scholarly journals Serum Vitamin D Levels Are Not Associated with Obstructive Lung Disease in the General Population: An NHANES Analysis (2007-2008 to 2009-2010)

2020 ◽  
Author(s):  
Mohamed I Seedahmed ◽  
Aaron D Baugh ◽  
Jordan A Kempker
Keyword(s):  
United States ◽  
Vitamin D ◽  
General Population ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Serum Vitamin ◽  
The United States ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Independent Association

ABSTRACTBackgroundObstructive lung disease is a significant cause of morbidity and healthcare burden within the United States. A growing body of evidence has suggested that vitamin D levels can influence the course or incidence of obstructive lung disease. However, there is an insufficient previous investigation of this association.Study Design and MethodsWe used the National Health and Nutrition Examination Survey (NHANES) cycles 2007-2008 and 2009-2010 spirometry results of individuals aged 40 years and older to assess the association between serum 25(OH)D levels and obstructive lung disease, as defined by the American Thoracic Society using the lower limit of normal (LLN). We used stage multivariate survey-logistic regression with backward selection.ResultsThe final model included body mass index, pack-years smoking history, and ethnicity. In the primary model, there was no association between vitamin D levels and obstructive lung disease. We noted an association between “Other Hispanic” self-identified race and serum Vitamin D levels wherein higher levels were associated with higher odds of obstructive lung disease in this ethnicity, but not among other racial or ethnic groups (OR= 1.48, p= 0.02).ConclusionsSerum Vitamin D levels among adults are not associated with the odds of obstructive lung disease in the general population. Results among non-Mexican Hispanic participants highlight the need for further research in minority populations. More work is needed to address the course and incidence of lung disease in the United States.RESEARCH IN CONTEXTWhat is the key question?In the general population, is there an independent association between Vitamin D and obstructive lung disease after controlling for relevant covariates?What is the bottom line?In exploring whether serum vitamin D levels are associated with odds of obstructive lung disease in the general US population, we did not find an independent association in the overall sample.Why read on?This paper adds nuance to the broad understanding of vitamin D’s role in lung pathophysiology.

scholarly journals Higher serum vitamin D levels are associated with decreased odds of obstructive lung disease in the general population: an NHANES analysis (2007–2008 to 2009–2010)

2020 ◽  
Vol 7 (1) ◽  
pp. e000798
Author(s):  
Mohamed Ismail Seedahmed ◽  
Aaron D Baugh ◽  
Jordan A Kempker
Keyword(s):  
Vitamin D ◽  
General Population ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Serum Vitamin ◽  
Smoking History ◽  
Primary Analysis ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Usa

BackgroundObstructive lung disease is a significant cause of morbidity and healthcare burden within the USA. A growing body of evidence has suggested that vitamin D levels can influence the course or incidence of obstructive lung disease. However, there is an insufficient previous investigation of this association.Study design and methodsWe used the National Health and Nutrition Examination Survey (NHANES) cycles 2007–2008 and 2009–2010 spirometry results of individuals aged 40 years and older to assess the association between serum 25-hydroxyvitamin D levels and obstructive lung disease, as defined by the American Thoracic Society using the lower limit of normal. We used stage multivariate survey-logistic regression.ResultsThe final model included age, gender, body mass index, pack-years smoking history, season, income-to-poverty ratio and race/ethnicity. In the primary analysis using vitamin D as a continuous variable, there was no association between vitamin D levels and obstructive lung disease. We noted a trend between ‘other Hispanic’ self-identified race and serum vitamin D levels wherein higher levels were associated with higher odds of obstructive lung disease in this ethnicity, but not among other racial or ethnic groups (OR (95% CI)=1.40 (0.98 to 1.99), p=0.06). In a secondary analysis, when vitamin D was measured as a categorical variable, there was a significant association between the highest levels of serum vitamin D levels and lesser odds of obstructive lung disease (OR (95% CI)=0.77 [0.61 to 0.98], p=0.04).ConclusionsHigher serum vitamin D levels among adults are associated with decreased odds of obstructive lung disease in the general population. Results among non-Mexican Hispanic participants highlight the need for further research in minority populations. More work is needed to address the course and incidence of lung disease in the USA.

