scholarly journals Predicting the genetic ancestry of 2.6 million New York City patients using clinical data

2019 ◽  
Author(s):  
Vijendra Ramlall ◽  
Kayla M. Quinnies ◽  
Rami Vanguri ◽  
Tal Lorberbaum ◽  
David B. Goldstein ◽  
...  
Keyword(s):  
New York ◽  
Clinical Data ◽  
Race And Ethnicity ◽  
Medical Center ◽  
Clinical Care ◽  
Clinical Information ◽  
Genetic Ancestry ◽  
Columbia University ◽  
Reduction Techniques ◽  
Dimensionality Reduction Techniques

AbstractAncestry is an essential covariate in clinical genomics research. When genetic data are available, dimensionality reduction techniques, such as principal components analysis, are used to determine ancestry in complex populations. Unfortunately, these data are not always available in the clinical and research settings. For example, electronic health records (EHRs), which are a rich source of temporal human disease data that could be used to enhance genetic studies, do not directly capture ancestry. Here, we present a novel algorithm for predicting genetic ancestry using only variables that are routinely captured in EHRs, such as self-reported race and ethnicity, and condition billing codes. Using patients that have both genetic and clinical information at Columbia University/ New York-Presbyterian Irving Medical Center, we developed a pipeline that uses only clinical data to predict the genetic ancestry of all patients of which more than 80% identify as other or unknown. Our ancestry estimates can be used in observational studies of disease inheritance, to guide genetic cohort studies, or to explore health disparities in clinical care and outcomes.

scholarly journals Association of Race and Ethnicity With Comorbidities and Survival Among Patients With COVID-19 at an Urban Medical Center in New York

2020 ◽  
Vol 3 (9) ◽  
pp. e2019795 ◽  
Author(s):  
Rafi Kabarriti ◽  
N. Patrik Brodin ◽  
Maxim I. Maron ◽  
Chandan Guha ◽  
Shalom Kalnicki ◽  
...  
Keyword(s):  
New York ◽  
Race And Ethnicity ◽  
Medical Center

scholarly journals Medical Informatics Training at Columbia University and the Columbia-Presbyterian Medical Center

1995 ◽  
Vol 04 (01) ◽  
pp. 125-129
Author(s):  
B. A. Allen ◽  
P. D. Clayton ◽  
J. J. Cimino
Keyword(s):  
Medical Informatics ◽  
Medical Center ◽  
Clinical Information ◽  
Information Management System ◽  
Advanced Technology ◽  
Columbia University ◽  
Postdoctoral Training ◽  
Unified Medical Language System ◽  
Part Time Faculty ◽  
Part Time

Abstract:The Department of Medical Informatics at Columbia University College of Physicians and Surgeons consists of a faculty of 17 full-and part-time faculty. The Department faculty collaborate with the Department of Computer Science and several clinical departments of the medical center. We offer courses in medical informatics, formal degrees (M.A., M.Phil. and Ph.D.) and a postdoctoral training program. In addition to academic offerings, the close affiliation with the Columbia-Presbyterian Medical Center and the primary responsibilities for clinical information systems offers trainees unique opportunities to work with and develop real-world applications. Faculty research programs include work on the Integrated Advanced Information Management System (IAIMS), Unified Medical Language System (UMLS), High-Perfor-mance Computing and Communications (HPCC), Electronic Medical Records, automated decision support and technology transfer through the Center for Advanced Technology.

Emergency Utilization and Trends in a Community Dental Clinic in Northern Manhattan: A Retrospective Study

2020 ◽  
Vol 44 (3) ◽  
pp. 135-141
Author(s):  
Evan Cyrkin ◽  
Aaron Myers ◽  
Jaffer Shariff ◽  
Richard Yoon
Keyword(s):  
New York ◽  
Medical Center ◽  
Columbia University ◽  
Dental Clinic ◽  
Chi Square ◽  
Design Data ◽  
Frequency Distributions ◽  
Chi Square Test ◽  
Dental Records ◽  
First Time

Purpose: To evaluate utilization and trends associated with patients who presented with emergencies at a community dental clinic at Columbia University Medical Center, New York, NY. Study design: Data from deidentified dental records of patients aged 0–12 years old who presented as emergencies for oral and dental reasons for 2012, 2013, and 2014 were collected. Variables analyzed included demographic information, oral diagnosis, and current health status. Frequency distributions analysis, chi-square test and analysis of variance (ANOVA) test were performed using Stata 13.0. Results: There were 4,328 dental and oral-related emergencies with a mean age of 6-years-old. Approximately 50% were females, 71% were Hispanic, and 90% had Medicaid managed care. Most emergencies (49%) were caries-related, 41% were considered atraumatic in nature, and approximately 10% were traumatic. About 10% of patients presented with comorbidities and 37% were either first-time patients or patients that presented exclusively for emergencies. Acute tooth pain (45%) caused by dental caries was the most common chief complaint. The trends for emergency presentations showed a significant decrease (p<.001) between years 2012–2014 for caries-related visits and a significant increase (p<.001) between 2012–2013 and 2012–2014 for atraumatic visits. Conclusions: Caries-related dental diagnoses were more common than trauma-related diagnoses. The most common caries-related diagnosis was pulp necrosis for both primary and permanent dentitions while the most common traumarelated diagnosis was subluxation for the primary dentition and enamel-dentin fracture for the permanent dentition.

