scholarly journals A Mathematical Model of Platelet Antiparasitic Action in Erythrocytes and Merozoites During Malaria Infection

2021 ◽  
Author(s):  
Felipe Alves Rubio ◽  
Hyun Mo Yang
Keyword(s):  
Mathematical Model ◽  
Infection Control ◽  
Blood Cells ◽  
Malaria Infection ◽  
Equilibrium Points ◽  
Oscillatory Behavior ◽  
System Of Equations ◽  
Giant Platelets ◽  
The Stability ◽  
Infectious Form

AbstractPlatelets have been seen traditionally as fragments of blood mediating coagulation. However, evidence during malaria infection suggests that platelets also act against merozoites, an infectious form of malaria in the bloodstream, and megakaryocytes can release giant platelets with a larger volume than normal platelets. We propose a mathematical model to study the interaction between red blood cells, merozoites, and platelets during malaria infection. We analyzed two cases of the interaction of platelets with malaria infection. In the first one, we considered the isolated action of normal platelets and, in the second one, the joint antiparasitic action of both normal and giant platelets. Numerical simulations were performed to evaluate the stability of the equilibrium points of the system of equations. The model showed that the isolated antiparasitic action of normal platelets corroborates malaria infection control. However, the system can converge to a presence-merozoite equilibrium point, or an oscillatory behavior may appear. The joint antiparasitic action of both normal and giant platelets eliminated the oscillatory behavior and drove the dynamics to converge to lower parasitic concentration than the case of isolated action of normal platelets. Moreover, the joint antiparasitic action of platelets proved more easily capable of eliminating the infection.

On the stability of a mathematical model for HIV(AIDS) - cancer dynamics

2021 ◽  
Vol 8 (4) ◽  
pp. 783-796
Author(s):  
H. W. Salih ◽  
◽  
A. Nachaoui ◽  
Keyword(s):  
Mathematical Model ◽  
Highly Active Antiretroviral Therapy ◽  
Lyapunov Method ◽  
Equilibrium Points ◽  
Hiv Treatment ◽  
Biochemical Processes ◽  
Highly Active ◽  
Biological Phenomena ◽  
The Stability ◽  
The Impact

In this work, we study an impulsive mathematical model proposed by Chavez et al. [1] to describe the dynamics of cancer growth and HIV infection, when chemotherapy and HIV treatment are combined. To better understand these complex biological phenomena, we study the stability of equilibrium points. To do this, we construct an appropriate Lyapunov function for the first equilibrium point while the indirect Lyapunov method is used for the second one. None of the equilibrium points obtained allow us to study the stability of the chemotherapeutic dynamics, we then propose a bifurcation of the model and make a study of the bifurcated system which contributes to a better understanding of the underlying biochemical processes which govern this highly active antiretroviral therapy. This shows that this mathematical model is sufficiently realistic to formulate the impact of this treatment.

scholarly journals Experimental and Mathematical Model for the Antimalarial Activity of Methanolic Root Extract of Azadirachta indica (Dongoyaro) in Mice Infected with Plasmodium berghei NK65

2020 ◽  
pp. 68-82
Author(s):  
Adeniyi Michael Olaniyi ◽  
Momoh Johnson Oshiobugie ◽  
Aderele Oluwaseun Raphael
Keyword(s):  
Mathematical Model ◽  
Azadirachta Indica ◽  
Plasmodium Berghei ◽  
Antimalarial Activity ◽  
Equilibrium Points ◽  
Standard Procedure ◽  
Root Extract ◽  
Globally Asymptotically Stable ◽  
The Stability ◽  
Group B

The study determines the experimental and mathematical model for the anti-plasmodial activity of methanolic root extract of Azadirachta indica in Swiss mice infected with Plasmodium berghei NK65. Phytochemical analyses, antimalarial activity of the methanolic root extract of A. indica was determined in mice infected with Plasmodium berghei NK65 using standard procedure. Liver biomarker enzymes were also determined. The model P. berghei induced free and P. berghei infected equilibrium were determined. The stability of the model equilibrium points was rigorously analyzed. The phytochemicals present in the extract include: alkaloid, flavonoid, saponin and phenolic compounds etc. The experimental study consists of five groups of five mice each per group. Group A, B, C, D and E were healthy, infected without treatment, infected mice treated with fansidar (10 mg/kg), chloroquine (10 mg/kg) and 250 mg/kg body weight of A. indica methanolic root extract respectively. The extract showed anti-plasmodial activity of 73.96%. The result was significant when compared with group B mice, though it was lower than that exhibited by fansidar (88.91%) and chloroquine (92.18%) for suppressive test. There were significant decrease (P<0.05) in plasma AST and ALT levels in the treated infected mice compared to the infected untreated mice. The results of the model showed that the P.berghei induced free equilibrium is locally and globally asymptotically stable at threshold parameter,  less than unity and unstable when  is greater than unity. Numerical simulations were carried out to validate the analytic results which are in agreement with the experimental analysis of this work.

