An innovative drug delivery system designed for very low flow rates: experimental and clinical evaluation

2004 ◽  
Vol 21 (Supplement 32) ◽  
pp. 28
Author(s):  
N. Lutter ◽  
E. Kozma ◽  
M. Richter ◽  
J. Schuettler
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Clinical Evaluation ◽  
Low Flow ◽  
Innovative Drug ◽  
Flow Rates

Metrology for drug delivery

2015 ◽  
Vol 60 (4) ◽  
Author(s):  
Peter Lucas ◽  
Stephan Klein
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Low Flow ◽  
European Research ◽  
Special Issue ◽  
Research Project ◽  
Flow Rates ◽  
European Research Project ◽  
Metrological Infrastructure

AbstractIn various recently published studies, it is argued that there are underestimated risks with infusion technology, i.e., adverse incidents believed to be caused by inadequate administration of the drugs. This is particularly the case for applications involving very low-flow rates, i.e., <1 ml/h and applications involving drug delivery by means of multiple pumps. The risks in infusing are caused by a lack of awareness, incompletely understood properties of the complete drug delivery system and a lack of a proper metrological infrastructure for low-flow rates. Technical challenges such as these were the reason a European research project “Metrology for Drug Delivery” was started in 2011. In this special issue of

Characterization of hyperbranched core‐multishell nanocarriers as an innovative drug delivery system for the application at the oral mucosa

2017 ◽  
Vol 53 (1) ◽  
pp. 57-65 ◽  
Author(s):  
J. Jager ◽  
K. Obst ◽  
S. B. Lohan ◽  
J. Viktorov ◽  
S. Staufenbiel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Oral Mucosa ◽  
Delivery System ◽  
Innovative Drug

scholarly journals Clinical Evaluation of a Novel Electromechanical Topical Ocular Drug Delivery System: Two Phase 1 Proof of Concept Studies

2020 ◽  
Vol Volume 14 ◽  
pp. 139-147
Author(s):  
Hugo Quiroz-Mercado ◽  
Ehud Ivri ◽  
Roberto Gonzalez-Salinas ◽  
Iraklis C Kourtis ◽  
Joseph Gilbert ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Clinical Evaluation ◽  
Phase 1 ◽  
Ocular Drug Delivery ◽  
Proof Of Concept ◽  
Two Phase

scholarly journals Microsponge Technology for Innovative Drug Delivery System

2020 ◽  
pp. 63-75
Author(s):  
Lendave A. S.
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Active Agent ◽  
Systemic Exposure ◽  
Analytical Techniques ◽  
Innovative Drug ◽  
Cutaneous Reactions

Microsponge drug delivery system (MDDS) technology holds a remarkable promise for achieving the aim of controlled and site-specific drug delivery which reduce systemic exposure and minimize local cutaneous reactions to active drug and as a result, has attracted huge interest of researchers. Microsponges consist of microporus beads, typically 10-25 microns in diameter, loaded with active agent. When carried out to the skin, the microsponge releases its active element on a time mode and also in reaction to different stimuli (rubbing, temperature, pH, and many others) which can be used ordinarily for topical and lately for oral management. This article gives a extensive assessment of Microsponges drug transport system discussing the concepts and practise methods. Appropriate analytical techniques for characterization of microsponges like particle size and its distribution, surface morphology, porosity, density, In Vitro drug release studies as well as applications of microsponge and future prospects are covered. Advantages/Potential functions, limitations and their possible remedies of the microsponge and programmable parameters are also mentioned. The microsponge are used in the sunscreens, creams, ointments, over the counter skin care preparations, which are meant for topical application. microsponge drug delivery can provide increased efficacy for topical active agent with enhanced safety, extended product stability.

