High-frequency pacing of scroll waves in a three-dimensional slab model of cardiac tissue

2021 ◽  
Vol 103 (4) ◽  
Author(s):  
Sergei F. Pravdin ◽  
Timur V. Nezlobinsky ◽  
Alexander V. Panfilov ◽  
Hans Dierckx
Keyword(s):  
High Frequency ◽  
Cardiac Tissue ◽  
Three Dimensional ◽  
Slab Model ◽  
Scroll Waves

scholarly journals Polymeric Biomaterials for the Treatment of Cardiac Post-Infarction Injuries

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1038
Author(s):  
Sonia Trombino ◽  
Federica Curcio ◽  
Roberta Cassano ◽  
Manuela Curcio ◽  
Giuseppe Cirillo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cardiac Tissue ◽  
Polymeric Nanoparticles ◽  
Three Dimensional ◽  
Cardiac Regeneration ◽  
Biological Properties ◽  
Positive Influence ◽  
Regenerative Process ◽  
Current Status ◽  
Polymeric Biomaterials

Cardiac regeneration aims to reconstruct the heart contractile mass, preventing the organ from a progressive functional deterioration, by delivering pro-regenerative cells, drugs, or growth factors to the site of injury. In recent years, scientific research focused the attention on tissue engineering for the regeneration of cardiac infarct tissue, and biomaterials able to anatomically and physiologically adapt to the heart muscle have been proposed as valuable tools for this purpose, providing the cells with the stimuli necessary to initiate a complete regenerative process. An ideal biomaterial for cardiac tissue regeneration should have a positive influence on the biomechanical, biochemical, and biological properties of tissues and cells; perfectly reflect the morphology and functionality of the native myocardium; and be mechanically stable, with a suitable thickness. Among others, engineered hydrogels, three-dimensional polymeric systems made from synthetic and natural biomaterials, have attracted much interest for cardiac post-infarction therapy. In addition, biocompatible nanosystems, and polymeric nanoparticles in particular, have been explored in preclinical studies as drug delivery and tissue engineering platforms for the treatment of cardiovascular diseases. This review focused on the most employed natural and synthetic biomaterials in cardiac regeneration, paying particular attention to the contribution of Italian research groups in this field, the fabrication techniques, and the current status of the clinical trials.

Abstract 020: Cell-sheet-based Bioengineered Human Cardiac Tissue Using Pluripotent Stem Cells For Heart Repair And Disease Models

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
Katsuhisa Matsuura ◽  
Tatsuya Shimizu ◽  
Nobuhisa Hagiwara ◽  
Teruo Okano
Keyword(s):  
Cardiac Tissue ◽  
Subcutaneous Tissue ◽  
Cell Sheet ◽  
Three Dimensional ◽  
Embryoid Bodies ◽  
Cardiac Differentiation ◽  
Cardiac Cell ◽  
Cell Sheets ◽  
High Efficient ◽  
Human Cardiac Tissue

We have developed an original scaffold-free tissue engineering approach, “cell sheet engineering”, and this technology has been already applied to regenerative medicine of various organs including heart. As the bioengineered three-dimensional cardiac tissue is expected to not only function for repairing the broad injured heart but also to be the practicable heart tissue models, we have developed the cell sheet-based perfusable bioengineered three-dimensional cardiac tissue. Recently we have also developed the unique suspension cultivation system for the high-efficient cardiac differentiation of human iPS cells. Fourteen-day culture with the serial treatments of suitable growth factors and a small compound in this stirring system with the suitable dissolved oxygen concentration produced robust embryoid bodies that showed the spontaneous beating and were mainly composed of cardiomyocytes (~80%). When these differentiated cells were cultured on temperature-responsive culture dishes after the enzymatic dissociation, the spontaneous and synchronous beating was observed accompanied with the intracellular calcium influx all over the area even after cell were detached from culture dishes as cell sheets by lowering the culture temperature. The cardiac cell sheets were mainly composed of cardiomyocytes (~80%) and partially mural cells (~20%). Furthermore, extracellular action potential propagation was observed between cell sheets when two cardiac cell sheets were partially overlaid, and this propagation was inhibited by the treatment with some anti-arrhythmic drugs. When the triple layered cardiac tissue was transplanted onto the subcutaneous tissue of nude rats, the spontaneous pulsation was observed over 2 months and engrafted cardiomyocytes were vascularized with the host tissue-derived endothelial cells. These findings suggest that cardiac cell sheets formed by hiPSC-derived cardiomyocytes might have sufficient properties for the creation of thickened cardiac tissue. Now we are developing the vascularized thickened human cardiac tissue by the repeated layering of cardiac cell sheets on the artificial vascular bed in vitro.

