scholarly journals Sex difference determined the role of sex hormone-binding globulin in obese children during short-term weight reduction program

Medicine ◽  
2017 ◽  
Vol 96 (19) ◽  
pp. e6834 ◽  
Author(s):  
Fu-Min Wang ◽  
Chien-Ming Lin ◽  
Shao-Hung Lien ◽  
Li-Wei Wu ◽  
Ching-Feng Huang ◽  
...  
Keyword(s):  
Sex Difference ◽  
Weight Reduction ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Obese Children ◽  
Short Term ◽  
Weight Reduction Program ◽  
Reduction Program

scholarly journals Effect of weight reduction on insulin sensitivity, sex hormone-binding globulin, sex hormones and gonadotrophins in obese children

2010 ◽  
Vol 163 (6) ◽  
pp. 895-900 ◽  
Author(s):  
N H Birkebæk ◽  
A Lange ◽  
P Holland-Fischer ◽  
K Kristensen ◽  
S Rittig ◽  
...  
Keyword(s):  
Weight Loss ◽  
Insulin Sensitivity ◽  
Weight Reduction ◽  
Serum Insulin ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Obese Children ◽  
Blood Samples ◽  
Before And After

ObjectiveObesity in men is associated with reduced insulin sensitivity and hypoandrogenism, while obesity in women is associated with reduced insulin sensitivity and hyperandrogenism. In children, the effect of obesity and weight reduction on the hypothalamo-pituitary–gonadal axis is rarely investigated. The aim of the present study was to investigate the effect of weight reduction in obese Caucasian children on insulin sensitivity, sex hormone-binding globulin (SHBG), DHEAS and the hypothalamo-pituitary–gonadal axis.MethodsOne hundred and sixteen (65 females) obese children with a median age of 12.3 (7–15) years were examined before and after a 10-week stay at a weight loss camp. Examination included anthropometry and fasting blood samples measuring plasma glucose, serum insulin, SHBG, DHEAS, testosterone, 17β-oestradiol, FSH and LH.ResultsBody mass index (BMI) decreased (P<0.01), insulin sensitivity and SHBG increased (P<0.01), independent of gender and puberty. The changes in insulin sensitivity and the changes in SHBG correlated significantly (P<0.01) independent of gender, puberty and the changes in BMI. Testosterone increased in boys (P<0.01) and tended to decrease in girls (P=0.05, in girls after menarche (P=0.03)). FSH increased in boys and girls. LH increased in boys and was unchanged in girls.ConclusionsDuring weight loss, insulin sensitivity and SHBG increased significantly in obese children, and the changes in insulin sensitivity and the changes in SHBG correlated significantly independent of gender, puberty and the changes in BMI. There was sexual dimorphism in the changes of testosterone, with the changes in boys towards increased virilisation and the changes in girls towards less virilisation.

Role of the Ovary in the Regulation of Sex Hormone Binding Globulin and Its Contribution to Peripheral Levels of Androstenedione

2009 ◽  
Vol 82 (04) ◽  
pp. 29-34 ◽  
Author(s):  
P. Bolufer ◽  
P. Antonio ◽  
R. Garcia ◽  
J. Munoz ◽  
A. Rodriguez ◽  
...  
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Delayed effects of short-term transdermal application of 7-oxo-dehydroepiandrosterone on its metabolites, some hormonal steroids and relevant proteohormones in healthy male volunteers

2005 ◽  
Vol 43 (2) ◽  
Author(s):  
Jarmila Šulcová ◽  
Richard Hampl ◽  
Martin Hill ◽  
Luboslav Stárka ◽  
Alois Nováček
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Healthy Male ◽  
Delayed Effect ◽  
Short Term ◽  
Delayed Effects ◽  
Healthy Male Volunteers ◽  
Male Volunteers ◽  
Transdermal Application

AbstractTwenty-one healthy male volunteers aged 20–70years were given transdermally 25mg of 7-oxo-dehydroepiandrosterone daily in the form of an emulgel for 8 consecutive days. Morning blood was collected as follows: before application, and after the first, fourth and eighth doses (days 0, 2, 5 and 9), and then at different time intervals after termination of the treatment (days 16, 23, 37, 51, 72 and 100). Cortisol, testosterone, epitestosterone, estradiol, dehydroepiandrosterone and its sulfate, 7α- and 7β-hydroxy-dehydroepiandrosterone, luteinizing hormone, follicle-stimulating hormone and sex hormone-binding globulin were measured in blood sera. In the course of treatment 7β-hydroxy-dehydroepiandrosterone was significantly increased; testosterone and gonadotropins were lowered, but only after the first dose. All other significant changes were observed duringthe period after termination of the application:7β-hydroxy-dehydroepiandrosterone remained increased for 28days, 7α-hydroxy-dehydroepiandrosterone, testosterone, estradiol and sex hormone-binding globulin were decreased as late as day 63 and 91, respectively. On the other hand, epitestosterone was significantly increased between days 23 and 100. The levels of all other parameters studied were not significantly changed. The study points to an immediate as well as delayed effect of the short-term transdermal application of 7-oxo-dehydroepiandrosterone on relevant hormonal parameters.

