Incidence of acute lung injury in the United States*

2003 ◽  
Vol 31 (6) ◽  
pp. 1607-1611 ◽  
Author(s):  
Christopher H. Goss ◽  
Roy G. Brower ◽  
Leonard D. Hudson ◽  
Gordon D. Rubenfeld
Keyword(s):  
United States ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
The United States

AABB survey of transfusion-related acute lung injury policies and practices in the United States

Transfusion ◽  
2007 ◽  
Vol 47 (9) ◽  
pp. 1679-1685 ◽  
Author(s):  
Patricia Kopko ◽  
Marianne Silva ◽  
Ira Shulman ◽  
Steven Kleinman
Keyword(s):  
United States ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
The United States ◽  
Policies And Practices

Impact of Acute Lung Injury and Acute Respiratory Distress Syndrome After Traumatic Brain Injury in the United States

Neurosurgery ◽  
2012 ◽  
Vol 71 (4) ◽  
pp. 795-803 ◽  
Author(s):  
Fred Rincon ◽  
Sayantani Ghosh ◽  
Saugat Dey ◽  
Mitchell Maltenfort ◽  
Matthew Vibbert ◽  
...  
Keyword(s):  
United States ◽  
Heart Failure ◽  
Traumatic Brain Injury ◽  
Congestive Heart Failure ◽  
Acute Respiratory Distress Syndrome ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Hospital Mortality ◽  
Distress Syndrome ◽  
The United States

AbstractBACKGROUND:Traumatic brain injury (TBI) is a major cause of disability, morbidity, and mortality. The effect of the acute respiratory distress syndrome and acute lung injury (ARDS/ALI) on in-hospital mortality after TBI remains controversial.OBJECTIVE:To determine the epidemiology of ARDS/ALI, the prevalence of risk factors, and impact on in-hospital mortality after TBI in the United States.METHODS:Retrospective cohort study of admissions of adult patients >18 years with a diagnosis of TBI and ARDS/ALI from 1988 to 2008 identified through the Nationwide Inpatient Sample.RESULTS:During the 20-year study period, the prevalence of ARDS/ALI increased from 2% (95% confidence interval [CI], 2.1%–2.4%) in 1988 to 22% (95% CI, 21%–22%) in 2008 (P < .001). ARDS/ALI was more common in younger age; males; white race; later year of admission; in conjunction with comorbidities such as congestive heart failure, hypertension, chronic obstructive pulmonary disease, chronic renal and liver failure, sepsis, multiorgan dysfunction; and nonrural, medium/large hospitals, located in the Midwest, South, and West continental US location. Mortality after TBI decreased from 13% (95% CI, 12%–14%) in 1988 to 9% (95% CI, 9%–10%) in 2008 (P < .001). ARDS/ALI-related mortality after TBI decreased from 33% (95% CI, 33%–34%) in 1988 to 28% (95% CI, 28%–29%) in 2008 (P < .001). Predictors of in-hospital mortality after TBI were older age, male sex, white race, cancer, chronic kidney disease, hypertension, chronic liver disease, congestive heart failure, ARDS/ALI, and organ dysfunctions.CONCLUSION:Our analysis demonstrates that ARDS/ALI is common after TBI. Despite an overall reduction of in-hospital mortality, ARDS/ALI carries a higher risk of in-hospital death after TBI.

scholarly journals Reducing Noninfectious Risks of Blood Transfusion

2011 ◽  
Vol 115 (3) ◽  
pp. 635-649 ◽  
Author(s):  
Brian M. Gilliss ◽  
Mark R. Looney ◽  
Michael A. Gropper ◽  
David S. Warner
Keyword(s):  
United States ◽  
Acute Lung Injury ◽  
Blood Transfusion ◽  
Lung Injury ◽  
Causes Of Death ◽  
The United States ◽  
Morbidity And Mortality ◽  
Circulatory Overload ◽  
Transfusion Reactions

As screening for transfusion-associated infections has improved, noninfectious complications of transfusion now cause the majority of morbidity and mortality associated with transfusion in the United States. For example, transfusion-related acute lung injury, transfusion-associated circulatory overload, and hemolytic transfusion-reactions are the first, second, and third leading causes of death from transfusion, respectively. These complications and others are reviewed, and several controversial methods for prevention of noninfectious complications of transfusion are discussed, including universal leukoreduction of erythrocyte units, use of male-only plasma, and restriction of erythrocyte storage age.

scholarly journals Review of Cases of E-Cigarette or Vaping Product Use-Associated Lung Injury (EVALI) and Brief Review of the Literature

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Amr Essa ◽  
Jeffrey Macaraeg ◽  
Nikhil Jagan ◽  
Daniel Kwon ◽  
Saboor Randhawa ◽  
...  
Keyword(s):  
United States ◽  
Lung Injury ◽  
The United States ◽  
Cigarette Use ◽  
Review Of The Literature ◽  
The Past ◽  
Product Use ◽  
Vitamin E Acetate ◽  
Pathologic Features ◽  
Growing Body

Since the appearance of the E-Cigarette in the early 2000s, its industry, popularity, and prevalence have risen dramatically. In the past, E-Cigarette use with the vaping of nicotine or cannabis products had been associated with a few reported cases of lung injury. However, in 2019, thousands of cases of E-Cigarette or vaping product use-associated lung injury (EVALI) were reported in the United States. Evidence linked this outbreak with vaping of tetrahydrocannabinol (THC). We report two confirmed cases of EVALI and their associated clinical, radiologic, and pathologic features. This report supports the growing body of information regarding EVALI. It also discusses various substances, particularly vitamin E acetate, which has been suggested as a causative agent.

Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model

Blood ◽  
2006 ◽  
Vol 107 (3) ◽  
pp. 1217-1219 ◽  
Author(s):  
Ulrich J. H. Sachs ◽  
Katja Hattar ◽  
Norbert Weissmann ◽  
Rainer M. Bohle ◽  
Timo Weiss ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Ex Vivo ◽  
The United States ◽  
Neutrophil Activation ◽  
Lung Model ◽  
Oxygen Species ◽  
Rat Lung ◽  
Cognate Antigen ◽  
Key Events

AbstractTransfusion-related acute lung injury (TRALI) is a hazardous complication of transfusion and has become the leading cause of transfusion-related death in the United States and United Kingdom. Although leukoagglutinating antibodies have been frequently shown to be associated with the syndrome, the mechanism by which they induce TRALI is poorly understood. Therefore, we reproduced TRALI in an ex vivo rat lung model. Our data demonstrate that TRALI induction by antileukocyte antibodies is dependent on the density of the cognate antigen but does not necessarily require leukoagglutinating properties of the antibody or the presence of complement proteins. Rather, antibody-mediated activation of neutrophils seems to initiate TRALI, a process that could be triggered by neutrophil stimulation with fMLP. Antibody-mediated neutrophil activation and subsequent release of reactive oxygen species may thus represent key events in the pathophysiologic cascade that leads to immune TRALI.

Mechanism of transfusion-related acute lung injury induced by HLA class II antibodies

Blood ◽  
2011 ◽  
Vol 117 (2) ◽  
pp. 669-677 ◽  
Author(s):  
Ulrich J. H. Sachs ◽  
Wiebke Wasel ◽  
Behnaz Bayat ◽  
Rainer M. Bohle ◽  
Katja Hattar ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Ex Vivo ◽  
Threshold Model ◽  
Human Leukocyte ◽  
The United States ◽  
Class Ii ◽  
Hla Class Ii ◽  
Monocyte Activation ◽  
Key Players

Abstract Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the United States and other countries. In most TRALI cases, human leukocyte antigen (HLA) class II antibodies are detected in implicated donors. However, the corresponding antigens are not present on the cellular key players in TRALI: neutrophils and endothelium. In this study, we identify monocytes as a primary target in HLA class II–induced TRALI. Monocytes become activated when incubated with matched HLA class II antibodies and are capable of activating neutrophils, which, in turn, can induce disturbance of an endothelial barrier. In an ex vivo rodent model, HLA class II antibody–dependent monocyte activation leads to severe pulmonary edema in a relevant period of time, whenever neutrophils are present and the endothelium is preactivated. Our data suggest that in most TRALI cases, monocytes are cellular key players, because HLA class II antibodies induce TRALI by a reaction cascade initiated by monocyte activation. Furthermore, our data support the previous assumption that TRALI pathogenesis follows a threshold model. Having identified the biologic mechanism of HLA class II antibody–induced TRALI, strategies to avoid plasma from immunized donors, such as women with a history of pregnancy, appear to be justified preventive measures.

scholarly journals Demographics, Substance Use Behaviors, and Clinical Characteristics of Adolescents With e-Cigarette, or Vaping, Product Use–Associated Lung Injury (EVALI) in the United States in 2019

2020 ◽  
Vol 174 (7) ◽  
pp. e200756 ◽  
Author(s):  
Susan H. Adkins ◽  
Kayla N. Anderson ◽  
Alyson B. Goodman ◽  
Evelyn Twentyman ◽  
Melissa L. Danielson ◽  
...  
Keyword(s):  
United States ◽  
Substance Use ◽  
Lung Injury ◽  
Clinical Characteristics ◽  
The United States ◽  
Product Use

scholarly journals Pulmonary Disease Related to E-Cigarettes

2020 ◽  
Vol 95 (1) ◽  
pp. 6-12
Author(s):  
So-Young Park
Keyword(s):  
United States ◽  
Smoking Cessation ◽  
Lung Injury ◽  
Pulmonary Disease ◽  
Potential Role ◽  
The United States

The potential role of E-cigarettes in smoking cessation is debatable, and whether they are harmful remains controversial worldwide. However, several cases of E-cigarette or vaping-associated lung injury (EVALI) have been reported in the United States. In this review, we discuss and summarize EVALI cases.

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