scholarly journals Temporal trends in incidence of childhood cancer in Switzerland, 1985-2014

2019 ◽  
Author(s):  
Grit Sommer ◽  
Matthias Schindler ◽  
Shelagh Redmond ◽  
Verena Pfeiffer ◽  
Garyfallos Konstantinoudis ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Temporal Trends ◽  
List Type ◽  
Standard Population ◽  
European Standard Population ◽  
Increasing Trend ◽  
Cns Tumours ◽  
Rising Incidence ◽  
Changes In Risk ◽  
Diagnostic Changes

STRUCTURED ABSTRACTBackgroundIncidence of childhood cancer increased in most countries worldwide, but the reasons are unclear. This study investigates trends in childhood cancer incidence in Switzerland from 1985 to 2014.MethodsWe extracted data on all childhood cancer cases diagnosed at ages 0-14 years in Switzerland from the Swiss Childhood Cancer Registry. We included ICCC-3 main groups I-XII and calculated age-standardised, cumulative, and age-specific incidence for different diagnostic groups. We analysed trends in annual age-standardised incidence using JoinPoint regression models.ResultsOver the study period from 1985-2014, 5104 of 5486 cancer diagnoses (93%) were microscopically verified. The proportion of children treated in paediatric cancer centres increased from 84% during 1985-1994 to 93% in 1995-2004 and 98% in 2005-2014 (p<0.001). Using the 2010 European standard population, age-standardised incidence was 143 in 1985-1994, 154 in 1995-2004, and 162 per million in 2005-2014. Over the period 1985-2014, incidence for all cancers increased by 0.7% (95% confidence interval [CI] 0.5-1.0) per year, 0.8% (95% CI 0.2%-1.4%) for leukaemias, 3.8% (95% CI 1.7%-6.0%) for epithelial neoplasms and melanomas, and 3.0% (95% CI 1.3%-4.6%) for CNS tumours for the period 1985-2002.ConclusionTrends in incidence were driven mostly by increases among leukaemias and CNS tumours. For CNS tumours, observed trends may be explained at least partially by diagnostic changes and improved registration. For leukaemias, rising incidence may be real and at least partly due to changes in risk factors.HighlightsIn Switzerland, incidence of childhood cancer increased by 18% from 1985-2014.Increase in incidence was mainly caused by brain tumours and leukaemias.Improved registration and diagnostics may have increased brain tumour incidence.Increasing trend for leukaemias may be real, but reasons remain elusive.

Temporal trends of the association between extreme temperatures and hospitalisations for schizophrenia in Hefei, China from 2005 to 2014

2021 ◽  
Vol 78 (5) ◽  
pp. 364-370
Author(s):  
Rubing Pan ◽  
Qizhi Wang ◽  
Weizhuo Yi ◽  
Qiannan Wei ◽  
Jian Cheng ◽  
...  
Keyword(s):  
Time Series Data ◽  
Temporal Trends ◽  
Extreme Temperature ◽  
Series Data ◽  
Extreme Temperatures ◽  
Distributed Lag ◽  
Increasing Trend ◽  
Related Hospitalisation ◽  
Extreme Cold ◽  
And Gender

ObjectiveWe aimed to examine the temporal trends of the association between extreme temperature and schizophrenia (SCZ) hospitalisations in Hefei, China.MethodsWe collected time-series data on SCZ hospitalisations for 10 years (2005–2014), with a total of 36 607 cases registered. We used quasi-Poisson regression and distributed lag non-linear model (DLNM) to assess the association between extreme temperature (cold and heat) and SCZ hospitalisations. A time-varying DLNM was then used to explore the temporal trends of the association between extreme temperature and SCZ hospitalisations in different periods. Subgroup analyses were conducted by age (0–39 and 40+ years) and gender, respectively.ResultsWe found that extreme cold and heat significantly increased the risk of SCZ hospitalisations (cold: 1st percentile of temperature 1.19 (95% CI 1.04 to 1.37) and 2.5th percentile of temperature 1.16 (95% CI 1.03 to 1.31); heat: 97.5th percentile of temperature 1.37 (95% CI 1.13 to 1.66) and 99th percentile of temperature 1.38 (95% CI 1.13 to 1.69)). We found a slightly decreasing trend in heat-related SCZ hospitalisations and a sharp increasing trend in cold effects from 2005 to 2014. However, the risk of heat-related hospitalisation has been rising since 2008. Stratified analyses showed that age and gender had different modification effects on temporal trends.ConclusionsThe findings highlight that as temperatures rise the body’s adaptability to high temperatures may be accompanied by more threats from extreme cold. The burden of cold-related SCZ hospitalisations may increase in the future.