Predictive Factors of Vitamin D Inadequacy among Older Adults in the United States

2019 ◽  
Vol 89 (1-2) ◽  
pp. 55-61 ◽  
Author(s):  
Sunkyung Lee ◽  
Euni Lee ◽  
Mary K. Maneno ◽  
Allan A. Johnson ◽  
Anthony K. Wutoh
Keyword(s):  
United States ◽  
Vitamin D ◽  
Predictive Factors ◽  
National Level ◽  
Serum Vitamin ◽  
Female Gender ◽  
The United States ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Vitamin D Supplements

Abstract. Optimal serum vitamin D levels are reported to be associated with many health benefits; however, few studies have determined predictive factors using national level data. An assessment of predictive factors for vitamin D inadequacy was conducted using National Health and Nutrition Examination Survey (NHANES) 2001–2006 data. Using the study sample including adults aged 40 years or more, data analysis was performed using the weighted multivariate logistic regression statistical procedure. The prevalence of vitamin D inadequacy (serum vitamin D <20 ng/ml) was 37.3%. Non-Hispanic Blacks were 6.4 times more likely to demonstrate vitamin D inadequacy compared to non-Hispanic Whites (ORadj=6.351; 95% CI 5.338, 7.555; p<0.0001). Also, female gender was a significant predictor of vitamin D inadequacy (ORadj=1.499; 95% CI 1.315, 1.708; p<0.0001) in multivariate models. Subjects who reported not taking vitamin D supplements in the past 30 days were more than twice as likely to be vitamin D inadequate compared with those who had taken dietary supplements containing vitamin D (ORadj=2.225; 95% CI 1.903, 2.601; p<0.0001). In conclusion, the strongest predictor of vitamin D inadequacy was non-Hispanic Black ethnicity. Other potential predictors included smoking, non-use of vitamin D supplements, abnormal BMI, collecting samples in winter, female gender, perception of own health condition as not excellent, lack of health care, and older age. More focused interventions targeting groups of United States residents with vitamin D inadequacy are needed.

Serum Vitamin D Levels in Orthopaedic Trauma Patients Living in the Northwestern United States

2013 ◽  
Vol 27 (5) ◽  
pp. e103-e106 ◽  
Author(s):  
Carson R. Bee ◽  
Daniel V. Sheerin ◽  
Thomas K. Wuest ◽  
Daniel C. Fitzpatrick
Keyword(s):  
United States ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Trauma Patients ◽  
Orthopaedic Trauma ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals The association between serum vitamin D levels and renal tubular dysfunction in a general population exposed to cadmium in China

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195682 ◽  
Author(s):  
Xiao Chen ◽  
Yan Dai ◽  
Zhongqiu Wang ◽  
Guoying Zhu ◽  
Xiaoqiang Ding ◽  
...  
Keyword(s):  
Vitamin D ◽  
General Population ◽  
Serum Vitamin ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Renal Tubular

scholarly journals Serum Vitamin D in Patients with Chronic Obstructive Lung Disease Does Not Correlate with Mortality – Results from a 10-Year Prospective Cohort Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53670 ◽  
Author(s):  
Dennis Back Holmgaard ◽  
Lone Hagens Mygind ◽  
Ingrid Louise Titlestad ◽  
Hanne Madsen ◽  
Palle Bach Nielsen Fruekilde ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Lung Disease ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Obstructive Lung Disease ◽  
Serum Vitamin ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Serum Vitamin D

scholarly journals Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS

Neurology ◽  
2017 ◽  
Vol 88 (17) ◽  
pp. 1623-1629 ◽  
Author(s):  
Milena A. Gianfrancesco ◽  
Pernilla Stridh ◽  
Brooke Rhead ◽  
Xiaorong Shao ◽  
Edison Xu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Disease Onset ◽  
Serum Vitamin ◽  
Human Leukocyte ◽  
The United States ◽  
Risk Scores ◽  
Total N ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Pediatric Onset

