scholarly journals Risk Factors for Esophageal Fistula Associated With Chemoradiotherapy for Locally Advanced Unresectable Esophageal Cancer

Medicine ◽  
2016 ◽  
Vol 95 (20) ◽  
pp. e3699 ◽  
Author(s):  
Takahiro Tsushima ◽  
Junki Mizusawa ◽  
Kazuki Sudo ◽  
Yoshitaka Honma ◽  
Ken Kato ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Locally Advanced ◽  
Esophageal Fistula

scholarly journals Pharyngocutaneous Fistulas Following Total Laryngectomy

2021 ◽  
Author(s):  
Alexandru Nicolaescu ◽  
Șerban V.G. Berteșteanu ◽  
Raluca Grigore ◽  
Mihnea Cojocărița-Condeescu ◽  
Bogdan Popescu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Total Laryngectomy ◽  
Locally Advanced ◽  
Esophageal Fistula ◽  
Vocal Rehabilitation ◽  
Multiple Factors ◽  
Concomitant Factors ◽  
Prolong Hospital Stay

Total laryngectomy is still the final therapeutic solution in cases of locally advanced laryngeal cancer, as well as in cases of therapeutic failure of organ-sparing surgery or radiation therapy. Following excision of the larynx, the remaining pharynx is reconstructed to obtain continuity of the upper digestive tract. One of the most common complications in these patients, despite constant refinement of the procedure, is the development of a pharyngo-cutaneous fistula. These fistulas prolong hospital stay and often require a second surgical procedure, increasing morbidity and cost for the patient, while diminishing his quality of life. Some risk-factors have been identified, but only some may be corrected before surgery to lower this risk. Managing the fistula once present depends on multiple factors, essential being the size of the fistula as well as the position and concomitant factors, with options ranging from conservative measures to aggressive reconstructive surgery with local miocutaneous flaps. Modern vocal rehabilitation with T.E.P. (tracheo-esophageal puncture) and vocal prosthesis placement presents a new challenge – because of the risk of developing a tracheo-esophageal fistula, with an even higher risk for the patient because of tracheal aspiration. Understanding healing mechanisms of these structures is key to proper management of this complication.

Risk factors and clinical courses of chemoradiation-related arterio-esophageal fistula in esophageal cancer patients with clinical invasion of the aorta

2011 ◽  
Vol 16 (4) ◽  
pp. 359-365 ◽  
Author(s):  
Hiroya Taniguchi ◽  
Kentaro Yamazaki ◽  
Narikazu Boku ◽  
Taro Funakoshi ◽  
Satoshi Hamauchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Cancer Patients ◽  
Esophageal Fistula

scholarly journals Risk factors for esophageal fistula in patients with locally advanced esophageal carcinoma receiving chemoradiotherapy

2018 ◽  
Vol Volume 11 ◽  
pp. 2311-2317 ◽  
Author(s):  
Yang Zhang ◽  
Zongjuan Li ◽  
Wei Zhang ◽  
Wei Chen ◽  
Yipeng Song
Keyword(s):  
Risk Factors ◽  
Esophageal Carcinoma ◽  
Locally Advanced ◽  
Esophageal Fistula

scholarly journals Development and validation of a risk prediction model for radiotherapy-related esophageal fistula in esophageal cancer

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Yiyue Xu ◽  
Linlin Wang ◽  
Bo He ◽  
Wanlong Li ◽  
Qiang Wen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Risk Prediction ◽  
External Validation ◽  
Individual Risk ◽  
Esophageal Fistula ◽  
Multivariable Analyses ◽  
Independent Risk Factors ◽  
Ecog Ps ◽  
Development And Validation

Abstract Objectives We aimed to identify the risk factors and provide a nomogram for the prediction of radiotherapy-related esophageal fistula in patients with esophageal cancer (EC) using a case-control study. Patients and methods Patients with esophageal fistula who received radiotherapy or chemoradiotherapy between 2003 and 2017 were retrospectively collected in two institutions. In the training cohort (TC), clinical, pathologic, and serum data of 136 patients (cases) who developed esophageal fistula during or after radiotherapy were enrolled and compared with 272 controls (1:2 matched with the diagnosis time of EC, sex, marriage, and race). After the univariable and multivariable logistic regression analyses, the independent risk factors were identified and incorporated into a nomogram. Then the nomogram for the risk prediction was externally validated in the validation cohort (VC; 47 cases and 94 controls) using bootstrap resampling. Results Multivariable analyses demonstrated that ECOG PS, BMI, T4, N2/3 and re-radiotherapy were independent factors for esophageal fistula. Then a nomogram was constructed with the C-index of 0.805 (95% CI, 0.762–0.848) for predicting the risk of developing esophageal fistula in EC patients receiving radiotherapy. Importantly, the C-index maintained 0.764 (95% CI, 0.683–0.845) after the external validation. Conclusions We created and externally validated the first risk nomogram of esophageal fistula associated with radiotherapy. This will aid individual risk stratification of patients with EC developing esophageal fistula.