scholarly journals Dynamics in Bank Crisis Model

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Tianshu Jiang ◽  
Mengzhe Zhou ◽  
Bi Shen ◽  
Wendi Xuan ◽  
Sijie Wen ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Complex Networks ◽  
Critical Point ◽  
Dynamic Systems ◽  
Degree Distribution ◽  
Equilibrium Points ◽  
Modified Model ◽  
The Past ◽  
Banking Market ◽  
The Stability

Bank crisis is grabbing more serious attention as several financial turmoils have broken out in the past several decades, which leads to a number of researches in this field. Comparing with researches carried out on basis of degree distribution in complex networks, this paper puts forward a mathematical model constructed upon dynamic systems, for which we mainly focus on the stability of critical point. After the model is constructed to describe the evolution of the banking market system, we devoted ourselves to find out the critical point and analyze its stability. However, to refine the stability of the critical point, we add some impulsive terms in the former model. And we discover that the bank crisis can be controlled according to the analysis of equilibrium points of the modified model, which implies the interference from outside may modify the robustness of the bank network.

scholarly journals Analysis of the SARS-CoV-2 Outbreak in Northern Cyprus using a Mathematical Model

2020 ◽  
Author(s):  
Tamer Sanlidag ◽  
Nazife Sultanoglu ◽  
Bilgen Kaymakamzade ◽  
Evren Hincal ◽  
Murat Sayan ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Equilibrium Points ◽  
Real Data ◽  
Northern Cyprus ◽  
The Stability ◽  
Disease Free ◽  
The Basic Reproduction Number

Abstract The present study studied the dynamics of SARS-CoV-2 in Northern-Cyprus (NC) by using real data and a designed mathematical model. The model consisted of two equilibrium points, which were disease-free and epidemic. The stability of the equilibrium points was determined by the magnitude of the basic reproduction number (𝑹𝟎). If 𝑹𝟎 < 1, the disease eventually disappears, if 𝑹𝟎 ≥ 1, the presence of an epidemic is stated. 𝑹𝟎 has been calculated patient zero, with a range of 2.38 to 0.65. Currently, the 𝑹𝟎 for NC was found to be 0.65, indicating that NC is free from the SARS-CoV-2 epidemic.

scholarly journals Analysis of the SARS-CoV-2 Outbreak in Northern Cyprus using a Mathematical Model

2020 ◽  
Author(s):  
Tamer Sanlidag ◽  
Nazife Sultanoglu ◽  
Bilgen Kaymakamzade ◽  
Evren Hincal ◽  
Murat Sayan ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Equilibrium Points ◽  
Real Data ◽  
Northern Cyprus ◽  
The Stability ◽  
Disease Free ◽  
The Basic Reproduction Number

Abstract The present study studied the dynamics of SARS-CoV-2 in Northern-Cyprus (NC) by using real data and a designed mathematical model. The model consisted of two equilibrium points, which were disease-free and epidemic. The stability of the equilibrium points was determined by the magnitude of the basic reproduction number (𝑹𝟎). If 𝑹𝟎 < 1, the disease eventually disappears, if 𝑹𝟎 ≥ 1, the presence of an epidemic is stated. 𝑹𝟎 has been calculated patient zero, with a range of 2.38 to 0.65. Currently, the 𝑹𝟎 for NC was found to be 0.65, indicating that NC is free from the SARS-CoV-2epidemic.

Fuzzy Parameter Based Mathematical Model on Forest Biomass

2018 ◽  
Vol 13 (04) ◽  
pp. 179-193 ◽  
Author(s):  
Prabir Panja
Keyword(s):  
Numerical Simulation ◽  
Mathematical Model ◽  
Time Delay ◽  
Human Population ◽  
Equilibrium Points ◽  
Forest Biomass ◽  
Simulation Results ◽  
The Stability ◽  
Fuzzy Parameter

In this paper, a fuzzy mathematical model has been developed by considering forest biomass, human population and technological effort for the conservation of forest biomass as separate compartments. We have assumed that the forest biomass and human population grows logistically. We have considered that forest biomass decreases due to industrialization, food, shelter, etc., for humans. For the conservation of forest biomass, some modern technological efforts have been used in this model. Also, time delay of use of modern technological effort for the conservation of forest biomass has been considered on forest biomass. According to the assumptions, a fuzzy mathematical model on forest biomass is formulated. Next we have determined different possible equilibrium points. Also, the stability of our proposed system around these equilibrium points has been discussed. Finally, some numerical simulation results have been presented for better understanding of our proposed mathematical model.

scholarly journals A new mathematical model for Zika virus transmission

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Shahram Rezapour ◽  
Hakimeh Mohammadi ◽  
Amin Jajarmi
Keyword(s):  
Mathematical Model ◽  
Fractional Order ◽  
Zika Virus ◽  
Fixed Point Theory ◽  
Equilibrium Points ◽  
Virus Transmission ◽  
Point Theory ◽  
Euler Method ◽  
Order Derivative ◽  
The Stability

