scholarly journals Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2

2020 ◽  
Author(s):  
Jianzhong Shi ◽  
Zhiyuan Wen ◽  
Gongxun Zhong ◽  
Huanliang Yang ◽  
Chong Wang ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Severe Acute Respiratory Syndrome ◽  
Close Contact ◽  
Domestic Animals ◽  
Sars Coronavirus ◽  
Animal Management ◽  
Global Pandemic ◽  
Respiratory Droplets ◽  
Animal Reservoirs

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19, which was first reported in Wuhan, China in December, 2019. Despite the tremendous efforts to control the disease, COVID-19 has now spread to over 100 countries and caused a global pandemic. SARS-CoV-2 is thought to have originated in bats; however, the intermediate animal sources of the virus are completely unknown. Here, we investigated the susceptibility of ferrets and animals in close contact with humans to SARS-CoV-2. We found that SARS-CoV-2 replicates poorly in dogs, pigs, chickens, and ducks, but efficiently in ferrets and cats. We found that the virus transmits in cats via respiratory droplets. Our study provides important insights into the animal reservoirs of SARS-CoV-2 and animal management for COVID-19 control.

scholarly journals Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2

Science ◽  
2020 ◽  
Vol 368 (6494) ◽  
pp. 1016-1020 ◽  
Author(s):  
Jianzhong Shi ◽  
Zhiyuan Wen ◽  
Gongxun Zhong ◽  
Huanliang Yang ◽  
Chong Wang ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Animal Models ◽  
Severe Acute Respiratory Syndrome ◽  
Close Contact ◽  
Sars Coronavirus ◽  
Airborne Transmission ◽  
Domesticated Animals ◽  
Animal Management ◽  
Global Pandemic

Severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) causes the infectious disease COVID-19 (coronavirus disease 2019), which was first reported in Wuhan, China, in December 2019. Despite extensive efforts to control the disease, COVID-19 has now spread to more than 100 countries and caused a global pandemic. SARS-CoV-2 is thought to have originated in bats; however, the intermediate animal sources of the virus are unknown. In this study, we investigated the susceptibility of ferrets and animals in close contact with humans to SARS-CoV-2. We found that SARS-CoV-2 replicates poorly in dogs, pigs, chickens, and ducks, but ferrets and cats are permissive to infection. Additionally, cats are susceptible to airborne transmission. Our study provides insights into the animal models for SARS-CoV-2 and animal management for COVID-19 control.

scholarly journals Disinfection of SARS-CoV-2 Contaminated Surfaces of Personal Items with UVC-LED Disinfection Boxes

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 598
Author(s):  
Maren Bormann ◽  
Mira Alt ◽  
Leonie Schipper ◽  
Lukas van de Sand ◽  
Mona Otte ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Close Contact ◽  
Credit Cards ◽  
Organic Matrix ◽  
Viral Loads ◽  
Small Aerosol ◽  
Time Periods ◽  
Respiratory Droplets ◽  
Glass Metal

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted from person to person by close contact, small aerosol respiratory droplets, and potentially via contact with contaminated surfaces. Herein, we investigated the effectiveness of commercial UVC-LED disinfection boxes in inactivating SARS-CoV-2-contaminated surfaces of personal items. We contaminated glass, metal, and plastic samples representing the surfaces of personal items such as smartphones, coins, or credit cards with SARS-CoV-2 formulated in an organic matrix mimicking human respiratory secretions. For disinfection, the samples were placed at different distances from UVC emitting LEDs inside commercial UVC-LED disinfection boxes and irradiated for different time periods (up to 10 min). High viral loads of SARS-CoV-2 were effectively inactivated on all surfaces after 3 min of irradiation. Even 10 s of UVC-exposure strongly reduced viral loads. Thus, UVC-LED boxes proved to be an effective method for disinfecting SARS-CoV-2-contaminated surfaces that are typically found on personal items.

scholarly journals Questioning COVID-19 Surface Stability and Fomite Spreading in Three Aeromedical Cases: A Case Series

