scholarly journals NOCTURNAL BLOOD PRESSURE DROP IN PATIENTS WITH RECENT ON SET OF DIABETES MELLITUS TYPE 2 AND ITS ASSOCIATION WITH MICROVASCULAR CORONARY PERFUSION

2019 ◽  
Vol 37 ◽  
pp. e142
Author(s):  
B. Nikolaidou ◽  
E. Gkaliagkousi ◽  
P. Anyfanti ◽  
A. Triantafyllou ◽  
A. Lazaridis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Pressure Drop ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Coronary Perfusion ◽  
Nocturnal Blood Pressure

scholarly journals Effectiveness of Chrono-Pharmacotherapy Depending on the Salt Sensitivity of Patients with Arterial Hypertension and Diabetes Mellitus Type 2

2019 ◽  
Vol 14 (6) ◽  
pp. 846-851
Author(s):  
V. V. Skibitskiy ◽  
A. A. Kiselev ◽  
A. V. Fendrikova
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Arterial Stiffness ◽  
Diabetes Mellitus Type 2 ◽  
Blood Pressure Monitoring ◽  
Aortic Pressure ◽  
Diabetes Mellitus Type ◽  
Pressure Monitoring ◽  
Central Aortic Pressure

Aim. To study the effect of two regimens of combined antihypertensive therapy during the day on daily monitoring of arterial pressure, central aortic pressure, and arterial stiffness, depending on the salt sensitivity of hypertensive patients with diabetes mellitus type 2. Material and methods. 130 hypertensive patients with type 2 diabetes mellitus were included into the study. They were divided into 2 subgroups: salt-sensitive (group 1) and salt-resistant (group 2), and then randomized to subgroups A and B of ongoing therapy: in the morning ramipril and indapamide retard, bedtime – amlodipine (subgroup 1A and 2A); or in the morning amlodipine and indapamide retard, bedtime – ramipril (subgroup 1B and 2B). Initially and after 24 weeks of antihypertensive therapy, 24-hour blood pressure monitoring was performed, the indices of central aortic pressure and arterial stiffness were determined. Results. After 24 weeks, in all subgroups, there was a significant positive dynamics of the parameters of 24-hour blood pressure monitoring, central aortic pressure and arterial stiffness indices. In the subgroup 1В, it was registered a significant improvement in the majority of parameters of 24-hour blood pressure monitoring (decrease in 24-hours systolic BP by 24.4%, 24-hours diastolic BP by 22.1%; p<0.05), central aortic pressure (decrease in aortal systolic BP by 15.9%, aortal diastolic BP by 20.8%; p<0.05) and vascular wall stiffness parameters (decrease in pulse wave velocity by 13.8%; p<0.05) in comparison with group 1A (decrease in 24-hours systolic BP by 17.5%, 24-hours diastolic BP by 14.6%, aortal systolic BP by 12.7%, aortal diastolic BP by 9.7%, pulse wave velocity by 9.2%; p<0.05 in comparison with the group 1B). In the case of salt-resistant patients, there were comparable positive changes in the parameters of 24-hour blood pressure monitoring, central aortic pressure and arterial stiffness indices against the background of both dosing regimens during the day. Conclusion. In the study, it was demonstrated the more pronounced antihypertensive and vasoprotective efficacy of the combination of thiazide-like diuretic with calcium channel blocker in the morning and ACE inhibitor in bedtime compared to the alternative regimen of prescribed pharmacotherapy in salt-sensitive patients, and comparable efficacy of both regimens in salt-resistant hypertensive patients with diabetes mellitus type 2.

scholarly journals The Effects of DPP4 Inhibitors on Lipid Status and Blood Pressure in Rats with Diabetes Mellitus Type 2

2019 ◽  
Vol 20 (4) ◽  
pp. 301-307 ◽  
Author(s):  
Stefani Bolevich ◽  
Nevena Draginic ◽  
Marijana Andjic ◽  
Nevena Jeremic ◽  
Sergey Bolevich ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Diabetes Mellitus Type 2 ◽  
Density Lipoprotein ◽  
Diabetes Mellitus Type ◽  
Albino Rats ◽  
Dpp4 Inhibitors ◽  
Lipid Status ◽  
Group I

