scholarly journals HUBUNGAN TEKANAN DARAH DAN LAMA MENDERITA DIABETES DENGAN LAJU FILTRASI GLOMERULUS PADA SUBJEK DIABETES MELITUS TIPE 2

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Nurmalasari Amira ◽  
Karel Pandelaki ◽  
Stella Palar

Abstract: Diabetes Mellitus Type 2 is a metabolic disease that has been a problem in regards of world health. In Indonesia, the prevalence and incident of this disease keeps on increasing with each passing year. The increasing of blood pressure, more often than not, accompanies the case of diabetes mellitus. This causes the increase of both morbidity and mortality rate because it increases the risk of complications, in both macro-vascular and micro-vascular, one of which is nephropathy diabetic. Purpose: This research is aimed in understanding the correlation between blood pressure and the amount of period of suffering diabetes with glomerulus filtration rate in subject with diabetes mellitus type 2. Methods: The research method used is analytic descriptive with cross sectional approach using secondary data. The amount of sample is 152 patients of diabetes mellitus type 2, who came for treatment in Polyclinic Endocrine and Metabolic RSUP Prof. Dr. R. D. Kandou, Manado, during the period of November to December 2013. Conclusion: The result of the analysis using spearman’s correlation shows that there is a substantial correlation between blood pressure and glomerulus filtration rate (p=0,000) with negative direction, which means that the higher one’s blood pressure, the lower one’s glomerulus filtration rate is. Also, there is no substantial correlation regarding the period of suffering diabetes (p=0,971), because the glomerulus filtration rate doesn’t only depends on how long someone has been having diabetes, and instead there are another factors that are influencing the kidney’s function, for example: hypertension. Keywords: blood pressure, glomerulus filtration rate, diabetes mellitus type 2    Abstrak: Diabetes Melitus tipe 2 merupakan penyakit metabolik yang telah menjadi masalah kesehatan dunia. Indonesia prevalensi dan insiden penyakit ini terus meningkat dari tahun ke tahun. Peningkatan tekanan darah sering menyertai penyakit diabetes melitus. Hal ini meningkatkan morbiditas dan mortalitas karena meningkatkan resiko terjadinya komplikasi baik makrovaskular dan mikrovaskular diantaranya nefropati diabetik. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan tekanan darah dan lama menderita diabetes dengan laju filtrasi glomerulus pada subjek diabetes melitus tipe 2. Metode: Jenis penelitian yang digunakan adalah deskriptif analitik dengan pendekatan cross sectional menggunakan data sekunder. Jumlah sampel sebanyak 152 pasien diabetes melitus tipe 2 yang berobat di Poliklinik Endokrin dan Metabolik RSUP Prof. Dr. R. D. Kandou Manado periode November - Desember 2013. Simpulan: Hasil analisis menggunakan spearman’s correlation menunjukkan bahwa ada hubungan yang bermakna antara tekanan darah dengan laju filtrasi glomerulus (p=0,000) dengan arah hubungan negatif yakni semakin tinggi tekanan darah maka filtrasi glomerulus semakin rendah, serta tidak ada hubungan bermakna dengan lama menderita diabetes (p=0,971) oleh karena laju filtrasi glomerulus tidak hanya bergantung pada lamanya menderita diabetes melainkan ada faktor lain yang mempengaruhi fungsi ginjal misalnya hipertensi. Kata kunci: Tekanan darah, laju filtrasi glomerulus, diabetes melitus tipe 2

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Finisia Noviyanti ◽  
Eva Decroli ◽  
Susila Sastri

