scholarly journals Parents' and guardians' views on the acceptability of a future Covid-19 vaccine: a multi-methods study in England

2020 ◽  
Author(s):  
Sadie L Bell ◽  
Richard Clarke ◽  
Sandra Mounier-Jack ◽  
Jemma L Walker ◽  
Pauline Paterson
Keyword(s):  
Rapid Development ◽  
Vaccine Safety ◽  
Lower Income ◽  
Structured Interviews ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
The Public ◽  
Income Groups ◽  
Self Protection

Background: The availability of a COVID-19 vaccine has been heralded as key to controlling the COVID-19 pandemic. COVID-19 vaccination programme success will rely on public willingness to be vaccinated. Methods: We used a multi-methods approach - involving an online cross-sectional survey and semi-structured interviews - to investigate parents' and guardians' views on the acceptability of a future COVID-19 vaccine. 1252 parents and guardians (aged 16+ years) who reported living in England with a child aged 18 months or under completed the survey. Nineteen survey respondents were interviewed. Findings: Most participants reported they would definitely accept or were unsure but leaning towards accepting a COVID-19 vaccine for themselves (Definitely 55.8%; Unsure but leaning towards yes 34.3%) and their child/children (Definitely 48.2%; Unsure but leaning towards yes 40.9%). Less than 4% of participants reported that they would definitely not accept a COVID-19 vaccine for themselves or their child/children. Participants were more likely to accept a COVID-19 vaccine for themselves than for their child/children. Participants that self-reported as Black, Asian, Chinese, Mixed or Other ethnicity were almost 3 times more likely to reject a COVID-19 vaccine for themselves and their children than White British, White Irish and White Other participants. Respondents from lower income households were also more likely to reject a COVID-19 vaccine. The main reason for vaccine acceptance was for self-protection from COVID-19. Common concerns were around COVID-19 vaccine safety and effectiveness, which were largely prompted by the newness and rapid development of the vaccine. Conclusion: To alleviate concerns, information on how COVID-19 vaccines are developed and tested, including their safety and efficacy, must be communicated clearly to the public. To prevent inequalities in uptake, it is crucial to understand and address factors that may affect COVID-19 vaccine acceptability in ethnic minority and lower-income groups who are disproportionately affected by COVID-19.

scholarly journals COVID-19 Vaccine Acceptability: A Cross-Sectional Mixed Methods Study in Sierra Leone

2021 ◽  
Author(s):  
Mahmud Sheku ◽  
Ralf Clemens ◽  
Sue Ann Costa Clemens ◽  
Jia Bainga Kangbai ◽  
Iynnah Kargbo ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Vaccine Development ◽  
Vaccine Safety ◽  
Structured Interviews ◽  
Cross Sectional Survey ◽  
Efficacy Evaluation ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
Media Reports ◽  
The Cost

Abstract Background: Global immunization is critical to combat the COVID-19 pandemic and the public's willingness to be vaccinated will determine the success of elimination efforts. We measured the acceptability of COVID-19 vaccine and views in Sierra Leone.Method: We used a multi-method study including an online cross-sectional survey and semi-structured interviews to assess the acceptance of and perceptions about COVID-19 vaccination among 2146 Sierra Leoneans aged 18 years and above. Results: Most survey respondents (80.1%, n = 1719) would accept COVID-19 vaccination for themselves and close family,but 19.9% (n = 427) would reject vaccination. If vaccination was mandatory the acceptance rate would increase to 85.0%, (n = 1,823), while 15.0% (n = 318) of responders would still reject. COVID-19 vaccine awareness was high among respondents (yes: 75.2% n = 1613, no: 24.8%, n = 533).Safety, immunity, and trust in vaccines were the main reasons for vaccine acceptance. Distrust, uncertainties about vaccine safety and effectivenessand lack of belief in the COVID-19 pandemic triggered through media reports were the mainreasons for rejecting the COVID-19 vaccination. With respect to vaccine,a small majority would prefer a less reactogenic vaccine even at the cost of a lower efficacy over a more effective but more reactogenic vaccine (55.7%, n = 1195 vs 41.5%, n = 890) while2.8% (n = 61) of respondents said they would reject any vaccine.Country of origin had an important role in vaccine acceptance: 32.4% (n = 1121) would accept a vaccine from any country if licensed locally, but15.1%(n = 511) would rejectvaccines even if licensed from China,12.6% (n = 437), India11.4% (n = 393), USA 8.0% (n = 276), Germany7.8% (n = 271), Russia 7.7% (n = 267), UKand 5.0% (n = 173)from Belgium.Conclusion: Sensitizing the public about the COVID-19 infection risk, vaccine development processesand ensuring vaccine safety through continuous communication and community engagement, with community leaders leading by example as well as the independent role of regulatory authorities in safety and efficacy evaluation, would improve COVID-19 vaccine acceptance.

