scholarly journals The Clinical COPD Questionnaire Correlated with BODE Index-A Cross-Sectional Study

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Shih-Feng Liu ◽  
Ching-Wan Tseng ◽  
Mei-Lien Tu ◽  
Chin-Chou Wang ◽  
Chia-Cheng Tseng ◽  
...  
Keyword(s):  
Health Status ◽  
Airflow Obstruction ◽  
Chronic Obstructive Lung Disease ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Bode Index ◽  
Measure Health Status ◽  
Global Initiative ◽  
A Prospective Study

The Global initiative for Chronic Obstructive Lung Disease (GOLD) staging has widely used in the stratification of the severity of COPD, while BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) index was proven superior to FEV1 in predicting mortality, exacerbation and disease severity in patients with COPD. Clinical COPD Questionnaire (CCQ), a questionnaire with ten items categorized into three domains (symptoms, functional state and mental state) was developed to measure health status of COPD patients. However, little is known about the relationship between CCQ score and BODE index. We performed a prospective study with the inclusion of 89 patients who were clinically stable after a 6-week-therapy for COPD symptoms comparing their health status assessed by CCQ, BODE index and GOLD staging. We found that the total CCQ score was correlated with BODE score (P<0.001) and GOLD staging (P<0.001); of three CCQ domains, the functional status correlated the most with BODE index (rS=0.670) and GOLD staging (rS=0.531), followed by symptoms (rS=0.482;rS=0.346, respectively), and mental status (rS=0.340;rS=0.236, respectively). Our data suggest that CCQ is a reliable and convenient alternative tool to evaluate the severity of COPD.

scholarly journals Microbial and host immune factors as drivers of COPD

2018 ◽  
Vol 4 (3) ◽  
pp. 00015-2018 ◽  
Author(s):  
Moana Mika ◽  
Izabela Nita ◽  
Laura Morf ◽  
Weihong Qi ◽  
Seraina Beyeler ◽  
...  
Keyword(s):  
Gene Expression ◽  
Respiratory Tract ◽  
Chronic Obstructive Lung Disease ◽  
Cross Sectional Study ◽  
Host Gene ◽  
Chronic Obstructive ◽  
Host Gene Expression ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Severe Copd

Compartmentalisation of the respiratory tract microbiota in patients with different chronic obstructive pulmonary disease (COPD) severity degrees needs to be systematically investigated. In addition, it is unknown if the inflammatory and emphysematous milieux in patients with COPD are associated with changes in the respiratory tract microbiota and host macrophage gene expression.We performed a cross-sectional study to compare non-COPD controls (n=10) to COPD patients (n=32) with different disease severity degrees. Samples (n=187) were obtained from different sites of the upper and lower respiratory tract. Microbiota analyses were performed by 16S ribosomal RNA gene sequencing and host gene expression analyses by quantitative real-time PCR of distinct markers of bronchoalveolar lavage cells.Overall, the microbial communities of severe COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) grade 3/4) patients clustered significantly differently to controls and less severe COPD (GOLD 1/2) patients (permutational multivariate ANOVA (MANOVA), p=0.001). However, we could not detect significant associations between the different sampling sites in the lower airways. In addition, the chosen set of host gene expression markers significantly separated COPD GOLD 3/4 patients, and we found correlations between the composition of the microbiota and the host data.In conclusion, this study demonstrates associations between host gene expression and microbiota profiles that may influence the course of COPD.

Differences Between COPD Patients of a Pulmonary Rehabilitation Program According to the mMRC Dyspnea Scale

2019 ◽  
Vol 15 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Jhonatan Betancourt-Peña ◽  
Vicente Benavides-Córdoba ◽  
Juan Carlos Avila-Valencia ◽  
Hamilton Elias Rosero-Carvajal
Keyword(s):  
Quality Of Life ◽  
Pulmonary Rehabilitation ◽  
Cross Sectional Study ◽  
Rehabilitation Program ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Bode Index ◽  
6Mwt Distance ◽  
Pulmonary Rehabilitation Program