AbstrakHipertensi seringkali menjadi kondisi komorbid yang menyertai diabetes melitus tipe 2. Diabetes melitus, hipertensi dan peningkatan LDL kolesterol merupakan keadaan yang sering dijumpai saling berkaitan. Tujuan penelitian ini adalah untuk melihat perbedaan kadar LDL kolesterol penderita diabetes melitus tipe 2 dengan dan tanpa hipertensi. Penelitian ini menggunakan desain cross sectional comparatif. Pengumpulan data dilakukan dengan observasi data rekam medis pasien diabetes melitus tipe 2 dengan dan tanpa hipertensi tahun 2011 di RS. Dr. M. Djamil Padang. Analisis statistik menggunakan uji chi-square dan uji t-berpasangan. Hasil penelitian menemukan kadar LDL kolesterol pada pasien diabetes melitus tipe 2 dengan hipertensi (137,56±41,43 mg/dl) lebih tinggi dibandingkan tanpa hipertensi (94,39±35,36 mg/dl). Uji chi-square menunjukkkan adanya hubungan yang bermakna antara peningkatan kadar LDL kolesterol dengan kejadian hipertensi (p<0,05). Uji t-berpasangan menunjukkan bahwa adanya perbedaan bermakna kadar LDL kolesterol antara kelompok pasien diabetes melitus dengan hipertensi dan tanpa hipertensi (p<0,05). Penelitian ini menyimpulkan adanya perbedaan yang bermakna kadar LDL kolesterol pada pasien diabetes melitus tipe 2 dengan hipertensi dan tanpa hipertensi di RS. Dr. M. Djamil Padang.Kata kunci: LDL kolesterol, diabetes melitus tipe 2, hipertensi AbstractHypertension is often a comorbid conditions that accompany diabetes mellitus type 2. Diabetes mellitus, hypertension and increased LDL cholesterol is a condition that is often be found related one another. The objective of this study was to determine difference LDL cholesterol level among diabetes melitus type 2 with hypertension and without hypertension.This research used cross-sectional comparatif design. The data was collected through observation of the patient’s medical records diabetes mellitus type 2 with hypertension and without hypertension in 2011 at the hospital Dr. M. Djamil Padang. The statistical analysis used was chi-square test and paired-T test. The results found that the levels of LDL cholesterol in patients with diabetes mellitus type 2 with hypertension (137,56±41,43) was higher than without hypertension (94,39±35,36). Chi square test was found that a significant correlation between elevates levels of LDL cholesterol to the incidence of hypertension (p<0,05). Paired-t test showed that there were significant differences of LDL cholesterol levels between groups of diabetes mellitus type 2 with hypertension and diabetes mellitus type 2 without hypertension (p<0,05).This research conclude that there are differences in the levels of LDL cholesterol in patients with diabetes melitus type 2 with hypertension and without hypertension in the hospital Dr. M. Djamil Padang in 2011.Keywords: LDL cholesterol, diabetes mellitus type 2, hypertension


