scholarly journals Neural Correlates of Effects of Internally versus Externally Guided Partnered Rehabilitative Tango for People with Parkinson's Disease

2021 ◽  
Author(s):  
Amrit Kashyap ◽  
Bruce Crosson ◽  
Venkatagiri Krishnamurthy ◽  
Keith McGregor ◽  
Ariyana Bozzorg ◽  
...  
Keyword(s):  
Primary Motor Cortex ◽  
Region Of Interest ◽  
Control Group ◽  
Neural Pathways ◽  
Imaging Data ◽  
Training Strategy ◽  
Before And After ◽  
Clinically Significant ◽  
Magnetic Resonance Imaging Mri ◽  
Almost All

Restoring function to damaged neural pathways, or promoting compensatory strategies to overcome dysfunctional neural pathways have been topics of inquiry within motor rehabilitation. This study considers these topics in Parkinsons disease (PD), where disruption within the striatal-thalamic-cortical (STC) circuits can cause impairment in internally guided (IG) movements. A related, but separate externally guided (EG) movement network, recruits the intact cerebellar-thalamic-cortical (CTC) loop to facilitate movement in response to sensory cues, and is effective in remediating motor function. Partnered dance with leading and following roles may be used as proxies for training IG and EG strategies respectively, in PD and can test which strategy is more effective in remediating effects of PD. Leaders determine variables associated with IG and communicate step amplitude, timing, and direction to the follower. Followers use an EG strategy to sense and interpret directional pressure cues from the leader and then enact an appropriate movement response. This study examines how IG and EG training strategy affects STC and CTC circuits and their behavioral outcomes to examine whether compensatory or direct entrainment of neural pathways is more effective in PD. Fifty-eight participants were recruited with mild-moderate PD (stages 1-3) and randomly assigned to EG, IG or non-dance education control group and assessed before and after 12 weeks of biweekly interventions. Participants were assessed with standard cognitive and motor behavioral measures and lay in a Magnetic Resonance Imaging (MRI) scanner while they tapped their foot under two conditions: internal (tapping a learned rhythm: IT) and external (participant taps in response to an assistants felt tap on the participants hand: ET) guidance. The foot-tapping data collected with an accelerometer were evaluated by analyzing the frequency spectrum to calculate amplitude and timing of the foot taps. The functional (fMRI) data were pre-processed (AFNI), registered (MNI), and analyzed for changes in activation using a general linear model in SAS and AFNI. Postintervention, both the EG and the IG groups showed clinically significant changes on disease severity, but the EG group showed improvements on cognitive, motor, and mood variables. The EG group also outperformed the IG group in the in-scanner task performance measured by the foot accelerometer. Imaging data revealed a significant increase in the EG group in the primary motor cortex lower limb region and the parts of the cerebellar circuits, particularly right Cerebellar Lobule VIIIa. The control group showed an increase in activity in the putamen compared to the IG and EG groups that could be due to a different compensatory pathway. All findings were corroborated using a region of interest approach examining the same pathways according to an atlas. Our results indicate that the most effective strategy for the PD participants involved external cues that increased activity in the compensatory CTC pathway, the primary motor region, and significant improvements on almost all behavioral measurements.

scholarly journals Assessment of Absorption of Glycated Nail Proteins in Patients with Diabetes Mellitus and Diabetic Retinopathy

Medicina ◽  
2020 ◽  
Vol 56 (12) ◽  
pp. 658
Author(s):  
Ieva Jurgeleviciene ◽  
Daiva Stanislovaitiene ◽  
Vacis Tatarunas ◽  
Marius Jurgelevicius ◽  
Dalia Zaliuniene
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Ftir Spectroscopy ◽  
Region Of Interest ◽  
Control Group ◽  
Before And After ◽  
Patients With Diabetes ◽  
Long Term Observation