Background: The modified Medical Research Council scale (mMRC) is a standardized measure of the effect of dyspnea on the activities of the daily life of patients suffering from Chronic Obstructive Pulmonary Disease (COPD). The aim of this study was to determine the differences in the quality of life, tolerance to effort and symptoms among patients with COPD with lower (mMRC 0-1) and greater symptoms (mMRC ≥2). Methods: Cross-sectional study that included patients admitted to a pulmonary rehabilitation program and who were classified into 2 groups: a group containing the less symptomatic patients and another group with the more symptomatic ones. We collected these patients’ sociodemographic, clinical, anthropometric, anxiety, depression and quality of life (SGRQ) data. Likewise, the subjects performed the 6-minute walk test (6MWT). Finally, we measured the multidimensional BODE index score. Results: 130 subjects were included, 35 presenting an mMRC of 0 to1 and 95 having an mMRC ≥ 2, with an age of 70.87 ± 9.45 years old. The 6MWT distance, the VO2e, the total score of SGRQ, and its domains of activities and impact showed significant differences between the groups (p <0.05). Significant correlations were found in the group presenting an mMRC of 0-1 between the mMRC and the FEV1 (p = 0.028), and in the group with an mMRC ≥2 for the FVC (p = 0.031), the 6MWT distance (p = 0.000), the VO2e (p = 0.010) and the BODE index (p = 0.000). Conclusion: Patients with an mMRC of 0 to1 had better results in the 6MWT, the VO2e and the SGRQ in comparison with the most symptomatic ones.

scholarly journals Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study

Thorax ◽  
2018 ◽  
Vol 73 (12) ◽  
pp. 1182-1185 ◽  
Author(s):  
Divya Mohan ◽  
Julia R Forman ◽  
Matthew Allinder ◽  
Carmel M McEniery ◽  
Charlotte Emma Bolton ◽  
...  
Keyword(s):  
Obstructive Lung Disease ◽  
Pulse Wave ◽  
Inflammatory Mediator ◽  
Chronic Obstructive Lung Disease ◽  
Aortic Pulse Wave Velocity ◽  
Aetiological Factor ◽  
Chronic Obstructive ◽  
Prognostic Role ◽  
Cross Sectional ◽  
Global Initiative

Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine whether aortic stiffness and quadriceps weakness are linked in COPD, and whether they are associated with the systemic inflammatory mediator—fibrinogen. Aortic pulse wave velocity (aPWV), quadriceps maximal volitional contraction (QMVC) force and fibrinogen were measured in 729 patients with stable, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages II–IV COPD. The cardiovascular and muscular manifestations exist independently (P=0.22, χ2). Fibrinogen was not associated with aPWV or QMVC (P=0.628 and P=0.621, respectively), making inflammation, as measured by plasma fibrinogen, an unlikely common aetiological factor.

scholarly journals Prediction of 30-Day Readmission for COPD Patients Using Accelerometer-Based Activity Monitoring

Sensors ◽  
2019 ◽  
Vol 20 (1) ◽  
pp. 217 ◽  
Author(s):  
Wen-Yen Lin ◽  
Vijay Kumar Verma ◽  
Ming-Yih Lee ◽  
Horng-Chyuan Lin ◽  
Chao-Sung Lai
Keyword(s):  
Activity Index ◽  
Airflow Obstruction ◽  
Chronic Obstructive Lung Disease ◽  
Walking Distance ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Bode Index ◽  
Copd Patients ◽  
Proposed Model ◽  
Readmission Risk

