Clinical Characteristics of Depressed Patients With a History of Suicide Attempts

IntroductionDepression is a complex disease associated with sleep, appetite and body weight disturbances as well as with the level of physical activity, all of which may be the risk factors for the development of metabolic disorders. Different physiological mechanisms as well as psychosocial factors such as gender, age, smoking, stress level, nutrition and level of physical activity can affect the metabolic syndrome (MS) development in depressed patients. It is considered that chronic stress causes depression and subsequent poor lifestyle that can lead to the MS development, which results in increased incidence of cardiovascular disease.AimTo determine the psychosocial and clinical characteristics of depressed patients with MS diagnosis.MethodsCross-sectional study was conducted on a sample of 80 patients suffering from depressive disorder. The structured socio-demographic questionnaire, MINI questionnaire, Hamilton Rating Scale for Depression (HAMD-17) and the Clinical Global Impression Scale (CGI) were used as diagnostic instruments. MS diagnosis was made according to NCEP/ATP III criteria.ResultsDepressive patients with MS diagnosis had a significantly higher frequency of suicide attempts, while MS diagnosis significantly more frequently was present in female patients. Increased intake of carbohydrates was an important characteristic of the depression as well as MS.ConclusionFurther studies are needed in order to explain the observed gender differences, and whether interventions focused on the treatment of depression may contribute to the acceptance of healthy lifestyles, particularly in changing of dietary habits, and thus indirectly contribute to the reduction of MS frequency.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Resilience and attempted suicide in depressed patients

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.1798 ◽

2017 ◽

Vol 41 (S1) ◽

pp. s887-s887

Author(s):

E. Gattoni ◽

C. Gramaglia ◽

D. Marangon ◽

A. Feggi ◽

C. Delicato ◽

...

Keyword(s):

Coping Strategies ◽

Clinical Characteristics ◽

Depressive Disorders ◽

Attempted Suicide ◽

Suicide Ideation ◽

Rating Scale ◽

Suicide Attempts ◽

Depressed Patients ◽

Resilience Scale ◽

Depressive Episodes

IntroductionAmong the patients, 6.6% with past-year major depressive disorders attempt suicide in their life. Resilience (the ability to respond positively to adversity) and coping strategies (the ability to manage living stresses) may be protective factors against suicide ideation and behavior. A study conducted on 100 abstinent substance dependent patients suggested that suicide attempters had significantly lower resilience scale scores. Other authors demonstrated that intrinsic religiosity, resilience, quality of life were associated with previous suicide attempts in depressed patients.AimTo examine the correlation among resilience, coping strategies and sociodemographic and clinical characteristics in depressed patients.MethodsFrom December 1st 2014 to December 31st 2015 we recruited inpatients and outpatients aged > 18 years with a diagnosis of depression (current or past). At baseline, patients were assessed with Montgomery Asberg Depression Rating Scale, Resilience Scale for Adult and Brief-COping with problems experienced; sociodemographic and clinical characteristics were gathered. Follow-up was conducted after 1 year in order to assess the possible presence of further depressive episodes and suicide attempts. Analysis was performed with SPSS.Results and discussionData collection are still ongoing; results and implications will be discussed. We expect to find higher attempted suicide rates in patients with lower resilience and less coping strategies.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Risk-Taking Propensity, Depression and Parasuicide

Australian & New Zealand Journal of Psychiatry ◽

10.3109/00048677609159510 ◽

1976 ◽

Vol 10 (3) ◽

pp. 269-273 ◽

Cited By ~ 3

Author(s):

Bruce Spittles ◽

Ken Bragan ◽

Basil James

Keyword(s):

Risk Taking ◽

Suicide Attempts ◽

Psychological Adaptation ◽

Psychiatric Unit ◽

Depressed Patients ◽

History Of ◽

The Relationship ◽

Inpatient Psychiatric Unit

One hundred patients admitted consecutively to an inpatient psychiatric unit were given questionnaires to measure risk-taking propensity and depression. The purpose was to study the relationship between risk-taking, depression, and recent suicide attempts. It was found that depressed patients showed a bimodal clustering towards the extremes of risk-taking. There was a history of suicide attempts only when a certain threshold of risk-taking was exceeded. These findings are discussed with relation to defensive styles of psychological adaptation and to arousal thresholds.

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Serum concentrations of iNos and IL-33 in depressed patients with a history of suicide attempts

European Neuropsychopharmacology ◽

10.1016/s0924-977x(17)31219-1 ◽

2017 ◽

Vol 27 ◽

pp. S650-S651

Author(s):

E.A. Ogłodek ◽

M.J. Just ◽

D.M. Moś ◽

K. Just ◽

A.D. Grzesińska ◽

...

