scholarly journals Randomized trials on non-pharmaceutical interventions for COVID-19 as of August 2021: a meta-epidemiological analysis

2021 ◽  
Author(s):  
Julian Hirt ◽  
Perrine Janiaud ◽  
Lars G. Hemkens
Keyword(s):  
Randomized Trials ◽  
The United States ◽  
World Health ◽  
Public Health Emergencies ◽  
Related Information ◽  
Screening Strategies ◽  
Health Organization ◽  
Clinical Trials Registry ◽  
Pharmaceutical Interventions

AbstractBackgroundNumerous non-pharmaceutical interventions (NPIs) were taken worldwide to contain the spread of the COVID-19 pandemic. We aimed at providing an overview of randomized trials assessing NPIs to prevent COVID-19.MethodsWe included all randomized trials assessing NPIs to prevent COVID-19 in any country and setting registered in ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform using the COVID-evidence platform (until 17 August 2021). We searched for corresponding publications in MEDLINE/PubMed, Google Scholar, the Living Overview of Evidence platform (L-OVE), and the Cochrane COVID-19 registry as well as for results posted in registries.ResultsWe identified 41 randomized trials. Of them, 11 were completed (26.8%) including 7 with published results. The 41 trials planned to recruit a median of 1,700 participants (IQR, 588 to 9,500, range 30 to 35,256,399) with a median planned duration of 8 months (IQR, 3 to 14, range 1 to 24). Most came from the United States (n=11, 26.8%). The trials mostly assessed protective equipment (n=11, 26.8%), COVID-19-related information and education programs (n=9, 22.0%), access to mass events under specific safety measures (n=5, 12.2%), testing and screening strategies (n=5, 12.2%), and hygiene management (n=5, 12.2%).ConclusionsWorldwide, 41 randomized trials assessing NPIs have been initiated with published results available to inform policy decisions for only 7 of them. A long-term research agenda including behavioral, environmental, social, and systems level interventions is urgently needed to guide policies and practices in the current and future public health emergencies.

Synchronized movement between US lumber futures and southern pine sawtimber prices and COVID-19 impacts

2022 ◽  
Author(s):  
Jianbang Gan ◽  
Nana Tian ◽  
Junyeong Choi ◽  
Matthew Pelkki
Keyword(s):  
Value Chain ◽  
The United States ◽  
World Health ◽  
Southern Pine ◽  
Low Frequencies ◽  
Time Frequency ◽  
The Us ◽  
The World ◽  
Health Organization

We analyzed the synchronized movements of lumber futures and southern pine sawtimber stumpage prices in the United States since 2011 and their response to COVID-19 events using wavelet analysis and event study. We found that the sawtimber and lumber prices have followed complex comovement patterns in the time-frequency domain and both reacted to COVID-19 events with a higher response intensity of the lumber price. Although they reacted differently to the early COVID-19 episodes and vaccine news, the sawtimber and lumber prices responded similarly to the COVID-19 pandemic declarations by the World Health Organization and US president, the US Food and Drug Administration panel’s recommendation of the first COVID-19 vaccine, and economic stimulus legislation. The patterns of synchronized movements between the sawtimber and lumber prices varied with time and frequency, but their comovement at low frequencies (>64 weeks) has strengthened since 2014 and been led by the lumber futures price; COVID-19 episodes have not changed this trend. The different magnitude of response of the two prices to the COVID-19 related events, as well as the long-term dominance of the lumber price in the comovement, reveals asymmetric price negotiation power and benefit distributions among the agents of the lumber value chain.

Strategically Positioned: Breastfeeding, Advocacy, and the Hands-On Nurse

2017 ◽  
Vol 23 (3) ◽  
pp. 192-200 ◽  
Author(s):  
Erika L. Gathron
Keyword(s):  
The United States ◽  
World Health ◽  
Grassroots Organizations ◽  
Breastfeeding Knowledge ◽  
The World ◽  
Short And Long Term ◽  
La Leche League ◽  
Health Organization ◽  
Physiological Benefits