2020 ◽  
Author(s):  
Sean Horoho ◽  
Stephen Musik ◽  
David Bryant ◽  
William Brooks ◽  
Ian M Porter
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Close Contact ◽  
Small Sample Size ◽  
Case Series ◽  
Small Sample ◽  
Posture Analysis ◽  
Surface Stability ◽  
Single Positive ◽  
Means Of Transmission ◽  
Respiratory Droplets

ABSTRACT It is well established that coronavirus disease 2019 is primarily transmitted through respiratory droplets, and there is mounting research speculation that it may also be transmitted via fomites. Several studies have shown that the virus can persist on both porous and nonporous surfaces for hours to days, depending upon the material. This article examines three cases of polymerase chain reaction–proven severe acute respiratory syndrome coronavirus 2 infection with several additional individuals meeting CDC close contact criteria. In 1 case, 195 downstream contacts were all tested to prevent a mass outbreak in a deployment posture. Analysis of these contacts yielded only a single positive test, which could be reasonably ascribed to respiratory droplet transmission. While these cases and their contacts ultimately represent a small sample size, we suggest fomite spread may not be a significant means of transmission for severe acute respiratory syndrome coronavirus 2 in real-world operational scenarios.

scholarly journals South Korean Nurses’ Experiences with Patient Care at a COVID-19-Designated Hospital: Growth after the Frontline Battle against an Infectious Disease Pandemic

2020 ◽  
Vol 17 (23) ◽  
pp. 9015
Author(s):  
Nayoon Lee ◽  
Hyun-Ju Lee
Keyword(s):  
Infectious Disease ◽  
Close Contact ◽  
Hospital Nurses ◽  
Post Traumatic Stress ◽  
Telephone Interviews ◽  
Post Traumatic Growth ◽  
Global Pandemic ◽  
Post Traumatic ◽  
Positive Experiences ◽  
Novel Coronavirus

COVID-19 is a respiratory disease caused by a novel coronavirus that quickly spread worldwide, resulting in a global pandemic. Healthcare professionals coming into close contact with COVID-19 patients experience mental health issues, including stress, depression, anxiety, post-traumatic stress disorder, and burnout. This study aimed to explore the experiences of COVID-19-designated hospital nurses in South Korea who provided care for patients based on their lived experiences. Eighteen nurses working in a COVID-19-designated hospital completed in-depth individual telephone interviews between July and September 2020, and the data were analyzed using Giorgi’s phenomenological methodology. The essential structure of the phenomenon was growth after the frontline battle against an infectious disease pandemic. Nine themes were identified: Pushed onto the Battlefield Without Any Preparation, Struggling on the Frontline, Altered Daily Life, Low Morale, Unexpectedly Long War, Ambivalence Toward Patients, Forces that Keep Me Going, Giving Meaning to My Work, and Taking Another Step in One’s Growth. The nurses who cared for patients with COVID-19 had both negative and positive experiences, including post-traumatic growth. These findings could be used as basic data for establishing hospital systems and policies to support frontline nurses coping with infectious disease control to increase their adaption and positive experiences.

scholarly journals EFFICACY OF SARS-COV-2 VACCINES - A BIG CHALLENGE ?

2021 ◽  
pp. 92-95
Author(s):  
Saumya Srivastava ◽  
Vandana Sardana
Keyword(s):  
Infectious Disease ◽  
Severe Acute Respiratory Syndrome ◽  
Social Distance ◽  
Prevention And Control ◽  
Infection Prevention ◽  
Close Contact ◽  
Infection Prevention And Control ◽  
Vaccine Candidates ◽  
The World ◽  
And Control

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and the resulting disease, the coronavirus infectious disease 2019 (COVID-19), have spread to millions of persons worldwide resulting in pandemic.The cases of Covid 19 doesn't seem to end to soon.There are about sixty-two million six hundred nineteen thousand three hundred ninety-ninecases at present in the world with India ranking second after USA with nine million three hundred ninetythree thousand thirty-nine cases.Adoption of infection prevention and control practices such as hand hygiene, respiratory etiquettes, and maintaining social distance are the important strategies for the containment of this deadly and stubborn novel corona virus.The multiple vaccine candidates are under trials,to evaluate their clinical efficacy.The vaccination aims is to generate immunity against COVID-19 and to protect oneself against the disease and limits the spread of disease to close contact

scholarly journals Absence of SARS-CoV-2 infection in cats and dogs in close contact with a cluster of COVID-19 patients in a veterinary campus

