A retrospective study of 280 nephrotic admissions from 1963 through 1967 at Children's Hospital Medical Center in Boston revealed that gram-negative bacilli have caused the majority of infections in hospitalized nephrotic children. The organisms isolated during this period included pneumococci, E. coli, proteus, klebsiella-enterobacter species, pseudomonas, and Serratia marcescens. This information is recorded to aid physicians in the selection of initial antibiotic therapy in the septic nephrotic patient.