scholarly journals A comparison of neuronal population dynamics measured with calcium imaging and electrophysiology

2019 ◽  
Author(s):  
Ziqiang Wei ◽  
Bei-Jung Lin ◽  
Tsai-Wen Chen ◽  
Kayvon Daie ◽  
Karel Svoboda ◽  
...  

SummaryCalcium imaging with fluorescent protein sensors is widely used to record activity in neuronal populations. The transform between neural activity and calcium-related fluorescence involves nonlinearities and a low-pass filter, but the effects of the transformation on analyses of neural populations are not well understood. We compared neuronal spikes and fluorescence in matched neural populations in behaving mice. We report multiple discrepancies between analyses performed on the two types of data, which were only partially resolved by spike inference algorithms applied to fluorescence. To model the relation between spiking and fluorescence we simultaneously recorded spikes and fluorescence from individual neurons. Using these recordings we developed a model transforming spike trains to synthetic-imaging data. The model recapitulated the differences in analyses. Our analysis highlights challenges in relating electrophysiology and imaging data, and suggests forward modeling as an effective way to understand differences between these data.


2017 ◽  
Vol E100.C (10) ◽  
pp. 858-865 ◽  
Author(s):  
Yohei MORISHITA ◽  
Koichi MIZUNO ◽  
Junji SATO ◽  
Koji TAKINAMI ◽  
Kazuaki TAKAHASHI


2016 ◽  
Vol 15 (12) ◽  
pp. 2579-2586
Author(s):  
Adina Racasan ◽  
Calin Munteanu ◽  
Vasile Topa ◽  
Claudia Pacurar ◽  
Claudia Hebedean




Author(s):  
Nanan Chomnak ◽  
Siradanai Srisamranrungrueang ◽  
Natapong Wongprommoon
Keyword(s):  


Sensors ◽  
2021 ◽  
Vol 21 (13) ◽  
pp. 4305
Author(s):  
Takamasa Terada ◽  
Masahiro Toyoura ◽  
Takahide Sato ◽  
Xiaoyang Mao

In this work, we propose a fabric electrode with a special structure that can play the role of a noise reduction filter. Fabric electrodes made of the conductive fabric have been used for long-term ECG measurements because of their flexibility and non-invasiveness; however, due to the large impedance between the skin and the fabric electrodes, noise is easily introduced into the ECG signal. In contrast to conventional work, in which chip-type passive elements are glued to the electrode to reduce noise, the proposed electrode can obtain a noise-reduced ECG by changing the structure of fabric. Specifically, the proposed electrode was folded multiple times to form a capacitor with a capacitance of about 3 nF. It is combined with the skin-electrode impedance to form a low-pass filter. In the experiment, we made a prototype of the electrodes and measured ECG at rest and during EMG-induced exercise. As a result, the SNR values at rest and during exercise were improved about 12.02 and 10.29 , respectively, compared with the fabric electrode without special structure. In conclusion, we have shown that changing the fabric electrode structure effectively removes noise in ECG measurement.



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