scholarly journals LH LepR neurons directly drive sustained food seeking behavior after AgRP neuronal deactivation via neuromodulation of NPY

2020 ◽  
Author(s):  
Younghee Lee ◽  
Ha Young Song ◽  
You Bin Kim ◽  
Kyu Sik Kim ◽  
Dong-Soo Ha ◽  
...  
Keyword(s):  
Feeding Behavior ◽  
Leptin Receptor ◽  
Feeding Behaviors ◽  
Approach Behavior ◽  
Food Search ◽  
Feeding Experiments ◽  
Neuron Activation ◽  
Imaging Results ◽  
Seeking Behavior ◽  
Food Seeking

1.AbstractAgouti-related protein (AgRP) has been believed to be the main driver of feeding behaviors ever since its discovery. However, recent studies using fiber photometry and optogenetics proved that feeding behaviors are not directly driven by AgRP neurons (temporal discrepancy between neuronal activity and behavior). To resolve this paradox, we conducted novel multi-phase feeding experiments to scrutinize the dynamics of AgRP. Fiber photometry study showed that AgRP neurons start to deactivate even before the initiation of the food search phase. Using optogenetics, we could prove that the feeding behavior induced by AgRP neuron activation had substantial temporal delay and the feeding behavior was sustained for substantial time even after cessation of optogenetic activation. These results indicate that AgRP neurons are not the direct driver of feeding behavior and another downstream neuron is the driver of feeding behavior. Leptin receptor (LepR) neurons in the lateral hypothalamus (LH). LH LepR neurons were activated before voluntary food search behavior initiation and showed robust increase after food approach behavior. Artificial activation of LH LepR neurons drives food search and food approach behavior. In accordance, chemogenetic activation of LepR neurons increased food search and food approach behaviors. Lastly, slice calcium imaging results showed the possibility that NPY from the AgRP neurons could be the downstream neuromodulator of AgRP neuron, driving LH LepR neuron activation. Overall, our study shows that AgRP neurons are not the direct drivers of feeding behavior, whereas LH LepR neurons directly drive sustained food seeking behavior.

scholarly journals Fluctuations in central and peripheral temperatures associated with feeding behavior in rats

2008 ◽  
Vol 295 (5) ◽  
pp. R1415-R1424 ◽  
Author(s):  
Michael S. Smirnov ◽  
Eugene A. Kiyatkin
Keyword(s):  
Feeding Behavior ◽  
Skin Temperature ◽  
Brain Activity ◽  
Temperature Fluctuations ◽  
Temporal Muscle ◽  
Temperature Changes ◽  
Food Container ◽  
Seeking Behavior ◽  
Lower Temperature ◽  
Food Seeking

We examined the pattern of temperature fluctuations in the nucleus accumbens (NAcc), temporal muscle, and skin, along with locomotion in food-deprived and nondeprived rats following the presentation of an open or closed food container and during subsequent eating or food-seeking behavior without eating. Although rats in food-deprived, quiet resting conditions had more than twofold lower spontaneous locomotion and lower temperature values than in nondeprived conditions, after presentation of a container, they consistently displayed food-seeking behavior, showing much larger and longer temperature changes. When the container was open, rats rapidly retrieved food and consumed it. Food consumption was preceded and accompanied by gradual increases in brain and muscle temperatures (∼1.5°C) and a weaker, delayed increase in skin temperature (∼0.8°C). All temperatures began to rapidly fall immediately after eating was completed, but NAcc and muscle temperatures returned to baseline after ∼35 min. When the container was closed and rats were unable to obtain food, they continued food-seeking activity during the entire period of presentation. Similar to eating, this activity was preceded and accompanied by gradual temperature increases in the brain and muscle, which were somewhat smaller than those during eating (∼1.2°C), with no changes in skin temperature. In contrast to trials with eating, NAcc and muscle temperatures continued to increase for ∼10 min after the container was removed from the cage and the rat continued food-seeking behavior, with a return to baselines after ∼50 min. These temperature fluctuations are discussed with respect to alterations in metabolic brain activity associated with feeding behavior, depending upon deprivation state and food availability.