Abstract The aim of the present study was to examine, evaluate and compare the effects of administered dipeptidyl peptidase-4 (DPP4) inhibitors saxagliptin and sitagliptin on lipid status parameters and blood pressure in rats with streptozotocine induced diabetes mellitus type 2. Forty-eight Wistar albino rats were divided randomly into 4 groups: 1. group I: control healthy group; 2. group II: rats with diabetes mellitus type 2; 3. group III: rats with diabetes mellitus type 2+ treated with 0.6 mg/kg of sitagliptin; 4. group IV: rats with diabetes mellitus type 2 treated with 0.45 mg/kg of saxagliptin. The rats from experimental groups were fed with a high-fat diet for 4 weeks and after 6–8 h of starvation received one dose of streptozotocin (STZ) intraperitoneally (25 mg/kg body weight) to induce type 2 diabetes mellitus (T2DM). Animals with fasting glucose above 7 mmol/L and insulin over 6 mmol/L were included in the study as rats with T2DM. Upon completion of the experiments, the blood was collected from the anesthetized animals and serum triglyceride (TG), total cholesterol (TCH), high density lipoprotein (HDL), and low density lipoprotein (LDL) were measured using spectrophotometry and commercial kits. At the beginning of the study and the day before sacrificing animals, the blood pressure and heart rate were measured by a tail-cuff noninvasive method. DPP4 inhibitors, as glucagon-like peptide-1 (GLP-1) agonists, were associated with modest reductions in DBP, LDL-C, TCH, and TGL and significant improvement in HDL, SBP and HR.

Characterization of blood pressure and daily stress in Mexican children with Diabetes Mellitus Type 2 risk factors

2015 ◽  
Vol 192 ◽  
pp. 106
Author(s):  
A.E. Soto-Piña ◽  
C. Flores Reséndiz ◽  
A.C. Fernández Gaxiola ◽  
A. Esquivel Roque ◽  
R. Valdés Ramos
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type ◽  
Daily Stress ◽  
Mexican Children

scholarly journals HUBUNGAN TEKANAN DARAH DAN LAMA MENDERITA DIABETES DENGAN LAJU FILTRASI GLOMERULUS PADA SUBJEK DIABETES MELITUS TIPE 2

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Nurmalasari Amira ◽  
Karel Pandelaki ◽  
Stella Palar
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Diabetes Mellitus Type 2 ◽  
Filtration Rate ◽  
Diabetes Mellitus Type ◽  
Cross Sectional ◽  
Substantial Correlation ◽  
Spearman’S Correlation ◽  
Diabetes Melitus