scholarly journals COVID-19 Vaccine Acceptance in a Sample From the United Arab Emirates General Adult Population: A Cross-Sectional Survey, 2020

2021 ◽  
Vol 9 ◽  
Author(s):  
Abdulaziz Hussain Albahri ◽  
Shahad Ahmed Alnaqbi ◽  
Asma Obaid Alshaali ◽  
Shatha Ahmed Alnaqbi ◽  
Shaikha Mohammad Shahdoor
Keyword(s):  
Influenza Vaccine ◽  
United Arab Emirates ◽  
Vaccine Safety ◽  
Vaccine Hesitancy ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
The Public ◽  
The Future ◽  
Vaccination Hesitancy

Introduction: The COVID-19 pandemic has placed a tremendous stress on economies and healthcare systems worldwide. Having a vaccine is one of the promising solutions. However, vaccination hesitancy is becoming a recognized future challenge. This study aims to evaluate the current vaccine hesitancy in a segment of the United Arab Emirates (UAE) general public and its associated factors.Methods: This was an online cross-sectional survey that took place from the 14th to the 19th of September 2020 across the UAE. The questionnaire asked the participants about their willingness to receive the COVID-19 vaccine in the future. Multivariable logistic regression analysis was used to assess the association between vaccination willingness and the participants' sociodemographic factors, experiences and beliefs regarding COVID-19, and previous influenza vaccine uptake.Results: There was a total of 2,705 participants; 72.5% were females, and 69.8% were Emirati nationals. A total of 1,627 (60.1%) participants were willing to take the COVID-19 vaccine in the future. There were statistically significant associations between the following factors and vaccine acceptance: male gender, non-Emiratis, younger age group, residents of Sharjah and the Northern Emirates, having lesser educational attainment, perceived increased personal or public risk of contracting the disease [aOR = 1.71, 95% CI (1.35–2.17), p < 0.0001; aOR = 1.84, 95% CI (1.44–2.36), p < 0.0001, respectively], and increased perception of serious outcome from the disease. Conversely, vaccine hesitancy was associated with unemployment, not receiving the influenza vaccine within the past 2 years [aOR = 0.36, 95% CI (0.30–0.44), p < 0.0001], not believing in the seriousness of the COVID-19 situation or the vaccine's ability to control the pandemic, and not believing that the public authorities are handling the pandemic adequately. Having contracted the disease or knowing someone who has did not show a statistically significant association with vaccine acceptance. Vaccine safety, side effects, and the belief that one needs to develop immunity naturally were the top reasons for vaccination hesitancy.Conclusion: Given the level of vaccine hesitancy in the study population, this needs to be evaluated in a more representative sample of the whole population. If confirmed, this would signify the need for coordinated local and international initiatives to combat vaccine misinformation and reassure the public regarding vaccine safety and efficacy.

scholarly journals Vaccine hesitancy among healthcare providers during COVID-19 pandemic

