scholarly journals Mechanical properties and in vitro characterization of polyvinyl alcohol-nano-silver hydrogel wound dressings

2014 ◽  
Vol 4 (1) ◽  
pp. 20130049 ◽  
Author(s):  
R. N. Oliveira ◽  
R. Rouzé ◽  
B. Quilty ◽  
G. G. Alves ◽  
G. D. A. Soares ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Saline Solution ◽  
Antimicrobial Effect ◽  
Wound Dressings ◽  
Solution Ph ◽  
Swelling Properties ◽  
In Vitro Characterization ◽  
Gamma Irradiated ◽  
Potential Use

Polyvinyl alcohol (PVA) hydrogels are materials for potential use in burn healing. Silver nanoparticles can be synthesized within PVA hydrogels giving antimicrobial hydrogels. Hydrogels have to be swollen prior to their application, and the common medium available for that in hospitals is saline solution, but the hydrogel could also take up some of the wound's fluid. This work developed gamma-irradiated PVA/nano-Ag hydrogels for potential use in burn dressing applications. Silver nitrate (AgNO 3 ) was used as nano-Ag precursor agent. Saline solution, phosphate-buffered solution (PBS) pH 7.4 and solution pH 4.0 were used as swelling media. Microstructural evaluation revealed an effect of the nanoparticles on PVA crystallization. The swelling of the PVA-Ag samples in solution pH 4.0 was low, as was their silver delivery, compared with the equivalent samples swollen in the other media. The highest swelling and silver delivery were related to samples prepared with 0.50% AgNO 3 , and they also presented lower strength in PBS pH 7.4 and solution pH 4.0. Both PVA-Ag samples were also non-toxic and presented antimicrobial activity, confirming that 0.25% AgNO 3 concentration is sufficient to establish an antimicrobial effect. Both PVA-Ag samples presented suitable mechanical and swelling properties in all media, representative of potential burn site conditions.

scholarly journals Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 389 ◽  
Author(s):  
Mónica C. Guadarrama-Acevedo ◽  
Raisa A. Mendoza-Flores ◽  
María L. Del Prado-Audelo ◽  
Zaida Urbán-Morlán ◽  
David M. Giraldo-Gomez ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Clinical Performance ◽  
Ex Vivo ◽  
High Capacity ◽  
Wound Dressings ◽  
In Vivo Studies ◽  
Potential Use

Non-biodegradable materials with a low swelling capacity and which are opaque and occlusive are the main problems associated with the clinical performance of some commercially available wound dressings. In this work, a novel biodegradable wound dressing was developed by means of alginate membrane and polycaprolactone nanoparticles loaded with curcumin for potential use in wound healing. Curcumin was employed as a model drug due to its important properties in wound healing, including antimicrobial, antifungal, and anti-inflammatory effects. To determine the potential use of wound dressing, in vitro, ex vivo, and in vivo studies were carried out. The novel membrane exhibited the diverse functional characteristics required to perform as a substitute for synthetic skin, such as a high capacity for swelling and adherence to the skin, evidence of pores to regulate the loss of transepidermal water, transparency for monitoring the wound, and drug-controlled release by the incorporation of nanoparticles. The incorporation of the nanocarriers aids the drug in permeating into different skin layers, solving the solubility problems of curcumin. The clinical application of this system would cover extensive areas of mixed first- and second-degree wounds, without the need for removal, thus decreasing the patient’s discomfort and the risk of altering the formation of the new epithelium.

In vitro biocompatibility evaluation of radiolytically synthesized silver/polyvinyl hydrogel nanocomposites for wound dressing applications

2020 ◽  
Vol 35 (4-5) ◽  
pp. 435-450
Author(s):  
Swaroop Kumaraswamy ◽  
Shrikant L Patil ◽  
Somashekarappa H Mallaiah
Keyword(s):  
Polyvinyl Alcohol ◽  
Gamma Irradiation ◽  
Wound Dressing ◽  
Wound Care ◽  
Crosslinking Agent ◽  
Homogeneous Distribution ◽  
Swelling Properties ◽  
In Vitro Biocompatibility ◽  
Hydrogel Nanocomposites

Nano silver/polyvinyl alcohol hydrogel nanocomposites have been prepared using gamma irradiation technique. Gamma irradiation serves as a crosslinking agent for the polyvinyl alcohol hydrogels and also acts as a reducing agent for reduction of Ag+ ions to zero valent Ag0 within the polyvinyl alcohol crosslinked network. The microstructural characteristics of the prepared composites were studied using powder X-ray diffraction, ultraviolet–visible spectroscopy, Fourier-transform infrared spectroscopy and field emission scanning electron microscopy analysis. The data obtained by these characterizations indicate the homogeneous distribution of silver nanoparticles on the polyvinyl alcohol network. The swelling properties and mechanical parameters of the silver/polyvinyl alcohol hydrogel nanocomposites tend to show improvements, making them a better material for wound care applications. The silver/polyvinyl alcohol hydrogel nanocomposites have shown good antibacterial potential against both Gram-positive and Gram-negative bacteria and shown nil or minimal cytotoxic effect on human melanoma (SK-MEL-2) and mouse melanoma (B16-F1) cell lines. Overall, it was concluded that under optimized condition, silver/polyvinyl alcohol hydrogel nanocomposites synthesized using gamma irradiation technique are excellent candidates for wound dressing application.