Background and objectives: Glycation occurs in a variety of human tissues and organs. Knowledge about the relationship between predictive biochemical factors such as absorption of glycated nail proteins and severity of type 2 diabetes mellitus (DM) and diabetic retinopathy (DR) remains limited. Materials and Methods: The study group consisted of patients with type 2 DM and DR (n = 32) and a control group (n = 28). Each patient underwent a comprehensive ophthalmic examination. The glycation process in nail clippings was evaluated in stages of in vitro glycation and deglycation stages. ATR–FTIR spectroscopy was used to calculate the infrared absorption in the region of interest. The absorption of solutions with nail clippings was evaluated by NanoDrop spectrophotometry. Absorption spectra differences before and after the exposure to fructosamine 3-kinase were compared between DM patients with DR and the control group. Results: The absorption of glycated nail protein greater than 83.00% increased the chance of developing DM and DR (OR = 15.909, 95% CI 3.914–64.660, p < 0.001). Absorption of glycated nail protein by ATR–FTIR spectroscopy in patients with DM and DR in vitro glycation was statistically significantly higher than in the control group; also absorption of solution with nails by NanoDrop spectroscopy was statistically significantly higher than in controls in vitro glycation and in vitro deglycation. After exposure to fructosamine 3-kinase, absorption of nail protein in DM + severe/proliferative DR group was statistically significantly lower in comparison with DM + mild/moderate group DR. Conclusions: Evaluation of glycated nail protein could be applied to evaluate the risk of having DM and for long-term observation of DM control.

Changes in perceptions and emotions before and after refeeding in anorexia nervosa: a pilot study

1994 ◽  
Vol 11 (2) ◽  
pp. 57-63 ◽  
Author(s):  
Sidney H Kennedy ◽  
Randy Katz ◽  
Christine G Ford ◽  
Elizabeth Ralevski
Keyword(s):  
Anorexia Nervosa ◽  
Hospital Treatment ◽  
Control Group ◽  
Food Cravings ◽  
Standard Meal ◽  
Group Of Seven ◽  
Control Subjects ◽  
Before And After ◽  
Patient Groups ◽  
Clinically Significant

AbstractObjective: Physiological and psychological distortions associated with eating are recognised within the syndrome of anorexia nervosa. The purpose of this study was to compare subgroups of restricting and bulimic anorexic patients (AN-R and AN-B) with control subjects, and with themselves after six weeks of refeeding and weight gain, on a series of indices before and after a standard meal. Method: Nineteen consecutively admitted female AN patients completed visual analogue ratings of hunger, satiety, depression, urge to binge, urge to vomit and food craving during the first week and sixth week of hospitalisation. A female control group of seven subjects completed similar ratings for one week. The patient ratings were compared to those of the control subjects at baseline before and after a meal. Further comparisons between the two patient groups were also carried out six weeks after treatment. Results: As expected, AN patients reported significantly higher ratings of depression, urges to vomit, urges to binge and higher satiety levels when compared to controls. Comparisons between the patient subgroups revealed that at baseline AN-B patients had significantly higher urges to vomit that AN-R patients after meals, and reported significantly less satiety both before and after eating. Also, an increase in depression after the meal, at baseline, was reported by both groups although after six weeks higher levels of depression were recorded before rather than after the meal. There was also a significant decrease in food cravings after six weeks compared to baseline for both patient groups.Conclusions: The findings in this study provide further evidence that clinically significant differences exist between subtypes of patients suffering from anorexia nervosa, and highlight the differential, change in various symptoms during intense hospital treatment.

scholarly journals Effects of Levothyroxine Treatment on Lipid Profile in Subclinical Hypothyroidism: A Randomized Clinical Trial

2015 ◽  
Vol 4 (2) ◽  
pp. 72-77
Author(s):  
Karoon Shahebrahimi ◽  
Rozita Naseri ◽  
Tahereh Sadat Kalantarian ◽  
Mehrali Rahimi ◽  
Farid Najafi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Lipid Profile ◽  
Subclinical Hypothyroidism ◽  
Serum Lipids ◽  
Intervention Group ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
Clinically Significant ◽  
Levothyroxine Treatment

