Rapid elevation of brain-derived neurotrophic factor production in the bilateral trigeminal ganglia by unilateral transection of the mental nerve in mice

Neuroreport ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Maiko Yamazaki ◽  
Tatsuru Tsurumaki ◽  
Yurie Yamada ◽  
Takeyasu Maeda ◽  
Kenji Seo
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Trigeminal Ganglia ◽  
Mental Nerve ◽  
Factor Production

scholarly journals Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals

2009 ◽  
Vol 94 (12) ◽  
pp. 1153-1160 ◽  
Author(s):  
Bente K. Pedersen ◽  
Maria Pedersen ◽  
Karen S. Krabbe ◽  
Helle Bruunsgaard ◽  
Vance B. Matthews ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Energy Homeostasis ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Production ◽  
Exercise Induced

scholarly journals Edaravone Enhances Brain-Derived Neurotrophic Factor Production in the Ischemic Mouse Brain

2015 ◽  
Vol 8 (2) ◽  
pp. 176-185 ◽  
Author(s):  
Satoshi Okuyama ◽  
Mayu Morita ◽  
Atsushi Sawamoto ◽  
Tsukasa Terugo ◽  
Mitsunari Nakajima ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Production

scholarly journals Altered production of brain-derived neurotrophic factor by peripheral blood immune cells in multiple sclerosis

2010 ◽  
Vol 16 (10) ◽  
pp. 1178-1188 ◽  
Author(s):  
Satoshi Yoshimura ◽  
Hirofumi Ochi ◽  
Noriko Isobe ◽  
Takuya Matsushita ◽  
Kyoko Motomura ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Peripheral Blood Mononuclear Cells ◽  
Neurotrophic Factor ◽  
Peripheral Blood ◽  
Interferon Beta ◽  
Mononuclear Cells ◽  
Brain Derived Neurotrophic Factor ◽  
Peripheral Blood Mononuclear ◽  
Factor Production ◽  
Multiple Sclerosis Patients

Background: Within multiple sclerosis lesions, brain-derived neurotrophic factor is detected in neurons and immunocytes. Objective: To clarify brain-derived neurotrophic factor production by peripheral blood immunocytes and its relationship with clinical parameters in multiple sclerosis. Methods: Serum brain-derived neurotrophic factor levels were measured by conventional enzyme-linked immunosorbent assay while brain-derived neurotrophic factor production by immunocytes was determined by an in situ enzyme-linked immunosorbent assay in 74 multiple sclerosis patients, 32 healthy controls, and 86 patients with other neurological diseases. The tyrosine kinase receptor TrkB expression level in peripheral blood mononuclear cells was measured by real-time polymerase chain reaction. Results: Multiple sclerosis patients showed significantly higher serum brain-derived neurotrophic factor levels than healthy controls and patients with other neurological diseases. Multiple sclerosis patients with high brain-derived neurotrophic factor levels were younger, and showed fewer relapse numbers than those with low brain-derived neurotrophic factor levels. Brain-derived neurotrophic factor production by T cells increased with age in healthy controls, but not in multiple sclerosis patients. Interferon beta induced a significant increase in serum brain-derived neurotrophic factor levels. Brain-derived neurotrophic factor production from T cells and TrkB expression levels in peripheral blood mononuclear cells were significantly enhanced in interferon beta-treated multiple sclerosis patients compared with untreated ones. Conclusions: A high brain-derived neurotrophic factor level is related to early mild disease in young multiple sclerosis patients. Interferon beta potentiates brain-derived neurotrophic factor production and brain-derived neurotrophic factor receptor expression in peripheral blood mononuclear cells, which may act beneficially.

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