scholarly journals Vaccine refusal and the endgame: walking the last mile first

2013 ◽  
Vol 368 (1623) ◽  
pp. 20120148 ◽  
Author(s):  
Diane S. Saint-Victor ◽  
Saad B. Omer

As multiple papers within this special issue illustrate, the dynamics of disease eradication are different from disease control. When it comes to disease eradication, ‘the last mile is longest’. For social and ecological reasons such as vaccine refusal, further ending incidence of a disease when it has reached low levels is frequently complex. Issues of non-compliance within a target population often influence the outcome of disease eradication efforts. Past eradication efforts confronted such obstacles towards the tail end of the campaign, when disease incidence was lowest. This article provides a comparison of non-compliance within polio, measles and smallpox campaigns, demonstrating the tendency of vaccine refusal to rise as disease incidence falls. In order to overcome one of the most intractable challenges to eradication, future disease eradication efforts must prioritize vaccine refusal from the start, i.e. ‘walk the last mile first’.

2017 ◽  
Vol 28 (1) ◽  
pp. 309-320 ◽  
Author(s):  
Scott Powers ◽  
Valerie McGuire ◽  
Leslie Bernstein ◽  
Alison J Canchola ◽  
Alice S Whittemore

Personal predictive models for disease development play important roles in chronic disease prevention. The performance of these models is evaluated by applying them to the baseline covariates of participants in external cohort studies, with model predictions compared to subjects' subsequent disease incidence. However, the covariate distribution among participants in a validation cohort may differ from that of the population for which the model will be used. Since estimates of predictive model performance depend on the distribution of covariates among the subjects to which it is applied, such differences can cause misleading estimates of model performance in the target population. We propose a method for addressing this problem by weighting the cohort subjects to make their covariate distribution better match that of the target population. Simulations show that the method provides accurate estimates of model performance in the target population, while un-weighted estimates may not. We illustrate the method by applying it to evaluate an ovarian cancer prediction model targeted to US women, using cohort data from participants in the California Teachers Study. The methods can be implemented using open-source code for public use as the R-package RMAP (Risk Model Assessment Package) available at http://stanford.edu/~ggong/rmap/ .


2018 ◽  
Vol 42 (2) ◽  
pp. 147-175 ◽  
Author(s):  
Vivian C. Wong ◽  
Peter M. Steiner ◽  
Kylie L. Anglin

Given the widespread use of nonexperimental (NE) methods for assessing program impacts, there is a strong need to know whether NE approaches yield causally valid results in field settings. In within-study comparison (WSC) designs, the researcher compares treatment effects from an NE with those obtained from a randomized experiment that shares the same target population. The goal is to assess whether the stringent assumptions required for NE methods are likely to be met in practice. This essay provides an overview of recent efforts to empirically evaluate NE method performance in field settings. We discuss a brief history of the design, highlighting methodological innovations along the way. We also describe papers that are included in this two-volume special issue on WSC approaches and suggest future areas for consideration in the design, implementation, and analysis of WSCs.


2001 ◽  
Vol 28 (1) ◽  
pp. 28-33 ◽  
Author(s):  
J. P. Damicone ◽  
K. E. Jackson

Abstract Two trials with iprodione and three trials with fluazinam were conducted to assess the effects of application method and rate on the control of Sclerotinia blight of peanut with fungicide. In order to concentrate the fungicides near the crown area where the disease causes the most damage, applications were made through a canopy opener with a single nozzle centered over the row to achieve a 30.5-cm-wide band (canopy opener), and through a single nozzle centered over the row to achieve a 46-cm-wide band (band). Broadcast applications were compared to these methods at rates of 0, 0.28, 0.56, and 1.12 kg/ha on the susceptible cultivar Okrun. Sclerotinia blight was severe, with > 70% disease incidence and < 2000 kg/ha yield for the untreated controls in each trial. Linear reductions in area under the disease progress curve (AUDPC), but not final disease incidence, with iprodione rate were significant (P < 0.05) for all methods of application. However, the rate of decrease did not differ among application methods. Linear increases in yield with rate of iprodione were greater for canopy opener compared to the band or broadcast applications. Only a 50% reduction in AUDPC and a maximum yield of < 2700 kg/ha was achieved with iprodione using the best method. At the maximum rate of 1.12 kg/ha, fluazinam provided > 75% disease control and > 4000 kg/ha yield for all application methods. Differences in disease control and yield among application methods only occurred at the 0.28 and 0.56 kg/ha rates of fluazinam. Reductions in AUDPC with fluazinam rate were quadratic for all application methods, but AUDPC values were less for the canopy opener and band methods at 0.28 and 0.56 kg/ha compared to the broadcast methods. The yield response to rate for broadcast applications of fluazinam was linear. However, predicted yield responses to fluazinam rate were quadratic for the band and canopy opener methods and approached the maximum response at 0.84 kg/ha. Targeting fungicide applications using the band and/or canopy opener methods was beneficial for fluazinam at reduced rates. Disease control with iprodione was not adequate regardless of application method.