Background: Studies demonstrated controversial results on subclinical hypothyroidism (SCH) regarding lipid profile alteration with or without Levothyroxine treatment. The purpose of this study is to investigate the effects of Levothyroxine on serum lipids in SCH. Materials and Methods: One hundred patients with SCH referred to Taleghani hospital in Kermanshah were recruited and randomly assigned into the intervention or the control group. Patients in intervention group received Levothyroxine 50-75 micrograms for three months. Patients in control group received the same placebo with the same dose and duration. Lipid profile was measured before and after the trial and the changes were compared between groups. (IRCT code: 138903244179N1). Results: Triglyceride, Total Cholesterol, LDL, HDL and Lipoprotein-A were measured before and after treatment. None of the factors showed significant difference either between or within groups, before and after the treatment (P<0.05). Conclusion: Treating with Levothyroxine does not have any clinically significant impact on lipid profile in SCH patients which indicates that we should not expect SCH patients to use Levothyroxine solely for lipid profile alternation, except those with other clinical indications for treatment.[GMJ.2015;4(2):72-77]

scholarly journals Neuronal correlates of affective theory of mind in schizophrenia out-patients: evidence for a baseline deficit

2010 ◽  
Vol 40 (10) ◽  
pp. 1607-1617 ◽  
Author(s):  
D. Mier ◽  
C. Sauer ◽  
S. Lis ◽  
C. Esslinger ◽  
J. Wilhelm ◽  
...  
Keyword(s):  
Social Cognition ◽  
Theory Of Mind ◽  
Emotion Recognition ◽  
Facial Expressions ◽  
Social Cognitive ◽  
Region Of Interest ◽  
Functional Brain Imaging ◽  
Control Group ◽  
Imaging Data ◽  
Schizophrenia Group

BackgroundSchizophrenia out-patients have deficits in affective theory of mind (ToM) but also on more basal levels of social cognition, such as the processing of neutral and emotional expressions. These deficits are associated with changes in brain activation in the amygdala and the superior temporal sulcus (STS). However, until now there have been no studies that examined these different levels of social cognition and their neurobiological underpinnings in patients within one design.MethodSixteen medicated schizophrenia out-patients and 16 matched healthy controls were studied with functional magnetic resonance imaging (fMRI) during a social cognition task that allows the investigation of affective ToM (aToM), emotion recognition and the processing of neutral facial expressions.ResultsPatients showed a deficit in emotion recognition and a more prominent deficit in aToM. The performance in aToM and in emotion recognition was correlated in the control group but not in the schizophrenia group. Region-of-interest analysis of functional brain imaging data revealed no difference between groups during aToM, but a hyperactivation in the schizophrenia group in the left amygdala and right STS during emotion recognition and the processing of neutral facial expressions.ConclusionsThe results indicate that schizophrenia out-patients have deficits at several levels of social cognition and provide the first evidence that deficits on higher-order social cognitive processes in schizophrenia may be traced back to an aberrant processing of faces per se.

Rhinomanometry for Preoperative and Postoperative Assessment of Nasal Obstruction

1989 ◽  
Vol 101 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Andrew S.D. Gordon ◽  
Thomas V. McCaffrey ◽  
Eugene B. Kern ◽  
John F. Pallanch
Keyword(s):  
Nasal Obstruction ◽  
Pituitary Surgery ◽  
Control Group ◽  
Study Group ◽  
Nasal Resistance ◽  
Airway Narrowing ◽  
Asymptomatic Patients ◽  
Before And After ◽  
Transsphenoidal Pituitary Surgery ◽  
Clinically Significant

In this retrospective study we used active, anterior mask rhinomanometric methods to measure nasal resistance before and after surgery for nasal obstruction. The study group comprised 60 patients with nasal obstruction who had 63 preoperative and postoperative rhinomanograms and the control group contained 14 asymptomatic patients who underwent rhinomanometric studies before transnasal, transsphenoidal pituitary surgery. Before surgery the study group had significantly higher total and combined unilateral nasal resistances than either the control group before surgery ( p < 0.05 and p < 0.01, respectively) or the study group after surgery ( p < 0.0001 for both comparisons). Surgery normalized the nasal resistances of the study group in relation to the control group. A total nasal resistance greater than 1 cm H2O/L/sec or a unilateral resistance greater than 3.5 cm H2O/L/sec suggests clinically significant nasal obstruction. Airway narrowing and obstructive symptoms correlated with airway resistance in the preoperative patient, but symptoms did not correlate well with postoperative resistance.

