scholarly journals Appropriate Correction for Multiple Comparisons in Decoding of ERP Data: A Re-Analysis of Bae & Luck (2018)

2019 ◽  
Author(s):  
Gi-Yeul Bae ◽  
Steven J. Luck
Keyword(s):  
Working Memory ◽  
Delay Interval ◽  
Multiple Comparisons ◽  
Alpha Band ◽  
Correction Procedure ◽  
Future Studies ◽  
Time Points ◽  
Scalp Distribution ◽  
Original Procedure ◽  
Decoding Accuracy

AbstractBae & Luck (2018) reported a study of visual working memory in which the orientation being held in memory was decoded from the scalp distribution of sustained ERP activity and alpha-band EEG oscillations. Decoding accuracy was compared to chance at each point during the delay interval, and a correction for multiple comparisons was applied to find clusters of consecutive above-chance time points that were stronger than would be expected by chance. However, the correction used in that study did not account for the autocorrelation of the noise and may have been overly liberal. Here, we describe a more appropriate correction procedure and apply it to the data from Bae & Luck (2018). We find that the major clusters of time points that were significantly above chance with the original correction procedure remained above chance with the updated correction procedure. However, some minor clusters that were significant with the original procedure were no longer significant with the updated procedure. We recommend that future studies use the updated correction procedure.

scholarly journals Temporal Dynamics of Attention during Encoding versus Maintenance of Working Memory: Complementary Views from Event-related Potentials and Alpha-band Oscillations

2015 ◽  
Vol 27 (3) ◽  
pp. 492-508 ◽  
Author(s):  
Nicholas E. Myers ◽  
Lena Walther ◽  
George Wallis ◽  
Mark G. Stokes ◽  
Anna C. Nobre
Keyword(s):  
Working Memory ◽  
Visual Information ◽  
Temporal Dynamics ◽  
Recall Performance ◽  
Event Related Potentials ◽  
Alpha Band ◽  
Related Potentials ◽  
Frontoparietal Control Network ◽  
Anticipatory Attention ◽  
Processing Differences

Working memory (WM) is strongly influenced by attention. In visual WM tasks, recall performance can be improved by an attention-guiding cue presented before encoding (precue) or during maintenance (retrocue). Although precues and retrocues recruit a similar frontoparietal control network, the two are likely to exhibit some processing differences, because precues invite anticipation of upcoming information whereas retrocues may guide prioritization, protection, and selection of information already in mind. Here we explored the behavioral and electrophysiological differences between precueing and retrocueing in a new visual WM task designed to permit a direct comparison between cueing conditions. We found marked differences in ERP profiles between the precue and retrocue conditions. In line with precues primarily generating an anticipatory shift of attention toward the location of an upcoming item, we found a robust lateralization in late cue-evoked potentials associated with target anticipation. Retrocues elicited a different pattern of ERPs that was compatible with an early selection mechanism, but not with stimulus anticipation. In contrast to the distinct ERP patterns, alpha-band (8–14 Hz) lateralization was indistinguishable between cue types (reflecting, in both conditions, the location of the cued item). We speculate that, whereas alpha-band lateralization after a precue is likely to enable anticipatory attention, lateralization after a retrocue may instead enable the controlled spatiotopic access to recently encoded visual information.

scholarly journals Mathematics Skills and Executive Functions Following Preterm Birth: A Longitudinal Study of 5-to 7- Year Old Children

2019 ◽  
Author(s):  
Julia Anna Adrian ◽  
Frank Haist ◽  
Natacha Akshoomoff
Keyword(s):  
Working Memory ◽  
Executive Functions ◽  
Processing Speed ◽  
Spatial Working Memory ◽  
Working Memory Capacity ◽  
Full Term ◽  
Healthy Children ◽  
Time Points ◽  
Mathematics Skills ◽  
Increased Risk

Early mathematics skills are an important predictor of later academic, economic and personal success. Children born preterm, about 10% of the US population, have an increased risk of deficits in mathematics. These deficits may be related to lower levels of executive functions and processing speed. We investigated the development of mathematics skills, working memory, inhibitory control and processing speed of healthy children born very preterm (between 25 and 32 weeks gestational age, n=51) and full-term (n=29). Children were tested annually from ages 5 to 7 years. We found persistent lower overall mathematics skills in the preterm group, driven by differences in more informal skills (e.g. counting) at earlier time points, and by differences in more formal skills (e.g. calculation) at later time points. We did not find significant differences between preterm and full-term born children in spatial working memory capacity or processing speed. However, these cognitive measures were significant predictors of mathematics skills in the preterm but not the full-term group, hinting towards the use of different strategies when solving problems.