2019 ◽  
Vol 1 (2) ◽  
pp. 195
Author(s):  
Inca Buntari Agustini

ABSTRAKDiabetes Melitus merupakan penyakit yang tidak dapat disembuhkan akan tetapi sangat memungkinkan untuk dikelola atau dikontrol. Dalam konteks pengelolaan penyakit DM, kesadaran ataupun disiplin diri penderita sangat diperlukan untuk membangun kemandirian dan mempertahankan kepatuhan penderita dalam melaksanakan manajemen pengobatan. Komponen manajemen perawatan DM terdiri dari lima pilar utama yang sudah menjadi panduan bagi praktisi kesehatan. Akan tetapi, perlu evaluasi yang nyata untuk mengetahui keberhasilan pelaksanaannya. Penelitian ini bertujuan untuk mengevaluasi pelaksanaan pilar utama diabetes pada pasien DM tipe 2.Desain penelitian yang digunakan adalah deskriptif kuantitatif dengan pendekatan cross-sectional. Penelitian dilakukan pada empat puskesmas di wilayah Denpasar, Bali dengan jumlah sampel 240 pasien DM tipe 2. Metode pengambilan sampel dilakukan dengan menggunakan teknik purposive sampling. Instrumen penelitian menggunakan kuesioner Summary of Diabetes Self Care Activities.Hasil analisa data menunjukkan bahwa 81 (33,8%) responden tidak mengikuti perencanaan diet sesuai dengan yang dianjurkan, 118 (49,2%) responden setiap hari melakukan latihan fisik ringan, 174 (72,5%) responden melakukan pemeriksaan gula darah satu kali seminggu, 199 (82,9%) mengkonsumsi obat diabetes setiap hari dan 200 (83,3%) responden telah melakukan perawatan kaki setiap hari.Hal ini menunjukkan bahwa pelaksanaan empat pilar utama diabetes sudah baik. Pelaksanaan pilar pertama diabetes yang belum baik dimungkinkan karena responden belum memahami pentingnya melaksanakan diet sesuai anjuran. Oleh sebab itu, sangat penting membuat model yang tepat untuk meningkatkan motivasi dan kesadaran responden dalam melaksanakan pilar utama diabetes sehingga berdampak siginifikan terhadap peningkatan kualitas hidup penderita. Kata kunci : diabetes melitus tipe 2, pilar utama diabetes ABSTRACT                Diabetes mellitus (DM) is a disease that is not curable but it is possible to be managed or controlled. In the context of DM management, patient awareness or self-discipline is needed to build and maintain the independence of patient compliance in implementing medication management. DM care management component consists of five main pillars which have become a guide for health practitioners. However, it should be a real evaluation to determine the success of the implementation. This study aims to evaluate the implementation of the main pillars of diabetes in patients with type 2 diabetes mellitus.               The design study was quantitative descriptive cross-sectional approach. The study was conducted at four clinics in Denpasar, Bali with a sample size of 240 patients with diabetes mellitus type 2. The sampling method was done by using purposive sampling technique. The research instrument used a questionnaire Summary of Diabetes Self-Care Activities.               The results of data analysis showed that 81 (33.8%) of respondents did not follow the diet plan in accordance with the recommended, 118 (49.2%) of respondents each day doing light physical exercise, 174 (72.5%) of respondents do blood sugar tests one times a week, 199 (82.9%) taking diabetes medication every day, and 200 (83.3%) of respondents have been doing foot care every day.               This shows that the implementation of the four pillars of diabetes has been good. Implementation of the first pillar of diabetes are not well possible because the respondents do not understand the importance of implementing the diet proverly. Therefore, it is very important to allow the right model to improve motivation and awareness of the respondents in implementing the main pillars of diabetes which impacted significantly on improving the quality of life of patients. Keywords: diabetes mellitus type 2, the main pillars of diabetes 


2016 ◽  
Vol 28 (03) ◽  
pp. 1650016
Author(s):  
Yu Chu-Su ◽  
Chien-Sheng Liu ◽  
Ruey-Shin Chen ◽  
Chii-Wann Lin

Background: The result of a standard urinary dipstick from a patient with diabetes mellitus type 2 can be used to predict the estimated glomerular filtration rate (eGFR). We designed a multilayer perceptron (MLP) to investigate the possibility and optimal number of variables for the prediction. Methods: A total of 299 volunteers with diabetes mellitus type 2 were included. The blood and urine samples from volunteers were analyzed for blood sugar, glycated hemoglobin, serum creatinine, and urine chemistry. The urine chemistry was examined by a standard urinary dipstick. Volunteer age and gender and six test items of the dipstick were set as eight variables for this study. The eight variables were grouped and examined for the optimal combination. The eight variables from 232 of 299 volunteers were used to train an MLP for the optimal variables. The performance of trained MLP was validated by the data from 69 of 232 volunteers. Results: The optimal combination for variables was the six test items of the dipstick and volunteer age. The area under the curve (0.928), accuracy (0.879), sensitivity (0.83), and specificity (0.88) of the trained MLP were examined. Conclusions: The results demonstrate the eGFR prediction potential of the results of a urinary dipstick using this method.


F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 7 ◽  
Author(s):  
Eduardo De la Cruz-Cano ◽  
Carlos Alfonso Tovilla-Zarate ◽  
Emilio Reyes-Ramos ◽  
Thelma Beatriz Gonzalez-Castro ◽  
Isela Juarez-Castro ◽  
...  