scholarly journals Thirst interneurons that promote water seeking and limit feeding behavior in Drosophila

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Dan Landayan ◽  
Brian P Wang ◽  
Jennifer Zhou ◽  
Fred W Wolf
Keyword(s):  
Feeding Behavior ◽  
Internal State ◽  
Local Interneuron ◽  
Gaba A ◽  
Order Processing ◽  
Neuron Activation ◽  
Central Brain ◽  
Seeking Behavior ◽  
Brain Circuit ◽  
Limit Feeding

Thirst is a motivational state that drives behaviors to obtain water for fluid homeostasis. We identified two types of central brain interneurons that regulate thirsty water seeking in Drosophila, that we term the Janu neurons. Janu-GABA, a local interneuron in the subesophageal zone, is activated by water deprivation and is specific to thirsty seeking. Janu-AstA projects from the subesophageal zone to the superior medial protocerebrum, a higher order processing area. Janu-AstA signals with the neuropeptide Allatostatin A to promote water seeking and to inhibit feeding behavior. NPF (Drosophila NPY) neurons are postsynaptic to Janu-AstA for water seeking and feeding through the AstA-R2 galanin-like receptor. NPF neurons use NPF to regulate thirst and hunger behaviors. Flies choose Janu neuron activation, suggesting that thirsty seeking up a humidity gradient is rewarding. These findings identify novel central brain circuit elements that coordinate internal state drives to selectively control motivated seeking behavior.

Associations Between Parent–Child Communication and Connectedness, Parent Feeding Behavior, and Child Body Mass in Pre-Adolescent Children

2020 ◽  
Author(s):  
Kristina D Lowe ◽  
Mark A Lott ◽  
Chad D Jensen
Keyword(s):  
Feeding Behavior ◽  
Body Mass ◽  
Weight Status ◽  
Community Sample ◽  
Feeding Strategies ◽  
Feeding Behaviors ◽  
Parent Child Communication ◽  
Parental Feeding ◽  
Parent Feeding ◽  
Parent Child

Abstract Objective  This study evaluated associations between parent–child connectedness and communication, parent feeding behaviors (restriction, pressure to eat, and monitoring), and age- and sex-standardized child body mass index (zBMI) in a sample of pre-adolescent children aged 8–12 years. Methods  A community sample of three hundred and eight child–parent dyads completed measures of communication and connectedness. Parents completed a feeding behavior measure and children were weighed and their height was measured. We examined whether parental feeding behaviors and parent–child communication and connectedness predicted child zBMI and whether parental feeding behaviors moderated the association between parent–child communication and connectedness and child zBMI. Results  Feeding restriction was positively associated with zBMI, while both pressure to eat and food monitoring exhibited negative associations with zBMI. Child-reported communication was inversely associated with zBMI and parental pressure to eat moderated this association such that lower pressure to eat predicted a stronger association between communication and zBMI. Conclusions  These findings are consistent with previous research suggesting that parent feeding strategies and parent–child communication are important contributors to child weight status. This study also provides preliminary evidence suggesting that adaptive parent–child communication is associated with lower body mass when parents avoid pressuring their child to eat. Our study provides an important extension of this body of research into middle childhood, a relatively understudied developmental stage.

scholarly journals The sigma-1 receptor as key common factor in cocaine and food-seeking behaviors

2019 ◽  
Vol 63 (4) ◽  
pp. R81-R92 ◽  
Author(s):  
David Aguinaga ◽  
Mireia Casanovas ◽  
Rafael Rivas-Santisteban ◽  
Irene Reyes-Resina ◽  
Gemma Navarro ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Drugs Of Abuse ◽  
Common Factor ◽  
G Protein Coupled Receptors ◽  
Sigma 1 Receptor ◽  
New Findings ◽  
Sigma 1 ◽  
Seeking Behavior ◽  
Food Seeking ◽  
G Protein Coupled

Addiction and eating disorders involve brain reward circuits. Binge eating predisposes to addictive behavior, while the cessation of exposure to drugs of abuse leads to reward activities, including intake of tasty foods. Cocaine use is associated with a decrease in food intake, with reversal after drug use is discontinued. Exciting new findings show that receptors for the ‘hunger’ hormone, ghrelin, directly interact with the sigma-1 receptor (σ1R), which is a target of cocaine. σ1Rs are key players in regulating dopaminergic neurotransmission and ghrelin-mediated actions. This review focuses on the σ1 receptor as a general neuroendocrine regulator by directly interacting with neuronal G-protein-coupled receptors. This review also covers the early mechanisms by which cocaine binding to σ1 blocks the food-seeking behavior triggered by ghrelin. Those findings appear as fundamental to understand common mechanisms in drug addiction and eating disorders.