Objective:To utilize Mendelian randomization to estimate the causal association between low serum vitamin D concentrations, increased body mass index (BMI), and pediatric-onset multiple sclerosis (MS) using genetic risk scores (GRS).Methods:We constructed an instrumental variable for vitamin D (vitD GRS) by computing a GRS for 3 genetic variants associated with levels of 25(OH)D in serum using the estimated effect of each risk variant. A BMI GRS was also created that incorporates the cumulative effect of 97 variants associated with BMI. Participants included non-Hispanic white individuals recruited from over 15 sites across the United States (n = 394 cases, 10,875 controls) and Sweden (n = 175 cases, 5,376 controls; total n = 16,820).Results:Meta-analysis findings demonstrated that a vitD GRS associated with increasing levels of 25(OH)D in serum decreased the odds of pediatric-onset MS (odds ratio [OR] 0.72, 95% confidence interval [CI] 0.55, 0.94; p = 0.02) after controlling for sex, genetic ancestry, HLA-DRB1*15:01, and over 100 non–human leukocyte antigen MS risk variants. A significant association between BMI GRS and pediatric disease onset was also demonstrated (OR 1.17, 95% CI 1.05, 1.30; p = 0.01) after adjusting for covariates. Estimates for each GRS were unchanged when considered together in a multivariable model.Conclusions:We provide evidence supporting independent and causal effects of decreased vitamin D levels and increased BMI on susceptibility to pediatric-onset MS.

scholarly journals Serum Vitamin D Deficiency among African American Women in the United States

2016 ◽  
Vol 19 (3) ◽  
pp. A173
Author(s):  
G Alem ◽  
MK Maneno ◽  
EB Ettienne ◽  
L Wingate
Keyword(s):  
United States ◽  
Vitamin D ◽  
African American ◽  
African American Women ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
The United States ◽  
American Women ◽  
Serum Vitamin D

scholarly journals Potential role of vitamin D in prevention of skeletal and extraskeletal diseases in older people

2015 ◽  
Vol 10 (1) ◽  
pp. 29
Author(s):  
Andrea Montagnani ◽  
Roberto Nardi ◽  
Michela Cercignani ◽  
Valerio Verdiani
Keyword(s):  
Vitamin D ◽  
General Population ◽  
Older People ◽  
Metabolic Diseases ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Published Data ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Wide Range

Vitamin D and calcium are essential for bone health. An adequate calcium-phosphorus product determines a high quality mineralization long lifetime. In older people, both calcium and vitamin D levels may be lower causing osteomalacia and/or osteoporosis with a higher risk of fracture. Epidemiological data have clearly associated serum vitamin D lower levels (deficiency) with bone fracture in older people, however, not univocal data exist in regard to a beneficial effect of vitamin D supplementation in general population. Although not systematic, the present review aims to make a narrative synthesis of the most recent published data on vitamin D effect not only on bone, classical target associated with vitamin D studies, but namely on extraskeletal diseases. In fact, recently, there has been an increasing interest on this latter issue with surprising findings. Vitamin D, and in particular its deficiency, seems to have a role in pathophysiological pathways in several diseases involving cardiovascular, central nervous system and neoplastic process. On the other hand, vitamin D supplementation may modify the outcome of a wide range of illnesses. Up to date the data are conflicting mainly because of difficulty to establish a consensus on the threshold of vitamin D deficit. The US Institute of Medicine recommends to distinguish a level of insufficiency [defined as 30-50 nmol/L or 16-25 ng/mL of 25(OH)D] and another of deficiency identified by 25(OH)D levels lower than 30 nmol/L (or &lt;16 ng/mL). This latter level is considered a minimum level necessary in older adults to minimize the risk of falls, fracture and probably to have some effects of vitamin D supplementation in extraskeletal diseases. Although there are no absolute certainties in such issue, the most recent data suggest that vitamin D deficiency, and its supplementation, may play an important role in a wide range of diseases other than in bone metabolic diseases in older but not in general population. For such reason a widespread measurement of vitamin D levels in general population, and not only in older, seems to be inappropriate and it could induce an overuse of vitamin D supplementation in situations in which its efficacy and cost-effectiveness have not been proven.

Sign in / Sign up

Export Citation Format

Share Document