Physical disuse contributes to widespread chronic mechanical hyperalgesia, tactile allodynia, and cold allodynia through neurogenic inflammation and spino-parabrachio-amygdaloid pathway activation

Pain ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yusuke Ohmichi ◽  
Mika Ohmichi ◽  
Ryoichi Tashima ◽  
Koji Osuka ◽  
Kaori Fukushige ◽  
...  
Keyword(s):  
Neurogenic Inflammation ◽  
Mechanical Hyperalgesia ◽  
Tactile Allodynia ◽  
Cold Allodynia ◽  
Pathway Activation

scholarly journals Nicotine deprivation increases pain intensity, neurogenic inflammation, and mechanical hyperalgesia among daily tobacco smokers.

2018 ◽  
Vol 127 (6) ◽  
pp. 578-589 ◽  
Author(s):  
Joseph W. Ditre ◽  
Emily L. Zale ◽  
Lisa R. LaRowe ◽  
Jesse D. Kosiba ◽  
Martin J. De Vita
Keyword(s):  
Pain Intensity ◽  
Neurogenic Inflammation ◽  
Mechanical Hyperalgesia ◽  
Nicotine Deprivation

Perfusion of the Mechanically Compressed Lumbar Ganglion With Lidocaine Reduces Mechanical Hyperalgesia and Allodynia in the Rat

2000 ◽  
Vol 84 (2) ◽  
pp. 798-805 ◽  
Author(s):  
Jun-Ming Zhang ◽  
Huiqing Li ◽  
Sorin J. Brull
Keyword(s):  
Flow Rate ◽  
Pain Syndrome ◽  
High Flow ◽  
Mechanical Hyperalgesia ◽  
Low Flow ◽  
Tactile Allodynia ◽  
Mechanical Stimuli ◽  
Treatment Groups ◽  
Behavioral Evidence ◽  
Central Pain Syndrome

The rat L5 dorsal root ganglion (DRG) was chronically compressed by inserting a hollow perforated rod into the intervertebral foramen. The DRG was constantly perfused through the hollow rod with either lidocaine or normal saline delivered by a subcutaneous osmotic pump. Behavioral evidence for neuropathic pain after DRG compression involved measuring the incidence of hindlimb withdrawals to both punctate indentations of the hind paw with mechanical probes exerting different bending forces (hyperalgesia) and to light stroking of the hind paw with a cotton wisp (tactile allodynia). Behavioral results showed that for saline-treated control rats: the withdrawal thresholds for the ipsilateral and contralateral paws to mechanical stimuli decreased significantly after surgery and the incidence of foot withdrawal to light stroking significantly increased on both ipsilateral and contralateral hind paws. Local perfusion of the compressed DRG with 2% lidocaine for 7 days at a low flow-rate (1 μl/h), or for 1 day at a high flow-rate (8 μl/h) partially reduced the decrease in the withdrawal thresholds on the ipsilateral foot but did not affect the contralateral foot. The incidence of foot withdrawal in response to light stroking with a cotton wisp decreased significantly on the ipsilateral foot and was completely abolished on the contralateral foot in the lidocaine treatment groups. This study demonstrated that compression of the L5 DRG induced a central pain syndrome that included bilateral mechanical hyperalgesia and tactile allodynia. Results also suggest that a lidocaine block, or a reduction in abnormal activity from the compressed ganglia to the spinal cord, could partially reduce mechanical hyperalgesia and tactile allodynia.

A hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn ameliorates hyperalgesia and allodynia in vincristine-induced neuropathic pain in rats

2015 ◽  
Vol 26 (4) ◽  
Author(s):  
Patrick Amoateng ◽  
Samuel Adjei ◽  
Dorcas Osei-Safo ◽  
Elvis Ofori Ameyaw ◽  
Believe Ahedor ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cold Water ◽  
Thermal Hyperalgesia ◽  
Ethanolic Extract ◽  
Mechanical Hyperalgesia ◽  
Sprague Dawley ◽  
Cold Allodynia ◽  
Sprague Dawley Rats ◽  
Vincristine Sulphate ◽  
Synedrella Nodiflora

Abstract: The hydro-ethanolic extract of: Neuropathic pain was induced in Sprague-Dawley rats by injecting 100 μg/kg of vincristine sulphate on alternative days for 6 days (days 0, 2, 4, 8, 10 and 12). Vincristine-induced cold allodynia, mechanical hyperalgesia and thermal hyperalgesia were measured pre-vincristine administration and on days 15, 17 and 19 post-vincristine administration. The rats were then treated withSNE and pregabalin produced analgesic properties observed as increased paw withdrawal latencies to mechanical, tactile, cold water stimuli and thermal hyperalgesic tests during the 5 days of treatment.: The findings suggest that hydro-ethanolic extract of

scholarly journals Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial Parts

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Luis Fernando Benitez Macorini ◽  
Joyce Alencar Santos Radai ◽  
Rafael Souza Maris ◽  
Saulo Euclides Silva-Filho ◽  
Maicon Matos Leitao ◽  
...  
Keyword(s):  
Folk Medicine ◽  
Ethanolic Extract ◽  
Mechanical Hyperalgesia ◽  
Edema Formation ◽  
Cold Allodynia ◽  
Freund’S Complete Adjuvant ◽  
Carrageenan Injection ◽  
Aerial Parts ◽  
Freund's Complete Adjuvant ◽  
Gomphrena Celosioides