Chronic obstructive pulmonary disease (COPD) claimed 3.0 million lives in 2016 and ranked 3rd among the top 10 global causes of death. Moreover, once diagnosed and discharged from the hospital, the 30-day readmission risk in COPD patients is found to be the highest among all chronic diseases. The existing diagnosis methods, such as Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019, Body-mass index, airflow Obstruction, Dyspnea, and Exercise (BODE) index, modified Medical Research Council (mMRC), COPD assessment test (CAT), 6-minute walking distance, which are adopted currently by physicians cannot predict the potential readmission of COPD patients, especially within the 30 days after discharge from the hospital. In this paper, a statistical model was proposed to predict the readmission risk of COPD patients within 30-days by monitoring their physical activity (PA) in daily living with accelerometer-based wrist-worn wearable devices. This proposed model was based on our previously reported PA models for activity index (AI) and regularity index (RI) and it introduced a new parameter, quality of activity (QoA), which incorporates previously proposed parameters, such as AI and RI, with other activity-based indices to predict the readmission risk. Data were collected from continuous PA monitoring of 16 COPD patients after hospital discharge as test subjects and readmission prediction criteria were proposed, with a 63% sensitivity and a 37.78% positive prediction rate. Compared to other clinical assessment, diagnosis, and prevention methods, the proposed model showed significant improvement in predicting the 30-day readmission risk.

scholarly journals Prevalence of airflow obstruction according GOLD, ATS and ERS criteria in symptomatic ever-smokers referring to a Pulmonary Rehabilitation Department

2015 ◽  
Vol 75 (3) ◽  
Author(s):  
N. Barbarito ◽  
A. Vaghi ◽  
E. De Mattia
Keyword(s):  
Lung Function ◽  
Pulmonary Rehabilitation ◽  
Airflow Obstruction ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
European Respiratory Society ◽  
Obstructive Pulmonary Disease ◽  
Former Smokers ◽  
Global Initiative ◽  
Copd Diagnosis

Aim. To evaluate in a Pulmonary Rehabilitation (PR) setting the prevalence of airflow obstruction (AO) in either current or former smokers ≥45 years old both with dyspnoea and with chronic productive cough, using European Respiratory society (ERS) statement (FEV1/SVC &lt;88 and &lt;89% predicted in men and women, respectively), American Thoracic Society (ATS) statement (FEV1/FVC &lt;75%), and Global Initiative for Chronic Obstructive Lung Disease (GOLD) statement (FEV1/FVC &lt;70%). Methods. Lung function tests were performed in each patient who was referred to our PR department due to respiratory diagnosis or symptoms. For analysis, in patients showing AO we used post-bronchodilator lung function values. Results. In 184 ever-smoker patients with symptoms of chronic obstructive pulmonary disease (COPD), the prevalence rates of AO were as follows: ERS = 89.7%, ATS = 76.6%, and GOLD = 63.6%. Patients with AO according ERS criteria showing moderate to severe (M/S) obstruction (i.e., FEV1 &lt;70% predicted) were 119. Patients with ERS M/S AO but without AO using either ATS or GOLD criteria were 8.4% and 19.3%, respectively. Conclusions. Prevalence of AO is highly dependent on which guidelines it is based. ATS and particularly GOLD statement can cause a large under-diagnosis even of moderate to severe COPD. Diagnosis of COPD may be overlooked if SVC is not performed.

scholarly journals Sarcopenia in COPD: relationship with COPD severity and prognosis

2015 ◽  
Vol 41 (5) ◽  
pp. 415-421 ◽  
Author(s):  
Tatiana Munhoz da Rocha Lemos Costa ◽  
Fabio Marcelo Costa ◽  
Carolina Aguiar Moreira ◽  
Leda Maria Rabelo ◽  
César Luiz Boguszewski ◽  
...  
Keyword(s):  
Lean Mass ◽  
Smoking Status ◽  
Airflow Obstruction ◽  
Chronic Obstructive Lung Disease ◽  
The Body ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Skeletal Muscle Index ◽  
Gold Stage ◽  
Copd Patients