Background: Diabetes mellitus and depression are highly prevalent conditions throughout the world and have significant impact on health outcomes. It has been estimated that diabetes mellitus type 2 affects about 246 million people in the world; nevertheless, incidence varies among countries. There is evidence that depression is associated with a poor metabolic control in patients with type 2 diabetes mellitus that present other health problems (such as hypertension and obesity). The aim of this study protocol is to determine if obesity increases the risk for depression in patient with diabetes type 2.Methods: The analysis will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).The studies suitable for inclusion will be assessed by the Newcastle-Ottawa Scale (NOS) to determine their methodological quality. To identify the studies of interest, we will search on PubMed and EBSCO databases. We will use the following keyword combinations: "Diabetes Mellitus type 2 AND obesity AND depression", "depression AND Diabetes Mellitus type 2", "Diabetes Mellitus type 2 AND body mass index cross sectional study", "depression AND obesity cross-sectional study". Causes for exclusion will be publications that studied patients diagnosed with diabetes mellitus type 1; articles that focused on the treatment and complications of diabetes mellitus type 2; publications that have studied other clinical or psychiatric conditions (for instance, seizure disorder or history of schizophrenia, bipolar disorder, psychotic symptoms or dementia).Conclusion: The results of this study will form the basis for a better understanding of the association between obesity and depression in patients with diabetes mellitus type 2, and will allow development of prediction tools and better interventions. It is evident that several modifiable and non-modifiable risk factors play an important role in the pathogenesis of diabetes among population. Currently, evidence for the deleterious effects of diabetes mellitus type 2 are based on cross-sectional or other observational designs. Therefore, this study will have important implications for future research and public health guidance.


2019 ◽  
Vol 8 (2) ◽  
pp. 67-74
Author(s):  
Asri Pandiangan ◽  
Kristian Pieri Ginting

Diabetes melitus  atau DM merupakan kelompok penyakit metabolic dengan karakteristik hiperglikemia yang terjadi akibat kelainan sekresi insulin, kelainan kerja insulin atau kedua-duanya. Prevalensi diabetes melitus pada penduduk usia>15 tahun sebesar 6,9%, Toleransi Glukosa Terganggu atau TGT sebesar 29,9% dan Gula Darah Puasa Terganggu atau GDPT sebesar 36,6%. Diabetes mellitus merupakan silent killer. Adapun gejala-gejala klasik pada diabetes adalah polifagi, polidipsi dan poliuri. Penanganan pasien diabetes terbagi atas terapi farmakologi dan non farmakologi. Literatur review ini bertujuan mengetahui efek pemberian ekstrak biji jintan hitam terhadap pasien diabetes mellitus tipe 2 sebagai terapi alternatif yang sudah dilakukan oleh peneliti sebelumnya. Metode yang digunakan dalam artikel ini adalah penelusuran artikel melalui database NCBI dan Google Scholar. Tahun penerbitan sumber pustaka adalah dari tahun 2001 sampai 2019 dengan 32 sumber pustaka. Berbagai penelitian eksperimental yang dilakukan menunjukkan bahwa kandungan bioaktif pada biji jintan hitam bermanfaat sebagai anti diabetes. Kandungan biji jintan hitam sebagai antioksidan dapat meningkatkan sekresi insulin dengan meningkatkan metabolism energi di mitokondria, meningkatkan jalur intraseluler pada reseptor dan menurunkan glukoneogenesis dengan menekan sintesis enzim glukoneogenik.   Kata kunci: diabetes melitus, thymoquine, anti diabetes   EFFECT OF BLACK SEED EXTRACT FOR DIABETES MELLITUS TYPE 2 AS ALTERNATIVE THERAPY   ABSTRACT Diabetes mellitus or DM  is an group metabolic disease with the hyperglycemia characteristic because of insulin secretion disorder, insulin activity or both of them. The prevalence of diabetes mellitus at the age > 15 years old, is 6.9 percent, 29.9 percent ImpairedGlucoseTolerance or IGT and 36.6 percent ImpairedFastingGlycaemia or IFG.. Diabetes mellitus is a silent killer. As for classic symptoms of diabetes are polyphagia, polydipsia and polyuria. Intervention for patient diabetes divided by pharmacological and non pharmacological intervention. This literature review aims to find out which effect of Black Seed for patient of diabetes mellitus type 2 as alternative therapythat have been done by previous researchers. The method used in this article is the search of articles through the NCBI and Google Scholar databases. The year of publication of library sources is from 2009 to 2018 with 29 library sources.Various experimental research conducted showed part bioactive component useful as antidiabetic. Bioactive component as antioxidant can increase insulin secretion by increasing energy metabolism at mitochondria and increasing intraceluler pathway on insulin receptor and reduce gluconeogenesis by reduce synthesis gluconeogenic enzyme.   Keywords: diabetes mellitus, thymoquinone, anti diabetic