Rising incidence of celiac disease in the Netherlands; an analysis of temporal trends from 1995 to 2010

2014 ◽  
Vol 49 (8) ◽  
pp. 933-941 ◽  
Author(s):  
Jordy P.W. Burger ◽  
Elisabeth A. Roovers ◽  
Joost P.H. Drenth ◽  
Jos W.R. Meijer ◽  
Peter J. Wahab
Keyword(s):  
Celiac Disease ◽  
The Netherlands ◽  
Temporal Trends ◽  
Rising Incidence

scholarly journals Antimicrobial Resistance among Respiratory Pathogens in Spain: Latest Data and Changes over 11 Years (1996-1997 to 2006-2007)

2010 ◽  
Vol 54 (7) ◽  
pp. 2953-2959 ◽  
Author(s):  
Emilio Pérez-Trallero ◽  
Jose E. Martín-Herrero ◽  
Ana Mazón ◽  
Celia García-Delafuente ◽  
Purificación Robles ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antimicrobial Resistance ◽  
Haemophilus Influenzae ◽  
Streptococcus Pyogenes ◽  
Temporal Trends ◽  
Surveillance Study ◽  
Respiratory Pathogens ◽  
Ampicillin Resistance ◽  
Increasing Trend

ABSTRACT A nationwide multicenter susceptibility surveillance study (Susceptibility to the Antimicrobials Used in the Community in España [SAUCE] project), SAUCE-4, including 2,559 Streptococcus pneumoniae, 2,287 Streptococcus pyogenes, and 2,736 Haemophilus influenzae isolates was carried out from May 2006 to June 2007 in 34 Spanish hospitals. Then, the results from SAUCE-4 were compared to those from all three previous SAUCE studies carried out in 1996-1997, 1998-1999, and 2001-2002 to assess the temporal trends in resistance and the phenotypes of resistance over the 11-year period. In SAUCE-4, on the basis of the CLSI breakpoints, penicillin (parenteral, nonmeningitis breakpoint) and cefotaxime were the antimicrobials that were the most active against S. pneumoniae (99.8% and 99.6%, respectively). Only 0.9% of isolates had a penicillin MIC of ≥2 μg/ml. In S. pyogenes, nonsusceptibility to erythromycin was observed in 19.4% of isolates. Among the H. influenzae isolates, a β-lactamase-positive prevalence of 15.7% was found. A statistically significant temporal decreasing trend over the 11-year period was observed for nonsusceptibility (from 60.0% to 22.9%) and resistance (from 36.5% to 0.9%) to penicillin and for the proportion of erythromycin-resistant isolates of S. pneumoniae of the macrolide-lincosamide-streptogramin B (MLSB) phenotype (from 98.4% to 81.3%). A similar trend was observed for the prevalence of ampicillin resistance (from 37.6% to 16.1%), β-lactamase production (from 25.7% to 15.7%), and β-lactamase-negative ampicillin resistance (BLNAR) in H. influenzae (from 13.5% to 0.7%). Among erythromycin-resistant isolates of S. pyogenes, a significant increasing trend in the prevalence of MLSB was observed (from 7.0% to 35.5%). SAUCE-4 confirms a generalized decline in the resistance of the main respiratory pathogens to the antimicrobials as well as a shift in their resistance phenotypes.

Abstract 5949: Abnormal NT-Pro-BNP Levels in Asymptomatic Long Term Survivors of Childhood Cancer Treated with Anthracyclines

