Surgery Related Factors Do Not Affect Short-Term Adjacent Segment Kinematics After Anterior Cervical Arthrodesis

Objective.To clarify the prevalence, risk factors, outcome, and outcome-related factors of hemophagocytic lymphohistiocytosis (HLH) in patients with dermatomyositis (DM), polymyositis (PM), or clinically amyopathic dermatomyositis (CADM).Methods.Data of patients with DM, PM, or CADM who were admitted to the First Affiliated Hospital of Zhejiang University from February 2011 to February 2019 were retrospectively collected. Patients diagnosed with HLH constituted the case group. A 1:4 case-control study was performed to identify risk factors for HLH in patients with DM, PM, or CADM through comparison, univariate, and multivariate logistic regression analysis. Intragroup comparison was made among patients with HLH to identify factors influencing unfavorable short-term outcome.Results.HLH was a rare (4.2%) but fatal (77.8%) complication in patients with DM, PM, or CADM. The retrospective case-control study revealed that higher on-admission disease activity (p = 0.008), acute exacerbation of interstitial lung disease (AE-ILD, p = 0.002), and infection (p = 0.002) were risk factors for complication of HLH in patients with DM, PM, or CADM. The following intragroup comparison showed that higher on-admission disease activity (p = 0.035) and diagnosis of CADM (p = 0.039) might influence the short-term outcome of patients with HLH. However, no risk factor was identified after false discovery rate correction.Conclusion.In this study, secondary HLH was a fatal complication, with higher on-admission disease activity, AE-ILD, and infection working as risk factors. The underlying role of infection and autoimmune abnormality in HLH in connective tissue disease was subsequently noted. Clinical factors influencing the short-term outcome of patients with secondary HLH require further study.

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Accelerated spondylotic changes adjacent to the fused segment following central cervical corpectomy: magnetic resonance imaging study evidence

Journal of Neurosurgery Spine ◽

10.3171/spi.2004.100.1.0002 ◽

2004 ◽

Vol 100 (1) ◽

pp. 2-6 ◽

Cited By ~ 29

Author(s):

Vaijayantee Kulkarni ◽

Vedantam Rajshekhar ◽

Lakshminarayan Raghuram

Keyword(s):

Magnetic Resonance ◽

Mr Imaging ◽

Imaging Study ◽

Degenerative Changes ◽

Adjacent Segment ◽

Mr Images ◽

Short Term ◽

Content Type ◽

Fine Print

Object. The authors studied whether cervical spine motion segments adjacent to a fused segment exhibit accelerated degenerative changes on short-term follow-up magnetic resonance (MR) imaging. Methods. Preoperative and short-term follow-up (mean duration 17.5 months, range 10–48 months) cervical MR images obtained in 44 patients who had undergone one- or two-level corpectomy for cervical spondylotic myelopathy were evaluated qualitatively and quantitatively. The motion segment adjacent to the fused segment and a segment remote from the fused segment were evaluated for indentation of the thecal sac, disc height, and sagittal functional diameter of the spinal canal on midsagittal T2-weighted MR images. Thecal sac indentations were classifed as mild, moderate, and severe. New indentations of the thecal sac of varying severity (mild in 17 patients [38.6%], moderate in 10 [22.7%], and severe in six [13.6%]) had developed at the adjacent segments in 33 (75%) of 44 patients. The degenerative changes were seen at the superior level in 11 patients, inferior level in 10 patients, and at both levels in 12 patients and resulted from both anterior and posterior element degeneration in the majority (23 [69.6%]) of patients. The remote segments showed mild thecal sac indentations in seven patients and moderate indentations in two patients (nine [20.5%] of 44). Compared with the changes at the remote segment, the canal size was significantly decreased at the superior adjacent segment by 0.9 mm (p = 0.007). No patient sustained a new neurological deficit due to adjacent-segment changes. Conclusions. On short-term follow-up MR imaging, levels adjacent to the fused segment exhibited more pronounced degenerative changes (compared with remote levels) in 75% of patients who had undergone one- or two-level central corpectomy.

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Obesity does not impact clinical outcome but affects cervical sagittal alignment and adjacent segment degeneration in short term follow-up after an anterior cervical decompression and fusion

The Spine Journal ◽

10.1016/j.spinee.2019.02.016 ◽

2019 ◽

Vol 19 (7) ◽

pp. 1146-1153 ◽

Cited By ~ 1

Author(s):

Bryce A. Basques ◽

Jannat M. Khan ◽

Philip K. Louie ◽

Jeremy Mormol ◽

Steven Heidt ◽

...