2020 ◽  
Author(s):  
Sarah Temmam ◽  
Alix Barbarino ◽  
Djérène Maso ◽  
Sylvie Behillil ◽  
Vincent Enouf ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Close Contact ◽  
Clinical Signs ◽  
Original Data ◽  
Domestic Animals ◽  
Rt Pcr ◽  
Immunoprecipitation Assay ◽  
Wild Fauna ◽  
Environment Exposure ◽  
Coronavirus Infection

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, in 2019, is responsible for the COVID-19 pandemic. It is now accepted that the wild fauna, probably bats, constitute the initial reservoir of the virus, but little is known about the role pets can play in the spread of the disease in human communities, knowing the ability of SARS-CoV-2 to infect some domestic animals. We tested 21 domestic pets (9 cats and 12 dogs) living in close contact with their owners (belonging to a veterinary community of 20 students) in which two students tested positive for COVID-19 and several others (n = 11/18) consecutively showed clinical signs (fever, cough, anosmia, etc.) compatible with COVID-19 infection. Although a few pets presented many clinical signs indicative for a coronavirus infection, no animal tested positive for SARS-CoV-2 by RT-PCR and no antibodies against SARS-CoV-2 were detectable in their blood using an immunoprecipitation assay. These original data can serve a better evaluation of the host range of SARS-CoV-2 in natural environment exposure conditions.

scholarly journals Insights Into the Changing Landscape of Coronavirus Disease 2019

2022 ◽  
Vol 11 ◽  
Author(s):  
Ruby A. Escobedo ◽  
Deepak Kaushal ◽  
Dhiraj K. Singh
Keyword(s):  
Infectious Disease ◽  
Personalized Medicine ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Manifestations ◽  
World Health ◽  
Disease Treatment ◽  
Global Pandemic ◽  
The World ◽  
Dynamic Landscape ◽  
Health Organization

Coronavirus disease 2019 (COVID-19) is a highly contagious, infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in late 2019 in Wuhan China. A year after the World Health Organization declared COVID-19 a global pandemic, over 215 million confirmed cases and approximately 5 million deaths have been reported worldwide. In this multidisciplinary review, we summarize important insights for COVID-19, ranging from its origin, pathology, epidemiology, to clinical manifestations and treatment. More importantly, we also highlight the foundational connection between genetics and the development of personalized medicine and how these aspects have an impact on disease treatment and management in the dynamic landscape of this pandemic.

scholarly journals Efficacy of bioflavonoids of FLAVOBA against severe acute respiratory syndrome-coronavirus 2 in vitro

2021 ◽  
Vol 8 (2) ◽  
pp. 95-99
Author(s):  
Abdelahhad Barbour ◽  
◽  
Lynda Gail Darlington ◽  
Michelle Mendenhall ◽  
Henriette Lerner ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Oral Care ◽  
Virucidal Activity ◽  
Oral Rinse ◽  
Global Pandemic ◽  
Transmission Reduction ◽  
Oral Decontamination ◽  
Respiratory Droplets ◽  
Virucidal Efficacy

Introduction The Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) is responsible for the global pandemic of Coronavirus disease-2019 (COVID-19). Human-to-human transmission occurs mainly through the aerosolization of respiratory droplets. Improved antisepsis of human and non-human surfaces has been identified as a key feature of transmission reduction. Flavobac, a complex of soluble bioflavonoids and hydroxylated phenolic structures used in oral care products, has demonstrated efficacy to act against microorganisms. This study evaluated nasal and oral antiseptic formulations of FLAVOBAC for the virucidal activity against SARS-CoV-2. Methodology FLAVOBAC nasal antiseptic formulations and FLAVOBAC oral rinse antiseptic formulations from 1-10% concentrations were assayed for virucidal efficacy against the SARS-CoV-2 virus. SARS-CoV-2 was exposed directly to the test compound for 60 seconds or 5 minutes. Compounds were then neutralized, and the surviving virus was quantified. Results All concentrations of nasal antiseptics and oral rinse antiseptics evaluated completely inactivated the SARS-CoV-2 virus. Conclusion Nasal and oral FLAVOBAC solutions are effective at inactivating the SARS-CoV-2 virus at a variety of concentrations after 60-second or 5-minute exposure times. The formulations tested have the potential to reduce the transmission of SARS-CoV-2 if used for nasal/oral decontamination, or surface decontamination in known or suspected cases of COVID-19.

