(s):  
Cell Differentiation ◽  
Point Mutation ◽  
Neuronal Cell ◽  
Sigma 1 Receptor ◽  
Sigma 1 ◽  
Neuronal Cell Differentiation

scholarly journals Neuronal cell differentiation of mesenchymal stem cells originating from canine amniotic fluid

Human Cell ◽  
2013 ◽  
Vol 27 (2) ◽  
pp. 51-58 ◽  
Author(s):  
Eun Young Kim ◽  
Kyung-Bon Lee ◽  
Jung Yu ◽  
Ji Hye Lee ◽  
Keun Jung Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Differentiation ◽  
Amniotic Fluid ◽  
Neuronal Cell ◽  
Neuronal Cell Differentiation

The sigma 1 receptor (S1R) is a potential therapeutic target for the treatment of Huntington's disease

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Endoplasmic Reticulum ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Therapeutic Target ◽  
Structural Integrity ◽  
Neuronal Cell ◽  
Glutamate Excitotoxicity ◽  
Potential Therapeutic Target ◽  
Sigma 1 Receptor ◽  
Sigma 1

During the progression of Huntington's disease (HD), changes in Ca2+ signaling cause neuronal cells to lose a range of functional properties. GABAergic medium spiny neurons (MSNs) are able to prevent Ca2+ imbalance in the early stages of the illness through a number of compensatory strategies. However, as people become older, their neuroprotective potential diminishes due to a decrease in metabolic activity and the generation of Ca2+-buffering proteins. Continuing Ca2+ regulation problems exhaust the cells' compensatory abilities, resulting in a continuous surge in cytosolic Ca2+ and neuronal degeneration.The sigma 1 receptor (S1R) is a potential therapeutic target for the treatment of HD because it regulates a number of cytosolic Ca2+-dependent signaling cascades. S1R activation by selective agonists protects neurons from glutamate excitotoxicity, reduces store-operated Ca2+ entry (SOCE) hyperactivation, and maintains the structural integrity of mitochondria-associated endoplasmic reticulum membranes (MAMs), which is required for synchronizing mitochondrial and endoplasmic reticulum (ER) activity to maintain cell bioenergetics balance. Because of the stability of Ca2+ signaling in neurons, pridopidine, a highly selective S1R agonist, has been demonstrated to protect neurons in cellular and animal models of HD.The synaptoprotective effect of pridopidine is very important since it is found in both cortical and striatal neurons, indicating that pridopidine has a systemic influence on HD therapy. Because synaptic dysfunctions are one of the earliest markers of neuropathology at the cellular level, normalization of Ca2+ balance by pridopidine may prevent disease development at the molecular level at the earliest stages. In this regard, the most significant therapeutic advantage of pridopidine will almost certainly be in preventative treatment, even before the start of the first clinical indications, which will improve neuronal cell compensatory abilities and significantly reduce the progression of HD.

scholarly journals PEDOT doped with algal, mammalian and synthetic dopants: polymer properties, protein and cell interactions, and influence of electrical stimulation on neuronal cell differentiation

2018 ◽  
Vol 6 (5) ◽  
pp. 1250-1261 ◽  
Author(s):  
P. J. Molino ◽  
L. Garcia ◽  
E. M. Stewart ◽  
M. Lamaze ◽  
B. Zhang ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Cell Differentiation ◽  
Neuronal Cells ◽  
Neuronal Cell ◽  
Cell Interactions ◽  
Polymer Properties ◽  
Neuronal Cell Differentiation

PEDOT films were electrochemically polymerised with synthetic and biological dopants, characterised, and their interactions with proteins and neuronal cells investigated.

Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation

2005 ◽  
Vol 82 (4) ◽  
pp. 542-550 ◽  
Author(s):  
Sang Min Lee ◽  
Jae Woong Lee ◽  
Youn Sook Song ◽  
Dae Youn Hwang ◽  
Yong Kyu Kim ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Ryanodine Receptor ◽  
Neuronal Cell ◽  
Neuronal Cell Differentiation ◽  
Presenilin 2
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