scholarly journals Brain predictors of fatigue in Rheumatoid Arthritis: a machine learning study

Author(s):  
María Goñi ◽  
Neil Basu ◽  
Alison D Murray ◽  
Gordon D Waiter

Background: Fatigue is a common and burdensome symptom in Rheumatoid Arthritis (RA), yet is poorly understood. Currently, clinicians rely solely on fatigue questionnaires, which are inherently subjective measures. For the effective development of future therapies and stratification, it is of vital importance to identify biomarkers of fatigue. In this study, we identify brain differences between RA patients who improved and did not improve their levels of fatigue, and we compared the performance of different classifiers to distinguish between these samples at baseline. Methods: Fifty-four fatigued RA patients underwent a magnetic resonance (MR) scan at baseline and 6 months later. At 6 months we identified those whose fatigue levels improved and those for whom it did not. More than 900 brain features across three data sets were assessed as potential predictors of fatigue improvement. These data sets included clinical, structural MRI (sMRI) and diffusion tensor imaging (DTI) data. A genetic algorithm was used for feature selection. Three classifiers were employed in the discrimination of improvers and non-improvers of fatigue: a Least Square Linear Discriminant (LSLD), a linear Support Vector Machine (SVM) and a SVM with Radial Basis Function kernel. Results: The highest accuracy (67.9%) was achieved with the sMRI set, followed by the DTI set (63.8%), whereas classification performance using clinical features was at the chance level. The mean curvature of the left superior temporal sulcus was most strongly selected during the feature selection step, followed by the surface are of the right frontal pole and the surface area of the left banks of the superior temporal sulcus. Conclusions: The results presented in this study evidence a superiority of brain metrics over clinical metrics in predicting fatigue changes. Further exploration of these methods may enable clinicians to triage patients towards the most appropriate fatigue alleviating therapies.

2013 ◽  
Vol 23 (06) ◽  
pp. 1350026 ◽  
Author(s):  
WEI-YEN HSU

In this study, we propose a recognition system for single-trial analysis of motor imagery (MI) electroencephalogram (EEG) data. Applying event-related brain potential (ERP) data acquired from the sensorimotor cortices, the system chiefly consists of automatic artifact elimination, feature extraction, feature selection and classification. In addition to the use of independent component analysis, a similarity measure is proposed to further remove the electrooculographic (EOG) artifacts automatically. Several potential features, such as wavelet-fractal features, are then extracted for subsequent classification. Next, quantum-behaved particle swarm optimization (QPSO) is used to select features from the feature combination. Finally, selected sub-features are classified by support vector machine (SVM). Compared with without artifact elimination, feature selection using a genetic algorithm (GA) and feature classification with Fisher's linear discriminant (FLD) on MI data from two data sets for eight subjects, the results indicate that the proposed method is promising in brain–computer interface (BCI) applications.


PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255307
Author(s):  
Fujun Wang ◽  
Xing Wang

Feature selection is an important task in big data analysis and information retrieval processing. It reduces the number of features by removing noise, extraneous data. In this paper, one feature subset selection algorithm based on damping oscillation theory and support vector machine classifier is proposed. This algorithm is called the Maximum Kendall coefficient Maximum Euclidean Distance Improved Gray Wolf Optimization algorithm (MKMDIGWO). In MKMDIGWO, first, a filter model based on Kendall coefficient and Euclidean distance is proposed, which is used to measure the correlation and redundancy of the candidate feature subset. Second, the wrapper model is an improved grey wolf optimization algorithm, in which its position update formula has been improved in order to achieve optimal results. Third, the filter model and the wrapper model are dynamically adjusted by the damping oscillation theory to achieve the effect of finding an optimal feature subset. Therefore, MKMDIGWO achieves both the efficiency of the filter model and the high precision of the wrapper model. Experimental results on five UCI public data sets and two microarray data sets have demonstrated the higher classification accuracy of the MKMDIGWO algorithm than that of other four state-of-the-art algorithms. The maximum ACC value of the MKMDIGWO algorithm is at least 0.5% higher than other algorithms on 10 data sets.


Author(s):  
Melih S. Aslan ◽  
Hossam Abd El Munim ◽  
Aly A. Farag ◽  
Mohamed Abou El-Ghar

Graft failure of kidneys after transplantation is most often the consequence of the acute rejection. Hence, early detection of the kidney rejection is important for the treatment of renal diseases. In this chapter, authors introduce a new automatic approach to classify normal kidney function from kidney rejection using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). The kidney has three regions named the cortex, medulla, and pelvis. In their experiment, they use the medulla region because it has specific responses to DCE-MRI that are helpful to identify kidney rejection. In the authors’ process they segment the kidney using the level sets method. They then employ several classification methods such as the Euclidean distance, Mahalanobis distance, and least square support vector machines (LS-SVM). The authors’preliminary results are very encouraging and reproducibility of the results was achieved for 55 clinical data sets. The classification accuracy, diagnostic sensitivity, and diagnostic specificity are 84%, 75%, and 96%, respectively.