scholarly journals Intermetallic REPtZn Compounds with TiNiSi-type Structure

2011 ◽  
Vol 66 (7) ◽  
pp. 671-676 ◽  
Author(s):  
Trinath Mishra ◽  
Rainer Pöttgen
Keyword(s):  
Rare Earth ◽  
Single Crystal ◽  
Coordination Number ◽  
High Frequency ◽  
Three Dimensional ◽  
Type Structure ◽  
Rare Earth Compounds ◽  
Crystal Data ◽  
X Ray Diffraction ◽  
X Ray

The equiatomic rare earth compounds REPtZn (RE = Y, Pr, Nd, Gd-Tm) were synthesized from the elements in sealed tantalum tubes by high-frequency melting at 1500 K followed by annealing at 1120 K and quenching. The samples were characterized by powder X-ray diffraction. The structures of four crystals were refined from single-crystal diffractometer data: TiNiSi type, Pnma, a = 707.1(1), b = 430.0(1), c = 812.4(1) pm, wR2 = 0.066, 602 F2, 21 variables for PrPt1.056Zn0.944; a = 695.2(1), b = 419.9(1), c = 804.8(1) pm, wR2 = 0.041, 522 F2, 21 variables for GdPt0.941Zn1.059; a = 688.2(1), b = 408.1(1), c = 812.5(1) pm, wR2 = 0.041, 497 F2, 22 variables for HoPt1.055Zn0.945; a = 686.9(1), b = 407.8(1), c = 810.4(1) pm, wR2 = 0.061, 779 F2, 20 variables for ErPtZn. The single-crystal data indicate small homogeneity ranges REPt1±xZn1±x. The platinum and zinc atoms build up three-dimensional [PtZn] networks (265 - 269 pm Pt-Zn in ErPtZn) in which the erbium atoms fill cages with coordination number 16 (6 Pt + 6 Zn + 4 Er). Bonding of the erbium atoms to the [PtZn] network proceeds via shorter RE-Pt distances, i. e. 288 - 293 pm in ErPtZn.

A Video Super Resolution Algorithm Based on Wavelet Coefficient

2014 ◽  
Vol 610 ◽  
pp. 425-428
Author(s):  
Wei Jian Liu ◽  
Si Da Xiao ◽  
Ruo He Yao
Keyword(s):  
High Frequency ◽  
Wavelet Coefficient ◽  
Three Dimensional ◽  
Super Resolution ◽  
Structural Similarity ◽  
Image Sequences ◽  
Discrete Wavelet ◽  
Resolution Image ◽  
Resolution Algorithm ◽  
Visual Results

In this paper, we propose a new super-resolution algorithm based on wavelet coefficient. The proposed algorithm uses discrete wavelet transform (DWT) to decompose the input low-resolution image sequences into four subband images, including LL, LH, HL, HH. Then the input images have been processed by the 3DSKR (Three Dimensional Steering Kernel Regression) super resolution (SR) algorithm, and the result replaces the LL subband image, while the three high-frequency subband images have been interpolated. Finally, combining all these images to generate a new high-resolution image by using inverse DWT. Proposed method has been verified on Calendar and Foliage by Matlab software platform. The peak signal-to-noise (PSNR), structural similarity (SSIM) and visual results are compared, and show that the computational complexity of the proposed algorithm decline by 30 percent compared with the existing algorithm to obtain the approximate results.