Breastfeeding, a health behavior that provides well-known benefits for mothers, infants, and children, is an essential strategy to improve public health. Breastfeeding can reduce the incidence of infant illness and death and provides both short- and long-term physiological benefits to mothers. National and international government agencies and grassroots organizations supporting breastfeeding include the World Health Organization, the United Nations International Children’s Emergency Fund, the World Alliance for Breastfeeding Action, the Centers for Disease Control and Prevention, and the La Leche League. In the United States, breastfeeding of infants was the norm until the late 1890s when the Progressive Era’s emphasis on science and modernity led to the transition of childbirth from residential in-home births to community-based hospital births and the aggressive rise of the baby formula industry. By 1966, only 18% of mothers were exclusively breastfeeding their infants at hospital discharge. This drastic decrease in breastfeeding reduced the percentage of mothers and grandmothers who could share their breastfeeding knowledge and experience. Nurses who provide care for women and infants are essential stakeholders in bridging the breastfeeding knowledge gap by offering education on the short- and long-term health benefits of breastfeeding to both mother and baby and timely encouragement to mothers during the most significant time for establishing lactation.

scholarly journals The Future of the World Health Organization: China and the United States Square Off

2020 ◽  
Vol 15 (4) ◽  
pp. 520-529
Author(s):  
Donald Lien ◽  
Joseph Kortsch
Keyword(s):  
United States ◽  
World Health Organization ◽  
Initial Response ◽  
The United States ◽  
World Health ◽  
Political Movements ◽  
The World ◽  
The Future ◽  
Health Organization

Summary The purpose of this essay is to discuss the ramifications of the 2020 COVID-19 pandemic on the future of the World Health Organization (WHO). In particular, the WHO has come under fire for its initial response and reporting of the pandemic, its acceptance of Chinese self-reporting and management of the crisis and dubious claims that it failed to acknowledge and respond to data from Taiwan that indicated human–to-human transmission was occurring. These alleged missteps have brought unwanted and intense international scrutiny on the organisation and have, perhaps, left its future uncertain. This essay examines the history and mandate of the WHO, its vulnerability to national and regional political movements and some likely outcomes for the near- and long-term future. Additionally, it briefly addresses how the WHO is used as a diplomatic surrogate for the UN, especially in matters relating to Taiwan.

scholarly journals Case Report: Mitral Valve Involvement and First-Degree Atrial-Ventricular Block in Two Patients With Multisystem Inflammatory Syndrome in Children

2021 ◽  
Vol 9 ◽  
Author(s):  
Paola Di Filippo ◽  
Massimiliano Raso ◽  
Marta Cacciatore ◽  
Roberta Patacchiola ◽  
Giulia Renda ◽  
...  
Keyword(s):  
Mitral Valve ◽  
The United States ◽  
World Health ◽  
Cutaneous Rash ◽  
Health Organization ◽  
High Level ◽  
Inflammatory Syndrome ◽  
Recommended Therapy

COVID-19 seems to be less frequent and severe in children compared to adults. Despite the very few symptoms usually found in children, great attention was recorded when in April 2020 a hyperinflammatory process in children with fever and multiorgan involvement after a paucisymptomatic COVID infection was reported. The United States Centers for Disease Control and the World Health Organization recognized and defined this syndrome as “Multisystem Inflammatory Syndrome in Children (MIS-C).” We describe two cases of MIS-C presenting with fever, cutaneous rash, and a mild cardiac involvement expressed with a transient mitral valve involvement and a first-degree atrioventricular block. Acute treatment was managed with intravenous immunoglobulin, oral aspirin, and intravenous corticosteroids reaching consequent good outcome. Clinical characteristics, treatment management, follow-up, and long-term evolution of children with MIS-C are still poorly defined. Further research is needed to better understand the pathogenesis of this newly described condition, to validate a high-level recommended therapy and a specific therapy tapering timings.

Hodgkin Disease/Lymphoma

2008 ◽  
Vol 6 (6) ◽  
pp. 594 ◽  
Author(s):  
_ _
Keyword(s):  
Intermediate Stage ◽  
The United States ◽  
Hodgkin Disease ◽  
World Health ◽  
Stage Disease ◽  
Treatment Considerations ◽  
Health Organization ◽  
Cure Rates ◽  
Recent Version