Electronics ◽  
2018 ◽  
Vol 7 (9) ◽  
pp. 199 ◽  
Author(s):  
Lucia Billeci ◽  
Magda Costi ◽  
David Lombardi ◽  
Franco Chiarugi ◽  
Maurizio Varanini

Atrial fibrillation (AF) is the most common cardiac disease and is associated with other cardiac complications. Few attempts have been made for discriminating AF from other arrhythmias and noise. The aim of this study is to present a novel approach for such a classification in short ECG recordings acquired using a smartphone device. The implemented algorithm was tested on the Physionet Computing in Cardiology Challenge 2017 Database and, for the purpose of comparison, on the MIT-BH AF database. After feature extraction, the stepwise linear discriminant analysis for feature selection was used. The Least Square Support Vector Machine classifier was trained and cross-validated on the available dataset of the Challenge 2017. The best performance was obtained with a total of 30 features. The algorithm produced the following performance: F1 Normal rhythm = 0.92; F1 AF rhythm: 0.82; F1 Other rhythm = 0.75; Global F1 = 0.83, obtaining the third best result in the follow-up phase of the Physionet Challenge. On the MIT-BH ADF database the algorithm gave the following performance: F1 Normal rhythm = 0.98; F1 AF rhythm: 0.99; Global F1 = 0.98. Since the algorithm reliably detect AF and other rhythms in smartphone ECG recordings, it could be applied for personal health monitoring systems.


2019 ◽  
Vol 47 (3) ◽  
pp. 154-170
Author(s):  
Janani Balakumar ◽  
S. Vijayarani Mohan

Purpose Owing to the huge volume of documents available on the internet, text classification becomes a necessary task to handle these documents. To achieve optimal text classification results, feature selection, an important stage, is used to curtail the dimensionality of text documents by choosing suitable features. The main purpose of this research work is to classify the personal computer documents based on their content. Design/methodology/approach This paper proposes a new algorithm for feature selection based on artificial bee colony (ABCFS) to enhance the text classification accuracy. The proposed algorithm (ABCFS) is scrutinized with the real and benchmark data sets, which is contrary to the other existing feature selection approaches such as information gain and χ2 statistic. To justify the efficiency of the proposed algorithm, the support vector machine (SVM) and improved SVM classifier are used in this paper. Findings The experiment was conducted on real and benchmark data sets. The real data set was collected in the form of documents that were stored in the personal computer, and the benchmark data set was collected from Reuters and 20 Newsgroups corpus. The results prove the performance of the proposed feature selection algorithm by enhancing the text document classification accuracy. Originality/value This paper proposes a new ABCFS algorithm for feature selection, evaluates the efficiency of the ABCFS algorithm and improves the support vector machine. In this paper, the ABCFS algorithm is used to select the features from text (unstructured) documents. Although, there is no text feature selection algorithm in the existing work, the ABCFS algorithm is used to select the data (structured) features. The proposed algorithm will classify the documents automatically based on their content.


2018 ◽  
Vol 2018 ◽  
pp. 1-21 ◽  
Author(s):  
Sizhou Sun ◽  
Jingqi Fu ◽  
Feng Zhu ◽  
Nan Xiong

The aims of this study contribute to a new hybrid model by combining ensemble empirical mode decomposition (EEMD) with multikernel function least square support vector machine (MKLSSVM) optimized by hybrid gravitation search algorithm (HGSA) for short-term wind speed prediction. In the forecasting process, EEMD is adopted to make the original wind speed data decomposed into intrinsic mode functions (IMFs) and one residual firstly. Then, partial autocorrelation function (PACF) is applied to identify the correlation between the corresponding decomposed components. Subsequently, the MKLSSVM using multikernel function of radial basis function (RBF) and polynomial (Poly) kernel function by weight coefficient is exploited as core forecasting engine to make the short-term wind speed prediction. To improve the regression performance, the binary-value GSA (BGSA) in HGSA is utilized as feature selection approach to remove the ineffective candidates and reconstruct the most relevant feature input-matrix for the forecasting engine, while real-value GSA (RGSA) makes the parameter combination optimization of MKLSSVM model. In the end, these respective decomposed subseries forecasting results are combined into the final forecasting values by aggregate calculation. Numerical results and comparable analysis illustrate the excellent performance of the EEMD-HGSA-MKLSSVM model when applied in the short-term wind speed forecasting.


2014 ◽  
Vol 26 (3) ◽  
pp. 557-591 ◽  
Author(s):  
Stefano Baccianella ◽  
Andrea Esuli ◽  
Fabrizio Sebastiani

Ordinal classification (also known as ordinal regression) is a supervised learning task that consists of estimating the rating of a data item on a fixed, discrete rating scale. This problem is receiving increased attention from the sentiment analysis and opinion mining community due to the importance of automatically rating large amounts of product review data in digital form. As in other supervised learning tasks such as binary or multiclass classification, feature selection is often needed in order to improve efficiency and avoid overfitting. However, although feature selection has been extensively studied for other classification tasks, it has not for ordinal classification. In this letter, we present six novel feature selection methods that we have specifically devised for ordinal classification and test them on two data sets of product review data against three methods previously known from the literature, using two learning algorithms from the support vector regression tradition. The experimental results show that all six proposed metrics largely outperform all three baseline techniques (and are more stable than these others by an order of magnitude), on both data sets and for both learning algorithms.


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