The impact of therapeutic relatives’ groups on the course of illness of schizophrenic patients

1995 ◽  
Vol 10 (1) ◽  
pp. 17-27 ◽  
Author(s):  
G Buchkremer ◽  
H Schulze Mönking ◽  
R Holle ◽  
WP Hornung
Keyword(s):  
Control Group ◽  
Course Of Illness ◽  
Self Help ◽  
Before And After ◽  
Schizophrenic Patients ◽  
Clinically Significant ◽  
Self Help Groups ◽  
The Impact ◽  
Relapse Rates

SummaryThis study considers the question of whether relapse rates among schizophrenic patients can be reduced by means of relatives' groups. In a randomized, controlled intervention study, two therapeutic strategies (therapeutic relatives' groups, initiated relatives' self-help groups) were compared with each other and with a control group. Interventions were confined to the relatives, with the patients continuing their standard treatment. The study involved 151 relatives of 99 chronic DSMIII schizophrenics. Data were collected before and after a 1-year intervention phase and in a 2-year follow-up. No difference existed between the groups with respect to rehospitalization data. However, numerous differences recorded in the psychopathological findings and in living and working circumstances suggest that therapeutic work with relatives is of clinically significant benefit.

scholarly journals Ultrasound elasticity imaging

2006 ◽  
Vol 9 (6) ◽  
pp. 1-7 ◽  
Author(s):  
W. E. Svensson ◽  
D. Amiras
Keyword(s):  
Clinical Investigation ◽  
Ultrasound Image ◽  
Region Of Interest ◽  
Physical Property ◽  
Elasticity Imaging ◽  
Elasticity Analysis ◽  
Imaging Data ◽  
Malignant Tumours ◽  
Before And After ◽  
Coefficient Of Elasticity

Before the advent of diagnostic imaging, palpation was one of the main methods of clinical investigation for the evaluation of tumours. Malignant tumours feel harder that benign ones and this physical property is related to their coefficient of elasticity. Direct comparison of tissue images before and after application of a force is too crude a measure of elasticity except at extremes of differences in elasticity. Analysis of the raw imaging data, which contains very much more information than can be displayed for visual perception, can detect very much smaller differences in elasticity.The radio frequency data of returning ultrasound echoes contain much more data than appears in an ultrasound image. Comparison, of the datasets of uncompressed tissue with compressed tissue, of a region of interest allows production of a strain (elasticity) image of that same region of interest. Change in tissue which is not visible on B-mode (greyscale) imaging can now be detected with real time strain imaging which is beginning to be developed on commercial ultrasound equipment. The information obtained with strain/elasticity imaging is now showing potential in influencing management of patients with breast problems.

Neuropsychological and structural brain changes in anorexia nervosa before and after refeeding

1996 ◽  
Vol 26 (1) ◽  
pp. 15-28 ◽  
Author(s):  
K. Kingston ◽  
G. Szmukler ◽  
D. Andrewes ◽  
B. Tress ◽  
P. Desmond
Keyword(s):  
Anorexia Nervosa ◽  
Significant Proportion ◽  
Normal Weight ◽  
Control Group ◽  
Consecutive Series ◽  
Duration Of Illness ◽  
Before And After ◽  
Brain Changes ◽  
Magnetic Resonance Imaging Mri ◽  
Inhibition And Memory

SynopsisThe neuropsychological performance and Magnetic Resonance Imaging (MRI) brain appearance of a consecutive series of 46 in-patients with anorexia nervosa (AN) was compared with hat of 41 normal-weight controls. The groups were matched for sex, age, estimated pre-morbid intelligence and education. AN patients who had gained at least 10% of their body weight were retested and rescanned. Controls were retested after a similar interval. The AN group performed significantly worse than the controls on tasks measuring attention, visuospatial ability and memory. On tasks assessing flexibility and learning, no group differences were evident although an examination of deficits in individuals revealed that more anorexics were impaired on both. Following treatment, the AN group improved relative to the control group only on those tasks assessing attention. Comparison of MRI measures showed a significant proportion of anorexics had enlarged lateral ventricles and dilated sulci on both cortical and cerebellar surfaces, but no dilatation was evident for the third and fourth ventricular measures. Improvements were found after treatment on some of the radiological measures but many differences remained. Relationships between morphological brain changes and cognitive impairments were weak. Lower weight, but not duration of illness, was associated with poorer performance on tasks assessing flexibility/inhibition and memory, and with greater MRI ventricular size.