Objective: To evaluate the prevalence of sarcopenia in COPD patients, as well as to determine whether sarcopenia correlates with the severity and prognosis of COPD. Methods: A cross-sectional study with COPD patients followed at the pulmonary outpatient clinic of our institution. The patients underwent dual-energy X-ray absorptiometry. The diagnosis of sarcopenia was made on the basis of the skeletal muscle index, defined as appendicular lean mass/height2 only for low-weight subjects and adjusted for fat mass in normal/overweight subjects. Disease severity (COPD stage) was evaluated with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. The degree of obstruction and prognosis were determined by the Body mass index, airflow Obstruction, Dyspnea, and Exercise capacity (BODE) index. Results: We recruited 91 patients (50 females), with a mean age of 67.4 ± 8.7 years and a mean BMI of 25.8 ± 6.1 kg/m2. Sarcopenia was observed in 36 (39.6%) of the patients, with no differences related to gender, age, or smoking status. Sarcopenia was not associated with the GOLD stage or with FEV1 (used as an indicator of the degree of obstruction). The BMI, percentage of body fat, and total lean mass were lower in the patients with sarcopenia than in those without (p < 0.001). Sarcopenia was more prevalent among the patients in BODE quartile 3 or 4 than among those in BODE quartile 1 or 2 (p = 0.009). The multivariate analysis showed that the BODE quartile was significantly associated with sarcopenia, regardless of age, gender, smoking status, and GOLD stage. Conclusions: In COPD patients, sarcopenia appears to be associated with unfavorable changes in body composition and with a poor prognosis.

scholarly journals Phenotypic Variation in Patients with Chronic Obstructive Pulmonary Disease in Primary Care

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Emmylou Beekman ◽  
Ilse Mesters ◽  
Mark G. Spigt ◽  
Eva A. M. van Eerd ◽  
Rik Gosselink ◽  
...  
Keyword(s):  
Primary Care ◽  
Health Status ◽  
Airway Obstruction ◽  
Physical Therapist ◽  
Patient Characteristics ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Phenotypic Differences

Introduction. Despite the high number of inactive patients with COPD, not all inactive patients are referred to physical therapy, unlike recommendations of general practitioner (GP) guidelines. It is likely that GPs take other factors into account, determining a subpopulation that is treated by a physical therapist (PT). The aim of this study is to explore the phenotypic differences between inactive patients treated in GP practice and inactive patients treated in GP practice combined with PT. Additionally this study provides an overview of the phenotype of patients with COPD in PT practice.Methods. In a cross-sectional study, COPD patient characteristics were extracted from questionnaires. Differences regarding perceived health status, degree of airway obstruction, exacerbation frequency, and comorbidity were studied in a subgroup of 290 inactive patients and in all 438 patients.Results. Patients treated in GP practice combined with PT reported higher degree of airway obstruction, more exacerbations, more vascular comorbidity, and lower health status compared to patients who were not referred to and treated by a PT.Conclusion. Unequal patient phenotypes in different primary care settings have important clinical implications. It can be carefully concluded that other factors, besides the level of inactivity, play a role in referral to PT.

Body Composition, Functional Status and Clinical Outcomes in Patients with Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 2 (1) ◽  
pp. 01-06
Author(s):  
González Helena
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Airflow Obstruction ◽  
Inverse Correlation ◽  
Cross Sectional Study ◽  
Fat Free Mass ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Muscular Function

Objective: To define the correlation between the Fat Free Mass Index (FFMI), the muscle function, degree of airflow obstruction, the respiratory symptoms and the number of exacerbations during the last year in patients with Chronic Obstructive Pulmonary Disease (COPD). Methods: Prospective and cross-sectional study of subjects older than 40 years with a clinical diagnosis of COPD who underwent measurement of the FFMI and muscular function to determine if these were correlated with the variables of severe COPD. Results: 55 patients Participated in the study. The FFMI was below 32.7% (n=18) and the strength diminished in 56.4% (n=31). In the sample, we found a direct and significant correlation between the FFMI and the FEV1* (predicted %), (p= 0,045). When analyzed by sex, men had a direct correlation between FFMI and the FEV1*(predicted %), (p=0,019), an inverse correlation between FFMI and the spirometric classification of the Global Initiative Obstructive Lung Disease (GOLD) (p=0,008) and between the muscular function and the symptoms (p=0, 03). In women no significant correlation was found. Conclusions: The conditions in mass and the muscular function were correlated with clinical variables and pulmonary function in men, but not in women. We did not find a correlation between corporal composition and the number of exacerbations.