Keyword(s):

Suicide Attempts ◽

Serum Concentrations ◽

Depressed Patients ◽

History Of

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Association of Genetic Variants in the Neurotrophic Receptor–Encoding GeneNTRK2and a Lifetime History of Suicide Attempts in Depressed Patients

Archives of General Psychiatry ◽

10.1001/archgenpsychiatry.2009.201 ◽

2010 ◽

Vol 67 (4) ◽

pp. 348 ◽

Cited By ~ 66

Author(s):

Martin A. Kohli ◽

Daria Salyakina ◽

Andrea Pfennig ◽

Susanne Lucae ◽

Sonja Horstmann ◽

...

Keyword(s):

Genetic Variants ◽

Suicide Attempts ◽

Lifetime History ◽

Depressed Patients ◽

History Of

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Suicide attempters: Clinical characteristics and management

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.2242 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S601-S601

Author(s):

E. Gattoni ◽

A. Feggi ◽

C. Gramaglia ◽

P. Bergamasco ◽

I. Coppola ◽

...

Keyword(s):

Depressive Symptoms ◽

Suicide Attempt ◽

Clinical Characteristics ◽

Depressive Disorders ◽

Attempted Suicide ◽

Rating Scale ◽

Suicide Attempts ◽

Suicidal Risk ◽

Suicide Attempters ◽

History Of

BackgroundSuicide attempts, defined as self-inflicted, potentially injurious behaviors with a nonfatal outcome, and with evidence of intent to die are extremely prevalent. Literature suggests that suicide is more common among males, while attempted suicide is more frequent among females. Depression, mental disorders, substance use disorders and history of suicidal behavior are important risk factors for suicide: the risk of suicide attempt is 3 to 12 times higher in psychiatric patients than in the general population.AimThe aim of our study was to compare severity of depressive symptoms in a sample of suicide attempters with a diagnosis of bipolar and related disorders or depressive disorders and in a sample of sex- and diagnosis-matched patients who do not commit a suicide attempt. The severity of attempted suicide and the suicidal risk in the hospital will be assessed as well.Material and methodsWe collected a sample of inpatients who committed a suicide attempt during 2015. For each attempter, we selected another sex- and diagnosis-matched patient with no history of attempted suicide. Socio-demographic and clinical characteristics of the sample were gathered. Assessment included: Montgomery-Asberg Depression Rating Scale (MADRS) for severity of depressive symptoms in both groups, Suicide Intent Scale (SIS) for the severity of attempted suicide and the suicidal risk with a nurse assessment for suicide.ResultsData collecting is still ongoing. We expected to find more severe symptoms in patients who attempted suicide. Clinical implication will be discussed.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Mapping Brain Microstructure and Network Alterations in Depressive Patients with Suicide Attempts Using Generalized Q-Sampling MRI

Journal of Personalized Medicine ◽

10.3390/jpm11030174 ◽

2021 ◽

Vol 11 (3) ◽

pp. 174

Author(s):

Vincent Chin-Hung Chen ◽

Chun-Ju Kao ◽

Yuan-Hsiung Tsai ◽

Roger S. McIntyre ◽

Jun-Cheng Weng

Keyword(s):

Statistical Analysis ◽

White Matter ◽

Theoretical Analysis ◽

Depressive Disorder ◽

Suicide Attempts ◽

Healthy Controls ◽

Graph Theoretical Analysis ◽

Depressed Patients ◽

Structural Differences ◽

History Of

Depressive disorder is one of the leading causes of disability worldwide, with a high prevalence and chronic course. Depressive disorder carries an increased risk of suicide. Alterations in brain structure and networks may play an important role in suicidality among depressed patients. Diffusion magnetic resonance imaging (MRI) is a noninvasive method to map white-matter fiber orientations and provide quantitative parameters. This study investigated the neurological structural differences and network alterations in depressed patients with suicide attempts by using generalized q-sampling imaging (GQI). Our study recruited 155 participants and assigned them into three groups: 44 depressed patients with a history of suicide attempts (SA), 56 depressed patients without a history of suicide attempts (D) and 55 healthy controls (HC). We used the GQI to analyze the generalized fractional anisotropy (GFA) and normalized quantitative anisotropy (NQA) values in voxel-based statistical analysis, topological parameters in graph theoretical analysis and subnetwork connectivity in network-based statistical analysis. GFA indicates the measurement of neural anisotropy and represents white-matter integrity; NQA indicates the amount of anisotropic spins that diffuse along fiber orientations and represents white-matter compactness. In the voxel-based statistical analysis, we found lower GFA and NQA values in the SA group than in the D and HC groups and lower GFA and NQA values in the D group than in the HC group. In the graph theoretical analysis, the SA group demonstrated higher local segregation and lower global integration among the three groups. In the network-based statistical analysis, the SA group showed stronger subnetwork connections in the frontal and parietal lobes, and the D group showed stronger subnetwork connections in the parietal lobe than the HC group. Alternations were found in the structural differences and network measurements in healthy controls and depressed patients with and without a history of suicide attempt.