Author(s):  
Sri Astuti ◽  
Yhona Paratmanitya ◽  
Wahyuningsih Wahyuningsih

<p><strong>ABSTRACT</strong></p><p><em><strong>Background</strong>: Diabetes mellitus (DM) can cause various chronic complications on the eyes, kidney, neuronal, and blood vessel. Family support is very important to motivate the patient in performing the treatment of diabetes mellitus or diet. Therefore, knowledge and family support can influence the undergoing treat mentor therapy of diabetes mellitus. Having the knowledge, patient can know impact of the disease and in the treatment of therapy that must be done. Good knowledge and family supports can improve patient compliance in undergoing diet.</em></p><p><em><strong>Objectives</strong>: To know the association between the knowledge level and family support with compliance in the diet therapy among the patients with diabetes mellitus type 2 in Puskesmas Kasihan II Bantul Yogyakarta.</em></p><p><em><strong>Methods</strong>: This was a quantitative descriptive research with cross sectional design. Sampling technique used was quota sampling, where sample were gained in accordance with research criteria of 68 people. Initially, data analysis used was Kolmogorov-Smirnov. Multivariate analysis used was multiple linier regression.</em></p><p><em><strong>Results</strong>: The research showed that the most of respondents had good knowledge level (82.4%) and also family support of the respondent towards compliance in the diet therapy of DM type 2 (51.5%). The compliance level of the respondents in the diet therapy of DM type 2 that was in the sufficient category as many as</em><br /><em>76.5%. Knowledge and family support did not relate with compliance in the diet of diabetes mellitus type 2 with p-value consecutively was 0.537 and 0.937. Knowledge level and family support had influence as many 11.5% toward diet pursuance. Knowledge level influenced more toward diet compliance (p=0.041).</em></p><p><em><strong>Conclusions</strong>: There was no association between knowledge level and family support with compliance in the diet therapy on the patient with diabetes mellitus type 2 in Puskesmas Kasihan II Bantul Yogyakarta.</em></p><p><strong>KEYWORDS</strong><em>: knowledge, family support, diabetes mellitus</em></p><p><strong>ABSTRAK</strong></p><p><em><strong>Latar belakang</strong>: Diabetes mellitus adalah keadaan hiperglikemi kronik yang disertai berbagai kelainan akibat gangguan hormonal yang menimbulkan berbagai komplikasi kronik pada mata, ginjal, saraf, dan pembuluh darah. Dukungan keluarga sangat penting untuk memotivasi pasien dalam menjalankan</em><br /><em>pengobatan ataupun diet diabetes mellitus. Oleh karena itu pengetahuan dan dukungan keluarga sangat mempengaruhi dalam menjalankan pengobatan maupun terapi diabetes mellitus, karena dengan pengetahuan yang dimiliki pasien bisa mengetahui tentang penyakitnya, dampak-dampak dari penyakitnya, </em><em>serta berpengaruh dalam pengobatan maupun terapi yang harus dilakukan, salah satunya adalah diet diabetes mellitus dan pengetahuan yang baik serta adanya dukungan dari keluarga dapat meningkatkan kepatuhan pasien dalam menjalani diet.</em></p><p><em><strong>Tujuan</strong>: Mengetahui hubungan pengetahuan dan dukungan keluarga dalam menjalani terapi diet di Puskemas Kasihan II Bantul Yogyakarta.</em></p><p><em><strong>Metode</strong>: Penelitian ini bersifat deskriptif kuantitatif dengan rancangan cross sectional. Teknik pengambilan sampel yang digunakan yaitu quota sampling dan diperoleh 68 orang. Teknik analisis data yang digunakan yaitu uji Kolmogorov-Smirnov. Analisis multivariat menggunakan regresi linear.</em></p><p><em><strong>Hasil</strong>: Penelitian menunjukkan tingkat pengetahuan responden sebagian besar tergolong baik yaitu sebanyak 82,4% (56 orang), dukungan keluarga responden terhadap kepatuhan dalam menjalani terapi diet DM tipe 2 yaitu sebagian besar dengan kategori baik sebanyak 51,5% (35 orang), tingkat kepatuhan responden dalam menjalani terapi diet DM tipe 2 yaitu dalam kategori cukup yaitu sebanyak 76,5% (52 orang). Untuk pengetahuan dan dukungan keluarga tidak ada hubungan dengan kepatuhan dalam menjalani diet diabetes mellitus tipe 2 dengan menggunakan rumus Kolmogorov-Smirnov didapatkan nilai p=0,537;&gt;0,05, nilai p=0,937; &gt;0,05. Koefi sien determinasi variabel bebas mempengaruhi variabel terikat sebesar 11,5 % oleh variabel tingkat pengetahuan dan dukungan keluarga.</em></p><p><em><strong>Kesimpulan</strong>: Tidak ada hubungan antara pengetahuan dan dukungan keluarga dengan kepatuhan dalam menjalani diet diabetes mellitus tipe 2 di Puskesmas Kasihan II Bantul Yogyakarta.</em></p><p><strong>KATA KUNCI</strong><em>: pengetahuan, dukungan keluarga, diabetes mellitus</em></p>


