Serum vitamin D levels and type 2 diabetic erectile dysfunction

Background: The 21st century has seen the rise of diabetes mellitus as one of the major metabolic issues as is vitamin D deficiency which has been found to be pandemic worldwide. The present study is an endeavor to study the status of serum vitamin D levels in relation to the glycemic and insulin resistance status in type 2 diabetes mellitus patients.Methods: The present is a cross-sectional study with a sample size of 100 type 2 diabetic subjects in the age group of 30-60 years. Serum vitamin D and Insulin levels were estimated using the ELISA technique. HbA1c levels were measured using immunoturbidimetric assays and plasma glucose levels were determined using glucose oxidase- peroxidase method.Results: The fasting plasma glucose, HbA1c and serum insulin levels were found to be significantly higher in those with vitamin D levels below the normal cut-off value of less than 30ng/ml (p value <0.01). Also, the insulin resistance calculated using HOMA-IR was found to be higher in those subjects having vitamin D deficiency or insufficiency.Conclusions: Hence, the study suggests that vitamin D deficiency contributes to further insulin resistance and poorer long-term diabetic control in type 2 diabetes mellitus subjects.

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SERUM VITAMIN D LEVEL IN TYPE 2 DIABETIC PATIENTS

The Professional Medical Journal ◽

10.29309/tpmj/2014.21.05.2549 ◽

2018 ◽

Vol 21 (05) ◽

pp. 992-997

Author(s):

Imran Ali Shaikh ◽

Naila Masood ◽

Shazia Memon

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Control Group ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Type 2 Diabetic

Objective: To find out serum vitamin D levels in type 2 DM patients in Hyderabad.Design: Cross sectional study. Setting: Private clinics, OPDs of government hospitals likeQasimabad, Latifabad and Pretabad. Duration: January to July 2013. Patients and Methods:Total 550 patients were selected, 450 patients (250 males and 200 females) taken from differentOPDs of Hyderabad and towns or Tehsils with diagnosis of type 2 Diabetes mellitus andanother 100 patients were taken as control (60 males and 40 females). The mean age was45.6 years. The written consent was obtained and demographic features were noted, 3cc ofblood was taken for estimation of vitamin D levels. The level of vitamin D was done on anElectrochemiluminescence Immuno Assay (ECLIA) at Diagnostic & Research laboratory LiaquatUniversity of Medical &Health sciences (LUMHS) Jamshoro, Sind. Results and Observations:Out of 550, 450 diabetic subjects tested for vitamin D, females were 44.4%and 55.5% weremales. The deficiency was seen in 33.7% patients (p <0.04) and Vitamin D insufficiency wasobserved in20% in both sex. In control group, the deficiency was observed in 23% in femalesand 20% in males while insufficiency noted in 5% in both sex. Conclusions: The study showedsignificant decreased levels of vitamin D in type 2 Diabetic subjects than normal individuals. Thevitamin D deficiency increased considerably in females with diabetes type 2.

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STUDY OF SERUM VITAMIN-D IN TYPE-2 DIABETES MELLITUS PATIENTS.

10.36106/gjra/3714362 ◽

2021 ◽

pp. 187-188

Author(s):

Ajay Jain ◽

Debina sarkar ◽

G.G. Kaushik ◽

Ankita Sharma

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Blood Sugar ◽

Healthy Subjects ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Type 2 Diabetic

Background: Type-2 diabetes mellitus (T2DM) is a progressive and chronic disease characterized by both β-cell dysfunction and increased insulin resistance. Diabetes mellitus is now considered a giant killer disease of the 21st century with its vicious prongs in the South-East Asian countries, specially India, which is rightly said to be the ''Diabetes Capital'' of the world. Vitamin D has important effects on insulin action, and may impact on a number of pathways which may be of importance in the development of type 2 diabetes mellitus. Materials & Methods: In this study 62 Type-2 diabetic patients, 62 healthy controls were enrolled. Biochemical analytes measured were Serum glucose (Fasting Blood Sugar & Post Prandial Blood Sugar), Glycosylated Haemoglobin, Serum Vitamin-D. Results: The mean Serum Vitamin-D in Type-2 diabetic subjects were (16.3 ±3.0) while in healthy subjects(controls) the values were (39.3±5.2) respectively. These values were found to be statistically highly signicant(p<0.001). Conclusion: Serum Vitamin-D levels were decreased in Type 2 diabetic subjects as compared to the values in healthy subjects(controls).