scholarly journals Improvement of Starch Digestion Usingα-Amylase Entrapped in Pectin-Polyvinyl Alcohol Blend

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Maurício Cruz ◽  
Kátia Fernandes ◽  
Cristine Cysneiros ◽  
Reginaldo Nassar ◽  
Samantha Caramori
Keyword(s):  
Polyvinyl Alcohol ◽  
Phosphate Buffer ◽  
Immobilized Enzyme ◽  
Biotechnological Applications ◽  
Solution Ph ◽  
Sodium Phosphate Buffer ◽  
Rate Of Dissolution ◽  
Water Ph ◽  
Repeated Use

Polyvinyl alcohol (PVA) and pectin blends were used to entrapα-amylase (Termamyl) using glutaraldehyde as a cross-linker. The effect of glutaraldehyde concentration (0.25, 0.5, 0.75, 1.0, and 1.25%) on the activity of the immobilized enzyme and rate of enzyme released was tested during a 24 h period. Characteristics of the material, such as scanning electron microscopy (SEM), tensile strength (TS), elongation, and rate of dissolution in water (pH 5.7), ruminal buffering solution (pH 7.0), and reactor containing 0.1 mol L−1sodium phosphate buffer (pH 6.5), were also analyzed. SEM results showed that the surfaces of the pectin/PVA/amylase films were highly irregular and rough. TS values increased as a function of glutaraldehyde concentration, whereas percentage of elongation (%E) decreased. Pectin/PVA/amylase films presented similar values of solubility in the tested solvents. The material obtained with 0.25% glutaraldehyde performed best with repeated use (active for 24 h), in a phosphate buffer reactor. By contrast, the material obtained with 1.25% glutaraldehyde presented higher performance duringin vitrotesting using an artificial rumen. The results suggest that pectin/PVA/amylase is a highly promising material for biotechnological applications.

In Vitro Characterization of Pressure Redistribution Among Commercially Available Wound Dressings

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jeffrey A Niezgoda ◽  
Jonathan A Niezgoda ◽  
Sandeep Gopalakrishnan
Keyword(s):  
Wound Dressings ◽  
In Vitro Characterization

In vitro and in vivo assays on egg white/polyvinyl alcohol/clay nanocomposite hydrogel wound dressings

2016 ◽  
Vol 27 (16) ◽  
pp. 1569-1583 ◽  
Author(s):  
Mohammad Sirousazar ◽  
Azinsadat Jahani-Javanmardi ◽  
Farshad Kheiri ◽  
Zuhair Muhammad Hassan
Keyword(s):  
Polyvinyl Alcohol ◽  
Egg White ◽  
Wound Dressings ◽  
Nanocomposite Hydrogel ◽  
In Vivo Assays

Preclinical assessment of chitosan–polyvinyl alcohol–graphene oxide nanocomposite scaffolds as a wound dressing

2021 ◽  
pp. 096739112110292
Author(s):  
Arash Montazeri ◽  
Fariba Saeedi ◽  
Yaser Bahari ◽  
Ahmad Ahmadi Daryakenari
Keyword(s):  
Graphene Oxide ◽  
Polyvinyl Alcohol ◽  
Wound Dressing ◽  
Biological Properties ◽  
Mouse Fibroblast ◽  
Wound Dressings ◽  
In Vivo Studies ◽  
Nanocomposite Scaffolds

The present research aimed to examine the biological properties of chitosan (CS)–polyvinyl alcohol (PVA) scaffolds reinforced with graphene oxide (GO) nanosheets, as wound dressings. The scaffolds were characterized by various techniques. The scanning electron microscopy (SEM) and thermogravimetry analyses (TGAs) were used to investigate distribution of the GO within the polymer. The viscoelastic properties were evaluated by dynamic mechanical thermal analysis (DMTA) to examine the quality of a wound dressing. In vitro and in vivo studies were conducted to assess the biocompatibility of the scaffolds as wound dressing. The cell viability and proliferation results indicated that mouse fibroblast cells (L929) could adhere on the 50CS–50PVA/3 wt% GO scaffold. Herewith, the fabricated CS–PVA–GO nanocomposite scaffolds are suggested as promising biomaterials for skin tissue engineering and wound dressing.

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