Association of Genetic Variants in the Neurotrophic Receptor–Encoding GeneNTRK2and a Lifetime History of Suicide Attempts in Depressed Patients

BackgroundAgainst a backdrop of increasing research, clinical and taxonomic attention in non-suicidal self-injury (NSSI), evidence suggests a link between NSSI and eating disorders (ED). The frequency estimates of NSSI in ED vary widely. Little is known about the sources of this variation, and no meta-analysis has quantified the association between ED and NSSI.MethodUsing random-effects meta-analyses, meta-regression analyses, and 1816–6466 unique participants with various ED, we estimated the weighted average percentage of individuals with ED, those with anorexia nervosa (AN) and those with bulimia nervosa (BN) who are reported to have a lifetime history of NSSI across studies. We further examined predictors of NSSI in ED.ResultsThe weighted average percentage of patients with a lifetime history of NSSI was 27.3% [95% confidence interval (CI) 23.8–31.0%] for ED, 21.8% (95% CI 18.5–25.6%) for AN, and 32.7% (95% CI 26.9–39.1%) for BN. The difference between BN and AN was statistically significant [odds ratio (OR) 1.77, 95% CI 1.14–2.77, p = 0.013]. The odds of NSSI increased by 24% for every 10% increase in the percentage of participants with histories of suicide attempts (OR 1.24, 95% CI 1.04–1.48, p = 0.020) and decreased by 26% for every 10% increase in the percentage of participants with histories of substance abuse (OR 0.74, 95% CI 0.58–0.95, p = 0.023).ConclusionsIn the specific context of ED, NSSI is highly prevalent and correlates positively with attempted suicide, urging for NSSI-focused treatments. A novel finding is that NSSI is potentially antagonized by substance abuse.

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Lifetime History of Suicide Attempts among Not Guilty by Reason of Insanity State Hospital Inpatients: The Roles of past Harmful Substance Use and Current Social Support

International Journal of Forensic Mental Health ◽

10.1080/14999013.2020.1775326 ◽

2020 ◽

Vol 19 (4) ◽

pp. 341-353

Author(s):

Sean M. Mitchell ◽

Sarah L. Brown ◽

Faith Scanlon ◽

Marc T. Swogger ◽

Darci Delgado ◽

...

Keyword(s):

Social Support ◽

Substance Use ◽

State Hospital ◽

Suicide Attempts ◽

Harmful Substance ◽

Lifetime History ◽

History Of ◽

Hospital Inpatients

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Bipolar disorder first episode and suicidal behavior: are there differences according to type of suicide attempt?

Brazilian Journal of Psychiatry ◽

10.1590/s1516-44462009000200006 ◽

2009 ◽

Vol 31 (2) ◽

pp. 114-118 ◽

Cited By ~ 15

Author(s):

Fernando Silva Neves ◽

Leandro Fernandes Malloy-Diniz ◽

Izabela Guimarães Barbosa ◽

Paulo Marcos Brasil ◽

Humberto Corrêa

Keyword(s):

Bipolar Disorder ◽

Logistic Regression ◽

Suicidal Behavior ◽

Suicide Attempts ◽

First Episode ◽

Mean Square ◽

Suicide Attempters ◽

Lifetime History ◽

Bipolar Ii ◽

History Of

OBJECTIVE: The objective of this study was to test the hypothesis that the polarity of the first mood episode may be a marker for suicidal behavior, particularly the violent subtype. METHOD: One hundred and sixty-eight patients diagnosed with bipolar disorder (DSM-IV) were grouped according to type of first episode: depression or manic/hypomanic. Groups were compared for demographic and clinical variables. We performed logistic regression in order to test the association between first episode polarity and suicidal behavior. RESULTS: We found that depressed patients have a lifetime history of more suicide attempts. However, univariate analysis of number of suicide attempts showed that the best model fits the bipolar II subtype (mean square = 15.022; p = 0.010) and lifetime history of psychotic episodes (mean square = 17.359; p = 0.021). Subgrouping the suicide attempts by subtype (violent or non-violent) revealed that manic/hypomanic patients had a greater tendency toward attempting violent suicide (21.2 vs. 14.7%, X² = 7.028, p = 0.03). Multiple logistic regression analysis confirmed this result. CONCLUSION: Depressed patients had more suicide attempts over time, which could be explained by the higher prevalence of bipolar II subtype in this group, whereas manic/hypomanic patients had a lifelong history of more frequent violent suicide attempts, not explained by any of the variables studied. Our results support the evidence that non-violent suicide attempters and violent suicide attempters tend to belong to different phenotypic groups.