Microsponges as Innovative Drug Delivery Systems

2012 ◽  
Vol 5 (1) ◽  
pp. 1597-1606
Author(s):  
Dipit Jagannath Ingale ◽  
N H Aloorkar ◽  
A S KulkarnI ◽  
R.A. Patil Patil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Systemic Circulation ◽  
Release Mechanism ◽  
Transdermal Drug Delivery System ◽  
Innovative Drug ◽  
Pharmaceutical Ingredients ◽  
Improved Stability ◽  
Highly Porous

Transdermal drug delivery system (TDDS) is not practicable for delivery of materials whose final target is skin itself. Controlled release of drugs onto the epidermis with assurance that the drug remains primarily localized and does not enter the systemic circulation in significant amounts is a challenging area of research. Microsponges are highly porous micro-sized particles with a unique ability for entrapping active pharmaceutical ingredients. To control the delivery rate of active agents to a predetermined site in human body has been one of the biggest challenges faced by scientists. Microsponges are safe biologically and offer unique advantage of programmable release. This technology offers entrapment of ingredients and is believed to contribute towards reduced side effects, improved stability, increased elegance and enhanced formulation flexibility. This technology is being used for topical formulations and also for oral administration. The present review describes microsponge technology including its preparation, characterization, programmable parameters and release mechanism of microsponge drug delivery system.

scholarly journals Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration

2018 ◽  
Vol 115 (13) ◽  
pp. E2997-E3006 ◽  
Author(s):  
Eleonora Vighi ◽  
Dragana Trifunović ◽  
Patricia Veiga-Crespo ◽  
Andreas Rentsch ◽  
Dorit Hoffmann ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Retinal Degeneration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photoreceptor Cells ◽  
Single Type ◽  
Innovative Drug ◽  
Blood Retinal Barrier ◽  
Liposomal Drug

Inherited retinal degeneration (RD) is a devastating and currently untreatable neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The vast genetic heterogeneity of RD, the lack of “druggable” targets, and the access-limiting blood–retinal barrier (BRB) present major hurdles toward effective therapy development. Here, we address these challenges (i) by targeting cGMP (cyclic guanosine- 3′,5′-monophosphate) signaling, a disease driver common to different types of RD, and (ii) by combining inhibitory cGMP analogs with a nanosized liposomal drug delivery system designed to facilitate transport across the BRB. Based on a screen of several cGMP analogs we identified an inhibitory cGMP analog that interferes with activation of photoreceptor cell death pathways. Moreover, we found liposomal encapsulation of the analog to achieve efficient drug targeting to the neuroretina. This pharmacological treatment markedly preserved in vivo retinal function and counteracted photoreceptor degeneration in three different in vivo RD models. Taken together, we show that a defined class of compounds for RD treatment in combination with an innovative drug delivery method may enable a single type of treatment to address genetically divergent RD-type diseases.

scholarly journals An Overview of Nanogel –Novel Drug Delivery System

2019 ◽  
Vol 7 (2) ◽  
pp. 47-55 ◽  
Author(s):  
Saloni Jain ◽  
Rahul Kumar Ancheria ◽  
Saumya Shrivastava ◽  
Shankar Lal Soni ◽  
Mukesh Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Target Cells ◽  
Innovative Drug ◽  
Device Implantation ◽  
Nonspecific Effects ◽  
High Degree ◽  
Novel Drug

Nanogels are innovative drug delivery system that can play an integral part in pointing out many issues related to old and modern courses of treatment such as nonspecific effects and poor stability. Biomedical and pharmaceutical applications of Nanogels have been explored for tissue regeneration, wound healing, surgical device, implantation, and peroral, rectal, vaginal, ocular, and transdermal drug delivery. Nanogels are proficiently internalized by the target cells, avoid accumulating in nontarget tissues thereby lower the therapeutic dosage and minimize harmful side effects. Nanogels may be defined as highly cross linked nano-sized hydrogels ranges from 20-200 nm. They can be administered through various routes, including oral, pulmonary, nasal, parenteral, intra-ocular etc. They have a high degree of drug loading capacity and it shows better permeation capabilities due to smaller size. Nanogels are the novel drug delivery systems for both hydrophilic and hydrophobic drugs.  

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