Author(s):  
Samuël Coghe

Disease control and public health have been key aspects of social and political life in sub-Saharan Africa since time immemorial. With variations across space and time, many societies viewed disease as the result of imbalances in persons and societies and combined the use of materia medica from the natural world, spiritual divination, and community healing to redress these imbalances. While early encounters between African and European healing systems were still marked by mutual exchanges and adaptations, the emergence of European germ theory-based biomedicine and the establishment of racialized colonial states in the 19th century increasingly challenged the value of African therapeutic practices for disease control on the continent. Initially, colonial states focused on preserving the health of European soldiers, administrators, and settlers, who were deemed particularly vulnerable to tropical climate and its diseases. Around 1900, however, they started paying more attention to diseases among Africans, whose health and population growth were now deemed crucial for economic development and the legitimacy of colonial rule. Fueled by new insights and techniques provided by tropical medicine, antisleeping sickness campaigns would be among the first major interventions. After World War I, colonial health services expanded their campaigns against epidemic diseases, but also engaged with broader public health approaches that addressed reproductive problems and the social determinants of both disease and health. Colonial states were not the only providers of biomedical healthcare in colonial Africa. Missionary societies and private companies had their own health services, with particular logics, methods, and focuses. And after 1945, international organizations such as the World Health Organization (WHO) and the United Nations Children’s Fund (UNICEF) increasingly invested in health campaigns in Africa as well. Moreover, Africans actively participated in colonial disease control, most notably as nurses, midwives, and doctors. Nevertheless, Western biomedicine never gained hegemony in colonial Africa. Many Africans tried to avoid or minimize participation in certain campaigns or continued to utilize the services of local healers and diviners, often in combination with particular biomedical approaches. To what extent colonial disease control impacted on disease incidence and demography is still controversially debated.


Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 358
Author(s):  
Giovanna Elisa Calabrò ◽  
Alessia Tognetto ◽  
Elettra Carini ◽  
Silvia Mancinelli ◽  
Laura Sarnari ◽  
...  

The World Health Organization (WHO), the United States (US) Centers for Disease Control and Prevention (CDC), the European Center for Disease Control (ECDC), and the immunization guidelines of many countries issue vaccination recommendations for adults and the elderly. However, the uptake of vaccination in these groups is generally low due to several reasons. The present study aimed to identify strategies implemented in Italy in unconventional settings to promote vaccination against influenza, pneumococcal, and herpes zoster virus (HZV) infections among these subjects, i.e., the at-risk adult population and the elderly. We conducted a literature review and a survey of experts. The literature search yielded seven strategies; all of these concerned influenza vaccination, while three also addressed pneumococcal and HZV vaccination. The survey of experts identified 15 strategies; 10 regarded influenza vaccination, while four regarded pneumococcal vaccination and one regarded HZV vaccination. Most of the strategies were implemented in hospital clinics and rest homes. Regarding influenza and pneumococcal vaccinations, the target population mainly comprised at-risk adults, while the elderly represented the main target population for HZV vaccination. Our results show that, in Italy, there are initiatives aimed at promoting vaccination in unconventional settings, but further efforts are required to assess their effectiveness and to further extend them.


Author(s):  
Chandar Kala ◽  
S. Gangopadhyay ◽  
S. L. Godara

Antagonistic potentiality of Trichoderma viride, T. harzianum and Pseudomonas fluorescens were evaluated against Fusarium oxysporum f. sp. ciceri under in vivo conditions. The effect of organic amendments viz; farm yard manure, vermicompost and mustard cake on disease control potentiality of test antagonists against chickpea wilt and on population dynamics of the antagonists and pathogen in soil was also studied. Maximum inhibition of mycelial growth of F. o. f. sp. ciceri was recorded in presence of P. fluorescens (%) followed by T. harzianum (%) and T. viride (%). Seed treatment with P. fluorescens was more effective in suppressing the disease incidence as compared to T. harzianum and T. viride. The disease control efficacy and population dynamics of all the three test antagonists was enhanced in response to application of organic amendments. Among the three organic amendments tested, mustard cake was most effective in enhancing the disease control potentiality of these antagonists.


2014 ◽  
Vol 58 (13) ◽  
pp. 1687-1695 ◽  
Author(s):  
Elizabeth Aranda ◽  
Cecilia Menjívar ◽  
Katharine M. Donato

In our introduction to this special issue, we describe how the immigration enforcement-first regime has consequences that extend beyond the supposed target population of undocumented immigrants and spill over to other groups, including legal permanent residents, U.S.-born Latinos/as, and other U.S.-born residents. The papers in this special issue address whether and how spillover effects exist and the form that they take. Often they include social, psychological, and in some cases, physical harm, and together they illustrate that directly or indirectly, U.S. policy’s emphasis on interior and external border enforcement affects all of us.


1992 ◽  
Vol 70 (5) ◽  
pp. 1093-1096 ◽  
Author(s):  
Dan O. Chellemi ◽  
Kerry O. Britton

Incidence and severity of dogwood anthracnose within the interior and exterior canopies of exposed dogwood (Cornus florida L.) trees and canopies of understory trees were recorded over a 53-day period during the summer of 1990. Concurrent measurements of vapor pressure deficit, air temperature, evaporative potential, and photosynthetically active radiation within the canopies were also recorded. Disease incidence was significantly lower in the exterior canopy of exposed trees than in other canopy locations. Disease severity was significantly different among all three canopy locations, with the lowest severity in exterior canopies of exposed trees and the greatest severity in canopies of understory trees. Of the climatic variables measured, evaporative potential provided the most consistent contrast among microclimates at the various canopy locations. Mean evaporative potentials averaged over 6- to 10-day intervals ranged from 0.00 g H2O h−1 in understory and exposed, interior canopies to 0.40 g H2O h−1 in exposed, exterior canopies. Disease incidence and severity were greater in canopies associated with low levels of evaporative potential. Key words: Cornus florida L., dogwood anthracnose, canopy microclimate, evaporative potential.


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