Essential role of PKCδ in histone deacetylase inhibitor-induced Epstein–Barr virus reactivation in nasopharyngeal carcinoma cells
2008 ◽
Vol 89
(4)
◽
pp. 878-883
◽
Keyword(s):
Histone deactylase inhibitors (HDACi) are common chemotherapeutic agents that stimulate Epstein–Barr virus (EBV) reactivation; the detailed mechanism remains obscure. In this study, it is demonstrated that PKCδ is required for induction of the EBV lytic cycle by HDACi. Inhibition of PKCδ abrogates HDACi-mediated transcriptional activation of the Zta promoter and downstream lytic gene expression. Nuclear translocation of PKCδ is observed following HDACi stimulation and its overexpression leads to progression of the EBV lytic cycle. Our study suggests that PKCδ is a crucial mediator of EBV reactivation and provides a novel insight to study the regulation of the EBV lytic cycle.
Keyword(s):
Keyword(s):
Marked Variation in Response of Consensus Binding Elements for the Rta Protein of Epstein-Barr Virus
2005 ◽
Vol 79
(15)
◽
pp. 9635-9650
◽
Keyword(s):
2004 ◽
Vol 78
(23)
◽
pp. 13028-13036
◽
Keyword(s):
2004 ◽
Vol 85
(6)
◽
pp. 1371-1379
◽
Keyword(s):
Keyword(s):