Intelligence and working memory systems: evidence of neural efficiency in alpha band ERD

2004 ◽  
Vol 20 (2) ◽  
pp. 212-225 ◽  
Author(s):  
R.H Grabner ◽  
A Fink ◽  
A Stipacek ◽  
C Neuper ◽  
A.C Neubauer
Keyword(s):  
Working Memory ◽  
Memory Systems ◽  
Alpha Band ◽  
Neural Efficiency

The different oscillation patterns of alpha band in the early and later stages of working memory maintenance

2016 ◽  
Vol 633 ◽  
pp. 220-226 ◽  
Author(s):  
Yuanjun Xie ◽  
Zhengquan Feng ◽  
Yuanyuan Xu ◽  
Chen Bian ◽  
Min Li
Keyword(s):  
Working Memory ◽  
Alpha Band

Discontinuation of Somatic Medication During Psychiatric Hospitalization

2014 ◽  
Vol 48 (11) ◽  
pp. 1415-1424 ◽  
Author(s):  
Heshu Abdullah-Koolmees ◽  
Helga Gardarsdottir ◽  
Lennart J. Stoker ◽  
Judith Vuyk ◽  
Toine C. G. Egberts ◽  
...  
Keyword(s):  
Crossover Study ◽  
Confidence Intervals ◽  
Index Date ◽  
Cox Regression ◽  
Psychiatric Hospitalization ◽  
The Other ◽  
Future Studies ◽  
Time Points ◽  
Relative Risks ◽  
Health Objective

Background: Psychiatric hospitalization can increase the risk of discontinuation of pharmacotherapy, which may negatively influence patients’ health. Objective: To investigate the association between psychiatric hospitalization and discontinuation of somatic medication. Methods: A retrospective crossover study was performed in patients admitted to a psychiatric hospital (index date), who had got somatic medication dispensed during the 3 months prior to hospitalization. Discontinuation of somatic medication was investigated at the following time points: index date and 3, 6, and 9 months before the index date. Relative risks (RR) with 95% confidence intervals (95% CIs) of discontinuing somatic medication at the index date versus the time points before the index date were estimated using Cox regression. Results: In all, 471 hospitalized patients were included in the study; 38.9% of the patients were discontinuers on the index date. RR for discontinuation of ≥1 somatic medication was 1.88 (95% CI = 1.55-2.27) at the index date compared with the other time points and highest for patients <45 years (RR = 2.83; 95% CI = 1.92-4.18). Conclusions: Psychiatric hospitalization was associated with an almost doubled risk of discontinuation of somatic medication. Future studies should address the influence of discontinuation of care on patients’ health.

Distinct effects of acute exercise and breaks in sitting on working memory and executive function in older adults: a three-arm, randomised cross-over trial to evaluate the effects of exercise with and without breaks in sitting on cognition

2019 ◽  
Vol 54 (13) ◽  
pp. 776-781 ◽  
Author(s):  
Michael J Wheeler ◽  
Daniel J Green ◽  
Kathryn A Ellis ◽  
Ester Cerin ◽  
Ilkka Heinonen ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Executive Function ◽  
Light Intensity ◽  
Visual Learning ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Intermittent Light ◽  
Time Points ◽  
Serum Bdnf