2021 ◽  
Vol 31 (Supplement_3) ◽  
Author(s):  
F Algabbani ◽  
A Algabbani
Keyword(s):  
Healthcare Providers ◽  
Vaccine Safety ◽  
Vaccine Hesitancy ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
Web Based ◽  
Global Health Issue ◽  
Vaccine Confidence ◽  
And Control

Abstract   Public trust in vaccines is a major global health issue. This study aims to assess the vaccine acceptance among healthcare workers and their confidence and hesitancy of the COVID19 vaccine. This was a multicenter cross-sectional survey conducted among healthcare providers in Riyadh, the capital of Saudi Arabia. Data collection was carried out between October and November of 2020 through a web-based survey. COVID19 vaccine hesitancy was assessed using eight structured items adapted from the 5Cs. About 34.6% (95% CI: 27.6%-42.4%) of participants were willing to vaccinate against COVID-19 and 44% (95% CI: 36.5%-51.9%) will recommend the vaccine to their patients. About 45% of participants were neutral regarding vaccine safety and 40% were neutral regarding vaccine effectiveness. Almost 70% believe that the duration of clinical studies of the COVID-19 vaccines affects their confidence in the efficacy and safety of the vaccine. Those who never hesitated or delayed taking any of the recommended vaccination were more likely to be willing to vaccinate COVID-19 (OR 5.46, 95% CI: 2.49-11.98). Assessing the level of vaccine confidence in the population and associated factors will help implement an effective national vaccine program to enhance vaccination uptake and control COVID19 spread during this pandemic. Key messages Vaccine hesitancy is challenging vaccination goals at the national and global level. Hesitancy from the population toward vaccine and concerns regarding its safety and efficacy was observed with the development of a novel vaccine for COVID19 a newly emerged infection.

scholarly journals COVID-19 Vaccine Acceptability: A Cross-Sectional Mixed Methods Study in Sierra Leone

2021 ◽  
Author(s):  
Mahmud Sheku ◽  
Ralf Clemens ◽  
Sue Ann Costa Clemens ◽  
Jia Bainga Kangbai ◽  
Iynnah Kargbo ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Vaccine Development ◽  
Vaccine Safety ◽  
Efficacy Evaluation ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
The Public ◽  
Development Processes ◽  
Media Reports ◽  
The Cost

Abstract Background Global immunization is critical to combat the COVID-19 pandemic and the public's willingness to be vaccinated will determine the success of elimination efforts. We measured the acceptability of COVID-19 vaccine and views in Sierra Leone. Results Most survey respondents (80.1%, n = 1719) would accept COVID-19 vaccination for themselves and close family, but 19.9% (n = 427) would reject vaccination. If vaccination was mandatory the acceptance rate would increase to 85.0%, (n = 1,823), while 15.0% (n = 318) of responders would still reject. COVID-19 vaccine awareness was high among respondents (yes: 75.2% n = 1613, no: 24.8%, n = 533). Safety, immunity, and trust in vaccines were the main reasons for vaccine acceptance. Distrust, uncertainties about vaccine safety and effectiveness and lack of belief in the COVID-19 pandemic triggered through media reports were the main reasons for rejecting the COVID-19 vaccination. With respect to vaccine, a small majority would prefer a less reactogenic vaccine even at the cost of a lower efficacy over a more effective but more reactogenic vaccine (55.7%, n = 1195 vs 41.5%, n = 890) while 2.8% (n = 61) of respondents said they would reject any vaccine. Country of origin had an important role in vaccine acceptance: 32.4% (n = 1121) would accept a vaccine from any country if licensed locally, but 15.1% (n = 511) would reject vaccines even if licensed from China,12.6% (n = 437), India 11.4% (n = 393), USA 8.0% (n = 276), Germany 7.8% (n = 271), Russia 7.7% (n = 267), UK and 5.0% (n = 173) from Belgium. Conclusion Sensitizing the public about the COVID-19 infection risk, vaccine development processes and ensuring vaccine safety through continuous communication and community engagement, with community leaders leading by example as well as the independent role of regulatory authorities in safety and efficacy evaluation, would improve COVID-19 vaccine acceptance.