Abstract We present a new mathematical model for the transmission of Zika virus between humans as well as between humans and mosquitoes. In this way, we use the fractional-order Caputo derivative. The region of the feasibility of system and equilibrium points are calculated, and the stability of equilibrium point is investigated. We prove the existence of a unique solution for the model by using the fixed point theory. By using the fractional Euler method, we get an approximate solution to the model. Numerical results are presented to investigate the effect of fractional derivative on the behavior of functions and also to compare the integer-order derivative and fractional-order derivative results.

scholarly journals Global Analysis of a Reaction-Diffusion Within-Host Malaria Infection Model with Adaptive Immune Response

Mathematics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 563 ◽  
Author(s):  
Ahmed Elaiw ◽  
Afnan Al Agha
Keyword(s):  
Immune Responses ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Malaria Infection ◽  
Global Analysis ◽  
Equilibrium Points ◽  
Reaction Diffusion ◽  
Antimalarial Drugs ◽  
Infection Model ◽  
Reaction Diffusion Model

Malaria is one of the most dangerous global diseases. This paper studies a reaction-diffusion model for the within-host dynamics of malaria infection with both antibody and cell-mediated immune responses. The model explores the interactions between uninfected red blood cells (erythrocytes), three types of infected red blood cells, free merozoites, CTLs and antibodies. It contains some parameters to measure the effect of antimalarial drugs and isoleucine starvation on the blood cycle of malaria infection. The basic properties of the model are discussed. All possible equilibrium points and the threshold conditions required for their existence are addressed. The global stability of all equilibria are proved by selecting suitable Lyapunov functionals and using LaSalle’s invariance principle. The characteristic equations are used to study the local instability conditions of the equilibria. Some numerical simulations are conducted to support the theoretical results. The results indicate that antimalarial drugs with high efficacy can clear the infection and take the system towards the disease-free state. Increasing the efficacy of isoleucine starvation has a similar effect as antimalarial drugs and can eliminate the disease. The presence of immune responses with low efficacy of treatments does not provide a complete protection against the disease. However, the immune responses reduce the concentrations of all types of infected cells and limit the production of malaria parasites.

scholarly journals Θ-SEIHRD mathematical model of Covid19-stability analysis using fast-slow decomposition

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10019
Author(s):  
OPhir Nave ◽  
Israel Hartuv ◽  
Uziel Shemesh
Keyword(s):  
Mathematical Model ◽  
Stability Analysis ◽  
Nonlinear Differential Equations ◽  
Equilibrium Points ◽  
Asymptotic Methods ◽  
Fast Subsystem ◽  
The Stability ◽  
System Variables ◽  
The Mathematical Model ◽  
Slow Decomposition

In general, a mathematical model that contains many linear/nonlinear differential equations, describing a phenomenon, does not have an explicit hierarchy of system variables. That is, the identification of the fast variables and the slow variables of the system is not explicitly clear. The decomposition of a system into fast and slow subsystems is usually based on intuitive ideas and knowledge of the mathematical model being investigated. In this study, we apply the singular perturbed vector field (SPVF) method to the COVID-19 mathematical model of to expose the hierarchy of the model. This decomposition enables us to rewrite the model in new coordinates in the form of fast and slow subsystems and, hence, to investigate only the fast subsystem with different asymptotic methods. In addition, this decomposition enables us to investigate the stability analysis of the model, which is important in case of COVID-19. We found the stable equilibrium points of the mathematical model and compared the results of the model with those reported by the Chinese authorities and found a fit of approximately 96 percent.

scholarly journals Local Stability Analysis of a Mathematical Model of the Interaction of Two Populations of Differential Equations (Host-Parasitoid)

2016 ◽  
Vol 5 (1) ◽  
pp. 9
Author(s):  
Dewi Anggreini
Keyword(s):  
Mathematical Model ◽  
Differential Equations ◽  
Stable Equilibrium ◽  
Jacobian Matrix ◽  
Equilibrium Points ◽  
Real Life ◽  
Host Population ◽  
Matrix Analysis ◽  
The Stability ◽  
Two Populations

<p>Mathematical model has many benefits in life, especially the development of science and application to other fields. The mathematical model seeks to represent real-life problems formulated mathematically to get the right solution. This research is the application of mathematical models in the field of biology that examines the interaction of the two populations that host populations and parasitoid populations. This study differs from previous studies that examine the interaction of two more species that prey and predators where predators kill prey quickly. In this study the parasitoid population slowly killing the host population by living aboard and take food from the host population it occupies. In this study of differential equations are used to construct a mathematical model was particularly focused on the stability of the local mathematical model of interaction of two differential equations that host and parasitoid populations. Stability discussed in this study are stable equilibrium points are obtained from the characteristic equation systems of differential equations host and parasitoid interactions. Type the stability of the equilibrium point is determined on the eigenvalues of the Jacobian matrix. Analysis of stability is obtained by determining the eigenvalues of the Jacobian matrix around equilibrium points. Having obtained the stable equilibrium points are then given in the form of charts and portraits simulation phase to determine the behavior of the system in the future.</p>

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