Keyword(s):

Clinical Outcome ◽

Sagittal Alignment ◽

Adjacent Segment Degeneration ◽

Adjacent Segment ◽

Short Term ◽

Anterior Cervical Decompression ◽

Cervical Sagittal Alignment

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Disability pensions in severely disturbed in-patient adolescents

The British Journal of Psychiatry ◽

10.1192/bjp.172.2.159 ◽

1998 ◽

Vol 172 (2) ◽

pp. 159-163 ◽

Cited By ~ 7

Author(s):

M. Pelkonen ◽

M. Marttunen ◽

E. Pulkkinen ◽

P. Laippala ◽

J. Lönnqvist ◽

...

Keyword(s):

Psychosocial Functioning ◽

Disability Pension ◽

Psychiatric Care ◽

Critical Time ◽

Working Capacity ◽

Short Term ◽

Related Factors ◽

Long Term Prognosis

BackgroundKnowledge of working capacity from adolescence until adulthood among severely disturbed in-patients is scarce.MethodIn a follow-up study of 61 adolescent in-patients, we studied associations between being on a disability pension 20 years after hospitalisation, and the patients' psychopathology and treatment-related factors during the hospitalisation and seven-year follow-up.ResultsOf the former in-patients. 27% had not been on a disability pension, 20% had short-term pension periods, and 53% were pensioned. Subjects whose overall psychosocial functioning had improved and who had not utilised in-patient services until the seven-year follow-up, had a better prognosis in terms of working capacity Half of the subjects who had not been on pension during the follow-up had received a diagnosis of conduct disorder at discharge, and half of those pensioned had a psychotic disorder.ConclusionsThe patients' level of psychosocial functioning and capability to work in young adulthood were associated with long-term prognosis in terms of working capacity Adolescence seems to be the critical time for intensive psychiatric care combined with vocational rehabilitation programmes.

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Health risk management behaviors and related factors among Japanese university students participating in short-term study abroad programs

Journal of Infection and Chemotherapy ◽

10.1016/j.jiac.2019.04.015 ◽

2019 ◽

Vol 25 (11) ◽

pp. 866-872

Author(s):

Michiyo Yamakawa ◽

Yuko Tanaka ◽

Megumi Sasai

Keyword(s):

Risk Management ◽

Health Risk ◽

Short Term ◽

Study Abroad Programs ◽

Term Study ◽

Related Factors ◽

Japanese University ◽

Short Term Study ◽

Health Risk Management ◽

Management Behaviors

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Effect of tibolone on tumor angiogenesis parameters in short-term treated women

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.10519 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 10519-10519

Author(s):

F. E. Frankenne ◽

C. Munaut ◽

F. Wijzen ◽

J. Planellas Gomez ◽

L. Kloosterboer ◽

...

Keyword(s):

Breast Cancer ◽

Breast Tumor ◽

Vascular Density ◽

Potential Mechanism ◽

Short Term ◽

Related Factors ◽

Increased Risk ◽

Before And After ◽

Pai 1 ◽

Neutral Effect

10519 Background: Large recent studies have shown increased mammographic density, breast pain and a marginally increased risk of breast cancer in women treated with continuous combined estrogen/progestogen (ccEPT), while tibolone has a minimal effect. A placebo-controled clinical trial (STEM), approved by several ethical comities, has been initiated to assess effect and potential mechanism of action of tibolone on breast tumor. We present the results on 12 angiogenesis-related parameters. Methods: 102 women with breast cancer who had to undergo a mastectomy were treated for 2 weeks with tibolone 2.5 mg/day or placebo. RNA was extracted from tumor snap-frozen biopsies (paired before and after treatments) and reverse-transcripted into 2 cDNA batches on which 6 distinct PCRs were performed in duplicate per parameter/sample. A vascular density (VD) index was determined on CD31 specifically stained tumor sections by counting 10 fields per section on 5 distinct sections per biopsy. Results: The validity of the VD evaluation is highlighted by the high correlation coefficient (r = 0.81) between the data within the placebo group at a 2 week interval. In the tumor samples, no change of the VD index was seen. Since it could be argued that VD index could not correctly reflect a modulation of angiogenesis after only 14 days of treatment, we looked at a potential change of the expression of a large array of angiogenesis-related factors (VEGFs, VEGFRs, PAI-1). No modification of the expression in any of these factors was observed. Conclusions: Our data lead to conclude that, in this study, tibolone displays a neutral effect on angiogenesis in breast tumor. [Table: see text]

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Do cancer-specific variables improve risk-adjusted hospital quality comparisons?