Hodgkin disease/lymphoma (HD/HL) is an uncommon malignancy; in 2008, an estimated 8220 new diagnoses and 1350 deaths will occur in the United States. The past few decades have seen significant progress in the management of HL; it is now curable in at least 80% of patients. In fact, cure rates for HL have increased so extensively that the overriding treatment considerations often relate to long-term toxicity, especially for patients with early- or intermediate-stage disease. The World Health Organization classification divides HL into 2 main types: classical and lymphocyte-predominant HL (CHL and LPHL). These guidelines discuss clinical management, focusing exclusively on patients from postadolescence through the seventh decade of life who do not have serious intercurrent disease. For the most recent version of the guidelines, please visit NCCN.org

scholarly journals Psychometric validation of the Chinese version of the PaArticular Scales among elderly residents in long-term care facilities with joint contractures

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yi-chang Chen ◽  
Keh-chung Lin ◽  
Chen-Jung Chen ◽  
Shu-Hui Yeh ◽  
Ay-Woan Pan ◽  
...  
Keyword(s):  
World Health Organization ◽  
Long Term Care ◽  
Chinese Version ◽  
World Health ◽  
Term Care ◽  
Joint Contractures ◽  
The World ◽  
Health Organization

Abstract Background Joint contractures, which affect activity, participation, and quality of life, are common complications of neurological conditions among elderly residents in long-term care facilities. This study examined the reliability and validity of the Chinese version of the PaArticular Scales in a population with joint contractures. Methods A cross-sectional study design was used. The sample included elderly residents older than 64 years with joint contractures in an important joint who had lived at one of 12 long-term care facilities in Taiwan for more than 6 months (N = 243). The Chinese version of the PaArticular Scales for joint contractures was generated from the English version through five stages: translation, review, back-translation, review by a panel of specialists, and a pretest. Test-retest reliability, internal consistency reliability, construct validity, and criterion validity were evaluated, and the results were compared with those for the World Health Organization Quality of Life scale and the World Health Organization Disability Assessment Schedule. Results The Chinese version of the PaArticular Scales had excellent reliability, with a Cronbach α coefficient of 0.975 (mean score, 28.98; standard deviation, 17.34). An exploratory factor analysis showed three factors and one factor with an eigenvalue > 1 that explained 75.176 and 62.83 % of the total variance in the Activity subscale and Participation subscale, respectively. The subscale-to-total scale correlation analysis showed Pearson correlation coefficients of 0.881 for the Activity subscale and 0.843 for the Participation subscale. Pearson’s product-moment correlation revealed that the correlation coefficient (r) between the Chinese version of the PaArticular Scales and the World Health Organization Disability Assessment Schedule was 0.770, whereas that for the World Health Organization Quality of Life scale was − 0.553; these values were interpreted as large coefficients. Conclusions The underlying theoretical model of the Chinese version of the PaArticular Scales functions well in Taiwan and has acceptable levels of reliability and validity. However, the Chinese version must be further tested for applicability and generalizability in future studies, preferably with a larger sample and in different clinical domains.

scholarly journals Malaria continues to select for sickle cell trait in Central Africa

2015 ◽  
Vol 112 (22) ◽  
pp. 7051-7054 ◽  
Author(s):  
Eric Elguero ◽  
Lucrèce M. Délicat-Loembet ◽  
Virginie Rougeron ◽  
Céline Arnathau ◽  
Benjamin Roche ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Genetic Disorder ◽  
Central Africa ◽  
The United States ◽  
Malaria Prevalence ◽  
Current Data ◽  
World Health ◽  
Human Populations ◽  
Health Organization

Sickle cell disease (SCD) is a genetic disorder that poses a serious health threat in tropical Africa, which the World Health Organization has declared a public health priority. Its persistence in human populations has been attributed to the resistance it provides to Plasmodium falciparum malaria in its heterozygous state, called sickle cell trait (SCT). Because of migration, SCT is becoming common outside tropical countries: It is now the most important genetic disorder in France, affecting one birth for every 2,400, and one of the most common in the United States. We assess the strength of the association between SCT and malaria, using current data for both SCT and malaria infections. A total of 3,959 blood samples from 195 villages distributed over the entire Republic of Gabon were analyzed. Hemoglobin variants were identified by using HPLCy (HPLC). Infections by three species of Plasmodium were detected by PCR followed by sequencing of a 201-bp fragment of cytochrome b. An increase of 10% in P. falciparum malaria prevalence is associated with an increase by 4.3% of SCT carriers. An increase of 10 y of age is associated with an increase by 5.5% of SCT carriers. Sex is not associated with SCT. These strong associations show that malaria remains a selective factor in current human populations, despite the progress of medicine and the actions undertaken to fight this disease. Our results provide evidence that evolution is still present in humans, although this is sometimes questioned by scientific, political, or religious personalities.