scholarly journals Factors Associated with Healthcare Workers’ (HCWs) Acceptance of COVID-19 Vaccinations and Indications of a Role Model towards Population Vaccinations from a Cross-Sectional Survey in Greece, May 2021

2021 ◽  
Vol 18 (19) ◽  
pp. 10558
Author(s):  
Konstantinos Fotiadis ◽  
Katerina Dadouli ◽  
Ioanna Avakian ◽  
Zacharoula Bogogiannidou ◽  
Varvara A. Mouchtouri ◽  
...  
Keyword(s):  
Role Models ◽  
Healthcare Workers ◽  
Role Model ◽  
Strong Association ◽  
Vaccine Safety ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
Information Campaigns ◽  
Attitudes And Practices

A Knowledge, Attitudes and Practices (KAP) study was conducted at the end of May 2021 engaging 1456 healthcare workers (HCWs) from 20 hospitals throughout Greece. Acceptance of vaccination against coronavirus disease 2019 (COVID-19) was estimated at 77.7%, with lower vaccine acceptance identified in nurses compared to physicians. Fears related to vaccine safety, lack of information and general knowledge about vaccinations, influenza vaccine acceptance, education level and years of practice were among the factors independently associated with vaccine acceptance. A strong association was identified between vaccination of HCWs in each health region and the population coverage, indicating that HCWs may be role models for the general population. Information campaigns should continue despite decisions taken regarding mandatory vaccinations.

scholarly journals Differential Effect of Vaccine Effectiveness and Safety on COVID-19 Vaccine Acceptance across Socioeconomic Groups in an International Sample

Vaccines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1010
Author(s):  
Stefania Kerekes ◽  
Mengdi Ji ◽  
Shu-Fang Shih ◽  
Hao-Yuan Chang ◽  
Harapan Harapan ◽  
...  
Keyword(s):  
Age Groups ◽  
Mainland China ◽  
Vaccine Safety ◽  
Vaccine Effectiveness ◽  
Effective Vaccine ◽  
Lower Income ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
The Us ◽  
Over Time

Controlling the spread of SARS-CoV-2 will require high vaccination coverage, but acceptance of the vaccine could be impacted by perceptions of vaccine safety and effectiveness. The aim of this study was to characterize how vaccine safety and effectiveness impact acceptance of a vaccine, and whether this impact varied over time or across socioeconomic and demographic groups. Repeated cross-sectional surveys of an opt-in internet sample were conducted in 2020 in the US, mainland China, Taiwan, Malaysia, Indonesia, and India. Individuals were randomized into receiving information about a hypothetical COVID-19 vaccine with different safety and effectiveness profiles (risk of fever 5% vs. 20% and vaccine effectiveness 50% vs. 95%). We examined the effect of the vaccine profile on vaccine acceptance in a logistic regression model, and included interaction terms between vaccine profile and socioeconomic/demographic variables to examine the differences in sensitivity to the vaccine profile. In total, 12,915 participants were enrolled in the six-country study, including the US (4054), China (2797), Taiwan (1278), Malaysia (1497), Indonesia (1527), and India (1762). Across time and countries, respondents had stronger preferences for a safer and more effective vaccine. For example, in the US in November 2020, acceptance was 3.10 times higher for a 95% effective vaccine with a 5% risk of fever, vs a vaccine 50% effective, with a 20% risk of fever (95% CI: 2.07, 4.63). Across all countries, there was an increase in the effect of the vaccine profile over time (p < 0.0001), with stronger preferences for a more effective and safer vaccine in November 2020 compared to August 2020. Sensitivity to the vaccine profile was also stronger in August compared to November 2020, in younger age groups, among those with lower income; and in those that are vaccine hesitant. Uptake of COVID-19 vaccines could vary in a country based upon effectiveness and availability. Effective communication tools will need to be developed for certain sensitive groups, including young adults, those with lower income, and those more vaccine hesitant.