BMJ Open ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. e046162
Author(s):  
Anton Hasselgren ◽  
Biraj Man Karmacharya ◽  
Ann-Katrin Stensdotter

ObjectivesThe objective was to determine the predictive potential of anthropometric indices to screen prevalent diabetes mellitus type 2 in a Norwegian population.DesignThis is a cross-sectional design to determine the potential association of waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), waist circumference (WC) and body mass index (BMI) with prevalent diabetes mellitus type 2 through logistic regression analysis. Receiver operating characteristic (ROC) curves were used to determine the predictive potential of the anthropometric indices. Youden’s index was applied to determine the optimal cut-off points for each anthropometric index.SettingThis study used cross-sectional data from the populations-based Health Study in Nord-Trøndelag which invited all citizens in the county above 20 years of age.ParticipantsThis study included all those who were non-pregnant and had complete data (N=50 042), 98.5% of the participants. The sample is to be considered representative for the population of Norway.Primary and secondary outcome measuresOR and ROC of the potential association between diabetes mellitus type 2 and anthropometric indices were the main planned and performed outcome measures.ResultsThe results suggest that the anthropometric indices performed differently within the Norwegian population with WHR and WHtR being the stronger predictor with (ROC) of 0.746 (0.735 to 0.757) and 0.741 (0.730 to 0.752). The predictive potential for the investigated anthropometric indices was generally stronger for women than men.ConclusionAnthropometric indices of size BMI and the highly correlated WC are less associated with prevalent diabetes mellitus type 2 than WHR (WC adjusted for hip circumference) or WHtR (WC adjusted for height) in a Norwegian population.


2020 ◽  
Vol 17 (2) ◽  
pp. 110-120
Author(s):  
Tri Yulianti ◽  
Lusi Anggraini

Diabetes mellitus is a chronic metabolic with high prevalence and it can increase the risk of the complications, if it not handled properly. Medication adherence is one of the determining factor to achive therapeutic outcome. This research aims to determine the affecting factors of adherence in  diabetes mellitus type 2 outpatient at RSUD Sukoharjo in 2020. This research type is  cross sectional with a purposive sampling technique. A total of 85 patients diabetes mellitus type 2 outpatient at RSUD Sukoharjo with inclusion criteria received OAD therapy (Oral Antidiabetic Drugs) or a combination of OAD with insulin for at least 1 month, recruited in this study. The data was collected from medical records and questionnaires. Adherence was measured by using the MARS 5 questionnaire (Medication Adherence Report Scale 5). Factors contributing to medication adherence was analyzed by using chi-square test. The results showed that 37 respondents (43.5%) were obedient. The significant factors of medication adherence are monthly income (p-value = 0.018 and OR = 2.887), Medication (p - value = 0.007 and OR = 3,551), the frequency of treatment (p-value = 0.006 and OR = 3,529) and blood glucose level (p-value = 0.006 and OR = 3,529).


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