Caregivers’ Feeding Behavior, Children's Eating Behavior, and Weight Status among Children of Preschool Age in China

2020 ◽  
Author(s):  
Jing Yuan ◽  
Xun Jiang ◽  
Tongyu Zhu ◽  
Yuhai Zhang ◽  
Yue Wang ◽  
...  
Keyword(s):  
Preschool Children ◽  
Feeding Behavior ◽  
Eating Behavior ◽  
Emotional Eating ◽  
Weight Status ◽  
Overweight And Obesity ◽  
Preschool Age ◽  
Weight Concerns ◽  
Feeding Behaviors ◽  
Cross Sectional

Abstract Background Childhood overweight and obesity have become significant public health challenges worldwide. This study aimed to explore whether caregivers’ feeding behavior and children’s eating behavior were associated with the weight status of preschool children in China.Methods A cross-sectional questionnaire was administered to 912 caregivers of preschool children from April to July 2016. Caregivers’ feeding behaviors were assessed by the Chinese Preschooler’s Caregiver Feeding Behavior Scale (CPCFBS). Children’s eating behaviors were evaluated using the Chinese Preschooler’s Eating Behavior Questionnaire (CPEBQ). After controlling for demographic characteristics, multiple linear regression and logistic regression analyses were performed to evaluate the relationship between caregivers’ feeding behavior, children's eating behavior, and children's body mass index (BMI). Results The results showed that weight concerns on the part of caregivers (β=0.53) and food responsiveness on the part of children (β=0.93) were positively correlated with children’s BMI, whereas caregivers’ responsibility for feeding (β=-0.68) and children’s external eating (β=-0.53) were negatively correlated with BMI. Among caregiver feeding behaviors, weight concerns (OR=4.54, P<0.001) and behavior-restricted feeding (OR=0.29, P<0.001) were positively correlated with children’s BMI. A child’s food responsiveness (OR=4.04, P<0.001) was also positively correlated with his/her BMI, while the child’s satiety responsiveness (OR=0.42, P<0.001) and emotional eating habits (OR=0.56, P<0.001) were negatively correlated with overweight/obesity status. Conclusions Our study demonstrated that children’s eating behavior and caregivers’ feeding behavior were associated with weight status among preschool children in China. Behavior interventions on caregivers as well as their children may prevent or reduce weight problems in preschool children. Trial registration This study was not a clinical experiment.

Cannabinoid Cb1 Receptor Antagonists/Inverse Agonists and Food-Seeking Behavior

2011 ◽  
pp. 441-456
Author(s):  
John D. Salamone ◽  
Kelly Sink ◽  
Kristen N. Segovia ◽  
Patrick A. Randall ◽  
Peter J. McLaughlin ◽  
...  
Keyword(s):  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Receptor Antagonists ◽  
Inverse Agonists ◽  
Seeking Behavior ◽  
Food Seeking ◽  
Cb1 Receptor Antagonists

scholarly journals Influence of Oilseed Rape Seed Treatment with Imidacloprid on Survival, Feeding Behavior, and Detoxifying Enzymes of Mustard Aphid, Lipaphis erysimi

Insects ◽  
2019 ◽  
Vol 10 (5) ◽  
pp. 144
Author(s):  
Fang Huang ◽  
Zhongping Hao ◽  
Fengming Yan
Keyword(s):  
Feeding Behavior ◽  
Oilseed Rape ◽  
Lipaphis Erysimi ◽  
Seed Coating ◽  
Detoxifying Enzymes ◽  
Feeding Behaviors ◽  
Mustard Aphid ◽  
Coating Agent ◽  
Aphid Feeding ◽  
Rape Seedlings

