scholarly journals The size of the trachea in warm-blooded animals, and its relationship to the weight, the surface area, the blood volume, and the size of the aorta

1912 ◽  
Vol 86 (584) ◽  
pp. 56-65 ◽  
Keyword(s):  
Body Weight ◽  
Surface Area ◽  
Cross Section ◽  
Body Surface ◽  
Body Fluid ◽  
The Body ◽  
Total Oxygen ◽  
Oxygen Capacity ◽  
Aortic Area ◽  
Main Factor

The analysis of data collected in connection with the investigation of a number of problems in immunity has led to a series of results, in part already published, bearing upon the blood and circulation. The conclusion was reached that in certain cases a precise and definite relationship to the body surface exists in warm-blooded animals in accordance with the formula W n / a = k , where W is the body weight of the animal, a represents the mass of the body fluid, tissue, or organ under investigation, k is a constant, and the value of n is approximately 0·70-0·72. In view of the fact that the carriage of oxygen is one of the chief functions of the circulation, and that the volume of the blood (1), (2), and the aortic area (3), (4), (area of cross-section of aorta), have been shown by us to be proportional to the body surface in warm-blooded animals, while, as we have also found, the total oxygen capacity is the main factor in determining the size of the heart (5), it appeared to be of interest to examine the size of the channel by which the oxygen gains access to the lungs.

scholarly journals Establishing Standards for Studying Renal Function in Mice through Measurements of Body Size-Adjusted Creatinine and Urea Levels

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Wellington Francisco Rodrigues ◽  
Camila Botelho Miguel ◽  
Marcelo Henrique Napimoga ◽  
Carlo Jose Freire Oliveira ◽  
Javier Emilio Lazo-Chica
Keyword(s):  
Renal Function ◽  
Body Weight ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Measurement Techniques ◽  
The Body ◽  
Urea Concentration ◽  
Time Points ◽  
Average Factor

Strategies for obtaining reliable results are increasingly implemented in order to reduce errors in the analysis of human and veterinary samples; however, further data are required for murine samples. Here, we determined an average factor from the murine body surface area for the calculation of biochemical renal parameters, assessed the effects of storage and freeze-thawing of C57BL/6 mouse samples on plasmatic and urinary urea, and evaluated the effects of using two different urea-measurement techniques. After obtaining 24 h urine samples, blood was collected, and body weight and length were established. The samples were evaluated after collection or stored at −20°C and −70°C. At different time points (0, 4, and 90 days), these samples were thawed, the creatinine and/or urea concentrations were analyzed, and samples were restored at these temperatures for further measurements. We show that creatinine clearance measurements should be adjusted according to the body surface area, which was calculated based on the weight and length of the animal. Repeated freeze-thawing cycles negatively affected the urea concentration; the urea concentration was more reproducible when using the modified Berthelot reaction rather than the ultraviolet method. Our findings will facilitate standardization and optimization of methodology as well as understanding of renal and other biochemical data obtained from mice.

Simplified Procedures for Calculating Drug Dosage from Body Weight in Infancy and Childhood

PEDIATRICS ◽  
1961 ◽  
Vol 27 (3) ◽  
pp. 503-506
Author(s):  
ANTHONY J. GLAZKO
Keyword(s):  
Body Weight ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Drug Dosage ◽  
The Body ◽  
Infancy And Childhood ◽  
Adult Dose ◽  
Fixed Power ◽  
Simplified Procedures

The primary purpose of this communication is to describe some rather simple procedures for calculating pediatric doses when they are proportional to a fixed power of body weight. It is generally recognized that dose requirements per unit of body weight are usually higher for children than for adults. Consequently the total dose is not directly prportional to the body weight, but appears to be more nearly proportional to the body surface area. This requires preliminary estimation of the body surface area with the assistance of various charts and tables, following which the dose can be calculated by simple proportion when the adult dose is known.

scholarly journals VI. Further experiments upon the blood volume of mammals and its relation to the surface area of the body

1912 ◽  
Vol 202 (282-293) ◽  
pp. 191-212 ◽  
Keyword(s):  
Body Weight ◽  
Surface Area ◽  
Blood Volume ◽  
Body Surface ◽  
Guinea Pigs ◽  
The Body ◽  
Wild Animals ◽  
Wild Rats ◽  
The Individual

In previous papers* we have shown that the blood volume of normal and healthy mammals, such as rabbits, guinea-pigs, and mice, is satisfactorily expressed by the formula B = W n / k , where B is the blood volume in cubic centimetres, W the weight of the individual in grammes, n approximately ⅔, and k a constant (calculated from the experiments), which varies with the particular species of animal. This formula indicates that the smaller and lighter animals of any given species, which have a relatively greater body surface than the heavier ones, have also a relatively greater blood volume—in other words, the blood volume can be expressed as a function of the body surface , and it must therefore be misleading to express it in per cent, of the body weight, since when so expressed it is not a constant for any given species of mammal. As it was of interest to ascertain whether wild animals of closely allied species would differ greatly as regards their blood volume from the above-mentioned tame animals, we have determined the blood volume of hares, wild rabbits, and wild rats.

