The Relationship Between Fatty Liver and Hyperinsulinemia in Obese Japanese Children

ObjectiveNon-alcoholic fatty liver disease (NAFLD) is one of the major causes of liver-related diseases but relationship between triglyceride glucose (TyG) and NAFLD in the elderly is not reported yet. In this study, we investigated the role of TyG index for predicting the incidence of NAFLD in the elderly.Design and settingThis is a prospective cohort study in Henan, China, from 2011 to 2018.Participants and methodsIn total, 46 693 elderly who participated in a routine physical examination programme from 2011 to 2018 were included in this study. TyG index was calculated as ln (fasting triglyceride (mg/dL)×fasting plasma glucose (mg/dL)/2), while NAFLD was defined as hepatic steatosis after excluding other causes based on the results of abdominal ultrasonography; Cox regression model was performed to explore the relationship between TyG index and NAFLD. Also, mediation effect was used to analyse the role of the TyG index in WHtR (waist-to-height ratio) and NAFLD.ResultsDuring the 149 041 person-years follow-up, a total of 5660 NAFLD events occurred (3.80/100 person-years). After adjusting for potential confounding factors, quartiles 4 of TyG index significantly increased the incidence of NAFLD compared with quartile 1, the HRs and 95% CI were 1.314 (1.234 to 1.457). In addition, TyG index played a partial mediating role in the relationship between WHtR and NAFLD and indirect effect was 1.009 (1.006 to 1.011).ConclusionHigher TyG index was associated with higher risk of NAFLD in the aged, and therefore, TyG index may be a novel predictor for incidence of NAFLD. Further, regular examination and evaluation of the TyG index might be useful for controlling the occurrence of NAFLD.

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Relationship Between Serum Uric Acid Levels and Nonalcoholic Fatty Liver Disease in Non-Obese Patients

Medicina ◽

10.3390/medicina55090600 ◽

2019 ◽

Vol 55 (9) ◽

pp. 600 ◽

Cited By ~ 5

Author(s):

Oral ◽

Sahin ◽

Turker ◽

Kocak

Keyword(s):

Uric Acid ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Control Group ◽

Nonalcoholic Fatty Liver ◽

Non Invasive ◽

Group I ◽

The Relationship

Background and objectives: Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors such as hypertension, diabetes, dyslipidemia, obesity, and hyperuricemia. We aim to investigate the relationship between uric acid and NAFLD in a non-obese and young population. Materials and Methods: This study was performed in January 2010–2019 with a group of 367 (225 patients in the NAFLD group and 142 in the control group) patients with liver biopsy-proven NAFLD or no NAFLD. Patients with NAFLD were classified according to the percentage of steatosis as follows, group I had 1–20% and group II >20%. Demographic, clinical, and laboratory (biochemical parameters) features were collected retrospectively. Results: The mean body mass index (BMI) and age of the patients were 26.41 ± 3.42 and 32.27 ± 8.85, respectively. The BMI, homeostatic model of assessment (HOMA-IR), and uric acid (UA) values of the NAFLD group were found to be significantly higher than those of the controls. A positive correlation was found between the NAFLD stage and UA. The following factors were independently associated with NAFLD: BMI, HOMA-IR, and UA. In addition, the cut-off value of UA was 4.75 mg/dl with a sensitivity of 45.8% and a specificity of 80.3%. Conclusions: UA is a simple, non-invasive, cheap, and useful marker that may be used to predict steatosis in patients with NAFLD.

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Emotional Engagement and School Adjustment in Late Childhood: The Relationship between School Liking and School Belonging in Japan

Psychological Reports ◽

10.2466/21.10.pr0.114k19w7 ◽

2014 ◽

Vol 114 (2) ◽

pp. 496-508 ◽

Cited By ~ 6

Author(s):

Yuko Honma ◽

Ichiro Uchiyama

Keyword(s):

School Adjustment ◽

Emotional Adjustment ◽

School Belonging ◽

Emotional Engagement ◽

Late Childhood ◽

Japanese Children ◽

School Work ◽

Grade 5 ◽

School Liking ◽

The Relationship

This study examined the relationship between school adjustment and emotional engagement in late childhood. Participants were Grade 5 and 6 Japanese children ( N = 304; 164 boys, 200 girls). The School Liking and Avoidance Questionnaire (SLAQ) was used to measure children's emotional adjustment to school. The School Adjustment Scale, which was used to assess emotional engagement, consists of four factors: “friendships,” “school work,” “teacher–child relationships,” and “school in general.” The last factor was used to measure school belonging.

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