Prevalence of methicillin-resistant, coagulase-negative staphylococci in neonatal intensive care units: findings from a tertiary care hospital in India

AbstractA biphasic outbreak of methicillin-resistantStaphylococcus aureusin intensive-care units of a German tertiary-care hospital afflicted 89 patients within 4 years. The spread of the outbreak most likely was facilitated by the contamination of mobile radiograph equipment. The outbreak was controlled by measures of hospital hygiene.

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Outbreak of Methicillin Resistant Staphylococcus aureus in Neonatal Intensive Care Unit in a Tertiary Care Hospital in Kolkata

IOSR Journal of Dental and Medical Sciences ◽

10.9790/0853-13456367 ◽

2014 ◽

Vol 13 (4) ◽

pp. 63-67

Author(s):

Dr.Susmita Bhattacharya ◽

◽

Dr.Kuhu Pal ◽

Dr.Jayanta Kumar Barua ◽

Ms. Sonia Jain ◽

...

Keyword(s):

Intensive Care Unit ◽

Staphylococcus Aureus ◽

Intensive Care ◽

Neonatal Intensive Care Unit ◽

Neonatal Intensive Care ◽

Methicillin Resistant Staphylococcus Aureus ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Methicillin Resistant

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Reduction in nosocomial infection with improved hand hygiene in intensive care units of a tertiary care hospital in Argentina

American Journal of Infection Control ◽

10.1016/j.ajic.2004.08.009 ◽

2005 ◽

Vol 33 (7) ◽

pp. 392-397 ◽

Cited By ~ 177

Author(s):

Victor D. Rosenthal ◽

Sandra Guzman ◽

Nasia Safdar

Keyword(s):

Intensive Care ◽

Hand Hygiene ◽

Nosocomial Infection ◽

Intensive Care Units ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital

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Detection of SARS-CoV-2 and Other Infectious Agents in Lower Respiratory Tract Samples Belonging to Patients Admitted to Intensive Care Units of a Tertiary-Care Hospital, Located in an Epidemic Area, during the Italian Lockdown

Microorganisms ◽

10.3390/microorganisms9010185 ◽

2021 ◽

Vol 9 (1) ◽

pp. 185

Author(s):

Adriana Calderaro ◽

Mirko Buttrini ◽

Sara Montecchini ◽

Giovanna Piccolo ◽

Monica Martinelli ◽

...

Keyword(s):

Intensive Care ◽

Respiratory Tract ◽

Intensive Care Units ◽

Lower Respiratory Tract ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Infectious Agents ◽

Epidemic Area ◽

Significant Difference

The aim of this study was the detection of infectious agents from lower respiratory tract (LRT) samples in order to describe their distribution in patients with severe acute respiratory failure and hospitalized in intensive care units (ICU) in an Italian tertiary-care hospital. LRT samples from 154 patients admitted to ICU from 27 February to 10 May 2020 were prospectively examined for respiratory viruses, including SARS-CoV-2, bacteria and/or fungi. SARS-CoV-2 was revealed in 90 patients (58.4%, 72 males, mean age 65 years). No significant difference was observed between SARS-CoV-2 positives and SARS-CoV-2 negatives with regard to sex, age and bacterial and/or fungal infections. Nonetheless, fungi were more frequently detected among SARS-CoV-2 positives (44/54, 81.4%, p = 0.0053). Candida albicans was the overall most frequently isolated agent, followed by Enterococcus faecalis among SARS-CoV-2 positives and Staphylococcus aureus among SARS-CoV-2 negatives. Overall mortality rate was 40.4%, accounting for 53 deaths: 37 among SARS-CoV-2 positives (mean age 69 years) and 16 among SARS-CoV-2 negatives (mean age 63 years). This study highlights the different patterns of infectious agents between the two patient categories: fungi were prevalently involved among SARS-CoV-2-positive patients and bacteria among the SARS-CoV-2-negative patients. The different therapies and the length of the ICU stay could have influenced these different patterns of infectious agents.

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In Vitro activity of a Novel Benzoquinolizine Antibiotic, Levonadifloxacin (WCK 771) against Blood Stream Gram-Positive Isolates from a Tertiary Care Hospital

Journal of Laboratory Physicians ◽

10.1055/s-0040-1720944 ◽

2020 ◽

Vol 12 (03) ◽

pp. 230-232

Author(s):

Dhruv Mamtora ◽

Sanjith Saseedharan ◽

Ritika Rampal ◽

Prashant Joshi ◽

Pallavi Bhalekar ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Blood Stream ◽

Tolerability Profile ◽

Care Hospital ◽

Coagulase Negative Staphylococci ◽

Gram Positive ◽

Methicillin Resistant

Abstract Background Blood stream infections (BSIs) due to Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) are associated with high mortality ranging from 10 to 60%. The current anti-MRSA agents have limitations with regards to safety and tolerability profile which limits their prolonged usage. Levonadifloxacin and its oral prodrug alalevonadifloxacin, a novel benzoquinolizine antibiotic, have recently been approved for acute bacterial skin and skin structure infections including diabetic foot infections and concurrent bacteremia in India. Methods The present study assessed the potency of levonadifloxacin, a novel benzoquinolizine antibiotic, against Gram-positive blood stream clinical isolates (n = 31) collected from January to June 2019 at a tertiary care hospital in Mumbai, India. The susceptibility of isolates to antibacterial agents was defined following the Clinical and Laboratory Standard Institute interpretive criteria (M100 E29). Results High prevalence of MRSA (62.5%), quinolone-resistant Staphylococcus aureus (QRSA) (87.5%), and methicillin-resistant coagulase-negative staphylococci (MR-CoNS) (82.35%) were observed among bacteremic isolates. Levonadifloxacin demonstrated potent activity against MRSA, QRSA, and MR-CoNS strains with significantly lower minimum inhibitory concentration MIC50/90 values of 0.5/1 mg/L as compared with levofloxacin (8/32 mg/L) and moxifloxacin (2/8 mg/L). Conclusion Potent bactericidal activity coupled with low MICs support usage of levonadifloxacin for the management of BSIs caused by multidrug resistant Gram-positive bacteria.

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