BODY SURFACE AS A BASIS FOR DOSAGE

PEDIATRICS ◽  
1959 ◽  
Vol 23 (1) ◽  
pp. 3-5
Author(s):  
GILBERT B. FORBES
Keyword(s):  
Body Weight ◽  
Linear Function ◽  
Surface Area ◽  
Body Surface ◽  
Clinical Investigation ◽  
Therapeutic Agents ◽  
The Body ◽  
Unit Body Weight ◽  
Area Rule ◽  
Older Child

MODERN therapeutic technology, with its array of drugs, sera and infusates, has demanded that the pediatrician devise some means whereby these materials can be given in proper dosage to subjects of widely varying size. At the same time modern clinical investigation has indicated the extent to which the human young differ metabolically and physiologically from adults. The practitioner has seen for himself that the dosage of many therapeutic agents is far from a simple linear function of body weight. The result has been the formulation of a number of dosage schemes, the most recent of which is the surface-area rule. In this scheme, dosage is expressed as grams or milliliters of a given material per square meter surface area rather than per unit body weight. Body surface is calculated from weight and height according to the conventional DuBois nomogram, or from weight alone. The use of this rule automatically provides the infant with a larger per kilogram dose than the older child. This is because surface area increases less rapidly than weight as the body grows.

Simple Rule for Converting Body Weight to Body Surface

PEDIATRICS ◽  
1974 ◽  
Vol 53 (6) ◽  
pp. 954-954
Author(s):  
Norman A. Harvey
Keyword(s):  
Body Weight ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
The Body ◽  
Simple Rule ◽  
Slide Rule ◽  
Small Children ◽  
Pocket Calculator ◽  
Decimal Fraction

The body surface area (BSA) in square meters is commonly used to determine daily body water and electrolyte needs. Most pediatric fluid and electrolyte problems are calculated in patients under 70 lb in body weight (1.004 sq m). To arrive at the proper decimal fraction of the BSA for infants and small children one needs a slide rule, nomogram or pocket calculator, all of which have a way of never being handy when needed. The standard formula (see below) may be used but this is a bother.

The Advantages of Surface Area of the Body as a Basis for Calculating Pediatric Dosages

PEDIATRICS ◽  
1959 ◽  
Vol 24 (3) ◽  
pp. 495-498
Author(s):  
NATHAN B. TALBOT ◽  
ROBERT H. RICHIE
Keyword(s):  
Body Weight ◽  
Surface Area ◽  
Body Fluid ◽  
The Body

The use of surface area of the body as a basis for calculating fluid dosages has been questioned in recent communications. This letter is being written to call attention to certain facts which the authors of these communications appear to have overlooked. One is that body fluid requirements, like many other body functions, are not directly proportional to body weight. For this reason, Oliver et al. find it necessary to use five separate ml/lb-factors to calculate the fluid allowances of infants, children and adults. As can be seen in the table at the bottom of Figure 1, these diminish as individuals grow larger. Darrow likewise lists a series of eight factors to calculate body fluid requirements. Specifically he recommends that calories expended per kilogram be assumed to vary between 45 and 50 in the newborn, 60 and 80 in infants of 3 to 10 kg, 45 and 60 in children of 10 to 15 kg and so on down to a range of 25 to 30 in individuals weighing more than 60 kg.

The use of Body Surface Index as a Better Clinical Health indicators Compare to Body Mass Index and Body Surface Area for Clinical Application

2018 ◽  
pp. 131-136
Author(s):  
Shirazu I. ◽  
Theophilus. A. Sackey ◽  
Elvis K. Tiburu ◽  
Mensah Y. B. ◽  
Forson A.
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Clinical Application ◽  
Body Surface ◽  
Body Height ◽  
Health Indicators ◽  
The Body ◽  
Body Parameters ◽  
The Relationship ◽  
Individual Body

The relationship between body height and body weight has been described by using various terms. Notable among them is the body mass index, body surface area, body shape index and body surface index. In clinical setting the first descriptive parameter is the BMI scale, which provides information about whether an individual body weight is proportionate to the body height. Since the development of BMI, two other body parameters have been developed in an attempt to determine the relationship between body height and weight. These are the body surface area (BSA) and body surface index (BSI). Generally, these body parameters are described as clinical health indicators that described how healthy an individual body response to the other internal organs. The aim of the study is to discuss the use of BSI as a better clinical health indicator for preclinical assessment of body-organ/tissue relationship. Hence organ health condition as against other body composition. In addition the study is `also to determine the best body parameter the best predict other parameters for clinical application. The model parameters are presented as; modeled height and weight; modelled BSI and BSA, BSI and BMI and modeled BSA and BMI. The models are presented as clinical application software for comfortable working process and designed as GUI and CAD for use in clinical application.