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Annelies M Mavinkurve-Groothuis ◽  
Jacqueline Groot-Loonen ◽  
Louise Bellersen ◽  
Milanthy S Pourier ◽  
Ton Feuth ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Late Onset ◽  
Troponin T ◽  
Plasma Concentrations ◽  
Left Ventricular ◽  
Internal Diameter ◽  
List Type ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Objectives : to document plasma concentrations of cardiac Troponin T (cTnT) and NT-pro-brain natriuretic peptide (NT-pro-BNP) in a large group of asymptomatic long term survivors of childhood cancer treated with anthracyclines, to study the relation of the abnormal biomarker levels with different risk factors for anthracycline-induced cardiotoxicity and conventional echocardiographic parameters. Methods : 122 asymptomatic survivors of childhood cancer underwent a detailed echocardiography. Blood samples were taken to determine the levels of NT-pro-BNP and cTnT. Results : None of the survivors had abnormal cTnT levels. The mean NT-pro-BNP level of our survivor group was 10 pmol/l (SD±9) with a range of 1–55 pmol/l. Thirteen percent of the survivors had abnormal NT-pro-BNP levels. Abnormal NT-pro-BNP levels were significantly related to cumulative anthracycline dosage (p<0.003). Eleven of 31 (35%) survivors treated with cumulative anthracycline dose of 300 mg/m 2 or more, had abnormal NT-pro-BNP levels which were significantly related to end-diastolic left ventricular internal diameter (LVIDd) indexed for body surface area (BSA) (p<0.01). Conclusion : Cardiac TnT does not contribute to the early detection of late onset anthracyline-induced cardiotoxicity. Abnormal levels of NT-pro-BNP were frequently detected in asymptomatic, long term survivors of childhood cancer. Follow up of these survivors, with both echocardiography and NT-pro-BNP, is essential to answer the question whether NT-pro-BNP is an early marker for late onset anthracycline-induced cardiotoxicity.

Abstract P398: Are the Trends in Age-Standardized Rates and Crude Numbers of Coronary Events Diverging? Results from the FINAMI Study for the Years 1993–2007

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Veikko Salomaa ◽  
Aki S Havulinna ◽  
Heli Koukkunen ◽  
Päivi Kärjä-Koskenkari ◽  
Arto Pietilä ◽  
...  
Keyword(s):  
Heart Failure ◽  
International Classification Of Diseases ◽  
Population Based ◽  
Cardiac Events ◽  
National Hospital Discharge Register ◽  
Incidence And Mortality ◽  
European Standard Population ◽  
Increasing Trend ◽  
Icd 10 ◽  
Coronary Events

Background and Aims: Age-standardized rates of acute coronary events have been declining in all western countries. Concerns have been raised, however, that the absolute numbers of cases may be increasing due to the aging of the population. We examined trends in acute coronary events using data from the FINAMI myocardial infarction (MI) register. We also analyzed trends in coronary and other cardiac events in the whole country, using both age-standardized rates and crude numbers of cases to elucidate the effect of aging of the population. Methods: FINAMI is a population-based MI register, which aims at registering all MI events occurring in the populations aged 35 or over in five geographical areas of Finland. Hospital records, death certificates and other relevant documents were scrutinized and cases were classified to diagnostic categories as recommended by the AHA in 2003. To obtain information on the whole country we used record linkage of the National Hospital Discharge Register and Causes of Death Register. International Classification of Diseases (ICD-10) codes I20-I25 were taken as coronary events, for fatal cases we also included I46, R96 and R98. Other cardiac events consisted of ICD-10 codes I30-I52, thus including heart failure and arrhythmias. Annual population counts for the denominators were obtained from the National Population Information System. Event rates were age-standardized to the European Standard Population. Trends for the rates were estimated using Poisson regression and for crude numbers using linear regression. Results: The FINAMI MI register recorded 15,776 (13,248 men and 11,657 women) incident (=first) coronary events during the study period. In whole country, the corresponding numbers of first coronary events were 406,222 (221,838 in men and 184,383 in women). In FINAMI areas, the coronary mortality declined an average by 4.5% per year in men (P<0.0001) and 4.7% per year in women (p<0.0001). Declines in the incidence were smaller but also very significant: 1.6% and 1.8% per year in men and women, respectively (p<0.0001 for both). In country-wide data, declines in the age-standardized incidence were of the same order of magnitude as in the FINAMI areas and the crude numbers of cases also showed a declining trend: 0.4% per year in men (p=0.046) and 1.5% per year in women (p<0.0001). The age-standardized incidence of other cardiac events showed significant declines in both sexes, but the crude numbers of cases showed a modest increasing trend among men (1.1% per year, p=0.038) while no change was observed in women. Conclusions: Age-standardized incidence and mortality of coronary events continue to decline in Finland. The crude numbers of coronary events have also declined at least until 2007, despite the aging of the population. However, crude numbers of other first cardiac events, including heart failure and arrhythmias, showed a modest increasing trend among men.

scholarly journals Mapping Evapotranspiration, Vegetation and Precipitation Trends in the Catchment of the Shrinking Lake Poopó

