Large body mass index and waist circumference are associated with high blood pressure and impaired fasting glucose in young Chinese men

2019 ◽  
Vol 24 (6) ◽  
pp. 289-293
Author(s):  
Ying-xiu Zhang ◽  
Shu-rong Wang
2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S502-S502
Author(s):  
Hugo E Marroquín ◽  
Dean Ortiz ◽  
Lindsey Larson ◽  
Katherine Franco ◽  
Andrej Spec ◽  
...  

Abstract Background HIV infection and antiretroviral therapy (ART) can lead to metabolic abnormalities associated with increased cardiovascular disease risk, some of these abnormalities (central obesity, elevated fasting glucose, triglycerides, and blood pressure and low HDL cholesterol) are in metabolic syndrome (MetS). The prevalence of MetS increases with age. Currently, the status of MetS in people with HIV (PWH) Guatemala is unknown. We assessed the prevalence of MetS and potential predictors in PWH participating in prospective cohort study at Hospital Roosevelt in Guatemala City. Methods We performed a cross-sectional analysis of PWH under 40 years old receiving ART for at least 6 months from July 2019 to March 2020. The harmonized criteria for MetS and the cut-off for waist circumference recommended by the Latin American Diabetes Association were used. Association between MetS and gender, place of residency, ethnicity, educational level, baseline and current CD4 count, smoking, alcohol consumption, physical activity, viral load, body mass index (BMI) and ART exposure was assessed in bivariate analysis. Potential predictors (p-value < 0.1) were included in a multivariate binary logistic regression model. Results Of total cohort of 757 participants enrolled390 (51.5%) were younger than 40 years. Of those under < 40 years, 150 (38.5%) were women, 59 (15.1%) Mayan, median age was 32 years (IQR 27, 37). 93 (23.8%) had MetS. Between group differences in Table 1. Of those with Met, 51 (54.8%) had elevated waist circumference, 87 (93.5%) elevated triglycerides, 83 (89.2%) low HDL-c, 56 (60.2%) elevated blood pressure and 35 (37.6%) elevated fasting glucose. Body mass index (BMI) ≥ 25 kg/m2 or higher and 2 years or more of cumulative non-nucleoside reverse transcription inhibitors (NNRTI) where more common in those < 40 years with MetS compared to those without MetS. On multivariable regression, MetS was associated with current CD4 count < 200 (OR 3.1; IC 1.51, 6.34; p-value < 0.01) and BMI ≥ 25 kg/m2 (OR; 6.53; IC 3.64, 11.73; p-value < 0.01). Table1. Between group differences (No MetS vs MetS) Conclusion Nearly one in every four PWH under 40 years old in our cohort was affected by MetS. Dyslipidemia (elevated triglycerides and low HDL-c) was the main driver of MetS. Lower CD4 count and overweight were predictors for MetS in PWH under 40. Disclosures Andrej Spec, MD, MSCI, Astellas (Grant/Research Support)Mayne (Consultant)Scynexis (Consultant)


2017 ◽  
Vol 41 (2) ◽  
pp. 135-140 ◽  
Author(s):  
William Rodrigues Tebar ◽  
Raphael Mendes Ritti-Dias ◽  
Breno Quintella Farah ◽  
Edner Fernando Zanuto ◽  
Luiz Carlos Marques Vanderlei ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wenli Zhang ◽  
Kun He ◽  
Hao Zhao ◽  
Xueqi Hu ◽  
Chunyu Yin ◽  
...  

Abstract Background The relationship between obesity and prevalent high blood pressure in older adults has predominantly been estimated using categorical measures of body mass index (BMI) and waist circumference (WC), masking the shape of the dose-response relationship. We aimed to examine the precise relationship of BMI, WC with high blood pressure and to assess the appropriate level of BMI and WC for high blood pressure. Methods We examined data for 126,123 individuals in Xinzheng city aged ≥60 years from a population based study from January to December 2019. Logistic regression and restricted cubic spline models were applied to assess the relationship and the appropriate level of BMI and WC for high blood pressure. An additive interaction analysis was used to test synergistic effects between a higher BMI and WC for high blood pressure. Results The full-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of an increase of 1 kg/m2 in BMI and 1 cm in WC for high blood pressure were 1.084 (1.080–1.087) and 1.026(1.024–1.027), respectively. Multivariable adjusted restricted cubic spline analyses showed the nonlinear relationships of BMI and WC with high blood pressure in both men and women (all P < 0.001). The risk of high blood pressure increased steeply with increasing BMI from ≥25 kg/m2 and WC ≥ 88 cm or 86 cm for males and females, respectively. And we observed a significant additive interaction between a higher BMI and WC such that the prevalence of high blood pressure was significantly enhanced. Conclusion These findings suggest increased high blood pressure prevalence in the older adults with increased BMI and WC. BMI ≤ 25 kg/m2 and WC ≤ 88 cm or 86 cm for males and females may be the best suggestion with regard to primary prevention of high blood pressure in older adults.