Imidacloprid application, as a seed coating agent on oilseed rape, is recommended to control mustard aphid, Lipaphis erysimi (Kaltenbach) (Hemiptera: Aphididae). In this study, responses of L. erysimi were investigated, including survival, feeding behavior, and detoxifying enzymes, on the oilseed rape seedlings grown from seeds coated with imidacloprid at rates of 6, 12, or 18 g active ingredient (a.i.)/kg seed. The results showed that the aphids’ survival rate, together with that of the progeny of the survivors, on the seed-treated seedlings significantly decreased. This indicates that the aphid population in fields can be suppressed effectively. The electrical penetration graph (EPG) technique was used to record aphid feeding behaviors on two-, four-, and six-leaf stages of oilseed rape seedlings that had been seed-coated with imidacloprid, and individual responses were revealed during the aphid feeding behavior. On the plants at the two-leaf stage, aphid feeding behaviors were influenced, showing decreased frequency of stylet penetration into the leaf (probe) or into the mesophyll cells (potential drops, pds for short), and shortened duration of stylet event in the leaf (probe) or in the phloem. On the plants at the four- and six-leaf stages, these impacts of imidacloprid were weakened; however, the saliva secretion duration in phloem was shortened to less than 5 min in all imidacloprid treatments. The activity of mixed-function oxidase in aphids maintained on the treated seedlings with imidacloprid was elevated. In conclusion, imidacloprid could be used as a seed coating agent for aphid control, but chemical resistance in aphids should not be ignored.

scholarly journals Effect of Dinotefuran, Permethrin, and Pyriproxyfen (Vectra® 3D) on the Foraging and Blood-Feeding Behaviors of Aedes albopictus Using Laboratory Rodent Model

Insects ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 507
Author(s):  
Younes Laidoudi ◽  
Djamel Tahir ◽  
Hacène Medkour ◽  
Marie Varloud ◽  
Oleg Mediannikov ◽  
...  
Keyword(s):  
Aedes Albopictus ◽  
Selection Index ◽  
Exposure Period ◽  
Blood Feeding ◽  
Feeding Behaviors ◽  
Host Seeking ◽  
Seeking Behavior ◽  
Feeding Effect ◽  
Rats And Mice ◽  
And Control

Dinotefuran-Permethrin-Pyriproxyfen (DPP) is used to kill and repel mosquitoes from dogs. However, the influence of the product on the host-seeking behavior of mosquitoes remains unknown. The interference of DPP with the host selection of unfed female Aedes albopictus was investigated. A total of 18 animals (9 mice and 9 rats) were divided into three groups of six animals each. DU: DPP treated rats (n = 3) with untreated mice (n = 3), UD: DPP treated mice (n = 3) with untreated rats (n = 3) and control UU: untreated mice (n = 3) and untreated rats (n = 3). In each group, the rats and mice were placed 30 cm apart. After sedation, the animals in each group were exposed twice (Day 1 and Day 7 post-treatment) for one hour to 71 ± 3 female mosquitoes. Mosquitoes were categorized after the 2-h post-exposure period as dead or alive. Blood-meal origin was determined from mosquitoes using a newly customized duplex qPCR. The highest values of forage ratio (1.36 ≥ wi ≤ 1.88) and selection index (0.63 ≥ Bi ≤ 0.94) for rat hosts indicates a preference of mosquitoes for this species as compared to mice when co-housed during the exposure. The mosquitoes only seldom fed on mice, even in the untreated group. The anti-feeding effect of DPP was therefore only assessed on rat’s hosts. The results showed that DPP, when directly applied on rats, provided a direct protection of 82% and 61% on Day 1 and Day 7, respectively, while when applied on mice hosts (UD), the DPP provided an indirect protection of 21% and 10% on Day 1 and Day 7, respectively. The results showed also that DPP, when applied on rats, provided a direct protection against Ae. albopictus bites. This effect did not result in increased exposure of the untreated host placed in the same cage at a distance of 30 cm.

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