P0039 PP INCIDENCE OF ABNORMAL LIVER ENZYMES IN OBESE CHILDREN REFERRED FOR WEIGHT REDUCTION PROGRAM

2004 ◽  
Vol 39 (Supplement 1) ◽  
pp. S71
Author(s):  
S. Narwal ◽  
N. A. V. Matthews ◽  
H. Anhalt ◽  
S. Tan ◽  
G. Wetzler ◽  
...  
Keyword(s):  
Weight Reduction ◽  
Liver Enzymes ◽  
Obese Children ◽  
Weight Reduction Program ◽  
Reduction Program

scholarly journals Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yutang Wang ◽  
Fadi J. Charchar
Keyword(s):  
Uric Acid ◽  
Sex Difference ◽  
Weighted Least Squares ◽  
Cross Sectional Study ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Least Squares Regression ◽  
Hormone Binding ◽  
Adolescent Boys ◽  
Cross Sectional

AbstractMen have higher circulating levels of uric acid than women. This sex difference is suspected to be a result of suppressive effects of estradiol on uric acid. If so, estradiol would be inversely associated with circulating uric acid. This study aimed to test this hypothesis. This cross-sectional study included 9472 participants (weighted sample size of 184,342,210) aged 12–80 years from the 2013 to 2016 US National Health and Nutrition Examination Survey. Associations of sex hormones with uric acid were analyzed using weighted least squares regression, adjusting for demographic characteristics, lifestyle risk factors, and comorbidities. Neither free nor bioavailable estradiol was inversely associated with circulating uric acid in adolescent boys or girls, or adult men or women, or perimenopausal women after full adjustment. The sex difference in uric acid was established during adolescence as a result of a dramatic increase in uric acid in adolescent boys. During adolescence, the increase in estradiol in girls over time was accompanied by a relatively unchanged level of uric acid. All three fractions of estradiol (free, bioavailable, and total) were positively associated with uric acid in adolescent boys and girls after full adjustment. In adolescent boys, all three fractions of testosterone were positively associated with serum uric acid, and sex hormone-binding globulin was inversely associated with uric acid after full adjustment. These results suggest that estradiol is not inversely associated with circulating uric acid in adolescents and the establishment of sex difference in circulating uric acid during adolescence is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys.

scholarly journals Characterization of mini-protein S, a recombinant variant of protein S that lacks the sex hormone binding globulin-like domain

1998 ◽  
Vol 330 (1) ◽  
pp. 389-396 ◽  
Author(s):  
Merel VAN WIJNEN ◽  
G. Jeanette STAM ◽  
T. G. Glenn CHANG ◽  
C. M. Joost MEIJERS ◽  
H. Pieter REITSMA ◽  
...  
Keyword(s):  
Recombinant Protein ◽  
Solid Phase ◽  
Anticoagulant Activity ◽  
Protein S ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Wild Type ◽  
Cofactor Activity

Protein S is a vitamin K-dependent glycoprotein involved in the regulation of the anticoagulant activity of activated protein C (APC). Also, an anticoagulant role for protein S, independent of APC, has been described. Protein S has a unique C-terminal sex hormone binding globulin (SHBG)-like domain that represents about half of the molecule. To define the role of this domain in APC cofactor activity and in binding to C4b-binding protein (C4BP), we have constructed a recombinant protein S molecule of N-terminal residues 1-242 that lacks the SHBG domain (mini-protein S). A panel of monoclonal antibodies directed against the N-terminal region of protein S recognized plasma-derived protein S, wild-type recombinant protein S and mini-protein S with similar affinities, whereas a monoclonal antibody that recognizes an epitope in the SHBG domain did not detect mini-protein S. Mini-protein S did not bind to C4BP in a solid-phase binding assay, and the cofactor activity of mini-protein S was not inhibited by preincubation with C4BP. In a plasma coagulation assay, the cofactor activity of mini-protein S was lower than wild-type or plasma-derived preparations. In contrast, no difference in APC cofactor activities was observed when the preparations were tested in purified systems that monitor the APC-mediated degradation of factors Va or VIIIa. In conclusion, we constructed a protein S molecule that fails to bind C4BP and still displays cofactor activity for APC. This confirms the role of the C-terminal SHBG region in C4BP binding and demonstrates that N-terminal residues 1-242 are sufficient for the expression of APC cofactor activity in a system using purified components. In plasma, however, the C-terminal SHBG region plays a role in the expression of optimal APC cofactor activity.

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