2019 ◽  
Vol 12 (1) ◽  
pp. 73 ◽  
Author(s):  
Juan Torres-Batlló ◽  
Belén Martí-Cardona ◽  
Ramiro Pillco-Zolá
Keyword(s):  
Land Cover ◽  
Vegetation Index ◽  
Temporal Trends ◽  
Temporal Analysis ◽  
Mountain Range ◽  
Water Losses ◽  
Essential Information ◽  
General Decline ◽  
Increasing Trend ◽  
Spatio Temporal

Lake Poopó is located in the Andean Mountain Range Plateau or Altiplano. A general decline in the lake water level has been observed in the last two decades, coinciding roughly with an intensification of agriculture exploitation, such as quinoa crops. Several factors have been linked with the shrinkage of the lake, including climate change, increased irrigation, mining extraction and population growth. Being an endorheic catchment, evapotranspiration (ET) losses are expected to be the main water output mechanism and previous studies demonstrated ET increases using Earth observation (EO) data. In this study, we seek to build upon these earlier findings by analyzing an ET time series dataset of higher spatial and temporal resolution, in conjunction with land cover and precipitation data. More specifically, we performed a spatio-temporal analysis, focusing on wet and dry periods, that showed that ET changes occur primarily in the wet period, while the dry period is approximately stationary. An analysis of vegetation trends performed using 500 MODIS vegetation index products (NDVI) also showed an overall increasing trend during the wet period. Analysis of NDVI and ET across land cover types showed that only croplands had experienced an increase in NDVI and ET losses, while natural covers showed either constant or decreasing NDVI trends together with increases in ET. The larger increase in vegetation and ET losses over agricultural regions, strongly suggests that cropping practices exacerbated water losses in these areas. This quantification provides essential information for the sustainable planning of water resources and land uses in the catchment. Finally, we examined the spatio-temporal trends of the precipitation using the newly available Climate Hazards Group Infrared Precipitation with Stations (CHIRPS-v2) product, which we validated with onsite rainfall measurements. When integrated over the entire catchment, precipitation and ET showed an average increasing trend of 5.2 mm yr−1 and 4.3 mm yr−1, respectively. This result suggests that, despite the increased ET losses, the catchment-wide water storage should have been offset by the higher precipitation. However, this result is only applicable to the catchment-wide water balance, and the location of water may have been altered (e.g., by river abstractions or by the creation of impoundments) to the detriment of the Lake Poopó downstream.

scholarly journals Temporal Trends and Spatial Patterns of Temperature and Its Extremes over the Beijing-Tianjin Sand Source Region (1960–2014), China

2018 ◽  
Vol 2018 ◽  
pp. 1-26
Author(s):  
Wei Wei ◽  
Baitian Wang ◽  
Kebin Zhang ◽  
Zhongjie Shi ◽  
Genbatu Ge ◽  
...  
Keyword(s):  
Source Region ◽  
Temporal Trends ◽  
Extreme Temperature ◽  
Spatiotemporal Variability ◽  
Mountain Area ◽  
Increasing Trend ◽  
Cold Tolerant ◽  
Temperature Indices ◽  
Slope Estimator ◽  
Sand Source

In order to examine temperature changes and extremes in the Beijing-Tianjin Sand Source Region (BTSSR), ten extreme temperature indices were selected, categorized, and calculated spanning the period 1960–2014, and the spatiotemporal variability and trends of temperature and extremes on multitimescales in the BTSSR were investigated using the Mann-Kendall (M-K) test, Sen’s slope estimator, and linear regression. Results show that mean temperatures have increased and extreme temperature events have become more frequent. Annual temperature has recorded a significant increasing trend over the BTSSR, in which 51 stations exhibited significant increasing trends (p<0.05); winter temperature recorded the most significant increasing trend in the northwest subregion. All extreme temperature indices showed warming trends at most stations; a higher warming slope in extreme temperature mainly occurred along the northeast border and northwest border and in the central-southern mountain area. As extreme low temperature events decrease, vegetation damage due to freezing temperatures will reduce and low cold-tolerant plants may expand their distribution range northward to revegetate barren areas in the BTSSR. However, in water-limited areas of the BTSSR, increasing temperatures in the growing season may exacerbate stress associated with plants relying on precipitation due to higher temperatures combining with decreasing precipitation.

scholarly journals Global carbon budgets estimated from atmospheric O<sub>2</sub>/N<sub>2</sub> and CO<sub>2</sub> observations in the western Pacific region over a 15-year period