scholarly journals Disinfection of SARS-CoV-2 contaminated surfaces of personal items with UVC-LED disinfection boxes

2021 ◽  
Author(s):  
Maren Bormann ◽  
Mira Alt ◽  
Leonie Schipper ◽  
Lukas van de Sand ◽  
Mona Otte ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Close Contact ◽  
Credit Cards ◽  
Organic Matrix ◽  
Viral Loads ◽  
Small Aerosol ◽  
Time Periods ◽  
Respiratory Droplets ◽  
Glass Metal

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted from person-to-person by close contact, small aerosol respiratory droplets and potentially via contact with contaminated surfaces. Here, we investigated the effectiveness of commercial UVC-LED disinfection boxes in inactivating SARS-CoV-2 contaminated surfaces of personal items. We contaminated glass, metal and plastic samples representing the surfaces of personal items such as smartphones, coins or credit cards with SARS-CoV-2 formulated in an organic matrix mimicking human respiratory secretions. For disinfection, the samples were placed at different distances from UVC emitting LEDs inside commercial UVC-LED disinfection boxes and irradiated for different time periods (up to 10 minutes). High viral loads of SARS-CoV-2 were effectively inactivated on all surfaces after 3 minutes of irradiation. Even 10 seconds of UVC-exposure strongly reduced viral loads. Thus, UVC-LED boxes proved to be an effective method for disinfecting SARS-CoV-2 contaminated surfaces that are typically found on personal items.

scholarly journals Efficacy of Povidone-Iodine Nasal and Oral Antiseptic Preparations Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)

2020 ◽  
pp. 014556132095723 ◽  
Author(s):  
Jesse S. Pelletier ◽  
Belachew Tessema ◽  
Samantha Frank ◽  
Jonna B. Westover ◽  
Seth M. Brown ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Povidone Iodine ◽  
Virucidal Activity ◽  
Oral Rinse ◽  
Global Pandemic ◽  
Transmission Reduction ◽  
Oral Decontamination ◽  
Respiratory Droplets ◽  
Virucidal Efficacy ◽  
Antiseptic Solutions

Introduction: Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the global pandemic of coronavirus disease 2019 (COVID-19). From the first reported cases in December 2019, the virus has spread to over 4 million people worldwide. Human-to-human transmission occurs mainly through the aerosolization of respiratory droplets. Transmission also occurs through contact with contaminated surfaces and other fomites. Improved antisepsis of human and nonhuman surfaces has been identified as a key feature of transmission reduction. There are no previous studies of povidone iodine (PVP-I) against SARS-CoV-2. This study evaluated nasal and oral antiseptic formulations of PVP-I for virucidal activity against SARS-CoV-2. This is the first report on the efficacy of PVP-I against the virus that causes COVID-19. Methods: Povidone iodine nasal antiseptic formulations and PVP-I oral rinse antiseptic formulations from 1% to 5% concentrations as well as controls were studied for virucidal efficacy against the SARS-CoV-2. Test compounds were evaluated for ability to inactivate SARS-CoV-2 as measured in a virucidal assay. SARS-CoV-2 was exposed directly to the test compound for 60 seconds, compounds were then neutralized, and surviving virus was quantified. Results: All concentrations of nasal antiseptics and oral rinse antiseptics evaluated completely inactivated the SARS-CoV-2. Conclusions: Nasal and oral PVP-I antiseptic solutions are effective at inactivating the SARS-CoV-2 at a variety of concentrations after 60-second exposure times. The formulations tested may help to reduce the transmission of SARS-CoV-2 if used for nasal decontamination, oral decontamination, or surface decontamination in known or suspected cases of COVID-19.

Sign in / Sign up

Export Citation Format

Share Document