scholarly journals Angiotensin converting enzyme (ACE) over‐expression in myelomonocytic cells markedly augments resistance to methicillin resistant S. aureus (MRSA) by increasing iNOS levels

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Vivekananda Datta ◽  
Derrick O Duodu ◽  
Xiao Gregory Shen ◽  
Sandrine Billet ◽  
Kenneth Bernstein
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Methicillin Resistant ◽  
Over Expression ◽  
Myelomonocytic Cells

scholarly journals Angiotensin-converting Enzyme Overexpression in Mouse Myelomonocytic Cells Augments Resistance toListeriaand Methicillin-resistantStaphylococcus aureus

2010 ◽  
Vol 285 (50) ◽  
pp. 39051-39060 ◽  
Author(s):  
Derick Okwan-Duodu ◽  
Vivekanand Datta ◽  
Xiao Z. Shen ◽  
Helen S. Goodridge ◽  
Ellen A. Bernstein ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Myelomonocytic Cells ◽  
Enzyme Overexpression

scholarly journals Vasodilators, Enhancers of Prevention through Exercise of COVID-19?

2020 ◽  
pp. 126-131
Author(s):  
Bogdan- Alexandru Hagiu
Keyword(s):  
Cardiovascular Disease ◽  
Virus Infection ◽  
Angiotensin Converting Enzyme ◽  
Disease Progression ◽  
Mitochondrial Biogenesis ◽  
Future Research ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Over Expression

The role of the angiotensin-converting enzyme 2 (ACE2) receptor in SARS-CoV-2 virus infection and disease progression is complex, and the interaction with exercise is being investigated. However, the virus binds to ACE2. The paper hypothesizes that exceeding the lactic threshold during exercise would cause, through hypoxia, over expression of ACE2. Vasodilators would prevent hypoxia and implicitly this fact. To the complexity of the phenomenon is added the possibility of preventing severe forms of COVID-19 through mitochondrial biogenesis induced by exercise. As a result, the paper examines the ability of antihypertensives used in combination with exercise to treat cardiovascular disease to prevent ACE2 over expression and to stimulate mitochondrial biogenesis. Future research is needed, but it is worth mentioning that some such hypertensives have been proposed for the treatment of COVID-19.

The Role of Angiotensin Converting Enzyme in Immunity: Shedding Light on Experimental Findings

2021 ◽  
Vol 21 ◽  
Author(s):  
Ziba Aghsaeifard ◽  
Reza Alizadeh
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Mhc Class Ii ◽  
Myeloid Cell ◽  
Bactericidal Effect ◽  
Neutrophil Function ◽  
Therapeutic Interventions ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Over Expression ◽  
Experimental Findings

: Angiotensin-converting enzyme (ACE) is a zinc-dependent dicarboxypeptidase with two catalytic components, which has an important role in regulating blood pressure by converting angiotensin I to angiotensin II. ACE breaks down other peptides besides angiotensin I and has a variety of physiological effects together with renal growth and reproduction in men. ACE also acts on innate and acquired immune systems, by affecting macrophage and neutrophil function, and these outcomes are exacerbated due to the overexpression of ACE. Over expression of ACE in macrophages imposes antitumor and antimicrobial response, and it enhances the ability of neutrophil to produced super peroxide that has bactericidal effect. ACE is also known to contribute in the expression of Major Histocompatibility Complex (MHC) class I and MHC class II peptides through enzymatic alterations of these peptides. Apprehending the expression of ACE and its effects on myeloid cell (myelogenous cells) activity can be promising in therapeutic interventions, including treatment of infection and malignancy.

Over-expression of angiotensin-converting enzyme (CD 143) on leukemic blasts as a clue for the activated local bone marrow RAS in AML

2006 ◽  
Vol 47 (5) ◽  
pp. 891-896 ◽  
Author(s):  
Salih Aksu ◽  
Yavuz Beyazit ◽  
Ibrahim C. Haznedaroglu ◽  
Hande Canpinar ◽  
Murat Kekilli ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Over Expression ◽  
Local Bone

scholarly journals Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 393 ◽  
Author(s):  
Kenneth E. Bernstein ◽  
Zakir Khan ◽  
Jorge F. Giani ◽  
Tuantuan Zhao ◽  
Masahiro Eriguchi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Immune Response ◽  
Angiotensin Converting Enzyme ◽  
Pressure Control ◽  
Recent Analysis ◽  
Immune Responsiveness ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Myelomonocytic Cells

Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.

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