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Risk-Taking Propensity, Depression and Parasuicide

Australian & New Zealand Journal of Psychiatry ◽

10.3109/00048677609159510 ◽

1976 ◽

Vol 10 (3) ◽

pp. 269-273 ◽

Cited By ~ 3

Author(s):

Bruce Spittles ◽

Ken Bragan ◽

Basil James

Keyword(s):

Risk Taking ◽

Suicide Attempts ◽

Psychological Adaptation ◽

Psychiatric Unit ◽

Depressed Patients ◽

History Of ◽

The Relationship ◽

Inpatient Psychiatric Unit

One hundred patients admitted consecutively to an inpatient psychiatric unit were given questionnaires to measure risk-taking propensity and depression. The purpose was to study the relationship between risk-taking, depression, and recent suicide attempts. It was found that depressed patients showed a bimodal clustering towards the extremes of risk-taking. There was a history of suicide attempts only when a certain threshold of risk-taking was exceeded. These findings are discussed with relation to defensive styles of psychological adaptation and to arousal thresholds.

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Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample

Psychiatric Genetics ◽

10.1097/ypg.0b013e3280c1e5fb ◽

2007 ◽

Vol 17 (5) ◽

pp. 308-310 ◽

Cited By ~ 27

Author(s):

Alexander Georgi ◽

Rami Abou Jamra ◽

Katrin Klein ◽

Angela Wolf Villela ◽

Johannes Schumacher ◽

...

Keyword(s):

Depressive Symptoms ◽

Genetic Variants ◽

German Sample ◽

Lifetime History ◽

History Of

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Lifetime history of suicide attempts is associated with poorer social skills in patients with bipolar disorder type I

Brazilian Journal of Psychiatry ◽

10.1590/s1516-44462010000200021 ◽

2010 ◽

Vol 32 (2) ◽

pp. 200-201 ◽

Cited By ~ 2

Author(s):

Cristiana Castanho de Almeida Rocca ◽

Luciana Gerchmann ◽

Lena Nabuco de Abreu ◽

Beny Lafer

Keyword(s):

Bipolar Disorder ◽

Social Skills ◽

Suicide Attempts ◽

Type I ◽

Lifetime History ◽

History Of ◽

Disorder Type

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Financial Strain, Suicidal Thoughts, and Suicidal Behavior Among US Military Personnel in the National Guard

Crisis ◽

10.1027/0227-5910/a000592 ◽

2019 ◽

Vol 40 (6) ◽

pp. 437-445

Author(s):

Craig J. Bryan ◽

AnnaBelle O. Bryan

Keyword(s):

Military Personnel ◽

Suicide Ideation ◽

Suicide Attempts ◽

National Guard ◽

Self Report ◽

Financial Strain ◽

Multiple Indicators ◽

Lifetime History ◽

Us Military ◽

History Of

Abstract. Background: Although financial strain is an identified risk factor for suicide among US military personnel, research is limited regarding the specific dimensions of financial strain that confer the greatest risk. Aims: The present study examined the associations among multiple indicators of financial strain, suicide ideation, and suicide attempts in a sample of US National Guard personnel, a high-risk subgroup of the US military. Method: National Guard personnel from Utah and Idaho ( n = 997) completed an anonymous online self-report survey. Weighted univariate and multivariate logistic regression was used to test hypothesized associations. Results: Lifetime history of suicide ideation was significantly more common among participants reporting recent income decrease, credit problems, and difficulty making ends meet, even when adjusting for other covariates. Lifetime history of suicide attempt was significantly associated with recent foreclosure or loan default, credit problems, and difficulty making ends meet, but only in univariate analyses. Recent credit problems were the only financial strain indicator that significantly predicted a history of suicide attempt among participants with a history of suicide ideation. Limitations: The present study includes self-report methodology and cross-sectional design. Conclusion: Although multiple indicators of financial strain are associated with increased risk for suicidal thinking among National Guard military personnel, credit problems had the strongest association with suicide attempts.

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