scholarly journals Conditionality of COVID-19 vaccine acceptance in European countries

2021 ◽  
Author(s):  
Leonardo w Heyerdahl ◽  
Muriel Vray ◽  
Benedetta Lana ◽  
Nastassia Tvardik ◽  
Nina Gobat ◽  
...  
Keyword(s):  
Public Health ◽  
Vaccine Coverage ◽  
Herd Immunity ◽  
Preventive Measure ◽  
Vaccine Safety ◽  
Health Campaigns ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
Public Health Campaigns

The COVID-19 vaccine rollout in recent months offers a powerful preventive measure that may help control SARS-CoV-2 transmission. Nevertheless, long-standing public hesitation around vaccines has heightened public health concerns that vaccine coverage may not achieve desired public health impacts.This cross-sectional survey was conducted online in December 2020 among 7000 respondents (aged 18 to 65) in Belgium, France, Germany, Italy, Spain, Sweden, and Ukraine. The survey included open text boxes for fuller explanation of responses. Projected COVID-19 vaccine coverage varied and may not be sufficiently high among certain populations to achieve herd immunity. Overall, 56.9% would accept a COVID-19 vaccine, 19.0% would not, and 24.1% did not know or preferred not to say. By country, between 44% (France) and 66% (Italy) of respondents would accept a COVID-19 vaccine. Respondents expressed conditionality in open responses, voicing concerns about vaccine safety and mistrust of authorities. Public health campaigns must tackle these safety concerns.

scholarly journals Motivation to COVID-19 Vaccination and Reasons for Hesitancy in Employees of a Czech Tertiary Care Hospital: A Cross-Sectional Survey

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 863
Author(s):  
Ladislav Štěpánek ◽  
Magdaléna Janošíková ◽  
Marie Nakládalová ◽  
Lubomír Štěpánek ◽  
Alena Boriková ◽  
...  
Keyword(s):  
Vaccination Coverage ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Vaccine Safety ◽  
Care Hospital ◽  
Cross Sectional Survey ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
History Of

High vaccination coverage among healthcare workers (HCWs) is crucial for managing the COVID-19 pandemic. The aim was to determine the demand for vaccination among all employees (n = 4553) of a tertiary care hospital after several weeks of the vaccine’s availability, and to analyze motives for acceptance and reasons for hesitancy through an anonymous online questionnaire. Upon the completion of data collection, the hospital’s vaccination coverage was at 69.8%. A total of 3550 completed questionnaires were obtained (2657 from vaccinated, 893 from unvaccinated employees). Significant predictors of vaccine acceptance were: age (odds ratio (OR) 1.01, 95% confidence interval (CI) 1.01–1.02), sex (OR (females) 0.58, 95% CI 0.45–0.75), job type (OR (non-physician HCWs) 0.54, 95% CI 0.41–0.72; OR (non-HCWs) 0.51, 95% CI 0.37–0.71), fear of COVID-19 (OR 1.4, 95% CI 1.34–1.46), history of COVID-19 (OR 0.41, 95% CI 0.34–0.49) and of influenza vaccination (OR 2.74, 95% CI 2.12–3.57). The most frequent motive for acceptance was the effort to protect family members (84%), while concerns about vaccine safety and side effects (49.4%), followed by distrust in the vaccine’s efficacy (41.1%) were the top reasons for hesitancy. To increase vaccination coverage among HCWs, it is necessary to raise awareness of vaccine safety and efficacy.

scholarly journals When it is available, will we take it? Public perception of hypothetical COVID-19 vaccine in Nigeria

2020 ◽  
Author(s):  
Yusuff Adebayo Adebisi ◽  
Aishat Jumoke Alaran ◽  
Obasanjo Afolabi Bolarinwa ◽  
Wuraola Akande-Sholabi ◽  
Don Eliseo Lucero-Prisno
Keyword(s):  
Public Perception ◽  
Antiviral Treatment ◽  
Geographical Location ◽  
P Value ◽  
Global Public Health ◽  
Cross Sectional Survey ◽  
Online Questionnaire ◽  
Cross Sectional ◽  
Vaccine Acceptance ◽  
The Public