scholarly journals Iron and Orange Extract on Hemoglobin among Anemic Pregnant Women in Nusa Tenggara Barat in 2018

2020 ◽  
pp. 8
Author(s):  
Shinta Novelia ◽  
Ariati Dewi ◽  
Sri Melinasari ◽  
Retno Widowati ◽  
Bunga Tiara Carolin
Keyword(s):  
Iron Deficiency ◽  
Pregnant Women ◽  
Sampling Technique ◽  
Control Group ◽  
Women Nurses ◽  
Significant Difference ◽  
Before And After ◽  
Quasi Experimental ◽  
Clinically Significant ◽  
And Control

Iron deficiency is the most common pathologic cause of anemia among pregnant women. Pregnant women with clinically significant iron deficiency may present with fatigue, weakness, pallor, tachycardia, and shortness of breath. An intervention is needed to improve hemoglobin among anemic pregnant women. This study aimed to analyze the effect of iron with orange extract on hemoglobin among anemic pregnant women in the Brang Rea health centers, Sumbawa Barat Regency, Nusa Tenggara Barat Province in 2017. The design was a quasi-experimental study. The population was 30 pregnant women who were anemic at the Brang Rea health center. A total population was used for sampling technique. Thirty anemic pregnant women were divided into the experiment and control group without randomization. The data were analyzed using descriptive statistics and inferential statistics. The results showed that there was a significant difference in hemoglobin before and after the intervention (p = 0.001, t = -21.1), and there was a significant difference in hemoglobin between the experimental group and the control group (p = 0.001, t = 5.19). Consuming iron, together with orange extract, could increase hemoglobin among anemic pregnant women. Nurses and midwives need to share health education about the way to consume iron to prevent anemia among pregnant women.

scholarly journals CURRENT COMPUTER TECHNOLOGIES IN THE DIAGNOSIS OF TRACHEOMALACIA IN PATIENTS WITH CICATRICIAL TRACHEAL STENOSIS IN THE PERIOPERATIVE PERIOD

2018 ◽  
Vol 99 (4) ◽  
pp. 197-203
Author(s):  
I. M. Koroleva ◽  
M. A. Mishchenko
Keyword(s):  
Tracheal Stenosis ◽  
Perioperative Period ◽  
Control Group ◽  
Mri Findings ◽  
Endoscopic Method ◽  
Clinically Significant ◽  
Magnetic Resonance Imaging Mri ◽  
Sensitivity Specificity ◽  
Diagnostic Capabilities

Objective: to analyze current radiodiagnostic techniques in identifying tracheomalacia (TM) and estimating its severity and extent in patients with cicatricial tracheal stenosis (CTS) and to determine the important characteristics of TM according to follow-up multislice computed tomography (MSCT) and magnetic resonance imaging (MRI) findings.Material and methods. The investigation included the results of examining 94 patients, 81 of whom were diagnosed with CTS. To analyze the efficiency of the studies, the patients were divided into three groups; a control group of patients was formed. The diagnosis of TM was verified by clinical examination, instrumental diagnosis, MSCT and MRI studies, and intraoperative revision. The patients’ postoperative features were taken into consideration. Diagnostic performance measures, such as sensitivity, specificity, and accuracy, were calculated. Static radiation techniques (MSCT and MRI) and follow-up procedures (fMSCT and fMRI) were compared.Results. The follow-up procedures were proven to be twice as informative for the detection of the symptoms of TM as the endoscopic method that is considered the main method for the diagnosis of pathological tracheal changes. The diagnostic capabilities of MSCT, fMSCT, MRI, and fMRI were determined; criteria for identifying TM were formulated. The use of the follow-up procedures to identify clinically significant TM in patients with CTS could radically alter surgical tactic in 36.9% of cases.Conclusion. The proposed algorithm for examination of patients with CTS, which includes follow-up radiation procedures to evaluate the functional state of the tracheal wall, makes it possible to determine an optimal treatment policy and to significantly reduce the risks of complications and disease recurrences.

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