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Relationship of depersonalization and suicidality in depressed patients

Vojnosanitetski pregled ◽

10.2298/vsp161201023t ◽

2018 ◽

Vol 75 (11) ◽

pp. 1065-1069

Author(s):

Suzana Tosic-Golubovic ◽

Olivera Zikic ◽

Violeta Slavkovic ◽

Gordana Nikolic ◽

Maja Simonovic

Keyword(s):

Suicidal Behaviour ◽

Protective Factor ◽

Suicide Ideation ◽

Suicide Attempts ◽

Psychiatric Morbidity ◽

Treatment Procedure ◽

Depressed Patients ◽

History Of ◽

Leading Symptom ◽

Relationship Of

Background/Aim. Depersonalization is considered to be the third leading symptom in psychiatric morbidity. The aim of this study was to investigate the correlation of depersonalization and different patterns of suicidal behaviour in patients suffering from depresssive disorder. Methods. The study included 119 depressed patients divided into two groups: the first group consisted of depressed patients with clinically manifested depersonalization according to the Cambridge Depresonalisation Scale presented score ? 70, and the second group consisted of the patients whithout clinically manifested depersonalization symptomatology, or, it was on the subsyndromal level. Subsequently, these two groups were compared regarding the suicidality indicators. Results. According to the Scale for Suicide Ideation of Beck, the depressed patients with depersonalization had statistically significantly higher scores regarding suicidal ideation, both active and passive, more often manifested suicidal desire, suicidal planning and overall suicidality (p < 0.000). Positive ideation, as a protective factor, was reduced in this group (p < 0.000). These patients had more previous suicide attempts (p < 0.001) and family history of suicides (p = 0.004). The depressed patients with depersonalization had 8 times more often active suicidal desire, 11 times more often passive suicidal desire and 5 times more often suicidal planning compared to patients without depersonalization. Conclusion. Suicidal potential, manifested in various patterns of suicidal behaviour among the patients suffering from depressive disorder with clinically manifested depersonalization is prominent. It is necessary to pay particular attention to depersonalization level during diagnostic and treatment procedure of the depressed patients having in mind that it may be associated with high suicidal potential.

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T114. Depressed Patients With History of Suicide Attempts Differ From Non-Attempters in Processing of Emotional Faces

Biological Psychiatry ◽

10.1016/j.biopsych.2018.02.450 ◽

2018 ◽

Vol 83 (9) ◽

pp. S172-S173

Author(s):

Joanna Szczepanik ◽

Jessica Reed ◽

Allison Nugent ◽

Carlos Zarate ◽

Elizabeth Ballard

Keyword(s):

Suicide Attempts ◽

Emotional Faces ◽

Depressed Patients ◽

History Of

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The Association Between Resting State Functional Connectivity and the Trait of Impulsivity and Suicidal Ideation in Young Depressed Patients With Suicide Attempts

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.567976 ◽

2021 ◽

Vol 12 ◽

Author(s):

Jun Cao ◽

Xiaorong Chen ◽

Jianmei Chen ◽

Ming Ai ◽

Yao Gan ◽

...

Keyword(s):

Suicidal Ideation ◽

Functional Connectivity ◽

Resting State ◽

Suicide Attempts ◽

Anterior Cingulate ◽

Resting State Functional Connectivity ◽

Depressed Patients ◽

History Of ◽

The Right ◽

Left Middle

Suicide is a leading cause of death among youth and is strongly associated with major depressive disorder (MDD). However, the neurobiological underpinnings of suicidal behaviour and the identification of risk for suicide in young depressed patients are not yet well-understood. In this study, we used a seed-based correlation analysis to investigate the differences in resting-state functional connectivity (RSFC) in depressed youth with or without a history of suicide attempts and healthy controls (HCs). Suicidal attempters (ATT group, n = 35), non-suicide attempters (NAT group, n = 18), and HCs exhibited significantly different RSFC patterns with the left superior prefrontal gyrus (L-SFG) and left middle prefrontal gyrus (L-MFG) serving as the regions of interest (ROIs). The ATT group showed decreased RSFC of the left middle frontal gyrus with the left superior parietal gyrus compared to the NAT and HC groups. Decreased RSFC between the left superior frontal gyrus and the right anterior cingulate cortex (rACC) was found in the ATT group compared to the NAT and HC groups. Furthermore, the left prefrontal-parietal connectivity was associated with suicidal ideation and levels of impulsivity, but RSFC of the left prefrontal cortex with the rACC was correlated exclusively with impulsivity levels and was not related to suicidal ideation in the ATT group. Our results demonstrated that altered RSFC of the prefrontal-parietal and prefrontal-rACC regions was associated with suicide attempts in depressed youth, and state-related deficits in their interconnectivity may contribute to traits, such as cognitive impairments and impulsivity to facilitate suicidal acts. Our findings suggest that the neural correlates of suicidal behaviours might be dissociable from those related to the severity of current suicidal ideation. Neural circuits underlying suicide attempts differ from those that underlie suicidal ideation.

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