2013 ◽  
Vol 4 (3) ◽  
pp. 14-22
Author(s):  
Temsutola Maken ◽  
Lalmunlien Robert Varte

Objective: Hypertension is related to increased body fat, which can be evaluated by anthropometric indicators among the Aos, a tribe of North-East India. Methods: Cross-sectional study with a sample of 1804 Ao adults (male= 890) (females= 914) aged 18 to 70 years. We considered the following anthropometric indicators: body mass index, waist circumference, waist-tohip ratio and waist-to-stature ratio. To identify predictors of high blood pressure, we adopted the analysis of receiver operating characteristic curves with a confidence interval of 95%. Result: For males, the area under curve with confidence intervals were BMI = 0.691 (0.67-0.712); waist circumference=0.757 (0.739-0.775); waist-to-hip ratio=0.692 (0.671-0.713); waist-to-stature ratio = 0.763 (0.745-0.781) and Conicity index = 0.734 (0.716-0.716). For females, the values were BMI = 0.754 (0.732-0.776); waist circumference = 0.762 (0.74-0.784); waist-to-hip ratio = 0.690 (0.668-0.784), waist-to-stature ratio=0.776 (0.753-0.799) and Conicity index=0.722 (0.701-0.743). Different cut off points of anthropometric indicators with better predictive power and their relevant sensitivities and specificities were identified. Conclusion: BMI does not show a very good area under the ROC curve. It seems that waist-to-stature ratio is the best predictor, followed by waist circumference and Conicity index among the males and results in high sensitivity and specificity to hypertension. We suggest the use of both waistto- stature ratio and waist circumference to predict hypertension among males. Among females, waist-to-stature ratio is the best predictor, followed by waist circumference and body mass index. DOI: http://dx.doi.org/10.3126/ajms.v4i3.6275 Asian Journal of Medical Sciences 4(2013) 15-22


2009 ◽  
Vol 40 (3) ◽  
pp. 208-215 ◽  
Author(s):  
Samuel Flores-Huerta ◽  
Miguel Klünder-Klünder ◽  
Lorenzo Reyes de la Cruz ◽  
José Ignacio Santos

2010 ◽  
Vol 63 (9-10) ◽  
pp. 611-615 ◽  
Author(s):  
Branka Koprivica ◽  
Teodora Beljic-Zivkovic ◽  
Tatjana Ille

Introduction. Insulin resistance is a well-known leading factor in the development of metabolic syndrome. The aim of this study was to evaluate metabolic effects of metformin added to sulfonylurea in unsuccessfully treated type 2 diabetic patients with metabolic syndrome. Material and methods. A group of thirty subjects, with type 2 diabetes, secondary sulfonylurea failure and metabolic syndrome were administered the combined therapy of sulfonylurea plus metformin for six months. Metformin 2000 mg/d was added to previously used sulfonylurea agent in maximum daily dose. Antihypertensive and hypolipemic therapy was not changed. The following parameters were assessed at the beginning and after six months of therapy: glycemic control, body mass index, waist circumference, blood pressure, triglycerides, total cholesterol and its fractions, homeostatic models for evaluation of insulin resistance and secretion (HOMA R, HOMA B) and C- peptide. Results. Glycemic control was significantly improved after six months of the combined therapy: (fasting 7.89 vs. 10.61 mmol/l. p<0.01; postprandial 11.12 vs. 12.61 mmol/l. p<0.01, p<0.01; glycosylated hemoglobin 6.81 vs. 8.83%. p<0.01). the body mass index and waist circumference were significantly lower (26.7 vs. 27.8 kg/m2, p<0.01 and 99.7 vs. 101.4 cm for men, p<0.01; 87.2 vs. 88.5 for women, p<0.01). Fasting plasma triglycerides decreased from 3.37 to 2.45 mmol/l (p<0.001) and HOMA R from 7.04 to 5.23 (p<0.001). No treatment effects were observed on blood pressure, cholesterol, and residual insulin secretion. Conclusion. Administration of metformin in type 2 diabetes with metabolic syndrome decreased cardiovascular risk factors by reducing glycemia, triglycerides, BMI, central obesity and insulin resistance.


2018 ◽  
Vol 30 (6) ◽  
pp. 561-571 ◽  
Author(s):  
Linda S. Adair ◽  
Christopher Kuzawa ◽  
Thomas McDade ◽  
Delia B. Carba ◽  
Judith B. Borja

Obesity, hypertension, and diabetes have risen dramatically in Asia, but few cohort studies track age and secular trends in these conditions. We use Cebu (The Philippines) Longitudinal Health and Nutrition survey data to document 1998 to 2015 prevalence and co-occurrence of body mass index (BMI; >25 kg/m2), high waist circumference (WC; >80 cm), elevated blood pressure (EBP; systolic ⩾130 or diastolic ⩾85 mm Hg), and type 2 diabetes among ~2000 women aged 29 to 62 years in 1998; and identify their relationship to community, household, and individual factors using longitudinal logistic regression. Prevalence (1998-2015) rates were 35% to 49%, BMI >25 kg/m2; 32% to 58% high WC; 21% to 59% EBP; and 2% to 14% diabetes. Only 20% of women had none of these conditions in 2015. Diabetes was strongly driven by age and secular trends in high WC related to higher socioeconomic status and urbanization. Hypertension increased with age in lower socioeconomic status rural and more affluent urban women. Results underscore the continuing need for public health measures to prevent obesity and to identify and treat hypertension and diabetes.


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