BackgroundSedentary behaviour is associated with impaired cognition, whereas exercise can acutely improve cognition.ObjectiveWe compared the effects of a morning bout of moderate-intensity exercise, with and without subsequent light-intensity walking breaks from sitting, on cognition in older adults.MethodsSedentary overweight/obese older adults with normal cognitive function (n=67, 67±7 years, 31.2±4.1 kg/m2) completed three conditions (6-day washout): SIT (sitting): uninterrupted sitting (8 hours, control); EX+SIT (exercise + sitting): sitting (1 hour), moderate-intensity walking (30 min), uninterrupted sitting (6.5 hours); and EX+BR (exercise + breaks): sitting (1 hour), moderate-intensity walking (30 min), sitting interrupted every 30 min with 3 min of light-intensity walking (6.5 hours). Cognitive testing (Cogstate) was completed at four time points assessing psychomotor function, attention, executive function, visual learning and working memory. Serum brain-derived neurotrophic growth factor (BDNF) was assessed at six time points. The 8-hour net area under the curve (AUC) was calculated for each outcome.ResultsWorking memory net AUC z-score·hour (95% CI) was improved in EX+BR with a z-score of +28 (−26 to +81), relative to SIT, −25 (−79 to +29, p=0.04 vs EX+BR). Executive function net AUC was improved in EX+SIT, −8 (− 71 to +55), relative to SIT, −80 (−142 to −17, p=0.03 vs EX+SIT). Serum BDNF net AUC ng/mL·hour (95% CI) was increased in both EX+SIT, +171 (−449 to +791, p=0.03 vs SIT), and EX+BR, +139 (−481 to +759, p=0.045 vs SIT), relative to SIT, −227 (−851 to +396).ConclusionA morning bout of moderate-intensity exercise improves serum BDNF and working memory or executive function in older adults, depending on whether or not subsequent sitting is also interrupted with intermittent light-intensity walking.Trial registration numberACTRN12614000737639.

scholarly journals Multiple types of navigational information are independently encoded in the population activities of the dentate gyrus neurons

2020 ◽  
Author(s):  
Tomoyuki Murano ◽  
Ryuichi Nakajima ◽  
Akito Nakao ◽  
Nao Hirata ◽  
Satoko Amemori ◽  
...  
Keyword(s):  
Machine Learning ◽  
Working Memory ◽  
Dentate Gyrus ◽  
Open Field ◽  
Activity Patterns ◽  
Spatial Coding ◽  
Motion Direction ◽  
Freely Moving ◽  
Types Of Information ◽  
Decoding Accuracy

AbstractThe dentate gyrus (DG) plays critical roles in cognitive functions such as learning, memory, and spatial coding, and its dysfunction is implicated in various neuropsychiatric disorders. However, it remains largely unknown how information is represented in this region. Here, we recorded neuronal activity in the DG using Ca2+ imaging in freely moving mice and analysed this activity using machine learning. The activity patterns of populations of DG neurons enabled us to successfully decode position, speed, and motion direction in an open field as well as current and future location in a T-maze, and each individual neuron was diversely and independently tuned to these multiple information types. In αCaMKII heterozygous knockout mice, which present deficits in spatial remote and working memory, the decoding accuracy of position in the open field and future location in the T-maze were selectively reduced. These results suggest that multiple types of information are independently distributed in DG neurons.

scholarly journals Emergence of stable sensory and dynamic temporal representations in the hippocampus during working memory

2018 ◽  
Author(s):  
Jiannis Taxidis ◽  
Eftychios Pnevmatikakis ◽  
Apoorva L. Mylavarapu ◽  
Jagmeet S. Arora ◽  
Kian D. Samadian ◽  
...  
Keyword(s):  
Working Memory ◽  
Calcium Imaging ◽  
Delay Time ◽  
Memory Task ◽  
Olfactory Cues ◽  
Sensory Cues ◽  
Time Points ◽  
Two Photon ◽  
Passive Exposure ◽  
Hippocampal Networks

ABSTRACTHippocampal networks form maps of experience through spiking sequences that encode sensory cues, space or time. But whether distinct rules govern the emergence, stability and plasticity of externally driven and internally-generated representations remains unclear. Using two-photon calcium imaging, we recorded CA1 pyramidal populations across multiple days, while mice learned and performed an olfactory, delayed, working-memory task. We observed anatomically intermixed spiking sequences, comprised of ‘odor-cells’ encoding olfactory cues, followed by ‘time-cells’ encoding odor-specific delay time-points. Odor-cells were reliably activated across trials and retained stable fields over days and different delays. In contrast, time-cells exhibited sparse, unreliable activation and labile fields that remapped over days and extended delays. Moreover, the number of odor-cells remained stable, whereas time-cells increased over days during learning of the task, but not during passive exposure. Therefore, multi-modal representations with distinct learning-related dynamics and stability can co-exist in CA1, likely driven by different neurophysiological and plasticity mechanisms.

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