PUBLIC HEALTH, NURSING AND MEDICAL SOCIAL WORK

PEDIATRICS ◽  
1951 ◽  
Vol 8 (4) ◽  
pp. 570-572
Keyword(s):  
Premature Infants ◽  
The United States ◽  
World Health ◽  
Multiple Birth ◽  
Expert Committee ◽  
Medical Social Work ◽  
Incidence And Mortality ◽  
Health Nursing ◽  
Health Organization ◽  
Intrinsic Variable

IN THE summary of the report of the Expert Committee on Prematurity of the World Health Organization, published in this column in February 1951, Dr. Ethel Dunham indicated the concern of the Expert Committee in regard to uniformity of information on the incidence and mortality of prematurity. The need for uniformity is particularly urgent in a field where there are so many intrinsic variable factors. It has been shown time and again that the ability of a premature infant to survive, under the best of care, is closely correlated with the birth weight, which in itself reflects the stage of maturity. In turn, the stage of maturity at a given weight is affected by sex, race, and whether the child is a single or one of a multiple birth. Uniformly, at a particular stage of maturity, male infants are larger than female, single births are larger than multiple births and, in the United States, white babies are larger than Negro babies. These considerations underline the danger of misinterpretation of so-called over-all rates for the incidence of prematurity and for the mortality of premature infants. For example, at any given weight, Negro premature infants are probably more mature and consequently have a better chance of surviving.

AVALIAÇÃO DA RELAÇÃO DO NÚMERO DE SINTOMÁTICOS RESPIRATÓRIOS E OS CASOS CONFIRMADOS DE TUBERCULOSE EM PALMAS-TO NO PERÍODO DE 2015-2016

2018 ◽  
Vol 5 (2) ◽  
pp. 29-33
Author(s):  
Robson de Sousa ◽  
Maria do Socorro Rocha Sarmento Nobre
Keyword(s):  
Early Identification ◽  
World Health ◽  
Epidemiological Surveillance ◽  
Cross Sectional ◽  
Public Health Activity ◽  
Transmission Chain ◽  
Keywords Tuberculosis ◽  
Health Organization ◽  
Term Objective

RESUMO Estratégia usada internacionalmente a busca ativa de sintomáticos respiratórios permite identificar precocemente pessoas com tosse por tempo igual ou superior a três semanas consideradas com suspeita de tuberculose pulmonar visando à descoberta dos casos bacilíferos. É uma atividade de saúde pública e deve ser realizada por todos os serviços de saúde de forma permanente. Com o objetivo de identificar os casos, interromper a cadeia de transmissão e reduzir a incidência da doença a longo prazo.  Objetivo: Conhecer os números de casos notificados de tuberculose e realizar um comparativo com os indicadores de sintomático respiratório no município de Palmas/TO entre os anos de 2015 e 2016. Método: O estudo é do tipo descritivo, de corte transversal e documental direta. Conclusão: Verifica-se que o número confirmado de TB da pesquisa do SR tanto para o ano de 2015 quanto para o ano de 2016 está muito aquém dos casos novos notificados, foi possível perceber a descontinuidade dos pacientes que são encaminhados para avaliação e que não há segmentos principalmente em relação ao resultado dos exames.   Palavras-chave: Tuberculose. Vigilância Epidemiológica. Organização Mundial da Saúde. ABSTRACT A strategy used internationally for the active search of respiratory symptomatic patients allows early identification of people with cough for a time equal to or greater than three weeks considered with suspicion of pulmonary tuberculosis in order to discover the bacilliferous cases. It is a public health activity and must be performed by all health services on an ongoing basis. In order to identify the cases, interrupt the transmission chain and reduce the incidence of the disease in the long term. Objective: To know the numbers of reported cases of tuberculosis and to carry out a comparison with the indicators of respiratory symptomatology in the municipality of Palmas / TO between the years 2015 and 2016. Method: The study is descriptive, cross-sectional and direct documentary. Conclusion: It is verified that the confirmed number of TB of the RS research for both the year 2015 and the year 2016 is well below the new cases reported, it was possible to perceive the discontinuity of the patients that are referred for evaluation and which are not mainly related to the results of the exams. Keywords: Tuberculosis. Epidemiological surveillance. World Health Organization.

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