Gomphrena celosioides Mart. (Amaranthaceae) is used in folk medicine as a natural analgesic, and in Brazil, the species of genus Gomphrena is used for rheumatism. However, scientific evidence which supports its popular use as an analgesic is scarce. This study assessed the antiarthritic and antihyperalgesic activities of the ethanolic extract obtained from G. celosioides aerial parts on Swiss or C57BL/6 mice. The antiarthritic and antihyperalgesic potential of Gomphrena celosioides was evaluated using paw edema, mechanical hyperalgesia, cold allodynia, carrageenan-induced pleurisy, articular inflammation zymosan-induced, Freund’s complete adjuvant-induced inflammation zymosan-induced peritonitis, and carrageenan-induced adhesion and rolling experiment models. All doses of G. celosioides (300, 700, and 1000 mg/kg) significantly reduced edema formation in all the intervals evaluated, whereas the mechanical hyperalgesia was reduced 3 hours after the carrageenan injection. The cold hyperalgesia was significantly decreased 3 (700 mg/kg) and 4 hours (700 and 1000 mg/kg) after the carrageenan injection. Ethanolic extract of G. celosioides at 1000 mg/kg reduced the total leukocyte number, without interfering in the protein extravasation in carrageenan-induced pleurisy model. Ethanolic extract of G. celosioides (300 mg/kg) was also able to reduce significantly the leukocyte migration in zymosan-induced articular edema, while a reduction of the adhesion and migration and leukocyte rolling was induced by the ethanolic extract of G. celosioides (300 mg/kg) in zymosan-induced peritonitis. In Freund’s complete adjuvant-induced inflammation model, an edema formation and mechanical hyperalgesia reduction were induced by the ethanolic extract of G. celosioides on day 22, whereas the cold allodynia was reduced on day 6 of treatment with the extract. These results show that ethanolic extract of G. celosioides has antihyperalgesic and antiarthritic potential in different acute and persistent models, explaining, at least in part, the ethnopharmacological relevance of this plant as a natural analgesic agent.

scholarly journals Transplantation of Bone Marrow-Derived Mononuclear Cells Improves Mechanical Hyperalgesia, Cold Allodynia and Nerve Function in Diabetic Neuropathy

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27458 ◽  
Author(s):  
Keiko Naruse ◽  
Jun Sato ◽  
Megumi Funakubo ◽  
Masaki Hata ◽  
Nobuhisa Nakamura ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Diabetic Neuropathy ◽  
Mononuclear Cells ◽  
Mechanical Hyperalgesia ◽  
Nerve Function ◽  
Cold Allodynia

scholarly journals Antiallodynic and anti-inflammatory effects of intrathecal R-PIA in a rat model of vincristine-induced peripheral neuropathy

2020 ◽  
Vol 73 (5) ◽  
pp. 434-444 ◽  
Author(s):  
Kyungmi Kim ◽  
Wonyeong Jeong ◽  
In Gu Jun ◽  
Jong Yeon Park
Keyword(s):  
Peripheral Neuropathy ◽  
Rat Model ◽  
Thermal Hyperalgesia ◽  
Mechanical Hyperalgesia ◽  
Cold Allodynia ◽  
Adenosine A1 Receptors ◽  
Tnf Α ◽  
Adenosine A1 ◽  
Α Level ◽  
Antiallodynic Effect

Background: Studies investigating the correlation between spinal adenosine A1 receptors and vincristine-induced peripheral neuropathy (VIPN) are limited. This study explored the role of intrathecal N6-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) in the rat model of VIPN. Methods: Vincristine (100 μg/kg) was intraperitoneally administered for 10 days (two 5-day cycles with a 2-day pause) and VIPN was induced in rats. Pain was assessed by evaluating mechanical hyperalgesia, mechanical dynamic allodynia, thermal hyperalgesia, cold allodynia, and mechanical static allodynia. Biochemically, tumor necrosis factor-alpha (TNF-α) level and myeloperoxidase (MPO) activity were measured in the tissue from beneath the sciatic nerve.Results: Vincristine administration resulted in the development of cold allodynia, mechanical hyperalgesia, thermal hyperalgesia, mechanical dynamic allodynia, and mechanical static allodynia. Intrathecally administered R-PIA (1.0 and 3.0 μg/10 μl) reversed vincristine-induced neuropathic pain (cold and mechanical static allodynia). The attenuating effect peaked 15 min after intrathecal administration of R-PIA after which it decreased until 180 min. However, pretreatment with 1,3-dipropyl-8-cyclopentylxanthine (DPCPX, 10 μg/10 μl) 15 min before intrathecal R-PIA administration significantly attenuated the antiallodynic effect of R-PIA. This antiallodynic effect of intrathecal R-PIA may be mediated through adenosine A1 receptors in the spinal cord. Intrathecally administered R-PIA also attenuated vincristine-induced increases in TNF-α level and MPO activity. However, pretreatment with intrathecal DPCPX significantly reversed this attenuation.Conclusions: These results suggest that intrathecally administered R-PIA attenuates cold and mechanical static allodynia in a rat model of VIPN, partially due to its anti-inflammatory actions.

Sign in / Sign up

Export Citation Format

Share Document