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Interactions between Serum Vitamin D Levels and Vitamin D Receptor Gene FokI Polymorphisms for Renal Function in Patients with Type 2 Diabetes

PLoS ONE ◽

10.1371/journal.pone.0051171 ◽

2012 ◽

Vol 7 (12) ◽

pp. e51171 ◽

Cited By ~ 12

Author(s):

Keitaro Yokoyama ◽

Akio Nakashima ◽

Mitsuyoshi Urashima ◽

Hiroaki Suga ◽

Takeshi Mimura ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Renal Function ◽

Vitamin D Receptor ◽

Receptor Gene ◽

Serum Vitamin ◽

Vitamin D Receptor Gene ◽

Serum Vitamin D ◽

Vitamin D Levels

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A Study for Evaluation of Serum Vitamin D Levels in Patients with type 2 Diabetes Mellitus with or without Complications

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v6i9.115 ◽

2018 ◽

Vol 6 (9) ◽

Author(s):

Dr Pankaj Kumar ◽

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels

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COMBINATORIAL EFFECT OF LEPTIN, TUMOR NECROSIS FACTOR-ΑLPHA, AND VITAMIN D IN PROGRESSION OF TYPE 2 DIABETES IN KASHMIRI POPULATION

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i10.28097 ◽

2018 ◽

Vol 11 (10) ◽

pp. 477 ◽

Cited By ~ 1

Author(s):

Sabhiya Majid ◽

Fouzia Rashid ◽

Ishrat Hussain ◽

Rakesh K Koul ◽

Jasiya Qadir ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Tumor Necrosis ◽

Serum Vitamin ◽

Healthy Controls ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Tnf Α ◽

Necrosis Factor

Objectives: Type 2 diabetes mellitus (T2DM) is a metabolic disorder usually characterized by hyperglycemia. Adipose tissue secretes bioactive substances known as adipocytokines including leptin, tumor necrosis factor-alpha (TNF-α), and adiponectin. These are considered as a bridge connecting obesity and insulin resistance. There is considerable epidemiological evidence to suggest a role of Vitamin D deficiency in the etiology of T2DM. This study was performed to evaluate and compare serum Vitamin D and adipocytokine levels in T2DM patients and healthy controls of Jammu and Kashmir region of India.Methods: A total of 200 T2DM patients and normal 200 healthy controls were considered for the study. Enzyme-linked immunosorbent assay was used to measure serum leptin and TNF-α levels. The Vitamin D levels were measured by chemiluminescent microparticle immunoassay method. Biochemical parameters were measured by the enzymatic method.Results: Our results concluded that basic metabolic parameters, TNF-α and leptin levels were significantly higher in cases than controls. The serum Vitamin D levels were found significantly lower among T2DM patients. No correlation of Vitamin D with leptin was observed in cases and controls. However, a positive correlation between leptin and TNF-α was noted in T2DM subjects as well as in controls with statistical significance being higher in females (r=0.500; p=0.001) as compared to males (r=0.298; p=0.036) in T2DM subjects as well as in controls (r=0.659; p=0.001; r=0.621; p=001).Conclusion: These results concluded that lowering of Vitamin D levels and upregulation of leptin and TNF-α altogether play an important role in the development of T2DM, and from correlation analysis, it could be predicted that leptin and TNF-α act in a synergistic manner toward the development of T2DM.

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