Sodium Regulation and Adaptation to Fresh Water in Gammarid Crustaceans

1968 ◽  
Vol 48 (2) ◽  
pp. 359-380
Author(s):  
D. W. SUTCLIFFE
Keyword(s):  
Body Weight ◽  
Fresh Water ◽  
Body Surface ◽  
Sea Water ◽  
Sodium Concentration ◽  
The Body ◽  
Outward Diffusion ◽  
Gammarus Zaddachi ◽  
Freshwater Habitats ◽  
Sodium Regulation

1. Sodium uptake and loss rates are given for three gammarids acclimatized to media ranging from fresh water to undiluted sea water. 2. In Gammarus zaddachi and G. tigrinus the sodium transporting system at the body surface is half-saturated at an external concentration of about 1 mM/l. and fully saturated at about 10 mM/l. sodium. In Marinogammarus finmarchicus the respective concentrations are six to ten times higher. 3. M. finmarchicus is more permeable to water and salts than G. zaddachi and G. tigrinus. Estimated urine flow rates were equivalent to 6.5% body weight/hr./ osmole gradient at 10°C. in M. finmarchicus and 2.8% body weight/hr./osmole gradient in G. zaddachi. The permeability of the body surface to outward diffusion of sodium was four times higher in M. finmarchicus, but sodium losses across the body surface represent at least 50% of the total losses in both M. finmarchicus and G. zaddachi. 4. Calculations suggest that G. zaddachi produces urine slightly hypotonic to the blood when acclimatized to the range 20% down to 2% sea water. In fresh water the urine sodium concentration is reduced to a very low level. 5. The process of adaptation to fresh water in gammarid crustaceans is illustrated with reference to a series of species from marine, brackish and freshwater habitats.

scholarly journals Microvilli on the External Surfaces of Gastropod Tentacles and Body-Walls

1963 ◽  
Vol s3-104 (68) ◽  
pp. 495-504
Author(s):  
NANCY J. LANE
Keyword(s):  
Free Surface ◽  
Surface Area ◽  
Body Surface ◽  
Body Wall ◽  
Free Cell ◽  
The Body ◽  
Outer Cell ◽  
Lamellar Bodies ◽  
Cell Surfaces ◽  
Histochemical Tests

In Helix aspersa the ‘cuticle’ on the free surface of the external epithelial cells of the optic tentacles has been shown to consist of a layer of microvilli. Microvilli are also present in the same species on the free cell borders of the body-wall, and in the slug Arion hortensis, on the outer cell surfaces of the external epithelium. In all three cases the microvilli are arranged in a hexagonal pattern. There are indications that branching may possibly occur. The microvilli have granular cores with cross- and longitudinal-striations and there are fibrillar connexions between their tips. On the tentacular and body surfaces of H. aspersa, the microvilli increase the surface area 15 and 12 times, respectively. On A. hortensis the increase in surface area is only 4 times. In H. aspersa, beneath the microvilli on the tips of the optic tentacles there is a layer, about 3 to 4 µ deep, composed of vertical, horizontal, and tangential fibres. Some of these fibres are attached to lamellar bodies, which may have a lipid content. Granules are also found among the fibres. Further, a greater depth of cuticle is found to be present on the tips of the inferior tentacles of H. aspersa than on their sides; this seems to indicate that a fibrillar layer, similar to that on the optic tentacles, may lie beneath the cuticle of microvilli on the tips of the inferior tentacles. A thicker cuticle is also found on the tips of the optic tentacles in other stylommatophoran pulmonates. It has not been found possible to ascertain whether the fibrillar layer is intracellular or extracellular, although the evidence points to the latter. Histochemical tests indicate that mucopolysaccharide is present on the surface of the cuticle. Electron micrographs show a granular precipitate caught on and between the fibrillae connecting the tips of the microvilli. It is suggested that the function of the microvilli is to hold the mucous secretions on the body-surface, which would give protection to the animals.

Correlation between the Minimal Cross-Sectional Area of the Nasal Cavity and Body Surface Area: Preliminary Results in Normal Patients

2002 ◽  
Vol 16 (4) ◽  
pp. 209-213 ◽  
Author(s):  
Martin Jurlina ◽  
Ranko Mladina ◽  
Krsto Dawidowsky ◽  
Davor Ivanković ◽  
Zeljko Bumber ◽  
...  
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Anterior Part ◽  
Inferior Turbinate ◽  
Objective Evaluation ◽  
Cross Sectional Area ◽  
The Body ◽  
Sectional Area ◽  
Cross Sectional

Nasal symptoms often are inconsistent with rhinoscopic findings. However, the proper diagnosis and treatment of nasal pathology requires an objective evaluation of the narrow segments of the anterior part of the nasal cavities (minimal cross-sectional area [MCSA]). The problem is that the value of MCSA is not a unique parameter for the entire population, but rather it is a distinctive value for particular subject (or smaller groups of subjects). Consequently, there is a need for MCSA values to be standardized in a simple way that facilitates the comparison of results and the selection of our treatment regimens. We examined a group of 157 healthy subjects with normal nasal function. A statistically significant correlation was found between the body surface area and MCSA at the level of the nasal isthmus and the head of the inferior turbinate. The age of subjects was not found a statistically significant predictor for the value of MCSA. The results show that the expected value of MCSA can be calculated for every subject based on anthropometric data of height and weight.

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