Utility of a cervical spine clearance protocol after trauma in children between 0 and 3 years of age

2010 ◽  
Vol 5 (3) ◽  
pp. 292-296 ◽  
Author(s):  
Richard C. E. Anderson ◽  
Peter Kan ◽  
Monique Vanaman ◽  
Jeanne Rubsam ◽  
Kristine W. Hansen ◽  
...  
Keyword(s):  
New York ◽  
Cervical Spine ◽  
Salt Lake ◽  
Medical Center ◽  
Pediatric Trauma ◽  
Salt Lake City ◽  
Young Patients ◽  
Clinical Information ◽  
Severe Injuries ◽  
Cervical Spine Injuries

Object Cervical spine clearance after trauma in children 0–3 years of age is deceptively difficult. Young children may not be able to communicate effectively, and severe injuries may require intubation and sedation. Currently, no published guidelines are available to aid in decision-making in these complex situations. The purpose of this study was to determine whether a safe and effective protocol-driven system could be developed for clearance of the cervical spine in noncommunicative children between 0 and 3 years of age. Methods Children 0–3 years of age, including intubated patients, who were admitted after trauma activation at Primary Children's Medical Center in Salt Lake City or the Children's Hospital of New York from 2002 to 2006 were managed according to a cervical spine clearance protocol. Data were collected in a prospective fashion. Radiographic and clinical methods of clearing the cervical spine, as well as the type and management of injuries, were recorded. Results A total of 2828 pediatric trauma activations required cervical spine clearance during the study period. Of these, 575 (20%) were children ≤ 3 years of age who were admitted to the hospital. To facilitate clearing the cervical spine in these children, plain radiographs (100%), CT studies (14%), and MR images (10%) were obtained. Nineteen ligamentous injuries (3.3%) and 9 fractures/dislocations (1.5%) were detected, with 4 patients requiring operative stabilization (0.7%). No late injuries have been detected. Conclusions The protocol used has been effective in detecting cervical spine injuries in noncommunicative children after trauma. The combination of clinical information and radiographic studies is essential for safely clearing the cervical spine in these complex situations. Clearance of the cervical spine without CT or MR imaging studies is possible in the majority of cases, even in very young patients.

Small-Bowel Allograft Biopsies in the Management of Small-Intestinal and Multivisceral Transplant Recipients: Histopathologic Review and Clinical Correlations

2012 ◽  
Vol 136 (7) ◽  
pp. 761-771 ◽  
Author(s):  
Helen Remotti ◽  
Sukanya Subramanian ◽  
Mercedes Martinez ◽  
Tomoaki Kato ◽  
Margret S. Magid
Keyword(s):  
New York ◽  
Small Bowel ◽  
Clinical Laboratory ◽  
Medical Center ◽  
Small Bowel Transplantation ◽  
Intestinal Failure ◽  
Lymphoproliferative Disease ◽  
Close Monitoring ◽  
Columbia University ◽  
Barr Virus

Context.—Intestinal transplant has become a standard treatment option in the management of patients with irreversible intestinal failure. The histologic evaluation of small-bowel allograft biopsy specimens plays a central role in assessing the integrity of the graft. It is essential for the management of acute cellular and chronic rejection; detection of infections, particularly with respect to specific viruses (cytomegalovirus, adenovirus, Epstein-Barr virus); and immunosuppression-related lymphoproliferative disease. Objective.—To provide a comprehensive review of the literature and illustrate key histologic findings in small-bowel biopsy specimen evaluation of patients with small-bowel or multivisceral transplants. Data Sources.—Literature review using PubMed (US National Library of Medicine) and data obtained from national and international transplant registries in addition to case material at Columbia University, Presbyterian Hospital, and Mount Sinai Medical Center, New York, New York. Conclusions.—Key to the success of small-bowel transplantation and multivisceral transplantation are the close monitoring and appropriate clinical management of patients in the posttransplant period, requiring coordinated input from all members of the transplant team with the integration of clinical, laboratory, and histopathologic parameters.

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