Impact of preoperative therapy for locally advanced thoracic esophageal cancer on the risk of perioperative complications: Results from multicenter phase III trial JCOG 1109.

2021 ◽  
Vol 39 (3_suppl) ◽  
pp. 162-162
Author(s):  
Kazuo Koyanagi ◽  
Ken Kato ◽  
Yoshinori Ito ◽  
Hiroyuki Daiko ◽  
Soji Ozawa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Perioperative Complications ◽  
Locally Advanced ◽  
Operation Time ◽  
Preoperative Therapy ◽  
Phase Iii ◽  
Hospital Death ◽  
Thoracic Esophageal Cancer ◽  
Phase Iii Trial

162 Background: We have conducted randomized three-arm phase III trial comparing cisplatin plus 5-FU (CF) versus docetaxel plus CF (DCF) versus radiation with CF (CF-RT) as preoperative therapy for locally advanced esophageal cancer, which is on-follow-up for primary analysis planned in 2023 (JCOG 1109). This study aimed to evaluate the influence of preoperative therapies on perioperative complications and risk factors for perioperative complications after three-arm preoperative therapies. Methods: Patients with potentially resectable advanced thoracic esophageal cancer were randomly assigned to three preoperative therapies and followed by open or thoracoscopic esophagectomy with regional lymphadenectomy. Clinical data, surgical results, and perioperative complications in the patients received DCF and CF-RT were compared with those in the patients received CF. Univariate and multivariate analyses were performed to explore the risk factors of perioperative complications. Results: Between December 2012 and July 2018, 601 patients were randomized (CF/DCF/CF-RT; 199/202/200). Of 589 eligible patients, 546 patients underwent surgery (185/183/178). Patients` characteristics were not different between arms. Median number of harvested lymph node in patients received CF-RT was significantly lower than that in patients received CF (49 vs. 58; P < 0.0001). Incidence of ≥ Grade 2 perioperative complications in patients received DCF was lower than that in patients received CF (44.8% vs. 56.2%; P = 0.036). Incidence of ≥ Grade 2 chylothorax in patients received CF-RT was higher than that in patients received CF (5.1% vs. 1.1%; P = 0.032). Incidence of reoperation and intra-hospital death in patients received DCF and CF-RT did not differ from that in patients received CF. Multivariate analysis showed that operation time (≥ median) and open esophagectomy were independently associated with an increase in ≥ Grade 2 perioperative complications. CF-RT was associated with an increase in occurrence of ≥ Grade 2 chylothorax (Relative Risk 4.84; P = 0.043). Conclusions: Preoperative DCF and CF-RT does not increase the risk of perioperative complications and mortality when compared with standard preoperative CF therapy, but CF-RT increases the risk of chylothorax after esophagectomy for advanced thoracic esophageal cancer.

Nutritional assessment and risk factors associated to malnutrition in patients with esophageal cancer

2020 ◽  
pp. 100638
Author(s):  
Jingjing Cao ◽  
Hongxia Xu ◽  
Wei Li ◽  
Zengqing Guo ◽  
Yuan Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Nutritional Assessment ◽  
Factors Associated

scholarly journals Global Burden, Risk Factors, and Trends of Esophageal Cancer: An Analysis of Cancer Registries from 48 Countries

Cancers ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 141
Author(s):  
Junjie Huang ◽  
Anastasios Koulaouzidis ◽  
Wojciech Marlicz ◽  
Veeleah Lok ◽  
Cedric Chu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
The Netherlands ◽  
Cancer Registries ◽  
Global Burden ◽  
Annual Percent Change ◽  
The United Kingdom ◽  
Incidence And Mortality ◽  
Elevated Cholesterol ◽  
Prevalence Of Obesity

This study aimed to examine the global burden, risk factors, and trends of esophageal cancer based on age, sex, and histological subtype. The data were retrieved from cancer registries database from 48 countries in the period 1980–2017. Temporal patterns of incidence and mortality were evaluated by average annual percent change (AAPC) using joinpoint regression. Associations with risk factors were examined by linear regression. The highest incidence of esophageal cancer was observed in Eastern Asia. The highest incidence of adenocarcinoma (AC) was found in the Netherlands, the United Kingdom, and Ireland. A higher AC/squamous cell carcinoma (SCC) incidence ratio was associated with a higher prevalence of obesity and elevated cholesterol. We observed an incidence increase (including AC and SCC) in some countries, with the Czech Republic (female: AAPC 4.66), Spain (female: 3.41), Norway (male: 3.10), Japan (female: 2.18), Thailand (male: 2.17), the Netherlands (male: 2.11; female: 1.88), and Canada (male: 1.51) showing the most significant increase. Countries with increasing mortality included Thailand (male: 5.24), Austria (female: 3.67), Latvia (male: 2.33), and Portugal (male: 1.12). Although the incidence of esophageal cancer showed an overall decreasing trend, an increasing trend was observed in some countries with high AC/SCC incidence ratios. More preventive measures are needed for these countries.

Sign in / Sign up

Export Citation Format

Share Document