Abstract: Diabetes Mellitus Type 2 is a metabolic disease that has been a problem in regards of world health. In Indonesia, the prevalence and incident of this disease keeps on increasing with each passing year. The increasing of blood pressure, more often than not, accompanies the case of diabetes mellitus. This causes the increase of both morbidity and mortality rate because it increases the risk of complications, in both macro-vascular and micro-vascular, one of which is nephropathy diabetic. Purpose: This research is aimed in understanding the correlation between blood pressure and the amount of period of suffering diabetes with glomerulus filtration rate in subject with diabetes mellitus type 2. Methods: The research method used is analytic descriptive with cross sectional approach using secondary data. The amount of sample is 152 patients of diabetes mellitus type 2, who came for treatment in Polyclinic Endocrine and Metabolic RSUP Prof. Dr. R. D. Kandou, Manado, during the period of November to December 2013. Conclusion: The result of the analysis using spearman’s correlation shows that there is a substantial correlation between blood pressure and glomerulus filtration rate (p=0,000) with negative direction, which means that the higher one’s blood pressure, the lower one’s glomerulus filtration rate is. Also, there is no substantial correlation regarding the period of suffering diabetes (p=0,971), because the glomerulus filtration rate doesn’t only depends on how long someone has been having diabetes, and instead there are another factors that are influencing the kidney’s function, for example: hypertension. Keywords: blood pressure, glomerulus filtration rate, diabetes mellitus type 2    Abstrak: Diabetes Melitus tipe 2 merupakan penyakit metabolik yang telah menjadi masalah kesehatan dunia. Indonesia prevalensi dan insiden penyakit ini terus meningkat dari tahun ke tahun. Peningkatan tekanan darah sering menyertai penyakit diabetes melitus. Hal ini meningkatkan morbiditas dan mortalitas karena meningkatkan resiko terjadinya komplikasi baik makrovaskular dan mikrovaskular diantaranya nefropati diabetik. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan tekanan darah dan lama menderita diabetes dengan laju filtrasi glomerulus pada subjek diabetes melitus tipe 2. Metode: Jenis penelitian yang digunakan adalah deskriptif analitik dengan pendekatan cross sectional menggunakan data sekunder. Jumlah sampel sebanyak 152 pasien diabetes melitus tipe 2 yang berobat di Poliklinik Endokrin dan Metabolik RSUP Prof. Dr. R. D. Kandou Manado periode November - Desember 2013. Simpulan: Hasil analisis menggunakan spearman’s correlation menunjukkan bahwa ada hubungan yang bermakna antara tekanan darah dengan laju filtrasi glomerulus (p=0,000) dengan arah hubungan negatif yakni semakin tinggi tekanan darah maka filtrasi glomerulus semakin rendah, serta tidak ada hubungan bermakna dengan lama menderita diabetes (p=0,971) oleh karena laju filtrasi glomerulus tidak hanya bergantung pada lamanya menderita diabetes melainkan ada faktor lain yang mempengaruhi fungsi ginjal misalnya hipertensi. Kata kunci: Tekanan darah, laju filtrasi glomerulus, diabetes melitus tipe 2

scholarly journals Efeitos do exercício físico sobre a pressão e rigidez arterial em pacientes com diabetes mellitus tipo 2: revisão de literatura

2016 ◽  
Vol 14 ◽  
pp. 290
Author(s):  
Mirian Rebeca Alves Moura ◽  
Paula Taysa da Rocha Bezerra ◽  
Melyssa Lima de Medeiros ◽  
Rodrigo Marcel Valentim da Silva
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Arterial Stiffness ◽  
Physical Exercise ◽  
Arterial Pressure ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Mellitus Type

Introduction: Diabetes mellitus type 2 increases the mortality and the risk of premature morbidity related to cardiovascular disease. High blood pressure stands out as the main morbidity in this diabetic patient and arterial stiffness by one of the common complications associated with the disease, both of which can precipitate the occurrence of vascular disorders. In this context, the physical exercise is considered an important component in the treatment of these patients, as it helps in the control of cardiovascular risk factors. Objective: To investigate the effects of the physical exercise on pressure and arterial stiffness in patients with type 2 Diabetes mellitus. Methods: This is a literature review conducted in the period March-April 2015 in MEDLINE, LILACS, SciELO, PubMed and Cochrane databases. The keywords used were "Type 2 Diabetes Mellitus", "Exercise", "Arterial Stiffness" and "Arterial Pressure", combined by the boolean operator "and" being considered for this review only studies published between 2009 and 2015. Results: A total of 146 publications, were select 8 studies that investigated the effects of physical exercise on blood pressure and arterial stiffness in patients with type 2 Diabetes mellitus. Of these, 6 studies investigated the effects of physical exercise on blood pressure, which was completed in 4 of them, that it was effective in promoting protective effects of blood pressure. With respect to arterial stiffness, analyzed in four studies, it was found that aerobic training was able to generate reductions in their values after 3 months of intervention, which however were not maintained after longer periods. Conclusion: The physical exercise can be appointed as a promising strategy for arterial pressure control in patients with diabetes mellitus type 2. With regard to arterial stiffness, it is assumed that structural vascular changes manifested in the disease process present irreversible characteristics and therefore can not be modified even after long periods of intervention.

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