scholarly journals Modulation of Near-Inertial Oscillations by Low-Frequency Current Variations on the Inner Scotian Shelf

2019 ◽  
Vol 49 (2) ◽  
pp. 329-352 ◽  
Author(s):  
Pengcheng Wang ◽  
Zhongjie He ◽  
Keith R. Thompson ◽  
Jinyu Sheng
Keyword(s):  
High Frequency ◽  
Spatial Scales ◽  
Slab Model ◽  
Boundary Current ◽  
Scotian Shelf ◽  
Inertial Oscillations ◽  
Study Region ◽  
Shelf Circulation ◽  
High Frequency Radar ◽  
Adcp Observations

AbstractNear-inertial oscillations (NIOs) on the inner Scotian shelf are studied using observations, a simple slab model, and two operational shelf circulation models. High-frequency radar and ADCP observations from December 2015 to February 2016 show that individual NIO events forced by time-varying wind stress typically lasted for three to four inertial periods. NIOs with speeds exceeding 0.25 m s−1 were observed in the offshore part of the study region, but their amplitudes decreased shoreward within ~40 km of the coast. The NIOs had spatial scales of ~80 and ~40 km in the alongshore and cross-shore directions, respectively. The NIO phases varied moving from west to east, consistent with the typical movement of winter storms across the study region. Evolving rotary spectral analysis reveals that the peak frequency fp of the NIOs varied with time by ~7% of the local inertial frequency. The variation in fp can be explained in part by local wind forcing as demonstrated by the slab model. The remaining variation in fp can be explained in part by variations in the background vorticity associated with changes in the strength and position of the Nova Scotia Current, an unstable baroclinic boundary current that runs along the coast to the southwest. Two operational shelf circulation models are used to examine the abovementioned features in the high-frequency-radar and ADCP observations. The models reproduce the spatial structure of the NIOs and, in a qualitative sense, the temporal variations of fp.

scholarly journals The Three-Dimensional Locating of VHF Broadband Lightning Interferometers

Atmosphere ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 317 ◽  
Author(s):  
Hengyi Liu ◽  
Shi Qiu ◽  
Wansheng Dong
Keyword(s):  
Time Resolution ◽  
High Frequency ◽  
Three Dimensional ◽  
High Time Resolution ◽  
Very High Frequency ◽  
Time Difference Of Arrival ◽  
Lightning Discharges ◽  
Total Lightning ◽  
Locating Information ◽  
Very High

VHF (Very High Frequency) lightning interferometers can locate and observe lightning discharges with a high time resolution. Especially the appearance of continuous interferometers makes the 2-D location of interferometers further improve in time resolution and completeness. However, there is uncertainty in the conclusion obtained by simply analyzing the 2-D locating information. Without the support of other 3-D total lightning locating networks, the 2-station interferometer becomes an option to obtain 3-D information. This paper introduces a 3-D lightning location method of a 2-station broadband interferometer, which uses the theodolite wind measurement method for reference, and gives the simulation results of the location accuracy. Finally, using the multi-baseline continuous 2-D locating method and the 3-D locating method, the locating results of one intra-cloud flash and the statistical results of the initiation heights of 61 cloud-to-ground flashes and 80 intra-cloud flashes are given. The results show that the two-station interferometer has high observation accuracy on both sides of the connection between the two sites. The locating accuracy will deteriorate as the distance between the radiation source and the two stations increases or the height decreases. The actual locating results are similar to those of the existing VHF TDOA (Time Difference of Arrival) lightning locating network.

Sign in / Sign up

Export Citation Format

Share Document