scholarly journals Evaluation of the Persian Transcript of the COPD Assessment Test in the Measurement of COPD Health Status in Iranian COPD Patients

2015 ◽  
Vol 8 (5) ◽  
pp. 225 ◽  
Author(s):  
Alireza Azargon ◽  
Mohammadreza Gholami ◽  
Ali Farhadi ◽  
Maryam Hadi Chegni ◽  
Abolfazl Zendedel
Keyword(s):  
Disease Severity ◽  
Chronic Obstructive Lung Disease ◽  
Airway Disease ◽  
Cross Sectional Study ◽  
Airflow Limitation ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Copd Assessment Test ◽  
The Relationship ◽  
Obstruction Severity

<p><strong>AIM:</strong> Chronic obstructive pulmonary disease is a completely irreversible obstructive airway disease. The COPD assessment test (CAT) is one of the standard methods for the clinical assessment of the disease, which is translated into Persian. This study investigated the reliability of the test and its relationship with the severity of the disease.</p><p><strong>METHODS:</strong> In this cross-sectional study, 120 patients filled out the Persian transcript of the test. After two weeks, the patients filled out the CAT test again. Obstruction severity was determined for all the patients using spirometry, and the patients were categorized into four groups according to the Global Initiative for Chronic Obstructive Lung Disease criteria. The relationship between the test scores and the disease severity wan validated.</p><p><strong>RESULTS:</strong> The mean age of the patients was 51.5 years. The Cronbach's alpha coefficient of the Persian transcript of the test was 0.872 in the first time, and 0.885 in the second time. Intragroup reliability, test re-test and intragroup correlations were significant for all the questions (&lt;0.001). The relationship between the test mean score and obstruction severity was significant, and the correlation between disease categorization in accordance with obstruction severity and categorization according to the test score was significant as well.</p><p><strong>CONCLUSION:</strong> The Persian transcript of the assessment test for COPD was reliable and is directly related to the disease severity according to airflow limitation.</p>

scholarly journals Prevalence and clinical significance of microalbuminuria and hypoxemia in patients with chronic obstructive pulmonary disease

2019 ◽  
Vol 6 (4) ◽  
pp. 1299
Author(s):  
Poonam Gupta ◽  
Anand Kumar ◽  
Ajeet Kumar Chaurasia ◽  
Arvind Gupta
Keyword(s):  
Blood Gases ◽  
Lung Function Test ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Spot Urine ◽  
Bode Index ◽  
Arterial Blood ◽  
Copd Patients

Background: Microalbuminuria is a sign of glomerular dysfunction in general and sign of tubulointerstitial disease to a lesser extent. Hypoxia induces endothelial cell to release a number of different vasoactive agents including endotheline-1, platelet derived growth factor (PDGF), nitric oxide; that causes endothelial injury and lead to microalbuminuria. This study was aimed to assess the prevalence of microalbuminuria in COPD patients and assess the Relationship of microalbuminuria with the disease severity in the forms of FEV1, PaO2, PaCO2, and BODE INDEX in COPD patients.Methods: Total 130 COPD patients were included in our cross sectional study. Total patients were divided into two groups, 1st group was COPD with microalbuminuria while 2nd group was COPD without microalbuminuria. Lung function test, 6 min walk distance, arterial blood pressure (BP), BODE index, arterial blood gases, fasting and post prandial plasma glucose and kidney function tests were measured. Screening for microalbuminuria was done by measuring urinary microalbumin in a random spot urine collection.Results: The prevalence of microalbuminuria was 29.23% in patients of COPD. As compared with COPD without microalbuminuria group, COPD with microalbuminuria group were more hypoxic (12% vs 74%, P=0.0001 ), more hypercapnic (22% vs 84%, p=0.00001) and most of the patients with grade III (16% vs 34%, p=0.00001) or grade IV (19% vs 47%, p=0.00001) severity (according to GOLD criteria).Conclusions: Patients with severe COPD with hypoxemia or hypercapnia were significantly associated with microalbuminuria.

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