2019 ◽  
Author(s):  
Yasunori Tohjima ◽  
Hitoshi Mukai ◽  
Toshinobu Machida ◽  
Yu Hoshina ◽  
Shin-Ichiro Nakaoka
Keyword(s):  
Mole Fraction ◽  
Temporal Trends ◽  
Heat Content ◽  
Western Pacific ◽  
Global Ocean ◽  
Carbon Sinks ◽  
Increasing Trend ◽  
Carbon Project ◽  
Global Carbon ◽  
The Western Pacific

Abstract. Time series of atmospheric O2/N2 ratio and CO2 mole fraction of flask samples obtained from NIES’s flask sampling network are presented. The network includes two ground sites, Hateruma Island (HAT, 24.05 °N, 123.81 °E) and Cape Ochiishi (COI, 43.17 °N, 145.50 °E), and cargo ships regularly sailing in the western Pacific. Based on temporal changes in fossil fuel-derived CO2 emissions, global atmospheric CO2 burden, and atmospheric potential oxygen (APO), which were calculated from the observed O2/N2 ratio and CO2 mole fraction according to APO = O2 + 1.1 × CO2, we estimated the global carbon sinks of the ocean and land biosphere for a period of more than 15 years. In this carbon budget calculation, we adopted a correction for the time-varying ocean O2 outgassing effect with an average of 0.43 PgC yr−1 for 2000–2016. The outgassing effect, attributed to global ocean warming, was evaluated under the assumption that the net ocean gas flux is proportional to the change in the ocean heat content for the 0–2000 m layer. The resulting oceanic and land biotic carbon sinks were 2.5 ± 0.6 PgC yr−1 and 1.6 ± 0.8 PgC yr−1, respectively, for a 17-year period (2000–2016) and 2.3 ± 0.6 PgC yr−1 and 2.0 ± 0.8 PgC yr−1, respectively, for a 14-year period (2003–2016). Despite the independent approaches, these sink values of this study agreed with those estimated by the Global Carbon Project (GCP) within a difference of about ±0.3 PgC yr−1. We examined the carbon sinks for an interval of five years to assess the temporal trends. The pentad (5-year) ocean sinks showed an increasing trend at a rate of 0.09 ± 0.02 PgC yr−2 during 2001–2014, while the pentad land sinks showed an increasing trend at a rate of 0.23 ± 0.03 PgC yr−2 for 2001–2009 and a decreasing trend at a rate of − 0.23 ± 0.05 PgC yr−2 during 2009–2014. Although there is good agreement in the trends of the pentad sinks between this study and that of GCP, the increasing rate of the pentad ocean sinks of this study was about two times larger than that of GCP.

scholarly journals 3 Advances in treating heart failure

2019 ◽  
Vol 95 (1130) ◽  
pp. 685.3-686
Author(s):  
Martin Cowie
Keyword(s):  
Heart Failure ◽  
Temporal Trends ◽  
Holistic Approach ◽  
Population Based ◽  
Social Needs ◽  
Circulatory Support ◽  
List Type ◽  
Advance Care ◽  
The Uk ◽  
New Diagnosis

The average age of a person with a new diagnosis of heart failure in the UK is now 80, and such a person is as likely to be female as male, to have 5–6 co-morbidities, and to be frail.1 Delivering appropriate care is a challenge, particularly where the evidence from clinical trials may be in patients who are typically 20 years younger and with less complex medical and social needs. Increased awareness of the need for a more holistic approach, with shared decision making, and advance care planning, is improving the experience and outcome of care, but there is marked variation across the NHS.2 3This talk will briefly summarise some of the recent advances in treating heart failure – particularly for those with systolic impairment of the left ventricle, and for those with valve disease. Mechanical circulatory support has improved greatly in recent years but is only ever an option for a tiny minority of patients. Treatment of co-morbidities, such as atrial fibrillation and diabetes, have also improved the outcome for those with heart failure. Despite much effort, cellular and genetic therapies remain a distant prospect. Digital approaches to care, and self-management, show considerable promise but integrating such approaches into a traditional healthcare system has proven challenging.The prognosis of heart failure has improved dramatically for many patients over the past 30 years –but the residual risk of mortality and urgent hospitalisation means that there is much work to be done.ReferencesConrad N, Judge A, Tran J, et al. Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet 2018;391:572–580.Chronic heart failure in adults: diagnosis and management (NG106). National Institute for Health and Care Excellence, September 2018. Available at: https://www.nice.org.uk/guidance/ng106Failure to Function: a review of the care received by patients who died in hospital following an admission with acute heart failure. National Confidential Enquiry into Perioperative Deaths, November 2019. Available at: https://www.ncepod.org.uk/2018report2/AHF%20full%20report.pdf

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