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.4_suppl.585 ◽

2012 ◽

Vol 30 (4_suppl) ◽

pp. 585-585 ◽

Cited By ~ 1

Author(s):

Ryan P. Merkow ◽

Thomas E. Kmiecik ◽

David J Bentrem ◽

Mark E Cohen ◽

Bruce L Hall ◽

...

Keyword(s):

Neoadjuvant Therapy ◽

Colorectal Resection ◽

Predictive Ability ◽

Hospital Quality ◽

Short Term ◽

Combined Model ◽

Related Factors ◽

Fit Statistics ◽

C Statistic ◽

Improved Model

585 Background: For patients undergoing surgery for cancer, it has been suggested that risk-adjustment with cancer-specific variables is needed when evaluating short-term outcomes. Our objectives were to assess the influence of cancer-related variables on postoperative complications and hospital quality comparisons. Methods: Patients from ACS NSQIP and NCDB who underwent colorectal resection for cancer were linked (2006-2008) to create a dataset containing robust information on comorbidities, complications, and oncologic variables. Three hierarchical models were developed predicting the NSQIP outcome 30-day mortality or any serious morbidity using variables from (1) NSQIP only, (2) NCDB only, and (3) a combined model using NSQIP and NCDB. Models were compared with fit statistics and hospital outlier agreement. Results: From 146 NSQIP hospitals, 11401 patients underwent a colorectal resection for cancer, of which, 1954 (17%) experienced a mortality or serious morbidity event. The first five variables selected in the NCDB-only model were Charlson comorbidity score, neoadjuvant therapy use, T stage, primary payer, and M stage (c-statistic, 0.64; AIC, 9886). The first five variables selected in the NSQIP-only model were ASA class, preop sepsis, albumin, surgical procedure, and COPD (c-statistic, 0.66; AIC, 9787). In the combined model, neoadjuvant therapy use was the only cancer-specific variable selected in the top five. The remaining variables were ASA class, preop sepsis, albumin, and wound class (c-statistic, 0.67; AIC, 9455). At the hospital-level, the NCDB-only model identified three high outliers (worse than expected) and one low outlier (better than expected). Both the NSQIP-only and combined models identified the same four high and two low outlying hospitals (kappa: 1.0), which agreed marginally with the NCDB-only model (kappa: 0.59). Conclusions: Addition of cancer-specific variables to NSQIP models slightly improved model fit; however, hospital outcome comparisons were identical. For patients with colorectal cancer undergoing resection, cancer-related factors have limited predictive ability for short-term outcomes and did not influence hospital quality comparisons.

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UP-03.074 Stone and Patient Related Factors in Connection with Short Term Complications Following E.S.W.L. Stone Management

Urology ◽

10.1016/j.urology.2011.07.1164 ◽

2011 ◽

Vol 78 (3) ◽

pp. S367

Author(s):

I.D. Chira ◽

V. Ambert ◽

B. Braticevici ◽

V. Jinga ◽

E. Salah ◽

...

Keyword(s):

Short Term ◽

Related Factors

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Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?

Nutrients ◽

10.3390/nu12092792 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2792

Author(s):

Monika Słupecka-Ziemilska ◽

Piotr Wychowański ◽

Monika Puzianowska-Kuznicka

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Pregnancy Complication ◽

Epigenetic Changes ◽

Negative Consequences ◽

Short Term ◽

Related Factors ◽

Epigenetic Programming

Gestational diabetes mellitus (GDM) is the most common pregnancy complication worldwide and may result in short-term and long-term consequences for offspring. The present review highlights evidence of epigenetic programming, mostly from human studies, which occurs in offspring exposed to maternal GDM during different stages of development, paying special attention to the differences in sensitivity of offspring to maternal hyperglycemia as a result of sex-related factors. We also aim to answer the following question: If these epigenetic changes are constant throughout the lifetime of the offspring, how do they present phenotypically?

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