AbstractIntroductionCOVID-19 pandemic is a global public health threat facing mankind. There is no specific antiviral treatment for COVID-19, and no vaccine is currently available. This study aimed to understand the perception of the public towards a hypothetical COVID-19 vaccine in Nigeria.MethodWe conducted a cross-sectional survey in August 2020 across the 36 states of Nigeria using an online questionnaire. The questionnaire includes sections on the demographic characteristics of the respondents and their perception regarding a hypothetical COVID-19 vaccine. A total of 517 respondents completed and returned the informed consent along with the questionnaire electronically. Data were coded and abstracted into the Microsoft Excel spreadsheet and loaded into the STATA 14 software for final analysis.ResultsThe results showed that more than half of the respondents were male 294 (56.9%). Most of the respondents (385, 74.5%) intend to take the COVID-19 vaccine when it becomes available. Among the 132 respondents that would not take the COVID-19 vaccine, the major reason for non-acceptance was unreliability of the clinical trials 49 (37.1%), followed by the belief that their immune system was sufficient to combat the virus 36 (27.3%). There were significant association between the age of the respondents and the COVID-19 vaccine acceptance (P-value=0.00) as well as geographical location and COVID-19 vaccine acceptance (P-value=0.02).ConclusionIt was observed that most of the respondents were willing to take the COVID-19 vaccine. Our findings reiterate the need to reassure the public that any vaccine that becomes available will be safe and effective. In addition, there is a need for the national health authorities to ensure the public trust is earned and all communities, including the marginalized populations, are engaged properly to ensure an optimal COVID-19 vaccine acceptance.

scholarly journals The PROMISES study: a mixed methods approach to explore the acceptability of salivary progesterone testing for preterm birth risk among pregnant women and trained frontline healthcare workers in rural India

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e040268
Author(s):  
Danielle Ashworth ◽  
Pankhuri Sharma ◽  
Sergio A Silverio ◽  
Simi Khan ◽  
Nishtha Kathuria ◽  
...  
Keyword(s):  
Mixed Methods ◽  
Preterm Birth ◽  
Pregnant Women ◽  
Barriers And Facilitators ◽  
Rural India ◽  
Structured Interviews ◽  
Framework Analysis ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Thematic Framework

IntroductionIndia has an overall neonatal mortality rate of 28/1000 live births, with higher rates in rural India. Approximately 3.5 million pregnancies in India are affected by preterm birth (PTB) annually and contribute to approximately a quarter of PTBs globally. Embedded within the PROMISES study (which aims to validate a low-cost salivary progesterone test for early detection of PTB risk), we present a mixed methods explanatory sequential feasibility substudy of the salivary progesterone test.MethodsA pretraining and post-training questionnaire to assess Accredited Social Health Activists (ASHAs) (n=201) knowledge and experience of PTB and salivary progesterone sampling was analysed using the McNemar test. Descriptive statistics for a cross-sectional survey of pregnant women (n=400) are presented in which the acceptability of this test for pregnant women is assessed. Structured interviews were undertaken with ASHAs (n=10) and pregnant women (n=9), and were analysed using thematic framework analysis to explore the barriers and facilitators influencing the use of this test in rural India.ResultsBefore training, ASHAs’ knowledge of PTB (including risk factors, causes, postnatal support and testing) was very limited. After the training programme, there was a significant improvement in the ASHAs’ knowledge of PTB. All 400 women reported the salivary test was acceptable with the majority finding it easy but not quick or better than drawing blood. For the qualitative aspects of the study, analysis of interview data with ASHAs and women, our thematic framework comprised of three main areas: implementation of intervention; networks of influence and access to healthcare. Qualitative data were stratified and presented as barriers and facilitators.ConclusionThis study suggests support for ongoing investigations validating PTB testing using salivary progesterone in rural settings.

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